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MACIVIVA

MAnufacturing process for Cold-chain Independent VIrosome-based VAccines

Total Cost €

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EC-Contrib. €

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Partnership

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 MACIVIVA project word cloud

Explore the words cloud of the MACIVIVA project. It provides you a very rough idea of what is the project "MACIVIVA" about.

oxygen    packaging    galenic    immunogens    intramuscularly    preserving    dosage    prevent    universal    instability    cold    degradations    kept    stability    powder    prone    refrigerated    chemical    vaccines    complementary    explore    sublingual    smes    physical    stabilization    forms    self    expertise    slow    formulations    administered    enhanced    insufficient    hours    reconstitution    freeze    inherently    industrial    spray    experts    intranasal    susceptible    radicals    pave    world    immunological    molecular    screening    manufacturing    modifications    prior    interdisciplinary    shear    invasive    formats    subcutaneously    immune    fundamental    ing    usually    solid    liquid    vaccine    life    degradation    excipients    generating    protection    scientific    direct    chain    upscale    storage    easily    administration    thermostable    careful    water    innovative    shelf    excellence    drying    42    dried    motion    prophylactic    bioactivity    nanopharmaceuticals    outside    harbor    maciviva    oral    virosome    therapeutic    routes    reconstituted   

Project "MACIVIVA" data sheet

The following table provides information about the project.

Coordinator
MYMETICS BV 

Organization address
address: J H OORTWEG 21
city: LEIDEN
postcode: 2333 CH
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 8˙438˙905 €
 EC max contribution 5˙338˙886 € (63%)
 Programme 1. H2020-EU.2.1.2.1. (Developing next generation nanomaterials, nanodevices and nanosystems)
 Code Call H2020-NMP-PILOTS-2014
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-04   to  2018-11-03

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MYMETICS BV NL (LEIDEN) coordinator 1˙755˙073.00
2    UPPERTON LIMITED UK (NOTTINGHAM) participant 1˙647˙777.00
3    CATALENT U.K. SWINDON ZYDIS LIMITED UK (SWINDON) participant 1˙061˙723.00
4    CHIMERA BIOTEC GMBH DE (DORTMUND) participant 874˙312.00
5    BACHEM AG CH (BUBENDORF) participant 0.00
6    MYMETICS SA CH (EPALINGES) participant 0.00

Map

 Project objective

MACIVIVA is a highly interdisciplinary consortium among well established and innovative SMEs with scientific excellence and complementary industrial world-leading experts with unique expertise and know-how in virosome technology, spray and freeze drying, large scale manufacturing and packaging. MACIVIVA will pave the path to other large scale thermostable nanopharmaceuticals products for therapeutic and prophylactic vaccines and other potential applications for direct application by non-invasive routes. Liquid products are inherently prone to physical and/or chemical modifications and degradations. Solid vaccine dosage formats (e.g. powder) may prevent molecular motion and shear-induced degradation, and slow down degradation involving water and oxygen radicals, resulting in improved stability and enhanced shelf-life of vaccines. The cold chain storage is still fundamental for preserving the bioactivity of most liquid and freeze-dried vaccines, and a reconstitution step prior to administration is required for freeze dried vaccines that are usually administered intramuscularly or subcutaneously. These reconstituted freeze dried vaccines harbor important instability and must be used within hours and kept refrigerated. Because most liquid and reconstituted freeze-dried vaccines are susceptible to degradations, it may affect the immunological properties of the immunogens, with unwanted immune responses or insufficient immune protection. For addressing liquid virosome-based vaccine instability and improving their shelf-life outside the cold chain, MACIVIVA will explore new galenic vaccine formulations through careful screening of excipients, stabilization and drying methods for generating new vaccine solid forms that can be easily self-administered. Robust “universal” manufacturing processes for upscale production of virosome dried powder for the non-invasive intranasal, oral and sublingual routes should be achieved by month 42.

 Deliverables

List of deliverables.
MACIVIVA webpage launching Websites, patent fillings, videos etc. 2019-05-30 11:28:43
MACIVIVA communication fact sheet Other 2019-05-30 11:28:50
MACIVIVA logo Other 2019-05-30 11:28:49

Take a look to the deliverables list in detail:  detailed list of MACIVIVA deliverables.

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The information about "MACIVIVA" are provided by the European Opendata Portal: CORDIS opendata.

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