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OncoViroMRI SIGNED

Brain Cancer Therapy Monitoring using a Novel Quantitative and Rapid Magnetic Resonance Imaging-based Method

Total Cost €

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EC-Contrib. €

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Partnership

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 OncoViroMRI project word cloud

Explore the words cloud of the OncoViroMRI project. It provides you a very rough idea of what is the project "OncoViroMRI" about.

company    mice    invasive    successful    cells    host    clinical    return    resonance    therapy    niche    methodology    competency    secondment    glioblastoma    gbm    university    normal    found    adults    destroy    interactions    technion    tenure    accurately    learning    goals    specificity    interdisciplinary    position    virus    additional    oncolytic    therapeutic    multiforme    location    quantitative    back    envisioned    harvard    environment    fatal    claiming    magnetic    surrounding    clinically    virotherapy    viruses    monitoring    career    accurate    researcher    modifying    viral    training    spread    acquired    nevertheless    allocated    school    performed    translation    track    frequent    speed    accordingly    sparing    replicate    imaging    infect    expanded    tumor    patient    care    models    rapid    machine    optimal    mri    ovs    devised    image    gaining    brain    selectively    predicting    sensitivity    insightec    quantifying    medical    genetically    skill    action    transport    detectable    outgoing   

Project "OncoViroMRI" data sheet

The following table provides information about the project.

Coordinator
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD 

Organization address
address: THE SENATE BUILDING TECHNION CITY 1
city: HAIFA
postcode: 32000
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 269˙998 €
 EC max contribution 269˙998 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD IL (HAIFA) coordinator 269˙998.00
2    Athinoula A. Martinos Center for Biomedical Imaging US (Charlestown) partner 0.00

Map

 Project objective

Glioblastoma multiforme (GBM) is the most common type of brain tumor found in adults and is fatal in all cases. A very promising therapeutic approach for GBM is the use of oncolytic viruses (OVs) that selectively infect, replicate in, and destroy tumor cells, while sparing the surrounding normal cells. Nevertheless, to achieve successful oncolytic virotherapy, frequent non-invasive monitoring of the process must be performed. This is crucial for gaining a better understanding of the interactions between the virus and its tumor-host and predicting a therapeutic response. Thus, the development of a non-invasive method, capable of accurately quantifying the location and extent of the viral spread in the tumor is highly required and is of great importance. Accordingly, the main research goal of this action is to develop a magnetic resonance imaging (MRI)- based method for accurate, quantitative, and rapid imaging of OVs delivery, and spread in clinically relevant tumor models. The devised interdisciplinary methodology includes: genetically modifying the therapeutic virus to be detectable in MRI; developing machine learning methods to increase the speed, specificity, and sensitivity in image-monitoring the virus; and evaluating the established methods using mice models of brain tumor therapy. The allocated training and research environment is optimal for achieving the proposal goals: an outgoing phase at Harvard Medical School, a secondment at a leading clinical MRI company (Insightec), enhancing translation potential, and a return phase at a leading university (Technion), ensuring the transport of knowledge back to the EU. The envisioned technology could be expanded to various additional clinical conditions, and its dissemination could improve patient care. The unique skill set to be acquired by the experienced researcher, would allow claiming a distinct niche of knowledge, increasing competency to a tenure-track position, and a research career in the EU.

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The information about "ONCOVIROMRI" are provided by the European Opendata Portal: CORDIS opendata.

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