Opendata, web and dolomites


Does reducing β-cell glucotoxicity increase the hyperglycaemia-lowering effect of physical exercise in type 2 diabetes?

Total Cost €


EC-Contrib. €






Project "GLUCOTOX" data sheet

The following table provides information about the project.


Organization address
address: Edgbaston
postcode: B15 2TT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Hyperglycaemia in type 2 diabetes (T2D) doubles mortality and arises due to failure of pancreatic β-cell insulin secretory function to overcome insulin resistance. Exercise reduces hyperglycaemia by improving insulin sensitivity and β-cell function; however, the variability of this beneficial effect is huge and is associated with high blood glucose and poor insulin secretion. Hyperglycaemia increases interleukin-(IL)1β levels causing β-cell death and insulin secretory dysfunction (glucotoxicity), and these phenomena are all elevated in T2D and are also augmented by IL-6, which alone is not toxic to β-cells. Interestingly, blood IL-6 levels are not only increased in T2D but are also increased following exercise due to secretion from muscle. Therefore the huge variability in the adaptation to exercise may be due to muscle IL-6-induced enhancement of IL-1β-induced β-cell dysfunction. Thus, exercise may be detrimental to T2D patients with β-cell glucotoxicity. Our objective is to determine the independent and interactive roles of IL-6 and IL-1β in the adaptations to exercise in T2D. We will achieve this by integrating the human physiology expertise of the Experienced Researcher with the transgenic mouse model expertise of the Supervisor to create a bench-to-bedside approach from which both the host institution and the experienced researcher will gain from in the future. Innovative muscle-specific IL-6 knockout mouse models and clinical anti-IL-1β drug treatment approaches will be used to ultimately increase the knowledge of how IL-6 and IL-1β interact, making it possible to optimise exercise therapy for all T2D patients, including those who would otherwise be classified as a “non-responder”.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GLUCOTOX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GLUCOTOX" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

GENESE 17 (2018)

Geometries of Exotic NuclEar StructurE 17

Read More  


Simulations of Topological Phases in Superconducting Circuits

Read More  

GAiNS (2020)

Gibberellic acid signaling and dynamics during arbuscular mycorrhizal symbiosis and rhizobial-legume symbiosis

Read More