Explore the words cloud of the OxygenSensing project. It provides you a very rough idea of what is the project "OxygenSensing" about.
The following table provides information about the project.
UNIVERSIDAD DE SEVILLA
|Coordinator Country||Spain [ES]|
|Total cost||2˙843˙750 €|
|EC max contribution||2˙843˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-11-01 to 2020-10-31|
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|1||UNIVERSIDAD DE SEVILLA||ES (SEVILLA)||coordinator||2˙843˙750.00|
Oxygen (O2) is essential for life on Earth. This proposal deals with the study of the molecular mechanisms underlying acute O2 sensing by cells, a long-standing issue that is yet to be elucidated. In recent years, the discovery of hypoxia inducible transcription factors and their regulation by the O2-dependent hydroxylases has provided a solid framework for understanding genetic responses to sustained (chronic) hypoxia. However the mechanisms of acute O2 sensing, necessary for the activation of rapid, life-saving, compensatory respiratory and cardiovascular reflexes (e.g. hyperventilation and sympathetic activation), are unknown. While the primary goal of the project is to characterize the molecular mechanisms underlying acute O2 sensing by arterial chemoreceptors (carotid body –CB- and adrenal medulla –AM-), we will also extend our study to other organs (e.g. pulmonary and systemic arteries) of the homeostatic acute O2-sensing system. We will investigate the role of mitochondria, in particular complex I (MCI), in acute O2 sensing. Previous data from our group demonstrated that rotenone, a MCI blocker, selectively occludes responsiveness to hypoxia in CB cells. In addition, our unpublished data indicate that sensitivity to hypoxia (but not to other stimuli) is lost in mice with genetic disruption of MCI genes in CB and AM cells. We have shown that the adult CB is a plastic organ that contains a population of multipotent neural stem cells. Hence, another objective of the project is to study the role of these stem cells in CB modulation (over- or infra-activation), which may participate in the pathogenesis of diseases. In the past, our group has made seminal contributions to unveiling the cellular bases of arterial chemoreception. The discovery of stem cells in the CB and the generation of new genetically modified mouse models, put us in a leading position to elucidate the molecular bases of acute O2 sensing and their biomedical implications.
|year||authors and title||journal||last update|
Ignacio Arias-Mayenco, Patricia GonzÃ¡lez-RodrÃguez, Hortensia Torres-Torrelo, Lin Gao, M. Carmen FernÃ¡ndez-AgÃ¼era, Victoria Bonilla-Henao, Patricia Ortega-SÃ¡enz, JosÃ© LÃ³pez-Barneo
Acute O 2 Sensing: Role of Coenzyme QH 2 /Q Ratio and Mitochondrial ROS Compartmentalization
published pages: 145-158.e4, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.05.009
|Cell Metabolism 28/1||2019-07-04|
M.Â Carmen FernÃ¡ndez-AgÃ¼era, Lin Gao, Patricia GonzÃ¡lez-RodrÃguez, C.Â Oscar Pintado, Ignacio Arias-Mayenco, Paula GarcÃa-Flores, Antonio GarcÃa-PergaÃ±eda, Alberto Pascual, Patricia Ortega-SÃ¡enz, JosÃ© LÃ³pez-Barneo
Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling
published pages: 825-837, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2015.09.004
|Cell Metabolism 22/5||2019-07-04|
Patricia Ortega-SÃ¡enz, David MacÃas, Konstantin L. Levitsky, JosÃ© A. RodrÃguez-GÃ³mez, Patricia GonzÃ¡lez-RodrÃguez, Victoria Bonilla-Henao, Ignacio Arias-Mayenco, JosÃ© LÃ³pez-Barneo
Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion
published pages: 7229-7248, ISSN: 0022-3751, DOI: 10.1113/JP272961
|The Journal of Physiology 594/24||2019-07-04|
David Macias, Andrew S Cowburn, Hortensia Torres-Torrelo, Patricia Ortega-SÃ¡enz, JosÃ© LÃ³pez-Barneo, Randall S Johnson
HIF-2Î± is essential for carotid body development and function
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.34681
VerÃ³nica Sobrino, Patricia GonzÃ¡lezâ€RodrÃguez, Valentina Annese, JosÃ© LÃ³pezâ€Barneo, Ricardo Pardal
Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia
published pages: e44598, ISSN: 1469-221X, DOI: 10.15252/embr.201744598
|EMBO reports 19/3||2019-07-04|
Lin Gao, Patricia GonzÃ¡lez-RodrÃguez, Patricia Ortega-SÃ¡enz, JosÃ© LÃ³pez-Barneo
Redox signaling in acute oxygen sensing
published pages: 908-915, ISSN: 2213-2317, DOI: 10.1016/j.redox.2017.04.033
|Redox Biology 12||2019-07-04|
Lin Gao, Victoria Bonilla-Henao, Paula GarcÃa-Flores, Ignacio Arias-Mayenco, Patricia Ortega-SÃ¡enz, JosÃ© LÃ³pez-Barneo
Gene expression analyses reveal metabolic specifications in acute O 2 -sensing chemoreceptor cells
published pages: 6091-6120, ISSN: 0022-3751, DOI: 10.1113/JP274684
|The Journal of Physiology 595/18||2019-07-04|
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