Opendata, web and dolomites


The dynamics of the mammalian epigenome during transcription factor-induced cell fate conversion

Total Cost €


EC-Contrib. €






 3Dconvert project word cloud

Explore the words cloud of the 3Dconvert project. It provides you a very rough idea of what is the project "3Dconvert" about.

translate    inefficient    integration    cell    reaching    undergoing    capture    acquiring    systemically    besides    frequency    special    maturity    dataset    technologies    insights    identity    scientific    dynamics    emphasis    capacity    difficult    conversion    signify    macrophages    considerable    breakthrough    topology    genomic    unbiased    dimensional    therapeutic    action    ips    independence    significantly    efficient    unravel    molecular    documenting    conformation    stem    poorly    exhaustive    cellular    remained    plasticity    underpin    transcription    maximize    advancing    professional    reveal    slow    critical    dynamic    mechanisms    precluded    uniquely    binding    chromosome    reprogramming    experimental    conversions    regulatory    barrier    cells    100    nearly    phenotype    medical    bear    genome    transdifferentiation    computational    gene    expression    fate    interdisciplinary    relationships    epigenetic    ultimately    put    pluripotent    classic    accompany    events   

Project "3Dconvert" data sheet

The following table provides information about the project.


Organization address
postcode: 8003

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Cell fate conversion processes bear considerable therapeutic potential yet are poorly understood, and have thus remained slow, inefficient and difficult to translate into medical applications. The low conversion frequency in current systems, such as classic reprogramming to ‘induced’ pluripotent stem (iPS) cells, has precluded a molecular study of the critical early conversion events. We propose an interdisciplinary, exhaustive and unbiased approach to unravel the molecular events that accompany cell fate conversion processes, in particular during the early phase, using two uniquely efficient and controllable experimental systems. Special emphasis will be put on documenting the dynamics of three-dimensional genome topology, as this potential epigenetic conversion barrier has not yet been systemically characterized during cell fate conversions. We will apply genome-wide chromosome conformation capture and other genomic technologies on B cells undergoing nearly 100% efficient transdifferentiation into macrophages or reprogramming into iPS cells. In-depth computational analyses and dataset integration will reveal the dynamic relationships between transcription factor binding, key epigenetic regulatory mechanisms including genome topology, and the gene expression changes that ultimately lead to the implementation of a new cellular phenotype. Acquiring such insights will signify a breakthrough in our understanding of the epigenetic features that underpin cell identity and plasticity. Besides significantly advancing the state-of-the-art, the proposed action will maximize the applicant’s capacity of reaching professional maturity and scientific independence.


year authors and title journal last update
List of publications.
2016 Bruno Di Stefano, Samuel Collombet, Janus Schou Jakobsen, Michael Wierer, Jose Luis Sardina, Andreas Lackner, Ralph Stadhouders, Carolina Segura-Morales, Mirko Francesconi, Francesco Limone, Matthias Mann, Bo Porse, Denis Thieffry, Thomas Graf
C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4
published pages: 371-381, ISSN: 1465-7392, DOI: 10.1038/ncb3326
Nature Cell Biology 18/4 2019-07-24
2017 Ai Ing Lim, Yan Li, Silvia Lopez-Lastra, Ralph Stadhouders, Franziska Paul, Armanda Casrouge, Nicolas Serafini, Anne Puel, Jacinta Bustamante, Laura Surace, Guillemette Masse-Ranson, Eyal David, Helene Strick-Marchand, Lionel Le Bourhis, Roberto Cocchi, Davide Topazio, Paolo Graziano, Lucia Anna Muscarella, Lars Rogge, Xavier Norel, Jean-Michel Sallenave, Matthieu Allez, Thomas Graf, Rudi W. Hendriks, Jean-Laurent Casanova, Ido Amit, Hans Yssel, James P. Di Santo
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation
published pages: 1086-1100.e10, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.02.021
Cell 168/6 2019-07-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "3DCONVERT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "3DCONVERT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MathematicsAnalogies (2019)

Mathematics Analogies

Read More  

QuanToPol (2020)

Quantum Topological Polaritonics

Read More  


Increasing the scope of CO2-utilising photoreactions: asymmetric photosynthesis of amino acids

Read More