Explore the words cloud of the ACTOMYO project. It provides you a very rough idea of what is the project "ACTOMYO" about.
The following table provides information about the project.
INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
|Coordinator Country||Portugal [PT]|
|Total cost||1˙499˙988 €|
|EC max contribution||1˙499˙988 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2021-06-30|
Take a look of project's partnership.
|1||INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC||PT (PORTO)||coordinator||1˙499˙988.00|
Cytokinesis completes cell division by partitioning the contents of the mother cell to the two daughter cells. This process is accomplished through the assembly and constriction of a contractile ring, a complex actomyosin network that remains poorly understood on the molecular level. Research in cytokinesis has overwhelmingly focused on signaling mechanisms that dictate when and where the contractile ring is assembled. By contrast, the research I propose here addresses fundamental questions about the structural and functional properties of the contractile ring itself. We will use the nematode C. elegans to exploit the power of quantitative live imaging assays in an experimentally tractable metazoan organism. The early C. elegans embryo is uniquely suited to the study of the contractile ring, as cells dividing perpendicularly to the imaging plane provide a full end-on view of the contractile ring throughout constriction. This greatly facilitates accurate measurements of constriction kinetics, ring width and thickness, and levels as well as dynamics of fluorescently-tagged contractile ring components. Combining image-based assays with powerful molecular replacement technology for structure-function studies, we will 1) determine the contribution of branched and non-branched actin filament populations to contractile ring formation; 2) explore its ultra-structural organization in collaboration with a world expert in electron microcopy; 3) investigate how the contractile ring network is dynamically remodeled during constriction with the help of a novel laser microsurgery assay that has uncovered a remarkably robust ring repair mechanism; and 4) use a targeted RNAi screen and phenotype profiling to identify new components of actomyosin contractile networks. The results from this interdisciplinary project will significantly enhance our mechanistic understanding of cytokinesis and other cellular processes that involve actomyosin-based contractility.
|year||authors and title||journal||last update|
ClÃ¡udia Pereira, Rita M. Reis, JosÃ© B. Gama, Ricardo Celestino, Dhanya K. Cheerambathur, Ana X. Carvalho, Reto Gassmann
Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment
published pages: 3408-3421.e8, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.08.056
|Current Biology 28/21||2020-04-01|
Ricardo Celestino, Morkos A. Henen, JosÃ© B. Gama, CÃ¡tia Carvalho, Maxwell McCabe, Daniel J. Barbosa, Alexandra Born, Parker J. Nichols, Ana X. Carvalho, Reto Gassmann, Beat VÃ¶geli
A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport
published pages: e3000100, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.3000100
|PLOS Biology 17/1||2020-04-01|
Fung-Yi Chan, Ana M. Silva, Joana Saramago, Joana Pereira-Sousa, Hailey E. Brighton, Marisa Pereira, Karen Oegema, Reto Gassmann, Ana Xavier Carvalho
The ARP2/3 complex prevents excessive formin activity during cytokinesis
published pages: 96-107, ISSN: 1059-1524, DOI: 10.1091/mbc.e18-07-0471
|Molecular Biology of the Cell 30/1||2020-04-01|
JosÃ© B. Gama, ClÃ¡udia Pereira, PatrÃcia A. SimÃµes, Ricardo Celestino, Rita M. Reis, Daniel J. Barbosa, Helena R. Pires, CÃ¡tia Carvalho, JoÃ£o Amorim, Ana X. Carvalho, Dhanya K. Cheerambathur, Reto Gassmann
Molecular mechanism of dynein recruitment to kinetochores by the Rodâ€“Zw10â€“Zwilch complex and Spindly
published pages: 943-960, ISSN: 0021-9525, DOI: 10.1083/jcb.201610108
|The Journal of Cell Biology 216/4||2020-04-01|
PatrÃcia A. SimÃµes, Ricardo Celestino, Ana X. Carvalho, Reto Gassmann
NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo
published pages: jcs212159, ISSN: 0021-9533, DOI: 10.1242/jcs.212159
|Journal of Cell Science 131/1||2020-04-01|
C.Thieleke-Matos, D.S.OsÃ³rio, A.X.Carvalho, E.Morais-de-SÃ¡
Emerging Mechanisms and Roles for Asymmetric Cytokinesis
published pages: , ISSN: , DOI:
|International Review of Cell and Molecular Biology||2020-04-01|
Neide Vieira, Carlos Bessa, Ana J. Rodrigues, Paulo Marques, Fung-Yi Chan, Ana Xavier de Carvalho, Margarida Correia-Neves, Nuno Sousa
Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans
published pages: 2027-2044, ISSN: 1420-682X, DOI: 10.1007/s00018-017-2719-2
|Cellular and Molecular Life Sciences 75/11||2020-04-01|
Silva AM, OsÃ³rio DS, Pereira AJ, Maiato H, Pinto IM, Rubinstein B, Gassmann R, Telley IA, Carvalho AX.
Robust gap repair in the contractile ring ensures timely completion of cytokinesis.
published pages: , ISSN: 0021-9525, DOI: 10.1083/jcb.201605080
|JOURNAL OF CELL BIOLOGY||2020-04-01|
Daniel J. Barbosa, Joana Duro, Bram Prevo, Dhanya K. Cheerambathur, Ana X. Carvalho, Reto Gassmann
Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport
published pages: e1006941, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006941
|PLOS Genetics 13/7||2020-04-01|
Sriyash Mangal, Jennifer Sacher, Taekyung Kim, Daniel Sampaio OsÃ³rio, Fumio Motegi, Ana Xavier Carvalho, Karen Oegema, Esther Zanin
TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis
published pages: 837-848, ISSN: 0021-9525, DOI: 10.1083/jcb.201706021
|The Journal of Cell Biology 217/3||2020-04-01|
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