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Super-resolution visualisation and manipulation of metaphase chromosomes

Total Cost €


EC-Contrib. €






 CHROMAVISION project word cloud

Explore the words cloud of the CHROMAVISION project. It provides you a very rough idea of what is the project "CHROMAVISION" about.

time    fuel    drug    near    metaphase    etiology    first    isolate    cancer    fluidic    single    fragile    platform    visualise    lysate    delivered    biologists    super    tweezers    lyse    instrument    chip    molecular    technique    zoom    mechanisms    diseased    combine    breakthrough    cells    abnormalities    tissue    humanity    decades    fertility    physiological    identification    microscope    3d    small    ing    chromosome    structural    opto    observation    aid    understand    imaging    resolution    aging    human    errors    neurological    cell    maternal    fundamental    heterogeneity    chromavision    discovery    complexity    fluorescence    automatically    monitoring    separate    sr3d    clinical    division    microfluidics    chromosomal    chromosomes    correlative    healthy    manipulation    samples    powerful    boundaries    impaired    diseases    microscopy    isolation    disorders    syndrome    individual    ctfm    discoveries    potentially    push    trap    pioneering   

Project "CHROMAVISION" data sheet

The following table provides information about the project.


Organization address
address: DE BOELELAAN 1105
postcode: 1081 HV

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 3˙567˙025 €
 EC max contribution 3˙567˙025 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2019-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 1˙054˙003.00
2    LUMICKS B.V. NL (AMSTERDAM) participant 937˙500.00
3    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 747˙320.00
5    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 111˙732.00


 Project objective

CHROMAVISION aims to develop a pioneering chromosome imaging and manipulation platform that will fuel the next decades of structural chromosome research. Chromosomal abnormalities are characteristic of many disorders such as cancer, impaired fertility due to maternal aging, and neurological disorders such as fragile X syndrome. If humanity is to fully understand the wide range of diseases that are associated to errors in cell division, we must be able to further 'zoom in' on healthy and diseased chromosomes in all their complexity. The CHROMAVISION platform will allow molecular biologists to automatically isolate individual chromosomes from small tissue or cell samples and have these delivered to a super-resolution microscope. Chromosome isolation and delivery is achieved by an opto-fluidic chip that is able to trap, visualise and lyse individual cells and separate metaphase chromosomes from cell lysate. Single chromosomes can be “hand-selected” and brought into focus of the Super-Resolution Correlative Tweezers Fluorescence Microscope (CTFM-SR3D) that is developed in CHROMAVISION. This instrument will for the first time enable 3D, super-resolution, real-time metaphase chromosome observation and manipulation studies under near-physiological conditions. The technique will push the boundaries of what is currently possible in microfluidics and super-resolution microscopy and combine these into a single powerful approach for chromosome studies. Furthermore, the platform will be applied in CHROMAVISION to address key challenges in clinical and fundamental chromosome research, potentially resulting in breakthrough discoveries. Better imaging and understanding of the chromosomal mechanisms will contribute to our knowledge of the etiology of human diseases and aid drug discovery. The platform will also have large clinical value, allowing identification and monitoring of e.g. cancer heterogeneity.


List of deliverables.
LOC for single cell capture and lysis Demonstrators, pilots, prototypes 2019-11-12 11:27:48
Second 3DSR-CTFM instrument Demonstrators, pilots, prototypes 2019-11-12 11:27:41
LoC prototypes for single cell chromosome analysis Demonstrators, pilots, prototypes 2019-11-12 11:27:41
Super-resolutions movies of segragation Websites, patent fillings, videos etc. 2019-11-12 11:27:29
Reproducible force-distance curves Documents, reports 2019-11-12 11:27:28
LOC for single cell chromosome analysis Demonstrators, pilots, prototypes 2019-11-12 11:27:17
Instrument and workflow for chromosome studies Demonstrators, pilots, prototypes 2019-11-12 11:27:22
Validation CTFM-SR3D in biological/medical setting Demonstrators, pilots, prototypes 2019-11-12 11:27:21
2 LOC to emulate chromatid segregation Demonstrators, pilots, prototypes 2019-11-12 11:27:24
Real-time data of UFB formation and resolution Documents, reports 2019-11-12 11:27:20
Field tested LOC for metaphase chromosome analysis Demonstrators, pilots, prototypes 2019-11-12 11:27:17
Protocol for producing 3D super-resolution images Documents, reports 2019-07-25 13:03:10
LOC for integration with optical tweezers & STED Demonstrators, pilots, prototypes 2019-07-25 13:03:10
First working 3DSR-CTFM instrument Demonstrators, pilots, prototypes 2019-07-25 13:03:10
Ethics documentation and Policies Documents, reports 2019-07-25 13:03:10
Collaborative and public website Websites, patent fillings, videos etc. 2019-07-25 13:03:10
Detailed communication and dissemination plan Documents, reports 2019-07-25 13:03:10
Bead-handles Demonstrators, pilots, prototypes 2019-07-25 13:03:10
Dissemination material & updates Websites, patent fillings, videos etc. 2019-07-25 13:03:10

Take a look to the deliverables list in detail:  detailed list of CHROMAVISION deliverables.


year authors and title journal last update
List of publications.
2018 Rodolphe Marie, Jonas N. Pedersen, Kalim U. Mir, Brian Bilenberg, Anders Kristensen
Concentrating and labeling genomic DNA in a nanofluidic array
published pages: 1376-1382, ISSN: 2040-3364, DOI: 10.1039/c7nr06016e
Nanoscale 10/3 2019-08-05
2018 Kata Sarlós, Andreas S. Biebricher, Anna H. Bizard, Julia A. M. Bakx, Anna G. Ferreté-Bonastre, Mauro Modesti, Manikandan Paramasivam, Qi Yao, Erwin J. G. Peterman, Gijs J. L. Wuite, Ian D. Hickson
Reconstitution of anaphase DNA bridge recognition and disjunction
published pages: 868-876, ISSN: 1545-9993, DOI: 10.1038/s41594-018-0123-8
Nature Structural & Molecular Biology 25/9 2019-08-05
2018 Victoria A. Bjerregaard, Lorenza Garribba, Cynthia T. McMurray, Ian D. Hickson, Ying Liu
Folate deficiency drives mitotic missegregation of the human FRAXA locus
published pages: 13003-13008, ISSN: 0027-8424, DOI: 10.1073/pnas.1808377115
Proceedings of the National Academy of Sciences 115/51 2019-08-05
2018 Marcus S. Carstensen, Xiaolong Zhu, Oseze Esther Iyore, N. Asger Mortensen, Uriel Levy, Anders Kristensen
Holographic Resonant Laser Printing of Metasurfaces Using Plasmonic Template
published pages: 1665-1670, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.7b01358
ACS Photonics 5/5 2019-08-05
2018 Özgün Özer, Rahul Bhowmick, Ying Liu, Ian D. Hickson
Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.24745
Oncotarget 9/22 2019-07-25
2018 Victoria A. Bjerregaard, Özgün Özer, Ian D. Hickson, Ying Liu
The detection and analysis of chromosome fragile sites
published pages: 471-482, ISSN: , DOI: 10.1007/978-1-4939-7306-4_31
Methods in Molecular Biology 2019-07-25
2018 Johan Eriksen, Julien Schira, Nadine Vincent, Celine Sabatel, Anders Kristensen, Rodolphe Marie
A lab-in-a-foil microfluidic reactor based on phaseguiding
published pages: 14-20, ISSN: 0167-9317, DOI: 10.1016/j.mee.2017.11.011
Microelectronic Engineering 187-188 2019-07-25
2017 Rahul Bhowmick, Ian D Hickson
\"The \"\"enemies within\"\": regions of the genome that are inherently difficult to replicate\"
published pages: 666, ISSN: 2046-1402, DOI: 10.12688/f1000research.11024.1
F1000Research 6 2019-07-25
2017 Ganesha P. Pitchai, Manuel Kaulich, Anna H. Bizard, Pablo Mesa, Qi Yao, Kata Sarlos, Werner W. Streicher, Erich A. Nigg, Guillermo Montoya, Ian D. Hickson
A novel TPR–BEN domain interaction mediates PICH–BEND3 association
published pages: 11413-11424, ISSN: 0305-1048, DOI: 10.1093/nar/gkx792
Nucleic Acids Research 45/19 2019-07-25
2017 Johan Eriksen, Brian Bilenberg, Anders Kristensen, Rodolphe Marie
Optothermally actuated capillary burst valve
published pages: 45101, ISSN: 0034-6748, DOI: 10.1063/1.4979164
Review of Scientific Instruments 88/4 2019-07-25
2017 Xiaolong Zhu, Wei Yan, Uriel Levy, N. Asger Mortensen, Anders Kristensen
Resonant laser printing of structural colors on high-index dielectric metasurfaces
published pages: e1602487, ISSN: 2375-2548, DOI: 10.1126/sciadv.1602487
Science Advances 3/5 2019-07-25
2017 Cameron L. C. Smith, Anil H. Thilsted, Jonas N. Pedersen, Tomas H. Youngman, Julia C. Dyrnum, Nicolai A. Michaelsen, Rodolphe Marie, Anders Kristensen
Photothermal Transport of DNA in Entropy-Landscape Plasmonic Waveguides
published pages: 4553-4563, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b08563
ACS Nano 11/5 2019-07-25
2017 Oren Lotan, Jonathan Bar-David, Cameron L.C. Smith, Sharon Yagur-Kroll, Shimshon Belkin, Anders Kristensen, Uriel Levy
Nanoscale Plasmonic V-Groove Waveguides for the Interrogation of Single Fluorescent Bacterial Cells
published pages: 5481-5488, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b02132
Nano Letters 17/9 2019-07-25
2017 Nicolai B. Larsen, Sascha E. Liberti, Ivan Vogel, Signe W. Jørgensen, Ian D. Hickson, Hocine W. Mankouri
Stalled replication forks generate a distinct mutational signature in yeast
published pages: 9665-9670, ISSN: 0027-8424, DOI: 10.1073/pnas.1706640114
Proceedings of the National Academy of Sciences 114/36 2019-07-25
2018 Kata Sarlós, Andreas Biebricher, Erwin J.G. Petermann, Gijs J.L. Wuite, Ian D. Hickson
Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase
published pages: 33647, ISSN: 0091-7451, DOI: 10.1101/sqb.2017.82.033647
Cold Spring Harbor Symposia on Quantitative Biology 2019-07-25
2017 Liqun Ren, Long Chen, Wei Wu, Lorenza Garribba, Huanna Tian, Zihui Liu, Ivan Vogel, Chunhui Li, Ian D. Hickson, Ying Liu
Potential biomarkers of DNA replication stress in cancer
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.16940
Oncotarget 2019-07-25

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