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PALE-Blu SIGNED

Understanding pathogen, livestock, environment interactions involving bluetongue virus

Total Cost €

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EC-Contrib. €

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Partnership

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 PALE-Blu project word cloud

Explore the words cloud of the PALE-Blu project. It provides you a very rough idea of what is the project "PALE-Blu" about.

btv    stronger    immune    genome    diagnosis    connectivity    basis    viruses    failures    hosts    act    vertebrae    compatible    events    serotype    replication    technologies    vaccination    incursion    new    brings    africa    source    subunit    serotypes    maps    induce    strategies    climate    infection    restricted    efficiency    supporting    livestock    institutes    surface    blu    culicoides    multiplexing    infections    individual    risks    reverse    modify    massive    surveillance    prevention    trade    proteins    assay    strain    cell    bluetongue    vectors    pale    innoculation    antiviral    spread    east    insect    protection    outbreaks    post    linked    ed    differences    productivity    localisation    emerge    diagnostic    proteases    saliva    lines    genes    diva    appropriate    btvs    caused    single    full    detect    adults    animal    agents    directions    vaccines    genetics    movements    1998    movement    turkey    elucidate    populations    emerged    endemic    losses    lineages    vector    fatalities    transmission    explore    genetic    species    mechanisms    accuracy    strains    cross    sequence    mixed    expertise    geographic    reproductive    generate    middle    regions   

Project "PALE-Blu" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF NOTTINGHAM 

Organization address
address: University Park
city: NOTTINGHAM
postcode: NG7 2RD
website: www.nottingham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.palebludata.com/
 Total cost 6˙039˙301 €
 EC max contribution 6˙039˙301 € (100%)
 Programme 1. H2020-EU.3.2.1.1. (Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience)
 Code Call H2020-SFS-2016-2
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) coordinator 1˙301˙601.00
2    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 640˙438.00
3    THE PIRBRIGHT INSTITUTE LBG UK (WOKING) participant 434˙822.00
4    STICHTING WAGENINGEN RESEARCH NL (WAGENINGEN) participant 418˙000.00
5    AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL FR (MAISONS ALFORT) participant 396˙250.00
6    ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELL'ABRUZZO E DEL MOLISE G CAPORALE IT (TERAMO) participant 393˙875.00
7    CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC FR (PARIS) participant 333˙365.00
8    FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT DE (GREIFSWALD-INSEL RIEMS) participant 290˙000.00
9    International Livestock Research Institute KE (Nairobi) participant 287˙851.00
10    STATENS VETERINAERMEDICINSKA ANSTALT SE (UPPSALA) participant 230˙000.00
11    INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA OA MP ES (MADRID) participant 203˙625.00
12    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 188˙705.00
13    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 172˙625.00
14    ENVIRONMENTAL RESEARCH GROUP OXFORD LIMITED UK (LEOMINSTER) participant 143˙281.00
15    INSTITUT PASTEUR DE TUNIS TN (TUNIS) participant 140˙000.00
16    INSTITUT AGRONOMIQUE ET VETERINAIRE HASSAN II MA (RABAT) participant 137˙500.00
17    INSTITUT SENEGALAIS DE RECHERCHES AGRICOLES SN (DAKAR) participant 129˙861.00
18    KAFKAS UNIVERSITESI TR (KARS) participant 110˙000.00
19    KIMRON VETERINARY INSTITUTE IL (Rishon L'Tzion) participant 87˙500.00

Map

 Project objective

New outbreaks caused by bluetongue viruses (BTVs) have emerged in European livestock every year since 1998. These events that have been linked to climate change, resulted in massive losses due to fatalities, reduced productivity, reproductive failures, restricted animal movements/trade, and surveillance/vaccination costs. PALE-Blu brings together European institutes with expertise in BTV research and diagnosis, with partners in endemic regions (Africa, the Middle East and Turkey) that act as a ‘source’ for BTV strains that emerge in Europe. Full-genome sequence-analyses will increase the accuracy of BTV-strain distribution maps, to identify pathways and mechanisms for spread into and within Europe, as well as appropriate prevention strategies. PALE-Blu will analyse the genetic connectivity of Culicoides vector populations in different regions, as well as the movements of individual BTV lineages and genes. Together with reverse genetics technologies and infection/replication studies in new Culicoides cell lines, or adults from different Culicoides species, this will elucidate the genetic basis for geographic localisation/movement of BTV strains and serotypes. We will analyse differences in saliva proteins from Culicoides species, their ability to modify the BTV surface proteins (proteases) and effects on efficiency of transmission (in both directions) between vertebrae hosts and insect-vectors. These studies will provide a better understanding of incursion risks for different BTV strains, supporting effective control strategies. PALE-BLU will explore more effective and cross-serotype subunit-vaccines that are DIVA assay compatible and generate a stronger immune response from a single innoculation. We will also explore the potential for use of antiviral agents to induce immediate protection post vaccination. More effective diagnostic systems to better detect mixed infections will also be developed by multiplexing existing or novel diagnostic assay systems.

 Deliverables

List of deliverables.
Spatial data base of vector distributions Other 2020-02-25 15:30:00
Adaptation and maintenance of spatial data website to include PALE-Blu data Websites, patent fillings, videos etc. 2020-02-25 15:29:59
Serotype specific qRT-PCR for novel BTV serotypes Documents, reports 2020-02-25 15:29:59
Project website Websites, patent fillings, videos etc. 2020-02-25 15:29:59
Reassortant strains between conventional and novel / atypical strains Documents, reports 2020-02-25 15:30:00
Updated website with environment / anthropogenic data Websites, patent fillings, videos etc. 2020-02-25 15:30:00
Refined spatial epizone maps Documents, reports 2020-02-25 15:29:59
List of required environmental and landscape factors Documents, reports 2020-02-25 15:29:59
Assess pathogenesis / horizontal transmission of BTV strains Documents, reports 2020-02-25 15:29:59
List of spatial data required Documents, reports 2020-02-25 15:30:00

Take a look to the deliverables list in detail:  detailed list of PALE-Blu deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 V. L. Fowler, E. L. A. Howson, J. Flannery, M. Romito, A. Lubisi, M. Agüero, P. Mertens, C. A. Batten, H. R. Warren, J. Castillo-Olivares
Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Assay for the Rapid Detection of African Horse Sickness Virus
published pages: 1579-1588, ISSN: 1865-1674, DOI: 10.1111/tbed.12549
Transboundary and Emerging Diseases 64/5 2020-02-25
2016 Cristina C. Celma, Meredith Stewart, Kerstin Wernike, Michael Eschbaumer, Lorenzo Gonzalez-Molleda, Emmanuel Breard, Claudia Schulz, Bernd Hoffmann, Andy Haegeman, Kris De Clercq, Stephan Zientara, Piet A. van Rijn, Martin Beer, Polly Roy
Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines
published pages: , ISSN: 0022-538X, DOI: 10.1128/JVI.01892-16
Journal of Virology 91/1 2020-02-25
2017 Maude Jacquot, Kyriaki Nomikou, Massimo Palmarini, Peter Mertens, Roman Biek
Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference
published pages: 20170919, ISSN: 0962-8452, DOI: 10.1098/rspb.2017.0919
Proceedings of the Royal Society B: Biological Sciences 284/1864 2020-02-25

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