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Amorphous and Evolutionary DNA Nanotechnology

Total Cost €


EC-Contrib. €






 AEDNA project word cloud

Explore the words cloud of the AEDNA project. It provides you a very rough idea of what is the project "AEDNA" about.

compositions    macroscopic    nanostructures    cell    mixing    functions    micromanipulation    arranged    compartmentalization    actuator    differentiation    microgels    adaptive    creation    distributed    ligand    biological    biocatalysis    molecular    nanoscaffolds    tissues    evolutionary    computation    robotics    smart    rna    superstructure    acid    populations    environmental    interacting    contain    sensitive    conceptual    sized    intelligence    bioprinting    explores    active    nanocomponents    artificial    first    optimization    optimize    intelligent    sensor    experiments    components    evolution    arrangement    programmed    nanotechnology    multicomponent    principles    3d    communication    chemical    pattern    aedna    dna    nucleic    materials    hybrid    microfluidics    techniques    directed    pave    programming    utilized    quorum    sensing    self    individuals    acids    differentiate    gel    identities    screen    behaviors    cells    amorphous    collective    circuits    functional    directions    soft    diverse    ing    scaled   

Project "AEDNA" data sheet

The following table provides information about the project.


Organization address
address: Arcisstrasse 21
postcode: 80333

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 2˙157˙697 €
 EC max contribution 2˙157˙697 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Amorphous and evolutionary DNA nanotechnology (AEDNA) explores novel conceptual directions and applications for DNA nanotechnology, which are based on intelligent, DNA-programmed soft hybrid materials, and the utilization of evolutionary principles for the optimization of nucleic acid nanocomponents. Amorphous DNA nanotechnology first aims at the creation of cell-sized, DNA-programmed microgels – DNA cells – with sensor, computation, communication, and actuator functions. Interacting DNA cells will be arranged into chemical cell consortia and artificial tissues using microfluidics, micromanipulation and 3D bioprinting techniques. Spatially distributed chemical circuits will then be utilized to establish collective behaviors such as quorum sensing, pattern formation, and self-differentiation within these consortia and tissues. The approach will be further scaled up to produce multicomponent DNA gel compositions that become active and differentiate upon mixing. In evolutionary nanotechnology, techniques derived from directed molecular evolution experiments will be applied to optimize the arrangement of functional nucleic acids on DNA and RNA nanoscaffolds. Compartmentalization and microfluidics will be utilized to screen for nucleic acid nanostructures capable of superstructure formation, and also for the development of ligand-sensitive components for molecular programming. An evolutionary approach will then be applied to amorphous DNA cells, resulting in DNA cell populations which contain individuals with different molecular identities. The proposal will pave the way for the creation of macroscopic materials with DNA-programmed intelligence, resulting in novel applications for DNA nanotechnology and molecular programming in diverse fields such as environmental and biological sensing, biocatalysis, smart adaptive materials, and soft robotics.


year authors and title journal last update
List of publications.
2019 Friedrich C. Simmel, Bernard Yurke, Hari R. Singh
Principles and Applications of Nucleic Acid Strand Displacement Reactions
published pages: 6326-6369, ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.8b00580
Chemical Reviews 119 2019-09-02
2019 Alessandro Cecconello, Friedrich C. Simmel
Controlling Chirality across Length Scales using DNA
published pages: 1805419, ISSN: 1613-6810, DOI: 10.1002/smll.201805419
Small 15 2019-09-02
2019 Aradhana Chopra, Sandra Sagredo, Guido Grossi, Ebbe Andersen, Friedrich Simmel
Out-of-Plane Aptamer Functionalization of RNA Three-Helix Tiles
published pages: 507, ISSN: 2079-4991, DOI: 10.3390/nano9040507
Nanomaterials 9/4 2019-09-04
2017 Friedrich C. Simmel, Rebecca Schulman
Self-organizing materials built with DNA
published pages: 913-919, ISSN: 0883-7694, DOI: 10.1557/mrs.2017.271
MRS Bulletin 42/12 2019-06-13
2018 Kilian Vogele, Thomas Frank, Lukas Gasser, Marisa A. Goetzfried, Mathias W. Hackl, Stephan A. Sieber, Friedrich C. Simmel, Tobias Pirzer
Towards synthetic cells using peptide-based reaction compartments
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06379-8
Nature Communications 9/1 2019-02-25
2018 Lukas Aufinger, Friedrich C. Simmel
Artificial Gel-Based Organelles for Spatial Organization of Cell-Free Gene Expression Reactions
published pages: 17245-17248, ISSN: 1433-7851, DOI: 10.1002/anie.201809374
Angewandte Chemie International Edition 57/52 2019-02-25

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