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YAK kinase regulated trypanosome quorum sensing

Total Cost €


EC-Contrib. €






 TRYP-QS project word cloud

Explore the words cloud of the TRYP-QS project. It provides you a very rough idea of what is the project "TRYP-QS" about.

environment    kinetoplastids    nutrient    signalling    exchange    proteins    sense    yak    regions    vitro    feeding    preparation    vivo    host    quiescence    afflicted    communicate    interactions    transcriptional    components    molecule    forms    post    population    action    pivotal    bloodstream    training    arrest    dissect    livestock    limitation    function    cell    tsetse    act    sub    regulation    quorum    genome    laboratory    optimise    extracellular    differ    hardship    yeasts    sensing    humans    researcher    contributes    disease    african    density    trypanosome    mammals    almost    transmission    stages    operates    screen    blood    additional    family    cytoplasm    molecules    transduction    kinase    exclusively    cellular    location    flies    gene    dyrk    sophisticated    specialised    africa    situation    signal    stumpy    mrna    slime    parasites    parasite    qs    encompassing    drive    benefit    relevance    trypanosomes    expression    monitor    nucleus    expertise    spread    mechanisms    malaria    death    molds    whilst    seems    signals    rnai    relocates    chances    saharan   

Project "TRYP-QS" data sheet

The following table provides information about the project.


Organization address
postcode: EH8 9YL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-05   to  2017-05-04


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00


 Project objective

African trypanosomes are parasites that cause disease in both humans and livestock throughout sub Saharan Africa, leading to death and hardship in afflicted regions. The disease is spread by blood-feeding tsetse flies and trypanosomes use sophisticated mechanisms to sense their environment in order to optimise their chances of transmission. In particular, whilst in the host bloodstream trypanosomes communicate with one another to monitor their own population density, this determining when they produce specialised transmission stages (so called ‘Stumpy’ forms). We have recently identified, using a genome-wide RNAi screen, components of the signal transduction pathway that drive this quorum sensing (QS) response. One component seems pivotal in the pathway- a molecule related to the YAK kinase of proteins. In yeasts and slime molds YAK kinase contributes to cell growth arrest in response to extracellular signals including nutrient limitation, whilst in mammals, related molecules of the DYRK family can also act in cellular quiescence. In this proposal we will investigate the function of trypanosome YAK kinase in the parasite's QS response. Specifically, we will investigate the kinase function in vitro and in vivo and dissect its action by following its location and targets. These are likely to differ from the situation in yeasts where YAK relocates to the nucleus and changes mRNA expression; in trypanosomes gene regulation is almost exclusively post transcriptional and likely operates within the cytoplasm. The function, location and interactions of YAK kinase in the QS signalling pathway is expected to provide comprehensive insight into how trypanosome parasites control their development in preparation for transmission, with additional important relevance for related parasites including other kinetoplastids and malaria. A two way benefit, encompassing training and expertise exchange between the researcher and host laboratory, will also be established.

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