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ACHILLES-HEEL SIGNED

Crop resistance improvement by mining natural and induced variation in host accessibility factors

Total Cost €

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EC-Contrib. €

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Partnership

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 ACHILLES-HEEL project word cloud

Explore the words cloud of the ACHILLES-HEEL project. It provides you a very rough idea of what is the project "ACHILLES-HEEL" about.

tackle    programs    century    beneficial    allelic    wheat    feed    crop    monocot    host    fungi    demands    genes    21st    mutualist    mutants    contrasting    global    breeding    mine    resistance    phytophthora    principles    rely    perform    symbiosis    alleles    constant    caused    completion    differential    relied    security    core    utilize    transcriptional    translation    keep    food    roots    dicot    achilles    grand    elucidate    broad    accessibility    colonization    races    hypothesis    employ    date    arms    profiling    pathogen    cell    probability    biology    durability    mechanisms    genetics    urgent    plants    filamentous    increasing    diseases    palmivora    yield    heel    unravel    pathogens    economically    commonalities    virulence    subset    germplasm    variation    barley    world    suitable    leaves    manipulation    hampered    disease    illustrate    solely    microbial    genomics    microbes    highlight    race    adjustment    differences    ahead    anatomies    plant   

Project "ACHILLES-HEEL" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.slcu.cam.ac.uk/research/schornack-group/achilles-heel
 Total cost 1˙991˙054 €
 EC max contribution 1˙991˙054 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙991˙054.00

Map

 Project objective

Increasing crop yield to feed the world is a grand challenge of the 21st century but it is hampered by diseases caused by filamentous plant pathogens. The arms race between pathogen and plant demands constant adjustment of crop germplasm to tackle emerging pathogen races with new virulence features. To date, most crop disease resistance has relied on specific resistance genes that are effective only against a subset of races. We cannot solely rely on classical resistance genes to keep ahead of the pathogens. There is an urgent need to develop approaches based on knowledge of the pathogen’s Achilles heel: core plant processes that are required for pathogen colonization. Our hypothesis is that disease resistance based on manipulation of host accessibility processes has a higher probability for durability, and is best identified using a broad host-range pathogen. I will employ the filamentous pathogen Phytophthora palmivora to mine plant alleles and unravel host processes providing microbial access in roots and leaves of monocot and dicot plants. In Aim 1 I will utilize plant symbiosis mutants and allelic variation to elucidate general mechanisms of colonization by filamentous microbes. Importantly, allelic variation will be studied in economically relevant barley and wheat to allow immediate translation into breeding programs. In Aim 2 I will perform a comparative study of microbial colonization in monocot and dicot roots and leaves. Transcriptional profiling of pathogen and plant will highlight common and contrasting principles and illustrate the impact of differential plant anatomies.

We will challenge our findings by testing beneficial fungi to assess commonalities and differences between mutualist and pathogen colonization. We will use genetics, cell biology and genomics to find suitable resistance alleles highly relevant to crop production and global food security. At the completion of the project, I expect to have a set of genes for resistance breeding.

 Publications

year authors and title journal last update
List of publications.
2017 Thomas Rey, Maxime Bonhomme, Abhishek Chatterjee, Aleksandr Gavrin, Justine Toulotte, Weibing Yang, Olivier André, Christophe Jacquet, Sebastian Schornack
The Medicago truncatula GRAS protein RAD1 supports arbuscular mycorrhiza symbiosis and Phytophthora palmivora susceptibility
published pages: 5871-5881, ISSN: 0022-0957, DOI: 10.1093/jxb/erx398
Journal of Experimental Botany 68/21-22 2020-01-15
2017 Edouard Evangelisti, Anna Gogleva, Thomas Hainaux, Mehdi Doumane, Frej Tulin, Clément Quan, Temur Yunusov, Kévin Floch, Sebastian Schornack
Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors
published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-017-0379-1
BMC Biology 15/1 2020-01-15

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