Opendata, web and dolomites

GLU-IMAGE SIGNED

Glutamate dynamics during visual stimulation and ketamine challenge in the human brain

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GLU-IMAGE project word cloud

Explore the words cloud of the GLU-IMAGE project. It provides you a very rough idea of what is the project "GLU-IMAGE" about.

trd    therapies    spatial    subjects    clarify    dynamics    missing    metabolic    university    patients    infusion    healthy    dynamic    optimal    energetic    ute    muw    monitor    activated    conventional    voxel    vascular    confirmed    mrsi    concentrations    action    reproducibly    applicability    coverage    standard    signals    echo    pioneering    critical    baseline    invasive    demands    resistant    therapy    anterior    ketamine    proton    glutamate    slice    breaking    group    unclear    pharmacologically    overcomes    limited    oxygenation    utilized    gold    potent    direct    metabolism    antagonist    cingulate    functional    vienna    thalamus    blood    accelerated    administration    voxels    clinical    vivo    tomography    insula    emission    correction    showed    selectively    while    ultra    disorder    mrs    measured    receptor    improvements    sv    cortex    brain    minute    exact    resolution    single    improvement    reliably    previously    time    glucose    dependent    urgently    monitoring    glutamatergic    sensitivity    acc    imaging    suggesting    medical    positron    image    depressive    methyl    human    understand    mechanism    treatment    motion    bold    ground    aspartate    glu    boost    elevated   

Project "GLU-IMAGE" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 186˙167 €
 EC max contribution 186˙167 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 186˙167.00

Map

 Project objective

While clinical experience confirmed ketamine, a glutamate (Glu) N-methyl-D-aspartate receptor antagonist, as a potent therapy of treatment-resistant major depressive disorder (TRD), the exact mechanism of ketamine’s action in the brain is unclear. Thus, a method to reliably and reproducibly monitor minute changes in Glu metabolism in the human brain is urgently needed to understand ketamine dynamics in vivo. So far, the pioneering work at the Medical University Vienna (MUW) showed ketamine-induced increase of vascular and metabolic responses measured as blood oxygenation level dependent (BOLD) signals in healthy subjects in thalamus, insula and anterior cingulate cortex (ACC), while others observed elevated glucose uptake using positron emission tomography, suggesting higher energetic demands and Glu response after ketamine infusion. Yet, a reliable and non-invasive method for direct monitoring of pharmacologically-induced dynamic Glu changes is still missing. Our group at MUW has recently developed a novel ground-breaking accelerated method for ultra-short echo time MRS imaging (UTE-MRSI) providing optimal Glu measures with critical sensitivity improvements compared to conventional proton single-voxel MRS (SV-MRS) and previously utilized MRSI approaches. Our method allows monitoring of Glu responses selectively in activated voxels and overcomes low spatial resolution, and limited coverage of SV-MRS that is the current gold standard for measurement of Glu concentrations and its dynamic changes in vivo (functional SV-MRS). The further improvement of UTE-MRSI by the implementation of the novel real-time motion correction will boost its applicability in clinical human studies. Thus, our UTE-MRSI will offer image-based multi-slice measurements of baseline Glu concentrations and its responses to ketamine administration with the potential to clarify ketamine’s mechanism of action in patients with TRD, and will allow monitoring of other novel glutamatergic therapies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GLU-IMAGE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GLU-IMAGE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

GENI (2019)

Gender, emotions and national identities: a new perspective on the abortion debates in Italy (1971-1981).

Read More  

ToMComputations (2019)

How other minds are represented in the human brain: Neural computations underlying Theory of Mind

Read More  

RealFlex (2019)

Real-time simulator-driver design and manufacturing based on flexible systems

Read More