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CREST UNDER TENSION TERMINATED

Mechano-regulation of neural crest cell differentiation.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CREST UNDER TENSION project word cloud

Explore the words cloud of the CREST UNDER TENSION project. It provides you a very rough idea of what is the project "CREST UNDER TENSION" about.

mechanoregulatory    cranial    developmental    influences    influence    structures    proliferation    hard    additionally    morphogenesis    transferable    odontoblasts    neural    ncc    multipotent    experts    mechano    regulation    signals    skeleton    biology    generation    exposed    shown    internationally    osteoblasts    population    recognised    tissue    governed    embryonic    mesenchymal    co    understand    epithelial    survival    mentored    hypothesis    differential    evolution    differentiation    behaviours    glia    yap    craniofacial    vertebrate    neuronal    tensions    soluble    give    similarly    skill    actinomyosin    chemicals    cell    fellow    deal    skills    regulatory    repair    stiff    manipulated    head    birth    interdisciplinary    generate    populations    vivo    training    soft    engineering    matrices    mechanisms    whilst    variety    stem    supervisors    chondrocytes    vitro    fate    migration    adult    regulated    transcriptional    nothing    forefront    crest    cells    taz    defects    hypothesized    adjacent    effectors    encompassing   

Project "CREST UNDER TENSION" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  0000-00-00

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Neural crest cells (NCC) are a unique vertebrate-specific population of multipotent cells that contribute to the development and evolution of the vertebrate head. During embryonic development, cranial NCC give rise to a variety of hard and soft tissue cells including osteoblasts, chondrocytes, odontoblasts, glia and neuronal cells. Whilst we understand a great deal about how growth factors and soluble chemicals determine the generation, migration, proliferation, survival and differentiation of the neural crest, nothing is known about how mechano-regulatory factors influence NCC fate. Recent evidence has shown that mesenchymal stem cell fate and cell behaviours are controlled by mechano-regulatory signals via the actinomyosin skeleton, and the co-transcriptional effectors, Yap and Taz. Given that NCC are similarly exposed to different mechanoregulatory influences from stiff and soft matrices and tensions generated by the differential growth and morphogenesis of adjacent epithelial and mesenchymal structures, it is hypothesized that NCC differentiation is also mechano-regulated. This proposal will use in vitro and in vivo approaches to test this hypothesis and determine if NCC fate is governed by mechano-regulatory signals, the differential regulation of the actinomyosin skeleton and Yap/Taz. The proposal will provide novel insight into the mechanisms of embryonic cell differentiation and craniofacial birth defects. Additionally, as neural crest stem cells have been identified in the adult, it will provide an understanding of how these may be manipulated to generate specific cell populations for tissue repair. The proposal will test a novel hypothesis and provide research training in a unique interdisciplinary skill set encompassing biology and engineering at the forefront of research field in addition to transferable skills. The Fellow will be mentored by two internationally recognised supervisors, who are experts in developmental biology and engineering.

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