Opendata, web and dolomites

ORGANO-GOLD CAT

Merging organo- and gold-catalysis to design cascade reactions: a shortcut toward molecular complexity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ORGANO-GOLD CAT project word cloud

Explore the words cloud of the ORGANO-GOLD CAT project. It provides you a very rough idea of what is the project "ORGANO-GOLD CAT" about.

strategies    activation    molecules    platform    evolution    ing    natural    compound    cultural    architecturally    preparing    fellow    lundbeck    catalytic    starting    structural    generation    single    move    molecule    carbocycles    majority    organocatalysis    era    furan    yields    screening    gold    changing    asymmetric    chemistry    place    competencies    play    hit    perception    comprising    innovation    catalysis    rate    heterocyclic    chiral    innovative    fused    pursue    scaffolds    broaden    space    diversity    conventional    chemical    moieties    basic    collection    excellent    candidates    enantiopure    pharma    discovery    probability    biological    diverse    compounds    structures    combine    point    guiding    methodology    possess    conceptually    underlying    fractions    optimal    pharmaceutical    candidate    vast    powerful    inspired    consequently    career    discoveries    assembling    ideal    biologically    position    reproducing    synthetic    libraries    nature    company    drug    world    generate   

Project "ORGANO-GOLD CAT" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.iciq.org/research/research_group/prof-paolo-melchiorre/
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 158˙121.00

Map

 Project objective

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. The proposed research aims to develop conceptually innovative catalytic methods to rapidly generate, in one single step, architecturally complex chiral natural-like compounds. Natural products have been selected in evolution and their underlying structural scaffolds define biologically relevant fractions of chemical space. Consequently, compound libraries inspired by natural structures deliver lead candidates with a higher hit-rate than conventional lead generation strategies.

We will pursue the proposed research project under the guiding principle that compound development should be driven by discoveries and innovation in chemical methodology. The goal of the research project is to combine the potential of asymmetric organocatalysis and gold catalysis, powerful fields of molecule activation, to find cost-effective synthetic methods for reproducing the rich structural diversity of natural molecules. Since the vast majority of natural products and drug-like compounds possess heterocyclic moieties, we will focus on preparing diverse heterocyclic compounds, especially based on the furan unit. The resulting synthetic platform will be used as an ideal starting point for assembling enantiopure chiral 2,3-furan fused carbocycles, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move

 Publications

year authors and title journal last update
List of publications.
2017 Mattia Silvi, Charlie Verrier, Yannick P. Rey, Luca Buzzetti, Paolo Melchiorre
Visible-light excitation of iminium ions enables the enantioselective catalytic ?-alkylation of enals
published pages: , ISSN: 1755-4330, DOI: 10.1038/nchem.2748
Nature Chemistry Journal published monthly 2019-07-25

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ORGANO-GOLD CAT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ORGANO-GOLD CAT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Widow Spider Mating (2020)

Immature mating as a novel tactic of an invasive widow spider

Read More  

TARGET SLEEP (2020)

Boosting motor learning through sleep and targeted memory reactivation in ageing and Parkinson’s disease

Read More  

CP-FTmmW Aminogen (2020)

Chemistry and structure of aminogen radicals using chirped-pulse Fourier transform (sub)millimeter rotational spectroscopy

Read More