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PIOMES

Pbx proteins as pioneer factors promoting signal specificity in mesodermal differentiation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PIOMES project word cloud

Explore the words cloud of the PIOMES project. It provides you a very rough idea of what is the project "PIOMES" about.

fate    somitic    pools    acquisition    skeletal    cellular    ways    combat    embryonic    mesodermal    central    specification    strategies    immunoprecipitation    date    healthy    binding    landscape    degenerative    types    had    streak    blood    competence    shape    cell    limited    mps    arise    cells    promotes    region    differentiation    organisms    assays    murine    progenitors    pioneer    transcriptional    routinely    efficiency    mastered    regenerative    analogous    treating    proteins    primitive    danstem    opening    transcription    life    recruitment    conceive    critical    postdoctoral    training    specify    diseases    combines    embryo    dynamics    purpose    wnt    mouse    chromatin    genetic    tools    strength    mesoderm    expressed    muscles    extensively    question    specified    lineage    regulation    insights    bone    rational    stem    tfs    epiblast    tf    signalling    vitro    esc    human    hescs    converting    muscle    dystrophies    pbx    ultimately    embryos    muscular   

Project "PIOMES" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://danstem.ku.dk/research1/ferretti-lab/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

The development of healthy organisms requires the formation of different cellular systems, such as a blood, bone and muscle. All these different cell types arise during embryonic life from specific pools of mesodermal progenitors (MPs). A central question is how distinct MPs are specified and ultimately why different cells respond to signalling pathways in different ways? Critical insights here are directly relevant to conceive strategies for increasing the efficiency of mesodermal differentiation aimed for treating muscular degenerative diseases. To date, in vitro, somitic mesoderm differentiation for regenerative purpose has had limited success. Wnt signalling promotes Embryonic Stem Cell (ESC) differentiation of all the MPs, including skeletal muscles. The activity of specific pioneer transcription factors (TFs) may be the key for converting Wnt signalling pathways into a specific transcriptional program. Pioneer TFs shape the chromatin landscape by opening the chromatin and allowing the recruitment of lineage specific TFs, and thus ultimately control the TF binding dynamics and the acquisition of a specific cell fate. Pbx proteins are pioneer TFs, which are specifically expressed in the primitive streak, the region of the embryo that will produce all mesoderm, and are critical for promoting mesodermal specification. Here, I will establish how Pbx proteins specify MPs and determine the competence of early mesoderm to respond to Wnt signalling. To this end, I will use mouse embryos and murine epiblast stem cells, which are analogous to human ESC (hESCs). My approach combines the strength of an in vitro ESC differentiation method, routinely used at DanStem, with chromatin immunoprecipitation and transcriptional regulation assays, which I have extensively mastered during my postdoctoral training. I expect that my findings will provide novel tools for rational design of strategies to combat genetic and degenerative muscular diseases, such as muscular dystrophies.

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The information about "PIOMES" are provided by the European Opendata Portal: CORDIS opendata.

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