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ENLIGHTEN SIGNED

INTEGRATION AND PROPAGATION OF IMMUNOLOGICAL SIGNALS DURING CANCER AND INFECTION

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ENLIGHTEN" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://research.pasteur.fr/en/team/dynamics-of-immune-responses/
 Total cost 2˙499˙994 €
 EC max contribution 2˙499˙994 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙499˙994.00

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 Project objective

The immune system uses both short- and long-range communication mechanisms to mount the coordinated and sophisticated cellular responses required to control microbial infections or fight tumors. Yet, our understanding of how immunological signals are integrated and propagated by individual cells in complex tissue microenvironments remains largely limited.

ENLIGHTEN is a research program dedicated to establish new mechanisms by which the immune system fight tumors or infections, based on the direct manipulation of immunological signals in vivo. In relevant mouse models of human disease, we will combine intravital imaging, fluorescent sensors and optogenetic actuators to control single cell functions in real-time. We wish to understand how T cells sense and interpret cell-contacts in lymphoid organs and in developing tumors at steady state or during immunotherapy. In addition, we aim to establish how cytokine and chemokine gradients form in tissues and are interpreted by immune cells during infection or cancer.

By determining the functional contribution of single immune cells in vivo, we aim to identify new paradigms for information transfer in the immune system during cancer or infection and to establish the combination of optogenetics and intravital imaging as a powerful strategy for decoding immune reactions in the context of disease pathogenesis.

 Publications

year authors and title journal last update
List of publications.
2018 Idan Milo, Marie Bedora-Faure, Zacarias Garcia, Ronan Thibaut, Leïla Périé, Guy Shakhar, Ludovic Deriano, Philippe Bousso
The immune system profoundly restricts intratumor genetic heterogeneity
published pages: eaat1435, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aat1435
Science Immunology 3/29 2019-10-07
2019 Marine Cazaux, Capucine L. Grandjean, Fabrice Lemaître, Zacarias Garcia, Richard J. Beck, Idan Milo, Jérémy Postat, Joost B. Beltman, Eleanor J. Cheadle, Philippe Bousso
Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity
published pages: 1038-1049, ISSN: 0022-1007, DOI: 10.1084/jem.20182375
The Journal of Experimental Medicine 216/5 2019-10-07
2018 Jérémy Postat, Romain Olekhnovitch, Fabrice Lemaître, Philippe Bousso
A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses
published pages: 654-665.e5, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.07.014
Immunity 49/4 2019-10-07
2018 Armelle Bohineust, Zacarias Garcia, Hélène Beuneu, Fabrice Lemaître, Philippe Bousso
Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division
published pages: 1481-1492, ISSN: 0022-1007, DOI: 10.1084/jem.20171708
The Journal of Experimental Medicine 215/5 2019-10-07

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The information about "ENLIGHTEN" are provided by the European Opendata Portal: CORDIS opendata.

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