Opendata, web and dolomites

GLU-IMAGE SIGNED

Glutamate dynamics during visual stimulation and ketamine challenge in the human brain

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GLU-IMAGE project word cloud

Explore the words cloud of the GLU-IMAGE project. It provides you a very rough idea of what is the project "GLU-IMAGE" about.

monitoring    group    infusion    ketamine    disorder    minute    pioneering    dynamic    while    direct    action    accelerated    optimal    human    medical    concentrations    urgently    overcomes    oxygenation    acc    limited    brain    spatial    improvement    blood    energetic    glucose    utilized    glutamatergic    resistant    pharmacologically    clinical    methyl    gold    trd    confirmed    standard    emission    cortex    conventional    measured    patients    positron    glu    functional    monitor    receptor    exact    mechanism    glutamate    time    image    baseline    ute    unclear    metabolism    activated    demands    invasive    insula    applicability    subjects    antagonist    improvements    university    therapy    muw    cingulate    therapies    voxels    motion    ground    sensitivity    understand    imaging    boost    voxel    showed    selectively    echo    breaking    reliably    anterior    healthy    previously    depressive    vascular    slice    bold    thalamus    ultra    critical    clarify    aspartate    coverage    potent    dynamics    correction    suggesting    mrs    treatment    single    administration    vivo    dependent    reproducibly    metabolic    missing    signals    elevated    tomography    mrsi    sv    resolution    proton    vienna   

Project "GLU-IMAGE" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 186˙167 €
 EC max contribution 186˙167 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 186˙167.00

Map

 Project objective

While clinical experience confirmed ketamine, a glutamate (Glu) N-methyl-D-aspartate receptor antagonist, as a potent therapy of treatment-resistant major depressive disorder (TRD), the exact mechanism of ketamine’s action in the brain is unclear. Thus, a method to reliably and reproducibly monitor minute changes in Glu metabolism in the human brain is urgently needed to understand ketamine dynamics in vivo. So far, the pioneering work at the Medical University Vienna (MUW) showed ketamine-induced increase of vascular and metabolic responses measured as blood oxygenation level dependent (BOLD) signals in healthy subjects in thalamus, insula and anterior cingulate cortex (ACC), while others observed elevated glucose uptake using positron emission tomography, suggesting higher energetic demands and Glu response after ketamine infusion. Yet, a reliable and non-invasive method for direct monitoring of pharmacologically-induced dynamic Glu changes is still missing. Our group at MUW has recently developed a novel ground-breaking accelerated method for ultra-short echo time MRS imaging (UTE-MRSI) providing optimal Glu measures with critical sensitivity improvements compared to conventional proton single-voxel MRS (SV-MRS) and previously utilized MRSI approaches. Our method allows monitoring of Glu responses selectively in activated voxels and overcomes low spatial resolution, and limited coverage of SV-MRS that is the current gold standard for measurement of Glu concentrations and its dynamic changes in vivo (functional SV-MRS). The further improvement of UTE-MRSI by the implementation of the novel real-time motion correction will boost its applicability in clinical human studies. Thus, our UTE-MRSI will offer image-based multi-slice measurements of baseline Glu concentrations and its responses to ketamine administration with the potential to clarify ketamine’s mechanism of action in patients with TRD, and will allow monitoring of other novel glutamatergic therapies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GLU-IMAGE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GLU-IMAGE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

STIMOS (2019)

Stimulation of Multiple Organoids Simultaneously

Read More  

BirthControlEnvirons (2019)

Contraception meets the environment: everyday contraceptive practices, politics, and futures in a toxic age

Read More  

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More