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GLU-IMAGE SIGNED

Glutamate dynamics during visual stimulation and ketamine challenge in the human brain

Total Cost €

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EC-Contrib. €

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Partnership

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 GLU-IMAGE project word cloud

Explore the words cloud of the GLU-IMAGE project. It provides you a very rough idea of what is the project "GLU-IMAGE" about.

standard    suggesting    functional    positron    therapy    metabolism    receptor    acc    reliably    urgently    sensitivity    accelerated    therapies    activated    image    measured    concentrations    missing    while    reproducibly    single    ground    signals    voxel    demands    emission    previously    monitoring    gold    aspartate    bold    mrs    anterior    baseline    glutamatergic    optimal    administration    utilized    imaging    selectively    understand    subjects    sv    showed    infusion    glucose    slice    brain    patients    clarify    pharmacologically    dynamics    monitor    ultra    oxygenation    university    improvements    healthy    trd    depressive    exact    echo    confirmed    treatment    cortex    direct    vienna    action    overcomes    coverage    muw    boost    dynamic    spatial    vivo    potent    human    breaking    energetic    motion    pioneering    disorder    thalamus    proton    invasive    applicability    tomography    vascular    metabolic    resolution    limited    clinical    glutamate    insula    unclear    minute    blood    cingulate    critical    dependent    ute    methyl    antagonist    medical    group    voxels    time    correction    resistant    glu    mrsi    mechanism    improvement    conventional    ketamine    elevated   

Project "GLU-IMAGE" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 186˙167 €
 EC max contribution 186˙167 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 186˙167.00

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 Project objective

While clinical experience confirmed ketamine, a glutamate (Glu) N-methyl-D-aspartate receptor antagonist, as a potent therapy of treatment-resistant major depressive disorder (TRD), the exact mechanism of ketamine’s action in the brain is unclear. Thus, a method to reliably and reproducibly monitor minute changes in Glu metabolism in the human brain is urgently needed to understand ketamine dynamics in vivo. So far, the pioneering work at the Medical University Vienna (MUW) showed ketamine-induced increase of vascular and metabolic responses measured as blood oxygenation level dependent (BOLD) signals in healthy subjects in thalamus, insula and anterior cingulate cortex (ACC), while others observed elevated glucose uptake using positron emission tomography, suggesting higher energetic demands and Glu response after ketamine infusion. Yet, a reliable and non-invasive method for direct monitoring of pharmacologically-induced dynamic Glu changes is still missing. Our group at MUW has recently developed a novel ground-breaking accelerated method for ultra-short echo time MRS imaging (UTE-MRSI) providing optimal Glu measures with critical sensitivity improvements compared to conventional proton single-voxel MRS (SV-MRS) and previously utilized MRSI approaches. Our method allows monitoring of Glu responses selectively in activated voxels and overcomes low spatial resolution, and limited coverage of SV-MRS that is the current gold standard for measurement of Glu concentrations and its dynamic changes in vivo (functional SV-MRS). The further improvement of UTE-MRSI by the implementation of the novel real-time motion correction will boost its applicability in clinical human studies. Thus, our UTE-MRSI will offer image-based multi-slice measurements of baseline Glu concentrations and its responses to ketamine administration with the potential to clarify ketamine’s mechanism of action in patients with TRD, and will allow monitoring of other novel glutamatergic therapies.

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