Opendata, web and dolomites

ORGANO-GOLD CAT

Merging organo- and gold-catalysis to design cascade reactions: a shortcut toward molecular complexity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ORGANO-GOLD CAT project word cloud

Explore the words cloud of the ORGANO-GOLD CAT project. It provides you a very rough idea of what is the project "ORGANO-GOLD CAT" about.

catalytic    enantiopure    natural    structural    organocatalysis    molecules    chemical    point    fused    nature    collection    probability    place    basic    discovery    era    starting    company    biological    libraries    assembling    strategies    innovation    comprising    reproducing    scaffolds    compound    excellent    chiral    move    generate    furan    single    career    chemistry    fractions    innovative    ideal    heterocyclic    rate    powerful    perception    drug    asymmetric    play    diversity    ing    combine    majority    synthetic    conventional    inspired    broaden    structures    yields    competencies    platform    generation    consequently    discoveries    pursue    candidates    compounds    molecule    changing    diverse    gold    methodology    catalysis    evolution    lundbeck    screening    pharma    activation    world    pharmaceutical    biologically    preparing    underlying    cultural    carbocycles    candidate    vast    hit    possess    fellow    optimal    architecturally    guiding    conceptually    moieties    position    space   

Project "ORGANO-GOLD CAT" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.iciq.org/research/research_group/prof-paolo-melchiorre/
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 158˙121.00

Map

 Project objective

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. The proposed research aims to develop conceptually innovative catalytic methods to rapidly generate, in one single step, architecturally complex chiral natural-like compounds. Natural products have been selected in evolution and their underlying structural scaffolds define biologically relevant fractions of chemical space. Consequently, compound libraries inspired by natural structures deliver lead candidates with a higher hit-rate than conventional lead generation strategies.

We will pursue the proposed research project under the guiding principle that compound development should be driven by discoveries and innovation in chemical methodology. The goal of the research project is to combine the potential of asymmetric organocatalysis and gold catalysis, powerful fields of molecule activation, to find cost-effective synthetic methods for reproducing the rich structural diversity of natural molecules. Since the vast majority of natural products and drug-like compounds possess heterocyclic moieties, we will focus on preparing diverse heterocyclic compounds, especially based on the furan unit. The resulting synthetic platform will be used as an ideal starting point for assembling enantiopure chiral 2,3-furan fused carbocycles, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move

 Publications

year authors and title journal last update
List of publications.
2017 Mattia Silvi, Charlie Verrier, Yannick P. Rey, Luca Buzzetti, Paolo Melchiorre
Visible-light excitation of iminium ions enables the enantioselective catalytic ?-alkylation of enals
published pages: , ISSN: 1755-4330, DOI: 10.1038/nchem.2748
Nature Chemistry Journal published monthly 2019-07-25

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ORGANO-GOLD CAT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ORGANO-GOLD CAT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More  

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More