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Merging organo- and gold-catalysis to design cascade reactions: a shortcut toward molecular complexity

Total Cost €


EC-Contrib. €






 ORGANO-GOLD CAT project word cloud

Explore the words cloud of the ORGANO-GOLD CAT project. It provides you a very rough idea of what is the project "ORGANO-GOLD CAT" about.

majority    cultural    combine    ing    drug    changing    synthetic    conceptually    generation    methodology    carbocycles    rate    biological    broaden    activation    nature    compounds    biologically    company    single    innovative    screening    innovation    chiral    generate    moieties    molecule    move    world    lundbeck    assembling    strategies    molecules    diversity    collection    optimal    discoveries    fused    preparing    evolution    consequently    compound    excellent    position    platform    conventional    yields    fellow    competencies    pharma    era    asymmetric    catalysis    gold    pursue    heterocyclic    discovery    pharmaceutical    hit    guiding    play    possess    starting    candidates    organocatalysis    fractions    space    natural    reproducing    powerful    architecturally    structures    chemistry    libraries    catalytic    candidate    chemical    scaffolds    career    comprising    diverse    place    enantiopure    inspired    probability    point    vast    underlying    basic    ideal    furan    perception    structural   

Project "ORGANO-GOLD CAT" data sheet

The following table provides information about the project.


Organization address
postcode: 43007

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. The proposed research aims to develop conceptually innovative catalytic methods to rapidly generate, in one single step, architecturally complex chiral natural-like compounds. Natural products have been selected in evolution and their underlying structural scaffolds define biologically relevant fractions of chemical space. Consequently, compound libraries inspired by natural structures deliver lead candidates with a higher hit-rate than conventional lead generation strategies.

We will pursue the proposed research project under the guiding principle that compound development should be driven by discoveries and innovation in chemical methodology. The goal of the research project is to combine the potential of asymmetric organocatalysis and gold catalysis, powerful fields of molecule activation, to find cost-effective synthetic methods for reproducing the rich structural diversity of natural molecules. Since the vast majority of natural products and drug-like compounds possess heterocyclic moieties, we will focus on preparing diverse heterocyclic compounds, especially based on the furan unit. The resulting synthetic platform will be used as an ideal starting point for assembling enantiopure chiral 2,3-furan fused carbocycles, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move


year authors and title journal last update
List of publications.
2017 Mattia Silvi, Charlie Verrier, Yannick P. Rey, Luca Buzzetti, Paolo Melchiorre
Visible-light excitation of iminium ions enables the enantioselective catalytic ?-alkylation of enals
published pages: , ISSN: 1755-4330, DOI: 10.1038/nchem.2748
Nature Chemistry Journal published monthly 2019-07-25

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The information about "ORGANO-GOLD CAT" are provided by the European Opendata Portal: CORDIS opendata.

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