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Exosomes as microenvironmental cue for engaging mesenchymal stem cells in osteosarcoma progression

Total Cost €


EC-Contrib. €






 S-OS project word cloud

Explore the words cloud of the S-OS project. It provides you a very rough idea of what is the project "S-OS" about.

behavior    aggressive    survival    responsible    occurs    mortality    metastasis    function    msc    events    exosomes    rapid    rnas    employ    layer    tendency    proteomics    altering    stop    regulatory    discover    stem    metastatic    wish    intercellular    revealed    interference    genetic    deep    mouse    urgently    techniques    lay    proteins    microenvironmental    heterogeneous    vesicles    mscs    mechanisms    dismal    therapeutical    identification    bone    secreted    interaction    treatment    groundwork    stromal    interactions    clinical    talk    mesenchymal    molecular    cells    intend    explored    reported    childhood    explore    onset    poorly    sites    develops    adolescent    unsuccessful    last    components    alterations    tumor    prospect    bioluminescent    surprisingly    spurt    driver    primarily    exosome    assays    30    tumorigenic    functional    sequencing    decades    recurrence    stroma    cross    models    unexplored    progression    malignant    xenograft    trials    extremely    pro    rate    cellular    signals    educate    alternative    stagnated    breakthrough    proved    underlying    communication    completely    osteosarcoma    os    adolescence   

Project "S-OS" data sheet

The following table provides information about the project.


Organization address
address: DE BOELELAAN 1117
postcode: 1081 HV

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VUMC NL (AMSTERDAM) coordinator 164˙679.00
2    STICHTING VU NL (AMSTERDAM) participant 919.00


 Project objective

Osteosarcoma (OS) is a very aggressive malignant bone tumor that develops primarily during childhood and adolescence. It is characterized by rapid growth, a strong tendency for recurrence and an extremely high metastatic potential. In the last three decades OS survival in the presence of metastasis has stagnated at a dismal 30%, clinical trials proved unsuccessful and no major breakthrough in the treatment of OS has been reported. To stop OS mortality, alternative therapeutical approaches urgently need to be explored. Studies into the molecular and cellular events underlying OS revealed complex and heterogeneous genetic alterations, which challenge the prospect of finding and exploiting an unique molecular driver underlying OS. Because OS onset occurs at sites of rapid bone growth during the adolescent growth spurt, microenvironmental factors and tumor stroma may have a defining role in OS development and progression. Surprisingly, the intercellular cross-talk between OS cells and components of the tumor stroma, in particular mesenchymal stem cells (MSCs), have been poorly investigated. Here I intend to demonstrate that tumor secreted vesicles called “exosomes” function as a key microenvironmental factor in OS progression by controlling tumor-stromal cells interactions. Specifically, we aim to explore whether MSC become pro-tumorigenic and pro-metastatic upon interaction with OS exosomes in bioluminescent mouse xenograft models. To identify the molecular signals (i.e. proteins and regulatory RNAs) in OS exosomes responsible for altering MSC behavior, we will employ state-of-the-art proteomics and deep-sequencing techniques. Finally, by means of functional assays we wish to discover the mechanisms by which OS exosome “educate” MSCs. The identification of and interference with this completely unexplored layer of communication will lay the groundwork for novel therapeutical approaches to stop OS high mortality rate.


year authors and title journal last update
List of publications.
2018 Maarten P. Bebelman, Martine J. Smit, D. Michiel Pegtel, S. Rubina Baglio
Biogenesis and function of extracellular vesicles in cancer
published pages: , ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2018.02.013
Pharmacology & Therapeutics 2019-06-18

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The information about "S-OS" are provided by the European Opendata Portal: CORDIS opendata.

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