Explore the words cloud of the Oscillations project. It provides you a very rough idea of what is the project "Oscillations" about.
The following table provides information about the project.
EUROPEAN MOLECULAR BIOLOGY LABORATORY
|Coordinator Country||Germany [DE]|
|Total cost||1˙439˙919 €|
|EC max contribution||1˙439˙919 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2020-08-31|
Take a look of project's partnership.
|1||EUROPEAN MOLECULAR BIOLOGY LABORATORY||DE (HEIDELBERG)||coordinator||1˙439˙919.00|
This project aims to reveal the origin and principal functions of spatiotemporal signalling oscillations in the context of embryonic development. Vertebrate embryo segmentation offers a particularly suitable context to study an assembly of ultradian, genetic oscillators, which in addition, exhibit striking synchronization that generates periodic, wave-like patterns.
Using the mouse model, in which three major signalling pathways (Wnt, Notch and Fgf) have been found to oscillate in activity with a period of ~2 hours, we aim to address the following key questions: How do signalling gradients control higher-order, spatiotemporal synchronization of genetic oscillators? What is the role of self-organization? What is the function of spatiotemporal signalling dynamics that are phase-shifted between multiple pathways for developmental patterning? To address these challenging questions, we bring together a unique combination of quantitative real-time imaging, novel ex vivo assays and multi-modal, i.e. genetic, chemical and physical functional perturbations.
To this end, we propose to employ customized knock-in reporter mouse lines developed in my lab and cutting edge microscopy for simultaneous quantification of multiple, oscillating signaling pathway activities and protein dynamics. We aim to combine these dynamic quantification with novel functional perturbations which are made possible due to a critical technical breakthrough achieved in my lab: an ex vivo primary cell culture assay that recapitulates mouse mesoderm patterning, including complex oscillatory wave patterns, and segment formation, in a simplified, 2-dimensional (2D) context. This ex vivo assay will allow an unprecedented versatility of (time-resolved) perturbations and simultaneous quantitative, dynamic read-out at both molecular and phenotypic level.
Our approach thus has an outstanding potential and is ideally positioned to reveal how temporal order emerges and impacts on developmental patterning.
|year||authors and title||journal||last update|
CharisiosÂ D. Tsiairis, Alexander Aulehla
Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns
published pages: 656-667, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.01.028
Katharina F. Sonnen, Volker M. Lauschke, Julia Uraji, Henning J. Falk, Yvonne Petersen, Maja C. Funk, Mathias Beaupeux, Paul FranÃ§ois, Christoph A. Merten, Alexander Aulehla
Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation
published pages: 1079-1090.e12, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.01.026
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "OSCILLATIONS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "OSCILLATIONS" are provided by the European Opendata Portal: CORDIS opendata.
Investigation and Monitoring of Time-varying Environments on Macro and Nano ScalesRead More
Molecular control of actin network architecture and mechanics during cell shape changesRead More
Resonances and Zeta Functions in Smooth Ergodic Theory and GeometryRead More