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EngineeringPercepts SIGNED

Reverse engineering sensory perception and decision making: bridging physiology, anatomy and behavior

Total Cost €

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EC-Contrib. €

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Partnership

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 EngineeringPercepts project word cloud

Explore the words cloud of the EngineeringPercepts project. It provides you a very rough idea of what is the project "EngineeringPercepts" about.

dendrites    individual    rodents    sensory    apical    input    mediated    tufted    layer    cortex    rodent    cortical    decide    internal    encoded    action    tools    percept    network    model    substrates    receive    mechanistic    underlying    multidisciplinary    decisions    data    species    coherent    coincide    platform    building    correlates    whisker    carlo    gap    local    evoked    questions    signal    inputs    recording    context    decision    outputs    vibrissal    engineering    reverse    respectively    function    virus    sub    answered    understanding    localizing    custom    tactile    triggers    injections    circuits    unmatched    biophysical    behavior    monte    functional    perceptual    basal    touch    strategy    output    single    cross    modalities    suggests    neural    neurons    sensation    imaging    networks    reconstruction    vivo    hypothesis    spiking    interplay    generalizable    combining    underlie    brain    burst    electrophysiology    populations    transform    thick    motor    simulations    tuft    mechanisms    synchronized    facial    detecting    cellular    l5tt    active    neuroscience    derive    computations    contact   

Project "EngineeringPercepts" data sheet

The following table provides information about the project.

Coordinator
stiftung caesar 

Organization address
address: Ludwig-Erhard-Allee 2
city: Bonn
postcode: 53175
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    stiftung caesar DE (Bonn) coordinator 1˙219˙000.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) participant 281˙000.00

Map

 Project objective

Understanding how the brain is able to transform sensory input into decisions is one of the major challenges of systems neuroscience. While recording/imaging during sensory-motor tasks identified neural substrates of sensation and action in various cortical areas, the crucial questions of 1) how these correlates are implemented within the underlying neural networks and 2) how their output triggers decisions, will only be answered when the individual functional measurements are integrated into a coherent model of all task-related circuits.

The goal of my proposal is to use the rodent vibrissal system for building such a model in the context of how a tactile-mediated percept is encoded by the interplay between biophysical, cellular and network mechanisms. Specifically, rodents decide to cross a gap when detecting its far side with a single facial whisker. This suggests that whisker contact with the platform, if synchronized with an internal motor signal, triggers the decision. My key hypothesis is that in sensory cortex layer 5 thick-tufted (L5tt) neurons receive touch and motor information via specific pathways that target basal and apical tuft dendrites, respectively. When localizing the far side of the gap, the two inputs coincide and result in burst spiking output to (sub)cortical areas, triggering the gap cross.

To test this hypothesis, I will determine all sensory/motor-related local and long-range inputs/outputs to/from L5tt neurons, measure whisker-evoked responses of these populations and use the data to constrain network simulations of active whisker touch. Using a multidisciplinary approach, combining in vivo electrophysiology, virus injections, custom imaging/reconstruction tools and Monte Carlo simulations, my reverse engineering strategy will provide unmatched mechanistic insight to perceptual decision making and will function as a show case – generalizable across sensory modalities and species – of how to derive computations that underlie behavior.

 Publications

year authors and title journal last update
List of publications.
2020 Robert Egger, Rajeevan T. Narayanan, Jason M. Guest, Arco Bast, Daniel Udvary, Luis F. Messore, Suman Das, Christiaan P.J. de Kock, Marcel Oberlaender
Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers
published pages: 122-137.e8, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.10.011
Neuron 105/1 2020-04-03
2015 Robert Egger, Arno C. Schmitt, Damian J. Wallace, Bert Sakmann, Marcel Oberlaender, Jason N. D. Kerr
Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites
published pages: 14072-14077, ISSN: 0027-8424, DOI: 10.1073/pnas.1518773112
Proceedings of the National Academy of Sciences 112/45 2019-05-24
2016 Itamar D. Landau, Robert Egger, Vincent J. Dercksen, Marcel Oberlaender, Haim Sompolinsky
The Impact of Structural Heterogeneity on Excitation-Inhibition Balance in Cortical Networks
published pages: 1106-1121, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.10.027
Neuron 92/5 2019-05-24
2017 Jörgen Kornfeld, Sam E Benezra, Rajeevan T Narayanan, Fabian Svara, Robert Egger, Marcel Oberlaender, Winfried Denk, Michael A Long
EM connectomics reveals axonal target variation in a sequence-generating network
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.24364
eLife 6 2019-05-24
2017 Gerardo Rojas-Piloni, Jason M. Guest, Robert Egger, Andrew S. Johnson, Bert Sakmann, Marcel Oberlaender
Relationships between structure, in vivo function and long-range axonal target of cortical pyramidal tract neurons
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00971-0
Nature Communications 8/1 2019-05-24
2017 Rajeevan T. Narayanan, Daniel Udvary, Marcel Oberlaender
Cell Type-Specific Structural Organization of the Six Layers in Rat Barrel Cortex
published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2017.00091
Frontiers in Neuroanatomy 11 2019-05-24
2018 Sam E. Benezra, Rajeevan T. Narayanan, Robert Egger, Marcel Oberlaender, Michael A. Long
Morphological characterization of HVC projection neurons in the zebra finch (Taeniopygia guttata)
published pages: , ISSN: 0021-9967, DOI: 10.1002/cne.24437
Journal of Comparative Neurology 2019-05-24
2018 Jason M. Guest, Mythreya M. Seetharama, Elizabeth S. Wendel, Peter L. Strick, Marcel Oberlaender
3D Reconstruction and Standardization of the Rat Facial Nucleus for Precise Mapping of Vibrissal Motor Networks
published pages: 171-186, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.09.031
Neuroscience 368 2019-05-24

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