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S-OS SIGNED

Exosomes as microenvironmental cue for engaging mesenchymal stem cells in osteosarcoma progression

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 S-OS project word cloud

Explore the words cloud of the S-OS project. It provides you a very rough idea of what is the project "S-OS" about.

occurs    poorly    reported    urgently    proteomics    heterogeneous    stromal    treatment    layer    explored    mortality    mscs    primarily    rnas    vesicles    progression    techniques    molecular    decades    genetic    revealed    identification    cross    sequencing    clinical    recurrence    bioluminescent    groundwork    msc    aggressive    behavior    onset    educate    proteins    metastatic    regulatory    prospect    intercellular    survival    alterations    responsible    adolescent    rate    stem    xenograft    intend    deep    stroma    cells    tendency    unsuccessful    alternative    interference    rapid    metastasis    mouse    underlying    sites    bone    communication    discover    tumorigenic    assays    altering    microenvironmental    spurt    malignant    trials    explore    therapeutical    function    extremely    proved    driver    stop    lay    30    events    completely    exosome    signals    stagnated    surprisingly    pro    functional    talk    wish    unexplored    components    secreted    mesenchymal    breakthrough    models    childhood    interactions    adolescence    last    exosomes    cellular    dismal    mechanisms    employ    interaction    os    develops    tumor    osteosarcoma   

Project "S-OS" data sheet

The following table provides information about the project.

Coordinator
STICHTING VUMC 

Organization address
address: DE BOELELAAN 1117
city: AMSTERDAM
postcode: 1081 HV
website: www.vumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.exosomes.nl/
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VUMC NL (AMSTERDAM) coordinator 164˙679.00
2    STICHTING VU NL (AMSTERDAM) participant 919.00

Map

 Project objective

Osteosarcoma (OS) is a very aggressive malignant bone tumor that develops primarily during childhood and adolescence. It is characterized by rapid growth, a strong tendency for recurrence and an extremely high metastatic potential. In the last three decades OS survival in the presence of metastasis has stagnated at a dismal 30%, clinical trials proved unsuccessful and no major breakthrough in the treatment of OS has been reported. To stop OS mortality, alternative therapeutical approaches urgently need to be explored. Studies into the molecular and cellular events underlying OS revealed complex and heterogeneous genetic alterations, which challenge the prospect of finding and exploiting an unique molecular driver underlying OS. Because OS onset occurs at sites of rapid bone growth during the adolescent growth spurt, microenvironmental factors and tumor stroma may have a defining role in OS development and progression. Surprisingly, the intercellular cross-talk between OS cells and components of the tumor stroma, in particular mesenchymal stem cells (MSCs), have been poorly investigated. Here I intend to demonstrate that tumor secreted vesicles called “exosomes” function as a key microenvironmental factor in OS progression by controlling tumor-stromal cells interactions. Specifically, we aim to explore whether MSC become pro-tumorigenic and pro-metastatic upon interaction with OS exosomes in bioluminescent mouse xenograft models. To identify the molecular signals (i.e. proteins and regulatory RNAs) in OS exosomes responsible for altering MSC behavior, we will employ state-of-the-art proteomics and deep-sequencing techniques. Finally, by means of functional assays we wish to discover the mechanisms by which OS exosome “educate” MSCs. The identification of and interference with this completely unexplored layer of communication will lay the groundwork for novel therapeutical approaches to stop OS high mortality rate.

 Publications

year authors and title journal last update
List of publications.
2018 Maarten P. Bebelman, Martine J. Smit, D. Michiel Pegtel, S. Rubina Baglio
Biogenesis and function of extracellular vesicles in cancer
published pages: , ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2018.02.013
Pharmacology & Therapeutics 2019-06-18

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