Opendata, web and dolomites


Investigating Ror2-dependent non-canonical Wnt signaling in bone remodeling

Total Cost €


EC-Contrib. €






Project "ROR2BONE" data sheet

The following table provides information about the project.


Organization address
address: Martinistrasse 52
postcode: 20251

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2018-11-02


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Wnt signaling is composed of the canonical and non-canonical pathways. Canonical Wnt signaling is dependent on β-catenin activation and has become a major focus for targeting osteoblast-mediated bone formation in the context of treating the debilitating disease osteoporosis. However, much less is known about the role of the non-canonical pathway in bone formation. Unpublished data of the host laboratory demonstrates that targeted deletion of the non-canonical Wnt signaling Receptor tyrosine kinase-like orphan receptor 2 (Ror2) in osteoblasts in mice causes a high bone turnover with increased bone formation and enhanced osteoclast-mediated bone resorption. I thus hypothesize that Ror2 regulates bone remodeling by altering signaling in osteoblasts and their interaction with osteoclasts. In Aim I, I will determine cell autonomous effects of Ror2 on osteoblasts by analyzing cell differentiation, proliferation, survival, and by performing functional studies both in vitro and in vivo. Additionally, since osteoblasts provide pro- and anti-differentiation signals to osteoclasts, Aim I will further explore if Ror2 alters the activity of these signals and investigate the resulting phenotypic changes in osteoclast function. In Aim II, I will undertake an in-depth experimental approach combined with an innovative bioinformatics analysis to investigate the osteoblast-specific non-canonical Wnt signaling cascade downstream of Ror2 after reconstituting Ror2-deficient cells with wild type or Ror2 mutants. Lastly, in Aim III I will directly address the therapeutic potential of Ror2 in several in vivo bone turnover models utilizing a chimeric Ror2-Fc soluble receptor. In summary, I will use state of the art in vivo and in vitro approaches to delineate the downstream Ror2 signaling cascade in osteoblasts and its functional effect on bone remodeling. This fellowship is instrumental in catalyzing career opportunities for me as it provides an ideal environment to reach my full potential.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ROR2BONE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ROR2BONE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NeoPur (2019)

New treatments and novel diagnostic tests for neonatal seizures based on purinergic signaling.

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More