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S-OS SIGNED

Exosomes as microenvironmental cue for engaging mesenchymal stem cells in osteosarcoma progression

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 S-OS project word cloud

Explore the words cloud of the S-OS project. It provides you a very rough idea of what is the project "S-OS" about.

layer    onset    xenograft    explore    mscs    revealed    tumorigenic    discover    techniques    intend    decades    function    develops    proved    stromal    adolescence    rate    msc    occurs    driver    wish    identification    primarily    childhood    exosome    interference    clinical    mesenchymal    urgently    components    metastatic    cross    explored    survival    breakthrough    reported    altering    alterations    os    lay    stroma    interaction    rnas    adolescent    tumor    mouse    metastasis    dismal    extremely    rapid    proteomics    spurt    stem    proteins    functional    responsible    behavior    molecular    30    educate    regulatory    surprisingly    models    bioluminescent    therapeutical    osteosarcoma    communication    last    mechanisms    unsuccessful    deep    alternative    cellular    secreted    intercellular    unexplored    completely    cells    sequencing    underlying    bone    signals    groundwork    treatment    sites    assays    stop    microenvironmental    vesicles    interactions    genetic    employ    heterogeneous    recurrence    malignant    mortality    talk    pro    trials    exosomes    stagnated    prospect    aggressive    progression    events    tendency    poorly   

Project "S-OS" data sheet

The following table provides information about the project.

Coordinator
STICHTING VUMC 

Organization address
address: DE BOELELAAN 1117
city: AMSTERDAM
postcode: 1081 HV
website: www.vumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.exosomes.nl/
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VUMC NL (AMSTERDAM) coordinator 164˙679.00
2    STICHTING VU NL (AMSTERDAM) participant 919.00

Map

 Project objective

Osteosarcoma (OS) is a very aggressive malignant bone tumor that develops primarily during childhood and adolescence. It is characterized by rapid growth, a strong tendency for recurrence and an extremely high metastatic potential. In the last three decades OS survival in the presence of metastasis has stagnated at a dismal 30%, clinical trials proved unsuccessful and no major breakthrough in the treatment of OS has been reported. To stop OS mortality, alternative therapeutical approaches urgently need to be explored. Studies into the molecular and cellular events underlying OS revealed complex and heterogeneous genetic alterations, which challenge the prospect of finding and exploiting an unique molecular driver underlying OS. Because OS onset occurs at sites of rapid bone growth during the adolescent growth spurt, microenvironmental factors and tumor stroma may have a defining role in OS development and progression. Surprisingly, the intercellular cross-talk between OS cells and components of the tumor stroma, in particular mesenchymal stem cells (MSCs), have been poorly investigated. Here I intend to demonstrate that tumor secreted vesicles called “exosomes” function as a key microenvironmental factor in OS progression by controlling tumor-stromal cells interactions. Specifically, we aim to explore whether MSC become pro-tumorigenic and pro-metastatic upon interaction with OS exosomes in bioluminescent mouse xenograft models. To identify the molecular signals (i.e. proteins and regulatory RNAs) in OS exosomes responsible for altering MSC behavior, we will employ state-of-the-art proteomics and deep-sequencing techniques. Finally, by means of functional assays we wish to discover the mechanisms by which OS exosome “educate” MSCs. The identification of and interference with this completely unexplored layer of communication will lay the groundwork for novel therapeutical approaches to stop OS high mortality rate.

 Publications

year authors and title journal last update
List of publications.
2018 Maarten P. Bebelman, Martine J. Smit, D. Michiel Pegtel, S. Rubina Baglio
Biogenesis and function of extracellular vesicles in cancer
published pages: , ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2018.02.013
Pharmacology & Therapeutics 2019-06-18

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