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OxygenSensing SIGNED

Molecular mechanisms of acute oxygen sensing.

Total Cost €

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EC-Contrib. €

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Partnership

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 OxygenSensing project word cloud

Explore the words cloud of the OxygenSensing project. It provides you a very rough idea of what is the project "OxygenSensing" about.

participate    bases    responsiveness    adult    genes    group    sympathetic    chemoreceptors    mci    reflexes    solid    elucidate    o2    body    pathogenesis    modulation    plastic    infra    put    stem    implications    earth    underlying    cardiovascular    issue    homeostatic    indicate    cells    pulmonary    demonstrated    systemic    sustained    contributions    population    dependent    disruption    sensing    genetically    sensitivity    hydroxylases    deals    discovery    framework    diseases    unveiling    mice    regulation    medulla    biomedical    molecular    unpublished    saving    generation    unknown    cellular    neural    transcription    life    arteries    contains    organs    genetic    elucidated    carotid    shown    primary    mechanisms    position    lost    made    cb    occludes    activation    blocker    hence    rotenone    oxygen    data    selectively    hyperventilation    chemoreception    stimuli    extend    chronic    adrenal    models    organ    hypoxia    seminal    mitochondria    multipotent    inducible    rapid    respiratory    compensatory    mouse    am    acute    arterial    modified   

Project "OxygenSensing" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SEVILLA 

Organization address
address: CALLE S. FERNANDO 4
city: SEVILLA
postcode: 41004
website: www.us.es

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://www.ibis-sevilla.es/investigacion/neurociencias/neurobiologia-celular-y-biofisica/lopez-barneo-jose.aspx
 Total cost 2˙843˙750 €
 EC max contribution 2˙843˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SEVILLA ES (SEVILLA) coordinator 2˙843˙750.00

Map

 Project objective

Oxygen (O2) is essential for life on Earth. This proposal deals with the study of the molecular mechanisms underlying acute O2 sensing by cells, a long-standing issue that is yet to be elucidated. In recent years, the discovery of hypoxia inducible transcription factors and their regulation by the O2-dependent hydroxylases has provided a solid framework for understanding genetic responses to sustained (chronic) hypoxia. However the mechanisms of acute O2 sensing, necessary for the activation of rapid, life-saving, compensatory respiratory and cardiovascular reflexes (e.g. hyperventilation and sympathetic activation), are unknown. While the primary goal of the project is to characterize the molecular mechanisms underlying acute O2 sensing by arterial chemoreceptors (carotid body –CB- and adrenal medulla –AM-), we will also extend our study to other organs (e.g. pulmonary and systemic arteries) of the homeostatic acute O2-sensing system. We will investigate the role of mitochondria, in particular complex I (MCI), in acute O2 sensing. Previous data from our group demonstrated that rotenone, a MCI blocker, selectively occludes responsiveness to hypoxia in CB cells. In addition, our unpublished data indicate that sensitivity to hypoxia (but not to other stimuli) is lost in mice with genetic disruption of MCI genes in CB and AM cells. We have shown that the adult CB is a plastic organ that contains a population of multipotent neural stem cells. Hence, another objective of the project is to study the role of these stem cells in CB modulation (over- or infra-activation), which may participate in the pathogenesis of diseases. In the past, our group has made seminal contributions to unveiling the cellular bases of arterial chemoreception. The discovery of stem cells in the CB and the generation of new genetically modified mouse models, put us in a leading position to elucidate the molecular bases of acute O2 sensing and their biomedical implications.

 Publications

year authors and title journal last update
List of publications.
2018 Ignacio Arias-Mayenco, Patricia González-Rodríguez, Hortensia Torres-Torrelo, Lin Gao, M. Carmen Fernández-Agüera, Victoria Bonilla-Henao, Patricia Ortega-Sáenz, José López-Barneo
Acute O 2 Sensing: Role of Coenzyme QH 2 /Q Ratio and Mitochondrial ROS Compartmentalization
published pages: 145-158.e4, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.05.009
Cell Metabolism 28/1 2019-07-04
2015 M. Carmen Fernández-Agüera, Lin Gao, Patricia González-Rodríguez, C. Oscar Pintado, Ignacio Arias-Mayenco, Paula García-Flores, Antonio García-Pergañeda, Alberto Pascual, Patricia Ortega-Sáenz, José López-Barneo
Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling
published pages: 825-837, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2015.09.004
Cell Metabolism 22/5 2019-07-04
2016 Patricia Ortega-Sáenz, David Macías, Konstantin L. Levitsky, José A. Rodríguez-Gómez, Patricia González-Rodríguez, Victoria Bonilla-Henao, Ignacio Arias-Mayenco, José López-Barneo
Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion
published pages: 7229-7248, ISSN: 0022-3751, DOI: 10.1113/JP272961
The Journal of Physiology 594/24 2019-07-04
2018 David Macias, Andrew S Cowburn, Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, José López-Barneo, Randall S Johnson
HIF-2α is essential for carotid body development and function
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.34681
eLife 7 2019-07-04
2018 Verónica Sobrino, Patricia González‐Rodríguez, Valentina Annese, José López‐Barneo, Ricardo Pardal
Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia
published pages: e44598, ISSN: 1469-221X, DOI: 10.15252/embr.201744598
EMBO reports 19/3 2019-07-04
2017 Lin Gao, Patricia González-Rodríguez, Patricia Ortega-Sáenz, José López-Barneo
Redox signaling in acute oxygen sensing
published pages: 908-915, ISSN: 2213-2317, DOI: 10.1016/j.redox.2017.04.033
Redox Biology 12 2019-07-04
2017 Lin Gao, Victoria Bonilla-Henao, Paula García-Flores, Ignacio Arias-Mayenco, Patricia Ortega-Sáenz, José López-Barneo
Gene expression analyses reveal metabolic specifications in acute O 2 -sensing chemoreceptor cells
published pages: 6091-6120, ISSN: 0022-3751, DOI: 10.1113/JP274684
The Journal of Physiology 595/18 2019-07-04

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