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S-OS SIGNED

Exosomes as microenvironmental cue for engaging mesenchymal stem cells in osteosarcoma progression

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 S-OS project word cloud

Explore the words cloud of the S-OS project. It provides you a very rough idea of what is the project "S-OS" about.

wish    stop    sequencing    occurs    mesenchymal    treatment    childhood    explored    behavior    lay    identification    mechanisms    exosomes    intend    trials    exosome    cells    communication    rapid    adolescent    driver    sites    therapeutical    unexplored    os    genetic    completely    tumorigenic    interference    proteomics    mouse    cross    regulatory    layer    metastatic    proteins    events    educate    cellular    prospect    talk    interactions    pro    models    primarily    stagnated    stroma    develops    proved    bioluminescent    msc    secreted    employ    intercellular    groundwork    mscs    tendency    recurrence    osteosarcoma    breakthrough    interaction    vesicles    signals    functional    rate    components    urgently    microenvironmental    tumor    spurt    deep    rnas    survival    revealed    molecular    adolescence    alternative    heterogeneous    malignant    aggressive    function    mortality    metastasis    xenograft    dismal    last    reported    assays    decades    progression    stromal    discover    30    alterations    surprisingly    underlying    unsuccessful    explore    responsible    stem    onset    techniques    extremely    poorly    clinical    bone    altering   

Project "S-OS" data sheet

The following table provides information about the project.

Coordinator
STICHTING VUMC 

Organization address
address: DE BOELELAAN 1117
city: AMSTERDAM
postcode: 1081 HV
website: www.vumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.exosomes.nl/
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VUMC NL (AMSTERDAM) coordinator 164˙679.00
2    STICHTING VU NL (AMSTERDAM) participant 919.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Osteosarcoma (OS) is a very aggressive malignant bone tumor that develops primarily during childhood and adolescence. It is characterized by rapid growth, a strong tendency for recurrence and an extremely high metastatic potential. In the last three decades OS survival in the presence of metastasis has stagnated at a dismal 30%, clinical trials proved unsuccessful and no major breakthrough in the treatment of OS has been reported. To stop OS mortality, alternative therapeutical approaches urgently need to be explored. Studies into the molecular and cellular events underlying OS revealed complex and heterogeneous genetic alterations, which challenge the prospect of finding and exploiting an unique molecular driver underlying OS. Because OS onset occurs at sites of rapid bone growth during the adolescent growth spurt, microenvironmental factors and tumor stroma may have a defining role in OS development and progression. Surprisingly, the intercellular cross-talk between OS cells and components of the tumor stroma, in particular mesenchymal stem cells (MSCs), have been poorly investigated. Here I intend to demonstrate that tumor secreted vesicles called “exosomes” function as a key microenvironmental factor in OS progression by controlling tumor-stromal cells interactions. Specifically, we aim to explore whether MSC become pro-tumorigenic and pro-metastatic upon interaction with OS exosomes in bioluminescent mouse xenograft models. To identify the molecular signals (i.e. proteins and regulatory RNAs) in OS exosomes responsible for altering MSC behavior, we will employ state-of-the-art proteomics and deep-sequencing techniques. Finally, by means of functional assays we wish to discover the mechanisms by which OS exosome “educate” MSCs. The identification of and interference with this completely unexplored layer of communication will lay the groundwork for novel therapeutical approaches to stop OS high mortality rate.

 Publications

year authors and title journal last update
List of publications.
2018 Maarten P. Bebelman, Martine J. Smit, D. Michiel Pegtel, S. Rubina Baglio
Biogenesis and function of extracellular vesicles in cancer
published pages: , ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2018.02.013
Pharmacology & Therapeutics 2019-06-18

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The information about "S-OS" are provided by the European Opendata Portal: CORDIS opendata.

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