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TRYP-QS

YAK kinase regulated trypanosome quorum sensing

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TRYP-QS project word cloud

Explore the words cloud of the TRYP-QS project. It provides you a very rough idea of what is the project "TRYP-QS" about.

forms    flies    population    disease    preparation    whilst    kinetoplastids    cytoplasm    slime    pivotal    sub    optimise    stages    expression    quorum    malaria    expertise    components    african    rnai    yak    spread    quiescence    molds    signals    signal    africa    training    contributes    monitor    saharan    nucleus    exclusively    gene    almost    drive    family    proteins    transduction    action    regulation    mechanisms    environment    mrna    cell    transmission    livestock    parasite    bloodstream    humans    mammals    nutrient    screen    molecule    encompassing    death    parasites    benefit    trypanosomes    trypanosome    yeasts    vitro    situation    relocates    density    signalling    operates    sense    additional    researcher    arrest    interactions    transcriptional    exchange    kinase    afflicted    feeding    seems    act    specialised    molecules    dyrk    regions    blood    extracellular    genome    function    stumpy    hardship    relevance    communicate    tsetse    limitation    cellular    host    dissect    laboratory    sophisticated    vivo    qs    post    differ    sensing    chances    location   

Project "TRYP-QS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://matthews.bio.ed.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-05   to  2017-05-04

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00

Map

 Project objective

African trypanosomes are parasites that cause disease in both humans and livestock throughout sub Saharan Africa, leading to death and hardship in afflicted regions. The disease is spread by blood-feeding tsetse flies and trypanosomes use sophisticated mechanisms to sense their environment in order to optimise their chances of transmission. In particular, whilst in the host bloodstream trypanosomes communicate with one another to monitor their own population density, this determining when they produce specialised transmission stages (so called ‘Stumpy’ forms). We have recently identified, using a genome-wide RNAi screen, components of the signal transduction pathway that drive this quorum sensing (QS) response. One component seems pivotal in the pathway- a molecule related to the YAK kinase of proteins. In yeasts and slime molds YAK kinase contributes to cell growth arrest in response to extracellular signals including nutrient limitation, whilst in mammals, related molecules of the DYRK family can also act in cellular quiescence. In this proposal we will investigate the function of trypanosome YAK kinase in the parasite's QS response. Specifically, we will investigate the kinase function in vitro and in vivo and dissect its action by following its location and targets. These are likely to differ from the situation in yeasts where YAK relocates to the nucleus and changes mRNA expression; in trypanosomes gene regulation is almost exclusively post transcriptional and likely operates within the cytoplasm. The function, location and interactions of YAK kinase in the QS signalling pathway is expected to provide comprehensive insight into how trypanosome parasites control their development in preparation for transmission, with additional important relevance for related parasites including other kinetoplastids and malaria. A two way benefit, encompassing training and expertise exchange between the researcher and host laboratory, will also be established.

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