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SCilS SIGNED

Studying Ciliary Signaling in Development and Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 SCilS project word cloud

Explore the words cloud of the SCilS project. It provides you a very rough idea of what is the project "SCilS" about.

biology    surface    esr    intersectoral    industry    segregate    robustness    concentrate    output    genetic    stage    etiology    overlapping    prospects    competences    proteomics    degree    sessions    models    private    organs    imaging    esrs    scils    cryo    edge    secondments    uncover    genomics    network    signaling    35    components    of    accomplished    cell    ciliopathy    dysfunctional    thereby    integrating    homeostasis    unavailable    designed    organization    zebrafish    expertise    hubs    public    phenotypes    bioinformatics    broad    cellular    settings    tissues    individual    resolution    academic    understand    microtubule    unparalleled    therapeutic    tomography    heterogeneous    disease    electron    feedback    cells    super    efficient    regulation    cutting    critical    attractive    traits    outstanding    structural    majority    industrial    interventions    400    severe    cilia    projections    give    academia    gt    people    signalling    organoid    mediated    stem    human    ciliary    sectors    career    ciliopathies    primary    biochemistry    multidisciplinary    training    create   

Project "SCilS" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 3˙844˙874 €
 EC max contribution 3˙844˙874 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 531˙239.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 892˙566.00
3    IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION FR (PARIS 15) participant 549˙604.00
4    NEWCELLS BIOTECH LIMITED UK (NEWCASTLE UPON TYNE) participant 303˙172.00
5    AARHUS UNIVERSITET DK (AARHUS C) participant 297˙522.00
6    OSPEDALE SAN RAFFAELE SRL IT (MILANO) participant 261˙499.00
7    CELL NETWORKS GMBH DE (HEIDELBERG) participant 252˙788.00
8    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 252˙788.00
9    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) participant 252˙788.00
10    ZECLINICS SL ES (BARCELONA) participant 250˙904.00

Map

 Project objective

SCilS will create a multidisciplinary and intersectoral European training network focusing on ciliary signalling in development and disease. Primary cilia are microtubule-based cell surface projections that have evolved to be key signalling hubs of our cells, as they concentrate or segregate components of major cellular signalling pathways. Control of ciliary signaling output requires a high degree of regulation and critical feedback, which is needed for robustness in development and cellular homeostasis of different tissues and organs. Dysfunctional cilia can therefore lead to >35 severe human genetic traits (ciliopathies) with highly heterogeneous, overlapping phenotypes. Ciliopathies affect as many as 1 in 400 people, and for the majority of cases efficient therapeutic interventions are currently unavailable. SCilS research aims to uncover the multi-level organization and regulation of cilia-mediated signalling pathways in order to understand ciliopathy disease etiology and identify novel therapeutic targets. This challenging task will be accomplished by integrating unique expertise and cutting edge technology available within the SCilS network, including structural biology, super resolution imaging and cryo-electron tomography, state-of-the-art genomics, proteomics and bioinformatics, (stem) cell biology and biochemistry, as well as organoid technology and zebrafish models. SCilS training will give Early Stage Researchers (ESRs) unparalleled training opportunities in outstanding academic and industrial settings through training-by-research via individual research projects, secondments, and network-wide training sessions. All individual training and research activities have been designed to provide each ESR with the necessary broad competences in state‐of‐the art academic and industrial research. The network will thereby make a career in both industry and academia attractive to the ESRs and improve their career prospects in both private and public sectors.

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The information about "SCILS" are provided by the European Opendata Portal: CORDIS opendata.

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