Opendata, web and dolomites


Advanced XFEL and Synchrotron based Probes of Protein Structure and Dynamics

Total Cost €


EC-Contrib. €






 X-probe project word cloud

Explore the words cloud of the X-probe project. It provides you a very rough idea of what is the project "X-probe" about.

fundamental    dynamics    disciplinary    regime    creates    network    building    engineers    pharmacology    created    biologists    ultrafast    cutting    insights    experimental    marie    proteins    advancements    photochemistry    training    cross    trained    lag    industrial    probe    swissfel    physical    close    maxiv    transformative    laboratories    structure    curie    developers    operative    serial    crystallography    soon    time    beamline    principal    tools    extract    academic    versed    small    generation    visionary    meet    electron    damage    edge    demands    cooperation    esrf    yield    female    radiation    dependent    nanotechnology    scientists    builds    ray    possibilities    facilities    free    laboratory    protein    technological    scientific    incorporates    changing    exist    separate    xfel    diverse    chemists    sources    forefront    femtosecond    interdisciplinary    intersectorial    biology    software    revolutionary    structural    entirely    individual    laser    innovative    young   

Project "X-probe" data sheet

The following table provides information about the project.


Organization address
address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 2˙331˙284 €
 EC max contribution 2˙331˙284 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    ASTRAZENECA AB SE (SODERTAELJE) participant 263˙659.00
3    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 263˙659.00
4    LUNDS UNIVERSITET SE (LUND) participant 263˙659.00
7    MOLIROM SRL IT (ROMA) participant 258˙061.00
8    UNIVERSITAET HAMBURG DE (HAMBURG) participant 249˙216.00
9    XTAL CONCEPTS GMBH DE (HAMBURG) participant 249˙216.00


 Project objective

This cross-disciplinary Marie Curie Innovative Training Network builds upon the transformative opportunities created by existing X-ray sources and new sources soon to be operative in Europe. These opportunities include using ultrafast X-ray sources to extract time-dependent structural information from proteins; and revolutionary possibilities created by X-ray Free Electron Laser radiation for an entirely new regime of pre-damage serial femtosecond crystallography. No lag should exist between building new sources and training the next generation of scientists well versed in using these facilities. Our research training will yield new scientific insights on fundamental properties of protein structure and dynamics: one of the most challenging problems in structural biology; and technological advancements in diverse fields from pharmacology to nanotechnology. X-probe creates close interdisciplinary collaboration between structural biologists, physical chemists, beamline engineers, software developers, and industrial partners. The rapidly changing state-of-the-art demands that young researchers are trained to meet these new experimental, technical and analysis challenges at the forefront of structural biology and photochemistry. X-probe’s interdisciplinary and intersectorial training network incorporates four leading European X-ray facilities (ESRF, MAXIV Laboratory, European XFEL, SwissFEL); three academic laboratories at the forefront developing X-ray tools to probe protein dynamics; and both large and small industrial partners. Four principal scientists in X-probe are female. X-probe builds close cooperation between traditionally separate fields of research at the very cutting edge of structural biology and creates a visionary training network that would not be possible within any of the individual partner states.


List of deliverables.
WAXS software suite Documents, reports 2019-09-09 11:37:55
International Final Conference Other 2019-09-09 11:37:55
Mid-term Dissemination and exploitation plan Documents, reports 2019-09-09 11:37:54
Short pulsed facility Documents, reports 2019-09-09 11:37:55
Micro crystals of light sensitive proteins Documents, reports 2019-09-09 11:37:55
New tools for nano-crystallography Demonstrators, pilots, prototypes 2019-09-09 11:37:54
Publish time-resolved diffraction/WAXS Documents, reports 2019-09-09 11:37:55
Publish novel structural insights Documents, reports 2019-09-09 11:37:54
Software packages for analysing X-ray diffraction Demonstrators, pilots, prototypes 2019-09-09 11:37:55
Crystallization of light sensitive proteins Documents, reports 2019-09-09 11:37:55
Final Dissemination and exploitation plan Documents, reports 2019-09-09 11:37:55
Website Websites, patent fillings, videos etc. 2019-09-09 11:37:53

Take a look to the deliverables list in detail:  detailed list of X-probe deliverables.


year authors and title journal last update
List of publications.
2018 Jenny Hering, Elin Dunevall, Margareta Ek, Gisela Brändén
Structural basis for selective inhibition of antibacterial target MraY, a membrane-bound enzyme involved in peptidoglycan synthesis
published pages: 1426-1435, ISSN: 1359-6446, DOI: 10.1016/j.drudis.2018.05.020
Drug Discovery Today 23/7 2019-09-09
2018 Daniela Baitan, Robin Schubert, Arne Meyer, Karsten Dierks, Markus Perbandt, Christian Betzel
Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
published pages: , ISSN: 1940-087X, DOI: 10.3791/57070
Journal of Visualized Experiments 138 2019-09-09
2019 Cécile Exertier, Lisa Milazzo, Ida Freda, Linda Celeste Montemiglio, Antonella Scaglione, Gabriele Cerutti, Giacomo Parisi, Massimiliano Anselmi, Giulietta Smulevich, Carmelinda Savino, Beatrice Vallone
Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41780-3
Scientific Reports 9/1 2019-09-09
2018 Przemyslaw Nogly, Tobias Weinert, Daniel James, Sergio Carbajo, Dmitry Ozerov, Antonia Furrer, Dardan Gashi, Veniamin Borin, Petr Skopintsev, Kathrin Jaeger, Karol Nass, Petra Båth, Robert Bosman, Jason Koglin, Matthew Seaberg, Thomas Lane, Demet Kekilli, Steffen Brünle, Tomoyuki Tanaka, Wenting Wu, Christopher Milne, Thomas White, Anton Barty, Uwe Weierstall, Valerie Panneels, Eriko Nango, So Iwata, Mark Hunter, Igor Schapiro, Gebhard Schertler, Richard Neutze, Jörg Standfuss
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser
published pages: eaat0094, ISSN: 0036-8075, DOI: 10.1126/science.aat0094
Science 2019-09-09
2018 Lorenzo Calisti, Matilde Cardoso Trabuco, Alberto Boffi, Claudia Testi, Linda Celeste Montemiglio, Amédée des Georges, Irene Benni, Andrea Ilari, Bartłomiej Taciak, Maciej Białasek, Tomasz Rygiel, Magdalena Król, Paola Baiocco, Alessandra Bonamore
Engineered ferritin for lanthanide binding
published pages: e0201859, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0201859
PLOS ONE 13/8 2019-09-09
2017 Lorenzo Calisti, Irene Benni, Matilde Cardoso Trabuco, Paola Baiocco, Barbara Ruzicka, Alberto Boffi, Elisabetta Falvo, Francesco Malatesta, Alessandra Bonamore
Probing bulky ligand entry in engineered archaeal ferritins
published pages: 450-456, ISSN: 0304-4165, DOI: 10.1016/j.bbagen.2016.10.007
Biochimica et Biophysica Acta (BBA) - General Subjects 1861/2 2019-09-09
2017 Dominik Oberthuer, Juraj Knoška, Max O. Wiedorn, Kenneth R. Beyerlein, David A. Bushnell, Elena G. Kovaleva, Michael Heymann, Lars Gumprecht, Richard A. Kirian, Anton Barty, Valerio Mariani, Aleksandra Tolstikova, Luigi Adriano, Salah Awel, Miriam Barthelmess, Katerina Dörner, P. Lourdu Xavier, Oleksandr Yefanov, Daniel R. James, Garrett Nelson, Dingjie Wang, George Calvey, Yujie Chen, Andrea Schmidt, Michael Szczepek, Stefan Frielingsdorf, Oliver Lenz, Edward Snell, Philip J. Robinson, Božidar Šarler, Grega Belšak, Marjan Maček, Fabian Wilde, Andrew Aquila, Sébastien Boutet, Mengning Liang, Mark S. Hunter, Patrick Scheerer, John D. Lipscomb, Uwe Weierstall, Roger D. Kornberg, John C. H. Spence, Lois Pollack, Henry N. Chapman, Saša Bajt
Double-flow focused liquid injector for efficient serial femtosecond crystallography
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep44628
Scientific Reports 7/1 2019-09-09
2016 Thomas A. White, Valerio Mariani, Wolfgang Brehm, Oleksandr Yefanov, Anton Barty, Kenneth R. Beyerlein, Fedor Chervinskii, Lorenzo Galli, Cornelius Gati, Takanori Nakane, Alexandra Tolstikova, Keitaro Yamashita, Chun Hong Yoon, Kay Diederichs, Henry N. Chapman
Recent developments in CrystFEL
published pages: 680-689, ISSN: 1600-5767, DOI: 10.1107/s1600576716004751
Journal of Applied Crystallography 49/2 2019-09-09
2018 Salah Awel, Richard A. Kirian, Max O. Wiedorn, Kenneth R. Beyerlein, Nils Roth, Daniel A. Horke, Dominik Oberthür, Juraj Knoska, Valerio Mariani, Andrew Morgan, Luigi Adriano, Alexandra Tolstikova, P. Lourdu Xavier, Oleksandr Yefanov, Andrew Aquila, Anton Barty, Shatabdi Roy-Chowdhury, Mark S. Hunter, Daniel James, Joseph S. Robinson, Uwe Weierstall, Andrei V. Rode, Saša Bajt, Jochen Küpper, Henry N. Chapman
Femtosecond X-ray diffraction from an aerosolized beam of protein nanocrystals
published pages: 133-139, ISSN: 1600-5767, DOI: 10.1107/s1600576717018131
Journal of Applied Crystallography 51/1 2019-09-09
2015 Valérie Panneels, Wenting Wu, Ching-Ju Tsai, Przemek Nogly, Jan Rheinberger, Kathrin Jaeger, Gregor Cicchetti, Cornelius Gati, Leonhard M. Kick, Leonardo Sala, Guido Capitani, Chris Milne, Celestino Padeste, Bill Pedrini, Xiao-Dan Li, Jörg Standfuss, Rafael Abela, Gebhard Schertler
Time-resolved structural studies with serial crystallography: A new light on retinal proteins
published pages: 41718, ISSN: 2329-7778, DOI: 10.1063/1.4922774
Structural Dynamics 2/4 2019-09-09
2018 Max O. Wiedorn, Dominik Oberthür, Richard Bean, Robin Schubert, Nadine Werner, Brian Abbey, Martin Aepfelbacher, Luigi Adriano, Aschkan Allahgholi, Nasser Al-Qudami, Jakob Andreasson, Steve Aplin, Salah Awel, Kartik Ayyer, Saša Bajt, Imrich Barák, Sadia Bari, Johan Bielecki, Sabine Botha, Djelloul Boukhelef, Wolfgang Brehm, Sandor Brockhauser, Igor Cheviakov, Matthew A. Coleman, Francisco Cruz-Mazo, Cyril Danilevski, Connie Darmanin, R. Bruce Doak, Martin Domaracky, Katerina Dörner, Yang Du, Hans Fangohr, Holger Fleckenstein, Matthias Frank, Petra Fromme, Alfonso M. Gañán-Calvo, Yaroslav Gevorkov, Klaus Giewekemeyer, Helen Mary Ginn, Heinz Graafsma, Rita Graceffa, Dominic Greiffenberg, Lars Gumprecht, Peter Göttlicher, Janos Hajdu, Steffen Hauf, Michael Heymann, Susannah Holmes, Daniel A. Horke, Mark S. Hunter, Siegfried Imlau, Alexander Kaukher, Yoonhee Kim, Alexander Klyuev, Juraj Knoška, Bostjan Kobe, Manuela Kuhn, Christopher Kupitz, Jochen Küpper, Janine Mia Lahey-Rudolph, Torsten Laurus, Karoline Le Cong, Romain Letrun, P. Lourdu Xavier, Luis Maia, Filipe R. N. C. Maia, Valerio Mariani, Marc Messerschmidt, Markus Metz, Davide Mezza, Thomas Michelat, Grant Mills, Diana C. F. Monteiro, Andrew Morgan, Kerstin Mühlig, Anna Munke, Astrid Münnich, Julia Nette, Keith A. Nugent, Theresa Nuguid, Allen M. Orville, Suraj Pandey, Gisel Pena, Pablo Villanueva-Perez, Jennifer Poehlsen, Gianpietro Previtali, Lars Redecke, Winnie Maria Riekehr, Holger Rohde, Adam Round, Tatiana Safenreiter, Iosifina Sarrou, Tokushi Sato, Marius Schmidt, Bernd Schmitt, Robert Schönherr, Joachim Schulz, Jonas A. Sellberg, M. Marvin Seibert, Carolin Seuring, Megan L. Shelby, Robert L. Shoeman, Marcin Sikorski, Alessandro Silenzi, Claudiu A. Stan, Xintian Shi, Stephan Stern, Jola Sztuk-Dambietz, Janusz Szuba, Aleksandra Tolstikova, Martin Trebbin, Ulrich Trunk, Patrik Vagovic, Thomas Ve, Britta Weinhausen, Thomas A. White, Krzysztof Wrona, Chen Xu, Oleksandr Yefanov, Nadia Zatsepin, Jiaguo Zhang, Markus Perbandt, Adrian P. Mancuso, Christian Betzel, Henry Chapman, Anton Barty
Megahertz serial crystallography
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06156-7
Nature Communications 9/1 2019-09-09
2017 Rebecka Andersson, Cecilia Safari, Robert Dods, Eriko Nango, Rie Tanaka, Ayumi Yamashita, Takanori Nakane, Kensuke Tono, Yasumasa Joti, Petra Båth, Elin Dunevall, Robert Bosman, Osamu Nureki, So Iwata, Richard Neutze, Gisela Brändén
Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-04817-z
Scientific Reports 7/1 2019-09-09
2018 Serhane Zerdane, Marco Cammarata, Lodovico Balducci, Roman Bertoni, Laure Catala, Sandra Mazerat, Talal Mallah, Martin N. Pedersen, Michael Wulff, Kosuke Nakagawa, Hiroko Tokoro, Shin-ichi Ohkoshi, Eric Collet
Probing Transient Photoinduced Charge Transfer in Prussian Blue Analogues with Time-Resolved XANES and Optical Spectroscopy
published pages: 272-277, ISSN: 1434-1948, DOI: 10.1002/ejic.201700657
European Journal of Inorganic Chemistry 2018/3-4 2019-09-09
2017 Kenneth R. Beyerlein, Dennis Dierksmeyer, Valerio Mariani, Manuela Kuhn, Iosifina Sarrou, Angelica Ottaviano, Salah Awel, Juraj Knoska, Silje Fuglerud, Olof Jönsson, Stephan Stern, Max O. Wiedorn, Oleksandr Yefanov, Luigi Adriano, Richard Bean, Anja Burkhardt, Pontus Fischer, Michael Heymann, Daniel A. Horke, Katharina E. J. Jungnickel, Elena Kovaleva, Olga Lorbeer, Markus Metz, Jan Meyer, Andrew Morgan, Kanupriya Pande, Saravanan Panneerselvam, Carolin Seuring, Aleksandra Tolstikova, Julia Lieske, Steve Aplin, Manfred Roessle, Thomas A. White, Henry N. Chapman, Alke Meents, Dominik Oberthuer
Mix-and-diffuse serial synchrotron crystallography
published pages: 769-777, ISSN: 2052-2525, DOI: 10.1107/s2052252517013124
IUCrJ 4/6 2019-09-09
2018 Irene Benni, Matilde Cardoso Trabuco, Enrico Di Stasio, Alessandro Arcovito, Alberto Boffi, Francesco Malatesta, Alessandra Bonamore, Simone De Panfilis, Valeria de Turris, Paola Baiocco
Excimer based fluorescent pyrene–ferritin conjugate for protein oligomerization studies and imaging in living cells
published pages: 12815-12822, ISSN: 2046-2069, DOI: 10.1039/c8ra00210j
RSC Advances 8/23 2019-09-09
2017 Haitao Zhang, Gye Won Han, Alexander Batyuk, Andrii Ishchenko, Kate L. White, Nilkanth Patel, Anastasiia Sadybekov, Beata Zamlynny, Michael T. Rudd, Kaspar Hollenstein, Alexandra Tolstikova, Thomas A. White, Mark S. Hunter, Uwe Weierstall, Wei Liu, Kerim Babaoglu, Eric L. Moore, Ryan D. Katz, Jennifer M. Shipman, Margarita Garcia-Calvo, Sujata Sharma, Payal Sheth, Stephen M. Soisson, Raymond C. Stevens, Vsevolod Katritch, Vadim Cherezov
Structural basis for selectivity and diversity in angiotensin II receptors
published pages: 327-332, ISSN: 0028-0836, DOI: 10.1038/nature22035
Nature 544/7650 2019-09-09
2017 A. Meents, M. O. Wiedorn, V. Srajer, R. Henning, I. Sarrou, J. Bergtholdt, M. Barthelmess, P. Y. A. Reinke, D. Dierksmeyer, A. Tolstikova, S. Schaible, M. Messerschmidt, C. M. Ogata, D. J. Kissick, M. H. Taft, D. J. Manstein, J. Lieske, D. Oberthuer, R. F. Fischetti, H. N. Chapman
Pink-beam serial crystallography
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01417-3
Nature Communications 8/1 2019-09-09
2019 Q. Y. Kong, M. G. Laursen, K. Haldrup, K. S. Kjær, D. Khakhulin, E. Biasin, T. B. van Driel, M. Wulff, V. Kabanova, R. Vuilleumier, S. Bratos, M. M. Nielsen, K. J. Gaffney, T. C. Weng, M. H. J. Koch
Initial metal–metal bond breakage detected by fs X-ray scattering in the photolysis of Ru 3 (CO) 12 in cyclohexane at 400 nm
published pages: 319-327, ISSN: 1474-905X, DOI: 10.1039/c8pp00420j
Photochemical & Photobiological Sciences 18/2 2019-09-09
2017 A. Jarnac, Xiaocui Wang, Å. U. J. Bengtsson, J. C. Ekström, H. Enquist, A. Jurgilaitis, D. Kroon, A. I. H. Persson, V.-T. Pham, C. M. Tu, J. Larsson
Communication: Demonstration of a 20 ps X-ray switch based on a photoacoustic transducer
published pages: 51102, ISSN: 2329-7778, DOI: 10.1063/1.4993730
Structural Dynamics 4/5 2019-09-09
2018 Henrik Enquist, Andrius Jurgilaitis, Amelie Jarnac, Åsa U. J. Bengtsson, Matthias Burza, Francesca Curbis, Christian Disch, J. Carl Ekström, Maher Harb, Lennart Isaksson, Marija Kotur, David Kroon, Filip Lindau, Erik Mansten, Jesper Nygaard, Anna I. H. Persson, Van Thai Pham, Michael Rissi, Sara Thorin, Chien-Ming Tu, Erik Wallén, Xiaocui Wang, Sverker Werin, Jörgen Larsson
FemtoMAX – an X-ray beamline for structural dynamics at the short-pulse facility of MAX IV
published pages: 570-579, ISSN: 1600-5775, DOI: 10.1107/S1600577517017660
Journal of Synchrotron Radiation 25/2 2019-09-09
2018 Przemyslaw Nogly, Tobias Weinert, Daniel James, Sergio Carbajo, Dmitry Ozerov, Antonia Furrer, Dardan Gashi, Veniamin Borin, Petr Skopintsev, Kathrin Jaeger, Karol Nass, Petra Båth, Robert Bosman, Jason Koglin, Matthew Seaberg, Thomas Lane, Demet Kekilli, Steffen Brünle, Tomoyuki Tanaka, Wenting Wu, Christopher Milne, Thomas White, Anton Barty, Uwe Weierstall, Valerie Panneels, Eriko Nango, So Iwata, Mark Hunter, Igor Schapiro, Gebhard Schertler, Richard Neutze, Jörg Standfuss
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser
published pages: eaat0094, ISSN: 0036-8075, DOI: 10.1126/science.aat0094
Science 2019-09-09
2017 Calisti L., Benni I., Cardoso Trabuco M., Baiocco P., Ruzicka B., Boffi A., Falvo E., Malatesta F. and Bonamore A.
Probing bulky ligand entry in engineered archaeal ferritins
published pages: , ISSN: 0304-4165, DOI: 10.5281/zenodo.2528583
Biochim Biophys Acta 2019-09-09
2017 de Turris V., Cardoso Trabuco M., Peruzzi G., Boffi A., Testi C., Vallone B., Montemiglio L.C., des Georges A., Calisti L., Benni I., Bonamore A. and Baiocco P.
Humanized archaeal ferritin as a tool for cell targeted delivery
published pages: , ISSN: 2040-3364, DOI: 10.5281/zenodo.2527178
nanoscale 2019-09-09
2017 Jonna K Hakulinen, Jenny Hering, Gisela Brändén, Hongming Chen, Arjan Snijder, Margareta Ek, Patrik Johansson
MraY–antibiotic complex reveals details of tunicamycin mode of action
published pages: 265-267, ISSN: 1552-4450, DOI: 10.1038/nchembio.2270
Nature Chemical Biology 13/3 2019-09-09
2016 Persson A.I.H., Jarnac A., Wang X., Enquist H., Jurgilaitis A. and J. Larsson
Studies of electron diffusion in photo-excited Ni using time-resolved X-ray diffraction
published pages: , ISSN: 0003-6951, DOI: 10.1063/1.4967470
Applied Physics Letters 2019-09-09

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "X-PROBE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "X-PROBE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.1.)

BIGMATH (2018)

Big Data Challenges for Mathematics

Read More  


Dementia: Intersectorial Strategy for Training and Innovation Network for Current Technology (DISTINCT)

Read More  

POLISS (2019)

Policies for Smart Specialisation

Read More