AEDNA SIGNED
Amorphous and Evolutionary DNA Nanotechnology
Total Cost €
0EC-Contrib. €
0Partnership
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0AEDNA project word cloud
Explore the words cloud of the AEDNA project. It provides you a very rough idea of what is the project "AEDNA" about.
Project "AEDNA" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITAET MUENCHEN
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | https://www.groups.ph.tum.de/en/e14/ |
| Total cost | 2˙157˙697 € |
| EC max contribution | 2˙157˙697 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-06-01 to 2021-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNISCHE UNIVERSITAET MUENCHEN | DE (MUENCHEN) | coordinator | 2˙157˙697.00 |
Map
Project objective
Amorphous and evolutionary DNA nanotechnology (AEDNA) explores novel conceptual directions and applications for DNA nanotechnology, which are based on intelligent, DNA-programmed soft hybrid materials, and the utilization of evolutionary principles for the optimization of nucleic acid nanocomponents. Amorphous DNA nanotechnology first aims at the creation of cell-sized, DNA-programmed microgels – DNA cells – with sensor, computation, communication, and actuator functions. Interacting DNA cells will be arranged into chemical cell consortia and artificial tissues using microfluidics, micromanipulation and 3D bioprinting techniques. Spatially distributed chemical circuits will then be utilized to establish collective behaviors such as quorum sensing, pattern formation, and self-differentiation within these consortia and tissues. The approach will be further scaled up to produce multicomponent DNA gel compositions that become active and differentiate upon mixing. In evolutionary nanotechnology, techniques derived from directed molecular evolution experiments will be applied to optimize the arrangement of functional nucleic acids on DNA and RNA nanoscaffolds. Compartmentalization and microfluidics will be utilized to screen for nucleic acid nanostructures capable of superstructure formation, and also for the development of ligand-sensitive components for molecular programming. An evolutionary approach will then be applied to amorphous DNA cells, resulting in DNA cell populations which contain individuals with different molecular identities. The proposal will pave the way for the creation of macroscopic materials with DNA-programmed intelligence, resulting in novel applications for DNA nanotechnology and molecular programming in diverse fields such as environmental and biological sensing, biocatalysis, smart adaptive materials, and soft robotics.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Friedrich C. Simmel, Bernard Yurke, Hari R. Singh Principles and Applications of Nucleic Acid Strand Displacement Reactions published pages: 6326-6369, ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.8b00580 |
Chemical Reviews 119 | 2019-09-02 |
| 2019 |
Alessandro Cecconello, Friedrich C. Simmel Controlling Chirality across Length Scales using DNA published pages: 1805419, ISSN: 1613-6810, DOI: 10.1002/smll.201805419 |
Small 15 | 2019-09-02 |
| 2019 |
Aradhana Chopra, Sandra Sagredo, Guido Grossi, Ebbe Andersen, Friedrich Simmel Out-of-Plane Aptamer Functionalization of RNA Three-Helix Tiles published pages: 507, ISSN: 2079-4991, DOI: 10.3390/nano9040507 |
Nanomaterials 9/4 | 2019-09-04 |
| 2017 |
Friedrich C. Simmel, Rebecca Schulman Self-organizing materials built with DNA published pages: 913-919, ISSN: 0883-7694, DOI: 10.1557/mrs.2017.271 |
MRS Bulletin 42/12 | 2019-06-13 |
| 2018 |
Kilian Vogele, Thomas Frank, Lukas Gasser, Marisa A. Goetzfried, Mathias W. Hackl, Stephan A. Sieber, Friedrich C. Simmel, Tobias Pirzer Towards synthetic cells using peptide-based reaction compartments published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06379-8 |
Nature Communications 9/1 | 2019-02-25 |
| 2018 |
Lukas Aufinger, Friedrich C. Simmel Artificial Gel-Based Organelles for Spatial Organization of Cell-Free Gene Expression Reactions published pages: 17245-17248, ISSN: 1433-7851, DOI: 10.1002/anie.201809374 |
Angewandte Chemie International Edition 57/52 | 2019-02-25 |
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