Explore the words cloud of the REPROWORM project. It provides you a very rough idea of what is the project "REPROWORM" about.
The following table provides information about the project.
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
|Coordinator Country||Germany [DE]|
|Total cost||1˙457˙938 €|
|EC max contribution||1˙457˙938 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-03-01 to 2021-02-28|
Take a look of project's partnership.
|1||MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)||DE (BERLIN)||coordinator||1˙457˙938.00|
Regenerating tissues by reprogramming cells has the potential to become a therapeutic approach for replacing lost tissues in patients suffering from injury or degenerative diseases such as Alzheimer’s or Muscular Dystrophy. Strategies to generate required tissues using embryonic stem cells or induced pluripotent stem cells (iPSCs) are associated with either ethical or medical safety issues. An alternative strategy is to directly reprogram cells to the required tissue type by forced expression of cell fate-inducing transcription factors (TFs). Direct reprogramming (DR) has the potential to circumvent unsafe proliferative pluripotent cell stages and it allows in vivo procedures. However to date, DR is successful in only a few cell types and it is not well understood why most cells are refractory to DR. Recently, we provided evidence that inhibitory mechanisms play an important role in restricting cell fate conversion. We identified factors inhibiting direct conversion of germ cells into specific neurons or muscle cells. Additionally, preliminary studies in our group revealed other factors that inhibit ectopic cell fate induction in somatic cells. The objective of this proposal is to further understand mechanisms that restrict DR. We aim to identify and characterize factors involved in safeguarding differentiated cells and thereby counteract induction of ectopic fates in different cells. We use C. elegans as an in vivo model and apply large-scale forward and reverse genetic screenings with high-throughput. Next generation sequencing, tissue-specific biochemistry (ChIP-seq, SILAC) and 4D imaging will be used to elucidate the molecular function of identified DR-regulating factors. Finally, we will test the ability to convert cells in aged animals and assess the effects of ageing on the ability to induce ectopic cell fates. Our research has the potential to facilitate the generation of specific tissues from different cellular contexts for future biomedical approaches.
|year||authors and title||journal||last update|
Anna Reid, Baris Tursun
Transdifferentiation: do transition states lie on the path of development?
published pages: 18-23, ISSN: 2452-3100, DOI: 10.1016/j.coisb.2018.07.004
|Current Opinion in Systems Biology 11||2020-01-29|
Ena Kolundzic, Andreas Ofenbauer, Selman I. Bulut, Bora Uyar, GÃ¼lkiz Baytek, Anne Sommermeier, Stefanie Seelk, Mei He, Antje Hirsekorn, Dubravka Vucicevic, Altuna Akalin, Sebastian Diecke, Scott A. Lacadie, Baris Tursun
FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells
published pages: 611-626.e12, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.07.006
|Developmental Cell 46/5||2020-01-29|
Andreas Ofenbauer, Baris Tursun
Strategies for in vivo reprogramming
published pages: 9-15, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2019.06.002
|Current Opinion in Cell Biology 61||2020-01-29|
Mahmoud M. Ibrahim, Aslihan Karabacak, Alexander Glahs, Ena Kolundzic, Antje Hirsekorn, Alexa Carda, Baris Tursun, Robert P. Zinzen, Scott A. Lacadie, Uwe Ohler
Determinants of promoter and enhancer transcription directionality in metazoans
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06962-z
|Nature Communications 9/1||2020-01-29|
Martina Hajduskova, GÃ¼lkiz Baytek, Ena Kolundzic, Alexander Gosdschan, Marlon Kazmierczak, Andreas Ofenbauer, Maria Lena Beato del Rosal, Sergej Herzog, Nida ul Fatima, Philipp Mertins, Stefanie Seelk-MÃ¼thel, Baris Tursun
MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegans
published pages: 121-139, ISSN: 0016-6731, DOI: 10.1534/genetics.118.301674
Selma Waaijers, Javier MuÃ±oz, Christian Berends, JoÃ£o J. Ramalho, Soenita S. Goerdayal, Teck Y. Low, Adja D. Zoumaro-Djayoon, Michael Hoffmann, Thijs Koorman, Roderick P. Tas, Martin Harterink, Stefanie Seelk, Jana Kerver, Casper C. Hoogenraad, Olaf Bossinger, Baris Tursun, Sander van den Heuvel, Albert J. R. Heck, Mike Boxem
A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large
published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-016-0286-x
|BMC Biology 14/1||2020-01-29|
Stefanie Seelk, Irene Adrian-Kalchhauser, BalÃ¡zs Hargitai, Martina Hajduskova, Silvia Gutnik, Baris Tursun, Rafal Ciosk
Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.15477
Ena Kolundzic, Stefanie Seelk, Baris Tursun
Application of RNAi and Heat-shock- induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
published pages: e56889, ISSN: 1940-087X, DOI: 10.3791/56889
|JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols in press||2020-01-29|
Thomas Wilhelm, Jonathan Byrne, Rebeca Medina, Ena KolundÅ¾iÄ‡, Johannes Geisinger, Martina Hajduskova, Baris Tursun, Holger Richly
Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans
published pages: 1561-1572, ISSN: 0890-9369, DOI: 10.1101/gad.301648.117
|Genes & Development 31/15||2020-01-29|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REPROWORM" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "REPROWORM" are provided by the European Opendata Portal: CORDIS opendata.