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PIOMES

Pbx proteins as pioneer factors promoting signal specificity in mesodermal differentiation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PIOMES project word cloud

Explore the words cloud of the PIOMES project. It provides you a very rough idea of what is the project "PIOMES" about.

regenerative    arise    conceive    primitive    progenitors    streak    insights    landscape    competence    healthy    combat    embryonic    combines    binding    types    wnt    vitro    differentiation    blood    specified    assays    fate    chromatin    cells    strength    efficiency    critical    opening    training    mastered    question    cellular    tools    mouse    specify    postdoctoral    expressed    embryo    treating    dystrophies    murine    region    promotes    tf    genetic    human    muscular    regulation    specification    somitic    ways    converting    epiblast    acquisition    transcriptional    tfs    had    muscle    hescs    pools    proteins    analogous    limited    immunoprecipitation    danstem    extensively    muscles    central    esc    mesoderm    cell    organisms    date    routinely    mps    transcription    embryos    diseases    rational    pbx    dynamics    ultimately    lineage    strategies    shape    stem    recruitment    skeletal    purpose    mesodermal    life    degenerative    signalling    pioneer    bone   

Project "PIOMES" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://danstem.ku.dk/research1/ferretti-lab/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

The development of healthy organisms requires the formation of different cellular systems, such as a blood, bone and muscle. All these different cell types arise during embryonic life from specific pools of mesodermal progenitors (MPs). A central question is how distinct MPs are specified and ultimately why different cells respond to signalling pathways in different ways? Critical insights here are directly relevant to conceive strategies for increasing the efficiency of mesodermal differentiation aimed for treating muscular degenerative diseases. To date, in vitro, somitic mesoderm differentiation for regenerative purpose has had limited success. Wnt signalling promotes Embryonic Stem Cell (ESC) differentiation of all the MPs, including skeletal muscles. The activity of specific pioneer transcription factors (TFs) may be the key for converting Wnt signalling pathways into a specific transcriptional program. Pioneer TFs shape the chromatin landscape by opening the chromatin and allowing the recruitment of lineage specific TFs, and thus ultimately control the TF binding dynamics and the acquisition of a specific cell fate. Pbx proteins are pioneer TFs, which are specifically expressed in the primitive streak, the region of the embryo that will produce all mesoderm, and are critical for promoting mesodermal specification. Here, I will establish how Pbx proteins specify MPs and determine the competence of early mesoderm to respond to Wnt signalling. To this end, I will use mouse embryos and murine epiblast stem cells, which are analogous to human ESC (hESCs). My approach combines the strength of an in vitro ESC differentiation method, routinely used at DanStem, with chromatin immunoprecipitation and transcriptional regulation assays, which I have extensively mastered during my postdoctoral training. I expect that my findings will provide novel tools for rational design of strategies to combat genetic and degenerative muscular diseases, such as muscular dystrophies.

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The information about "PIOMES" are provided by the European Opendata Portal: CORDIS opendata.

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