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ACHILLES-HEEL SIGNED

Crop resistance improvement by mining natural and induced variation in host accessibility factors

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ACHILLES-HEEL project word cloud

Explore the words cloud of the ACHILLES-HEEL project. It provides you a very rough idea of what is the project "ACHILLES-HEEL" about.

virulence probability heel genetics illustrate manipulation utilize constant monocot race urgent 21st tackle caused resistance translation adjustment cell microbial demands beneficial disease keep fungi phytophthora differential leaves rely pathogens programs mechanisms principles symbiosis century date hypothesis ahead anatomies world highlight differences filamentous arms palmivora hampered plants subset profiling feed alleles increasing elucidate solely yield allelic barley core relied employ durability mutualist variation genes microbes colonization achilles transcriptional mine races breeding dicot grand completion commonalities plant biology mutants pathogen crop security germplasm broad economically genomics unravel food diseases accessibility roots contrasting global host perform suitable wheat

Project "ACHILLES-HEEL" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.slcu.cam.ac.uk/research/schornack-group/achilles-heel
Total cost	1˙991˙054 €
EC max contribution	1˙991˙054 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	1˙991˙054.00

Map

Project objective

Increasing crop yield to feed the world is a grand challenge of the 21st century but it is hampered by diseases caused by filamentous plant pathogens. The arms race between pathogen and plant demands constant adjustment of crop germplasm to tackle emerging pathogen races with new virulence features. To date, most crop disease resistance has relied on specific resistance genes that are effective only against a subset of races. We cannot solely rely on classical resistance genes to keep ahead of the pathogens. There is an urgent need to develop approaches based on knowledge of the pathogen’s Achilles heel: core plant processes that are required for pathogen colonization. Our hypothesis is that disease resistance based on manipulation of host accessibility processes has a higher probability for durability, and is best identified using a broad host-range pathogen. I will employ the filamentous pathogen Phytophthora palmivora to mine plant alleles and unravel host processes providing microbial access in roots and leaves of monocot and dicot plants. In Aim 1 I will utilize plant symbiosis mutants and allelic variation to elucidate general mechanisms of colonization by filamentous microbes. Importantly, allelic variation will be studied in economically relevant barley and wheat to allow immediate translation into breeding programs. In Aim 2 I will perform a comparative study of microbial colonization in monocot and dicot roots and leaves. Transcriptional profiling of pathogen and plant will highlight common and contrasting principles and illustrate the impact of differential plant anatomies.

We will challenge our findings by testing beneficial fungi to assess commonalities and differences between mutualist and pathogen colonization. We will use genetics, cell biology and genomics to find suitable resistance alleles highly relevant to crop production and global food security. At the completion of the project, I expect to have a set of genes for resistance breeding.

Publications

List of publications.
year	authors and title	journal	last update
2017	Thomas Rey, Maxime Bonhomme, Abhishek Chatterjee, Aleksandr Gavrin, Justine Toulotte, Weibing Yang, Olivier AndrÃ©, Christophe Jacquet, Sebastian Schornack The Medicago truncatula GRAS protein RAD1 supports arbuscular mycorrhiza symbiosis and Phytophthora palmivora susceptibility published pages: 5871-5881, ISSN: 0022-0957, DOI: 10.1093/jxb/erx398	Journal of Experimental Botany 68/21-22	2020-01-15
2017	Edouard Evangelisti, Anna Gogleva, Thomas Hainaux, Mehdi Doumane, Frej Tulin, ClÃ©ment Quan, Temur Yunusov, KÃ©vin Floch, Sebastian Schornack Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-017-0379-1	BMC Biology 15/1	2020-01-15

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