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Interdisciplinary Training Network for Validation of Gram-Negative Antibacterial Targets

Total Cost €


EC-Contrib. €






 INTEGRATE project word cloud

Explore the words cloud of the INTEGRATE project. It provides you a very rough idea of what is the project "INTEGRATE" about.

gram    identification    validation    pathogen    designed    mode    gene    fitness    global    health    technologies    resistance    mutual    infections    disciplines    secondment    synthesis    assembled    framework    silico    host    committed    reverse    platform    coupled    molecular    report    preclinical    threats    sectors    ranging    cooperation    latest    fragmentation    bacterial    series    posing    screening    11    rising    esrs    vivo    alternatives    eight    encompassing    academic    direct    seamlessly    innovative    exposed    individual    antimicrobials    reducing    council    compound    2011    discovery    events    human    biochemistry    clearance    negative    inter    biology    form    stage    team    agents    training    recommendation    action    contributions    mechanisms    intention    thereby    vitro    accomplished    parliament    treatment    students    submitted    immune    plan    threat    organic    exposure    beneficiaries    antimicrobial    animal    antibacterial    networking    mesh    15    integrate   

Project "INTEGRATE" data sheet

The following table provides information about the project.


Organization address
address: VIA UNIVERSITA 12
city: PARMA
postcode: 43100

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 2˙793˙330 €
 EC max contribution 2˙793˙330 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PARMA IT (PARMA) coordinator 516˙122.00
4    ITA-SUOMEN YLIOPISTO FI (KUOPIO) participant 269˙145.00
5    APTUIT (VERONA) SRL IT (VERONA) participant 258˙061.00
6    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) participant 250˙560.00
8    TAROS CHEMICALS GMBH & CO KG DE (Dortmund) participant 249˙216.00
9    UNIVERZA V LJUBLJANI SI (LJUBLJANA) participant 234˙997.00
12    Finnish Patent Office and Registration FI (Helsinki) partner 0.00
13    Matera, Lda PT (Cantanhede) partner 0.00
14    TTY-SAATIO FI (TAMPERE) partner 0.00


 Project objective

Antimicrobial resistance is posing a continuously-rising threat to global health. Indeed, one key recommendation from the recent “Action plan against the rising threats from Antimicrobial Resistance” report (submitted by the Commission to the European Parliament and Council (15.11.2011)) is the development of effective antimicrobials or alternatives for treatment of human and animal infections. The INTEGRATE project is a direct response to this. We have assembled a team of 10 beneficiaries from eight EU member states, encompassing both academic and non-academic sectors and different disciplines, to form a consortium committed to training Early Stage Researchers (ESRs) in the discovery and preclinical validation of novel Gram-negative antibacterial agents and antibacterial targets. The principle aim of the consortium is to provide a training platform where students are exposed to every aspect of the antimicrobial discovery process, ranging from target identification and validation, through organic synthesis, in silico design and compound screening, to mode-of-action and possible resistance mechanisms. This exposure will be accomplished through a concrete secondment plan, coupled with a series of high-level consortium-wide training events and networking programmes. Our intention is to reverse the current fragmentation of approaches towards antibacterial discovery through mutual cooperation. The INTEGRATE training framework is built on an innovative research project aimed at targeting important but non-essential gene products as an effective means of reducing bacterial fitness, thereby facilitating clearance of the pathogen by the host immune system. To achieve this, the individual work programmes have been designed to seamlessly inter-mesh contributions from the fields of in silico design, organic synthesis, molecular biology and biochemistry, and the very latest in vitro and in vivo screening technologies.


List of deliverables.
Kick-off Meeting Other 2020-02-06 16:17:21
ESR recruitments Other 2020-02-06 16:17:21
SAB Other 2020-02-06 16:17:21
Website Websites, patent fillings, videos etc. 2020-02-06 16:17:21
PCDPs Other 2020-02-06 16:17:21
Gender Equality in Science Course Other 2020-02-06 16:17:21
Short course Other 2020-02-06 16:17:21

Take a look to the deliverables list in detail:  detailed list of INTEGRATE deliverables.


year authors and title journal last update
List of publications.
2017 Alyssa McVey, Sean Bartlett and Martin Welch
Targeting the glyoxylate shunt for antibacterial intervention in Pseudomonas aeruginosa
published pages: , ISSN: , DOI:
2017 Alyssa McVey, Sean Bartlett, Martin Welch
Structural and functional characterisation of the glyoxylate shunt enzymes from Pseudomonas aeruginosa - ORAL CONFERENCE TALK
published pages: , ISSN: , DOI:
2017 Alyssa C. McVey, Prasanthi Medarametla, Xavier Chee, Sean Bartlett, Antti Poso, David R. Spring, Taufiq Rahman, Martin Welch
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa
published pages: 5539-5549, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.7b00852
Biochemistry 56/41 2020-02-06
2018 Martina Durcik, Päivi Tammela, Michaela Barančoková, Tihomir Tomašič, Janez Ilaš, Danijel Kikelj, Nace Zidar
Synthesis and Evaluation of N -Phenylpyrrolamides as DNA Gyrase B Inhibitors
published pages: 186-198, ISSN: 1860-7179, DOI: 10.1002/cmdc.201700549
ChemMedChem 13/2 2020-02-06
2018 Joana Magalhães, Giannamaria Annunziato, Nina Franko, Marco Pieroni, Barbara Campanini, Agostino Bruno, Gabriele Costantino
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets
published pages: 710-723, ISSN: 1549-9596, DOI: 10.1021/acs.jcim.7b00733
Journal of Chemical Information and Modeling 58/3 2020-02-06
2018 Nina Franko, Konstantinos Grammatoglou, Barbara Campanini, Gabriele Costantino, Aigars Jirgensons, Andrea Mozzarelli
Inhibition of O -acetylserine sulfhydrylase by fluoroalanine derivatives
published pages: 1343-1351, ISSN: 1475-6366, DOI: 10.1080/14756366.2018.1504040
Journal of Enzyme Inhibition and Medicinal Chemistry 33/1 2020-02-06
2018 Prasanthi Medarametla, Viviana Gatta, Tommi Kajander, Tuomo Laitinen, Päivi Tammela, Antti Poso
Structure-Based Virtual Screening of LsrK Kinase Inhibitors to Target Quorum Sensing
published pages: 2400-2407, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800548
ChemMedChem 13/22 2020-02-06
2018 Carlos Moreno-Cinos, Elisa Sassetti, Irene G. Salado, Gesa Witt, Siham Benramdane, Laura Reinhardt, Cristina Durante Cruz, Jurgen Joossens, Pieter Van der Veken, Heike Brotz-Oesterhelt, Päivi Tammela, Mathias Winterhalter, Philip Gribbon, Björn Windshügel, Koen Augustyns
α-Amino diphenyl phosphonates as novel inhibitors of Escherichia coli ClpP protease
published pages: , ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01466
Journal of Medicinal Chemistry 2020-02-06
2018 Joana Magalhães, Nina Franko, Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Anna Nikitjuka, Andrea Mozzarelli, Stefano Bettati, Anna Karawajczyk, Aigars Jirgensons, Barbara Campanini, Gabriele Costantino
Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms
published pages: 31-43, ISSN: 1475-6366, DOI: 10.1080/14756366.2018.1518959
Journal of Enzyme Inhibition and Medicinal Chemistry 34/1 2020-02-06
2018 Silvia Stotani, Viviana Gatta, Federico Medda, Mohan Padmanaban, Anna Karawajczyk, Päivi Tammela, Fabrizio Giordanetto, Dimitrios Tzalis, Simona Collina
A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing
published pages: 2545, ISSN: 1420-3049, DOI: 10.3390/molecules23102545
Molecules 23/10 2020-02-06
2018 Tihomir Tomašič, Michaela Barančoková, Nace Zidar, Janez Ilaš, Päivi Tammela, Danijel Kikelj
Design, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors
published pages: 1700333, ISSN: 0365-6233, DOI: 10.1002/ardp.201700333
Archiv der Pharmazie 351/1 2020-02-06
2016 Silvia Stotani, Christoph Lorenz, Matthias Winkler, Federico Medda, Edwige Picazo, Raquel Ortega Martinez, Anna Karawajczyk, Jorge Sanchez-Quesada, Fabrizio Giordanetto
Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening
published pages: 330-336, ISSN: 2156-8952, DOI: 10.1021/acscombsci.6b00005
ACS Combinatorial Science 18/6 2020-02-06
2018 Joana Magalhães, Nina Franko, Giannamaria Annunziato, Martin Welch, Stephen K. Dolan, Agostino Bruno, Andrea Mozzarelli, Stefano Armao, Aigars Jirgensons, Marco Pieroni, Gabriele Costantino, Barbara Campanini
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design
published pages: 1444-1452, ISSN: 1475-6366, DOI: 10.1080/14756366.2018.1512596
Journal of Enzyme Inhibition and Medicinal Chemistry 33/1 2020-02-06
2017 Žiga Jakopin, Janez Ilaš, Michaela Barančoková, Matjaž Brvar, Päivi Tammela, Marija Sollner Dolenc, Tihomir Tomašič, Danijel Kikelj
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors
published pages: 171-184, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.02.046
European Journal of Medicinal Chemistry 130 2020-02-06
2018 Michaela Barančoková, Danijel Kikelj, Janez Ilaš
Recent progress in the discovery and development of DNA gyrase B inhibitors
published pages: 1207-1227, ISSN: 1756-8919, DOI: 10.4155/fmc-2017-0257
Future Medicinal Chemistry 10/10 2020-02-06
2016 Michaela Barančoková, Janez Ilaš, Marina Gjorgjieva, Tihomir Tomašič, Päivi Tammela, Vanesa Garrido, Antonio Felici, and Danijel Kikelj
Discovery of novel Gyrase B and GyraseB/Topoisomerase IV (ParE) dual Inhibitors with in vitro antibacterial activity
published pages: , ISSN: , DOI:
2016 Gjorgjieva M1, Tomašič T1, Barančokova M1, Katsamakas S1,2, Ilaš J1, Tammela P3, Peterlin Mašič L1, Kikelj D1.
Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors
published pages: 8941-8954, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00864
Journal of Medicinal Chemistry Vol. 59, iss. 19 (2016) 2020-02-06
2017 A Felici, M Antolini, M. Negri, V. Garrido Estevez, R Zahler, L Rahme, M Pucci, Aldo Feriani, and Daniele Andreotti
Design, synthesis and in vitro profiling of novel inhibitors of Pseudomonas aeruginosa MvfR
published pages: , ISSN: , DOI:
2016 Joana Magalhães, Giannamaria Annunziato, Marco Pieroni, Nina Franko, Barbara Campanini, Andrea Mozzarelli, Vanesa Estevez, Antonio Felici, and Gabriele Costantino
Enzyme inhibition as a new strategy to overcome Multidrug Resistant Bacteria
published pages: , ISSN: , DOI:
2016 Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Barbara Campanini, Thelma A. Pertinhez, Chiara Pecchini, Agostino Bruno, Joana Magalhães, Stefano Bettati, Nina Franko, Andrea Mozzarelli, Gabriele Costantino
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O -acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR
published pages: 78-87, ISSN: 1475-6366, DOI: 10.1080/14756366.2016.1218486
Journal of Enzyme Inhibition and Medicinal Chemistry 31/sup4 2020-02-06
2017 Tomašič T1, Mirt M2, Barančoková M2, Ilaš J2, Zidar N2, Tammela P3, Kikelj D2
Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors.
published pages: 338-349, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2016.10.038
Bioorganic & Medicinal Chemistry Vol. 25, Iss. 1 (2017) 2020-02-06

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