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CREST UNDER TENSION TERMINATED

Mechano-regulation of neural crest cell differentiation.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CREST UNDER TENSION project word cloud

Explore the words cloud of the CREST UNDER TENSION project. It provides you a very rough idea of what is the project "CREST UNDER TENSION" about.

engineering    actinomyosin    nothing    deal    head    exposed    regulated    generate    hypothesized    understand    shown    mechanisms    developmental    morphogenesis    supervisors    mechanoregulatory    differential    soft    crest    experts    proliferation    cells    yap    vitro    population    neuronal    recognised    tissue    stem    mechano    adjacent    stiff    survival    odontoblasts    populations    fate    governed    interdisciplinary    epithelial    training    hard    adult    birth    influences    give    similarly    vivo    signals    osteoblasts    internationally    encompassing    variety    evolution    biology    transferable    embryonic    skill    generation    craniofacial    cell    structures    migration    matrices    multipotent    chemicals    mentored    manipulated    mesenchymal    soluble    cranial    additionally    glia    fellow    ncc    regulation    taz    skills    repair    defects    forefront    effectors    behaviours    influence    tensions    hypothesis    co    transcriptional    regulatory    skeleton    neural    chondrocytes    vertebrate    differentiation    whilst   

Project "CREST UNDER TENSION" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  0000-00-00

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Neural crest cells (NCC) are a unique vertebrate-specific population of multipotent cells that contribute to the development and evolution of the vertebrate head. During embryonic development, cranial NCC give rise to a variety of hard and soft tissue cells including osteoblasts, chondrocytes, odontoblasts, glia and neuronal cells. Whilst we understand a great deal about how growth factors and soluble chemicals determine the generation, migration, proliferation, survival and differentiation of the neural crest, nothing is known about how mechano-regulatory factors influence NCC fate. Recent evidence has shown that mesenchymal stem cell fate and cell behaviours are controlled by mechano-regulatory signals via the actinomyosin skeleton, and the co-transcriptional effectors, Yap and Taz. Given that NCC are similarly exposed to different mechanoregulatory influences from stiff and soft matrices and tensions generated by the differential growth and morphogenesis of adjacent epithelial and mesenchymal structures, it is hypothesized that NCC differentiation is also mechano-regulated. This proposal will use in vitro and in vivo approaches to test this hypothesis and determine if NCC fate is governed by mechano-regulatory signals, the differential regulation of the actinomyosin skeleton and Yap/Taz. The proposal will provide novel insight into the mechanisms of embryonic cell differentiation and craniofacial birth defects. Additionally, as neural crest stem cells have been identified in the adult, it will provide an understanding of how these may be manipulated to generate specific cell populations for tissue repair. The proposal will test a novel hypothesis and provide research training in a unique interdisciplinary skill set encompassing biology and engineering at the forefront of research field in addition to transferable skills. The Fellow will be mentored by two internationally recognised supervisors, who are experts in developmental biology and engineering.

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lastchecktime (2025-04-28 22:48:25) correctly updated