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OncoViroMRI SIGNED

Brain Cancer Therapy Monitoring using a Novel Quantitative and Rapid Magnetic Resonance Imaging-based Method

Total Cost €

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EC-Contrib. €

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Partnership

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 OncoViroMRI project word cloud

Explore the words cloud of the OncoViroMRI project. It provides you a very rough idea of what is the project "OncoViroMRI" about.

models    virotherapy    optimal    mice    technion    return    transport    modifying    acquired    location    allocated    detectable    clinical    care    multiforme    monitoring    accordingly    oncolytic    resonance    virus    clinically    methodology    tenure    envisioned    predicting    devised    tumor    accurately    environment    additional    action    interdisciplinary    harvard    replicate    patient    position    host    learning    specificity    cells    career    ovs    competency    outgoing    interactions    secondment    destroy    gaining    claiming    spread    viruses    nevertheless    quantitative    surrounding    translation    machine    training    university    adults    image    expanded    infect    niche    company    glioblastoma    magnetic    skill    performed    school    insightec    back    mri    accurate    sparing    fatal    track    invasive    researcher    rapid    goals    therapeutic    normal    genetically    quantifying    viral    found    imaging    medical    successful    speed    selectively    gbm    sensitivity    brain    therapy    frequent   

Project "OncoViroMRI" data sheet

The following table provides information about the project.

Coordinator
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD 

Organization address
address: THE SENATE BUILDING TECHNION CITY 1
city: HAIFA
postcode: 32000
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 269˙998 €
 EC max contribution 269˙998 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD IL (HAIFA) coordinator 269˙998.00
2    Athinoula A. Martinos Center for Biomedical Imaging US (Charlestown) partner 0.00

Map

 Project objective

Glioblastoma multiforme (GBM) is the most common type of brain tumor found in adults and is fatal in all cases. A very promising therapeutic approach for GBM is the use of oncolytic viruses (OVs) that selectively infect, replicate in, and destroy tumor cells, while sparing the surrounding normal cells. Nevertheless, to achieve successful oncolytic virotherapy, frequent non-invasive monitoring of the process must be performed. This is crucial for gaining a better understanding of the interactions between the virus and its tumor-host and predicting a therapeutic response. Thus, the development of a non-invasive method, capable of accurately quantifying the location and extent of the viral spread in the tumor is highly required and is of great importance. Accordingly, the main research goal of this action is to develop a magnetic resonance imaging (MRI)- based method for accurate, quantitative, and rapid imaging of OVs delivery, and spread in clinically relevant tumor models. The devised interdisciplinary methodology includes: genetically modifying the therapeutic virus to be detectable in MRI; developing machine learning methods to increase the speed, specificity, and sensitivity in image-monitoring the virus; and evaluating the established methods using mice models of brain tumor therapy. The allocated training and research environment is optimal for achieving the proposal goals: an outgoing phase at Harvard Medical School, a secondment at a leading clinical MRI company (Insightec), enhancing translation potential, and a return phase at a leading university (Technion), ensuring the transport of knowledge back to the EU. The envisioned technology could be expanded to various additional clinical conditions, and its dissemination could improve patient care. The unique skill set to be acquired by the experienced researcher, would allow claiming a distinct niche of knowledge, increasing competency to a tenure-track position, and a research career in the EU.

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The information about "ONCOVIROMRI" are provided by the European Opendata Portal: CORDIS opendata.

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