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PALE-Blu SIGNED

Understanding pathogen, livestock, environment interactions involving bluetongue virus

Total Cost €

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EC-Contrib. €

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Partnership

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 PALE-Blu project word cloud

Explore the words cloud of the PALE-Blu project. It provides you a very rough idea of what is the project "PALE-Blu" about.

full    emerge    modify    stronger    assay    trade    adults    serotype    proteins    animal    connectivity    sequence    directions    strains    linked    failures    institutes    diva    appropriate    restricted    subunit    genetic    ed    strategies    act    replication    losses    livestock    generate    spread    events    turkey    differences    movement    btv    mixed    surveillance    lines    caused    diagnostic    surface    1998    explore    productivity    africa    diagnosis    accuracy    regions    pale    genetics    basis    endemic    infection    massive    emerged    insect    source    single    serotypes    saliva    geographic    strain    elucidate    expertise    mechanisms    detect    cell    risks    cross    fatalities    transmission    species    movements    blu    climate    supporting    reverse    maps    culicoides    incursion    efficiency    protection    new    compatible    bluetongue    proteases    east    vaccination    hosts    vector    prevention    immune    infections    multiplexing    vertebrae    induce    middle    vaccines    outbreaks    viruses    post    vectors    antiviral    populations    btvs    technologies    brings    genome    reproductive    agents    localisation    genes    innoculation    individual    lineages   

Project "PALE-Blu" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF NOTTINGHAM 

Organization address
address: University Park
city: NOTTINGHAM
postcode: NG7 2RD
website: www.nottingham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://www.palebludata.com/
 Total cost 6˙039˙301 €
 EC max contribution 6˙039˙301 € (100%)
 Programme 1. H2020-EU.3.2.1.1. (Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience)
 Code Call H2020-SFS-2016-2
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) coordinator 1˙301˙601.00
2    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 640˙438.00
3    THE PIRBRIGHT INSTITUTE LBG UK (WOKING) participant 434˙822.00
4    STICHTING WAGENINGEN RESEARCH NL (WAGENINGEN) participant 418˙000.00
5    AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL FR (MAISONS ALFORT) participant 396˙250.00
6    ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELL'ABRUZZO E DEL MOLISE G CAPORALE IT (TERAMO) participant 393˙875.00
7    CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC FR (PARIS) participant 333˙365.00
8    FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT DE (GREIFSWALD-INSEL RIEMS) participant 290˙000.00
9    International Livestock Research Institute KE (Nairobi) participant 287˙851.00
10    STATENS VETERINAERMEDICINSKA ANSTALT SE (UPPSALA) participant 230˙000.00
11    INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA OA MP ES (MADRID) participant 203˙625.00
12    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 188˙705.00
13    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 172˙625.00
14    ENVIRONMENTAL RESEARCH GROUP OXFORD LIMITED UK (LEOMINSTER) participant 143˙281.00
15    INSTITUT PASTEUR DE TUNIS TN (TUNIS) participant 140˙000.00
16    INSTITUT AGRONOMIQUE ET VETERINAIRE HASSAN II MA (RABAT) participant 137˙500.00
17    INSTITUT SENEGALAIS DE RECHERCHES AGRICOLES SN (DAKAR) participant 129˙861.00
18    KAFKAS UNIVERSITESI TR (KARS) participant 110˙000.00
19    KIMRON VETERINARY INSTITUTE IL (Rishon L'Tzion) participant 87˙500.00

Map

 Project objective

New outbreaks caused by bluetongue viruses (BTVs) have emerged in European livestock every year since 1998. These events that have been linked to climate change, resulted in massive losses due to fatalities, reduced productivity, reproductive failures, restricted animal movements/trade, and surveillance/vaccination costs. PALE-Blu brings together European institutes with expertise in BTV research and diagnosis, with partners in endemic regions (Africa, the Middle East and Turkey) that act as a ‘source’ for BTV strains that emerge in Europe. Full-genome sequence-analyses will increase the accuracy of BTV-strain distribution maps, to identify pathways and mechanisms for spread into and within Europe, as well as appropriate prevention strategies. PALE-Blu will analyse the genetic connectivity of Culicoides vector populations in different regions, as well as the movements of individual BTV lineages and genes. Together with reverse genetics technologies and infection/replication studies in new Culicoides cell lines, or adults from different Culicoides species, this will elucidate the genetic basis for geographic localisation/movement of BTV strains and serotypes. We will analyse differences in saliva proteins from Culicoides species, their ability to modify the BTV surface proteins (proteases) and effects on efficiency of transmission (in both directions) between vertebrae hosts and insect-vectors. These studies will provide a better understanding of incursion risks for different BTV strains, supporting effective control strategies. PALE-BLU will explore more effective and cross-serotype subunit-vaccines that are DIVA assay compatible and generate a stronger immune response from a single innoculation. We will also explore the potential for use of antiviral agents to induce immediate protection post vaccination. More effective diagnostic systems to better detect mixed infections will also be developed by multiplexing existing or novel diagnostic assay systems.

 Deliverables

List of deliverables.
Spatial data base of vector distributions Other 2020-02-25 15:30:00
Adaptation and maintenance of spatial data website to include PALE-Blu data Websites, patent fillings, videos etc. 2020-02-25 15:29:59
Serotype specific qRT-PCR for novel BTV serotypes Documents, reports 2020-02-25 15:29:59
Project website Websites, patent fillings, videos etc. 2020-02-25 15:29:59
Reassortant strains between conventional and novel / atypical strains Documents, reports 2020-02-25 15:30:00
Updated website with environment / anthropogenic data Websites, patent fillings, videos etc. 2020-02-25 15:30:00
Refined spatial epizone maps Documents, reports 2020-02-25 15:29:59
List of required environmental and landscape factors Documents, reports 2020-02-25 15:29:59
Assess pathogenesis / horizontal transmission of BTV strains Documents, reports 2020-02-25 15:29:59
List of spatial data required Documents, reports 2020-02-25 15:30:00

Take a look to the deliverables list in detail:  detailed list of PALE-Blu deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 V. L. Fowler, E. L. A. Howson, J. Flannery, M. Romito, A. Lubisi, M. Agüero, P. Mertens, C. A. Batten, H. R. Warren, J. Castillo-Olivares
Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Assay for the Rapid Detection of African Horse Sickness Virus
published pages: 1579-1588, ISSN: 1865-1674, DOI: 10.1111/tbed.12549
Transboundary and Emerging Diseases 64/5 2020-02-25
2016 Cristina C. Celma, Meredith Stewart, Kerstin Wernike, Michael Eschbaumer, Lorenzo Gonzalez-Molleda, Emmanuel Breard, Claudia Schulz, Bernd Hoffmann, Andy Haegeman, Kris De Clercq, Stephan Zientara, Piet A. van Rijn, Martin Beer, Polly Roy
Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines
published pages: , ISSN: 0022-538X, DOI: 10.1128/JVI.01892-16
Journal of Virology 91/1 2020-02-25
2017 Maude Jacquot, Kyriaki Nomikou, Massimo Palmarini, Peter Mertens, Roman Biek
Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference
published pages: 20170919, ISSN: 0962-8452, DOI: 10.1098/rspb.2017.0919
Proceedings of the Royal Society B: Biological Sciences 284/1864 2020-02-25

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