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SCilS SIGNED

Studying Ciliary Signaling in Development and Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 SCilS project word cloud

Explore the words cloud of the SCilS project. It provides you a very rough idea of what is the project "SCilS" about.

biology    thereby    35    sessions    secondments    degree    organs    ciliopathy    signaling    public    tomography    create    academia    network    resolution    etiology    understand    edge    mediated    genomics    therapeutic    expertise    stem    critical    surface    broad    stage    phenotypes    cryo    components    interventions    severe    academic    super    cilia    cell    organoid    disease    individual    tissues    training    attractive    regulation    competences    400    intersectoral    structural    proteomics    concentrate    ciliary    projections    scils    imaging    integrating    esr    gt    robustness    designed    biochemistry    unparalleled    zebrafish    of    people    cells    dysfunctional    private    microtubule    human    hubs    outstanding    multidisciplinary    homeostasis    traits    unavailable    segregate    ciliopathies    industrial    settings    efficient    electron    esrs    bioinformatics    uncover    majority    primary    prospects    cutting    accomplished    overlapping    sectors    cellular    output    heterogeneous    career    genetic    feedback    industry    models    signalling    organization    give   

Project "SCilS" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 3˙844˙874 €
 EC max contribution 3˙844˙874 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 531˙239.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 892˙566.00
3    IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION FR (PARIS 15) participant 549˙604.00
4    NEWCELLS BIOTECH LIMITED UK (NEWCASTLE UPON TYNE) participant 303˙172.00
5    AARHUS UNIVERSITET DK (AARHUS C) participant 297˙522.00
6    OSPEDALE SAN RAFFAELE SRL IT (MILANO) participant 261˙499.00
7    CELL NETWORKS GMBH DE (HEIDELBERG) participant 252˙788.00
8    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 252˙788.00
9    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) participant 252˙788.00
10    ZECLINICS SL ES (BARCELONA) participant 250˙904.00

Map

 Project objective

SCilS will create a multidisciplinary and intersectoral European training network focusing on ciliary signalling in development and disease. Primary cilia are microtubule-based cell surface projections that have evolved to be key signalling hubs of our cells, as they concentrate or segregate components of major cellular signalling pathways. Control of ciliary signaling output requires a high degree of regulation and critical feedback, which is needed for robustness in development and cellular homeostasis of different tissues and organs. Dysfunctional cilia can therefore lead to >35 severe human genetic traits (ciliopathies) with highly heterogeneous, overlapping phenotypes. Ciliopathies affect as many as 1 in 400 people, and for the majority of cases efficient therapeutic interventions are currently unavailable. SCilS research aims to uncover the multi-level organization and regulation of cilia-mediated signalling pathways in order to understand ciliopathy disease etiology and identify novel therapeutic targets. This challenging task will be accomplished by integrating unique expertise and cutting edge technology available within the SCilS network, including structural biology, super resolution imaging and cryo-electron tomography, state-of-the-art genomics, proteomics and bioinformatics, (stem) cell biology and biochemistry, as well as organoid technology and zebrafish models. SCilS training will give Early Stage Researchers (ESRs) unparalleled training opportunities in outstanding academic and industrial settings through training-by-research via individual research projects, secondments, and network-wide training sessions. All individual training and research activities have been designed to provide each ESR with the necessary broad competences in state‐of‐the art academic and industrial research. The network will thereby make a career in both industry and academia attractive to the ESRs and improve their career prospects in both private and public sectors.

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The information about "SCILS" are provided by the European Opendata Portal: CORDIS opendata.

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