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CREST UNDER TENSION TERMINATED

Mechano-regulation of neural crest cell differentiation.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CREST UNDER TENSION project word cloud

Explore the words cloud of the CREST UNDER TENSION project. It provides you a very rough idea of what is the project "CREST UNDER TENSION" about.

repair    governed    odontoblasts    chemicals    signals    populations    hypothesized    chondrocytes    population    developmental    transferable    whilst    nothing    skill    vivo    head    defects    tensions    taz    actinomyosin    skeleton    neural    generate    differential    shown    additionally    birth    ncc    multipotent    generation    mechano    influence    similarly    evolution    adjacent    matrices    mechanoregulatory    internationally    mesenchymal    vitro    crest    manipulated    neuronal    hard    soft    cells    mentored    recognised    regulation    epithelial    encompassing    glia    deal    vertebrate    interdisciplinary    regulatory    fellow    craniofacial    proliferation    skills    adult    fate    stiff    osteoblasts    supervisors    exposed    hypothesis    training    soluble    co    biology    mechanisms    give    yap    forefront    morphogenesis    effectors    engineering    differentiation    embryonic    experts    structures    understand    variety    influences    tissue    behaviours    survival    cranial    transcriptional    stem    cell    migration    regulated   

Project "CREST UNDER TENSION" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  0000-00-00

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Neural crest cells (NCC) are a unique vertebrate-specific population of multipotent cells that contribute to the development and evolution of the vertebrate head. During embryonic development, cranial NCC give rise to a variety of hard and soft tissue cells including osteoblasts, chondrocytes, odontoblasts, glia and neuronal cells. Whilst we understand a great deal about how growth factors and soluble chemicals determine the generation, migration, proliferation, survival and differentiation of the neural crest, nothing is known about how mechano-regulatory factors influence NCC fate. Recent evidence has shown that mesenchymal stem cell fate and cell behaviours are controlled by mechano-regulatory signals via the actinomyosin skeleton, and the co-transcriptional effectors, Yap and Taz. Given that NCC are similarly exposed to different mechanoregulatory influences from stiff and soft matrices and tensions generated by the differential growth and morphogenesis of adjacent epithelial and mesenchymal structures, it is hypothesized that NCC differentiation is also mechano-regulated. This proposal will use in vitro and in vivo approaches to test this hypothesis and determine if NCC fate is governed by mechano-regulatory signals, the differential regulation of the actinomyosin skeleton and Yap/Taz. The proposal will provide novel insight into the mechanisms of embryonic cell differentiation and craniofacial birth defects. Additionally, as neural crest stem cells have been identified in the adult, it will provide an understanding of how these may be manipulated to generate specific cell populations for tissue repair. The proposal will test a novel hypothesis and provide research training in a unique interdisciplinary skill set encompassing biology and engineering at the forefront of research field in addition to transferable skills. The Fellow will be mentored by two internationally recognised supervisors, who are experts in developmental biology and engineering.

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