Explore the words cloud of the EngineeringPercepts project. It provides you a very rough idea of what is the project "EngineeringPercepts" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-08-01 to 2020-07-31|
Take a look of project's partnership.
|1||stiftung caesar||DE (Bonn)||coordinator||1˙219˙000.00|
|2||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (Munich)||participant||281˙000.00|
Understanding how the brain is able to transform sensory input into decisions is one of the major challenges of systems neuroscience. While recording/imaging during sensory-motor tasks identified neural substrates of sensation and action in various cortical areas, the crucial questions of 1) how these correlates are implemented within the underlying neural networks and 2) how their output triggers decisions, will only be answered when the individual functional measurements are integrated into a coherent model of all task-related circuits.
The goal of my proposal is to use the rodent vibrissal system for building such a model in the context of how a tactile-mediated percept is encoded by the interplay between biophysical, cellular and network mechanisms. Specifically, rodents decide to cross a gap when detecting its far side with a single facial whisker. This suggests that whisker contact with the platform, if synchronized with an internal motor signal, triggers the decision. My key hypothesis is that in sensory cortex layer 5 thick-tufted (L5tt) neurons receive touch and motor information via specific pathways that target basal and apical tuft dendrites, respectively. When localizing the far side of the gap, the two inputs coincide and result in burst spiking output to (sub)cortical areas, triggering the gap cross.
To test this hypothesis, I will determine all sensory/motor-related local and long-range inputs/outputs to/from L5tt neurons, measure whisker-evoked responses of these populations and use the data to constrain network simulations of active whisker touch. Using a multidisciplinary approach, combining in vivo electrophysiology, virus injections, custom imaging/reconstruction tools and Monte Carlo simulations, my reverse engineering strategy will provide unmatched mechanistic insight to perceptual decision making and will function as a show case – generalizable across sensory modalities and species – of how to derive computations that underlie behavior.
|year||authors and title||journal||last update|
Robert Egger, Rajeevan T. Narayanan, Jason M. Guest, Arco Bast, Daniel Udvary, Luis F. Messore, Suman Das, Christiaan P.J. de Kock, Marcel Oberlaender
Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers
published pages: 122-137.e8, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.10.011
Robert Egger, Arno C. Schmitt, Damian J. Wallace, Bert Sakmann, Marcel Oberlaender, Jason N. D. Kerr
Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites
published pages: 14072-14077, ISSN: 0027-8424, DOI: 10.1073/pnas.1518773112
|Proceedings of the National Academy of Sciences 112/45||2019-05-24|
Itamar D. Landau, Robert Egger, Vincent J. Dercksen, Marcel Oberlaender, Haim Sompolinsky
The Impact of Structural Heterogeneity on Excitation-Inhibition Balance in Cortical Networks
published pages: 1106-1121, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.10.027
JÃ¶rgen Kornfeld, Sam E Benezra, Rajeevan T Narayanan, Fabian Svara, Robert Egger, Marcel Oberlaender, Winfried Denk, Michael A Long
EM connectomics reveals axonal target variation in a sequence-generating network
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.24364
Gerardo Rojas-Piloni, Jason M. Guest, Robert Egger, Andrew S. Johnson, Bert Sakmann, Marcel Oberlaender
Relationships between structure, in vivo function and long-range axonal target of cortical pyramidal tract neurons
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00971-0
|Nature Communications 8/1||2019-05-24|
Rajeevan T. Narayanan, Daniel Udvary, Marcel Oberlaender
Cell Type-Specific Structural Organization of the Six Layers in Rat Barrel Cortex
published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2017.00091
|Frontiers in Neuroanatomy 11||2019-05-24|
Sam E. Benezra, Rajeevan T. Narayanan, Robert Egger, Marcel Oberlaender, Michael A. Long
Morphological characterization of HVC projection neurons in the zebra finch (Taeniopygia guttata)
published pages: , ISSN: 0021-9967, DOI: 10.1002/cne.24437
|Journal of Comparative Neurology||2019-05-24|
Jason M. Guest, Mythreya M. Seetharama, Elizabeth S. Wendel, Peter L. Strick, Marcel Oberlaender
3D Reconstruction and Standardization of the Rat Facial Nucleus for Precise Mapping of Vibrissal Motor Networks
published pages: 171-186, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.09.031
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The information about "ENGINEERINGPERCEPTS" are provided by the European Opendata Portal: CORDIS opendata.
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