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ProteinConjugates SIGNED

A training network for the chemical site-selective modification of proteins: Preparation of the next-generation of therapeutic chemically-defined protein conjugates

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ProteinConjugates" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://www.ff.ul.pt/proteinconjugatesitn/
 Total cost 2˙542˙771 €
 EC max contribution 2˙542˙770 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 741˙939.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 273˙287.00
3    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 273˙287.00
4    INSTITUT CURIE FR (PARIS) participant 262˙875.00
5    UNIVERSITAT WIEN AT (WIEN) participant 255˙934.00
6    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 249˙216.00
7    UNIVERSIDAD DE LA RIOJA ES (LA RIOJA) participant 247˙872.00
8    Faculdade de Farmácia da Universidade de Lisboa PT (Lisboa) participant 238˙356.00
9    UNIVERSITAET ULM DE (ULM) participant 0.00
10    HOVIONE FARMACIENCIA SA PT (LOURES) partner 0.00
11    PHARMAMAR, S.A. ES (COLMENAR VIEJO (MADRID)) partner 0.00

Map

 Project objective

ProteinConjugates is an inter- and multi-disciplinary network for the education of talented young scientists who will learn how to rationally design and construct the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer or rheumatoid arthritis. A complementary interaction between academy and pharmaceutical industry is at the centre of such a network, which involves 8 academic groups and 1 SME partner as beneficiaries, and 2 leading European industrial partner organizations that will host secondments while providing training. The combined expertise of the beneficiaries and industrial partners in synthesis of complex molecules, molecular dynamics, supramolecular self-assembly, site-selective chemical protein modification, protein/antibody engineering, cancer therapeutics and drug development together with the experience in project management and training of PhDs and Postdocs of the PIs, will create a multidisciplinary environment where 10 young researchers can foster their knowledge and skills while developing the most innovative ideas in the emerging fields of chemical site-selective protein modification and protein biotherapeutics. Exposure to the highly dynamic and multidisciplinary ProteinConjugates environment will contribute to the education of the next generation of leaders in the emerging field of protein biotherapeutics, a key area of research and drug development for Europe's competitiveness.

 Deliverables

List of deliverables.
Project Finish Other 2020-04-24 23:09:55
A new GMP manufacturing platform Other 2020-04-24 23:12:35
Construction of sillafin based drug delivery systems Other 2020-04-24 23:11:55
Summer School Other 2020-04-24 23:09:43
Construction of protein-based nanostructures modified with CAIX ligands Other 2020-04-24 23:11:40
Evaluation of a new vascular targeting ADC Other 2020-04-24 23:12:08
Winter School Other 2020-04-24 23:08:43
Construction of a new Transtuzumab-marine drug ADC Other 2020-04-24 23:10:46
Construction of a new Transtuzumab-SN38 ADC Other 2020-04-24 23:10:32
Construction of anti-MUC1-fluorofore conjugate Other 2020-04-24 23:11:27
Construction of a new CXCR4-bortezomib ADC Other 2020-04-24 23:11:14
Construction of a new Fab (trastuzumab)-doxoribicin ADC Other 2020-04-24 23:11:03
New modified silaffins for drug-delivery based on silica nanoparticles Other 2020-04-24 23:10:07
Construction of a new DM1-antibody L19 ADC vascular targeting ADC Other 2020-04-24 23:10:20
Evaluation of a new CXR4-bortezobib ADC Other 2020-04-24 23:12:50
Evaluation of a new homogeneous ADC against HER2 Other 2020-04-24 23:12:21
New method for the site-selective cysteine modification Other 2020-01-15 14:12:52
Website completion Websites, patent fillings, videos etc. 2020-01-15 14:12:52
New protein based nanoparticles Other 2020-01-15 14:12:52
A new method for disulfide bridging with boronic acid coordinating handles Other 2020-01-15 14:12:52
A new anti-MUC1-antibody 4 UR PDE PU 20 The method involves the design of a new anti-MUC1-antibody with high affinity and selectivity for modified MUC1 glycopeptides Other 2020-01-15 14:12:52
Project Kick-off Other 2020-01-15 14:12:52
New method for site-selective tryptophan modification Other 2020-01-15 14:12:52
A new method for the disulphide bridging Other 2020-01-15 14:12:52
New modified synthetic lectins Other 2020-01-15 14:12:52
New method for the site-selective lysine modification Other 2020-01-15 14:12:52
Construction of lectin based drug delivery systems Other 2020-01-15 14:12:52
Vacancies advertisement Other 2020-01-15 14:12:52

Take a look to the deliverables list in detail:  detailed list of ProteinConjugates deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia
published pages: 2155-2168, ISSN: 0887-6924, DOI: 10.1038/s41375-019-0434-8
Leukemia 33/9 2020-03-06
2019 Maria J. Matos, Claudio D. Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L. Saar, Ismael Compañón, Francisco Corzana, Tuomas P. J. Knowles, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation
published pages: 6640-6644, ISSN: 1433-7851, DOI: 10.1002/anie.201901405
Angewandte Chemie International Edition 58/20 2020-03-06
2019 Maria J. Matos, Claudio D. Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L. Saar, Ismael Compañón, Francisco Corzana, Tuomas P. J. Knowles, Gonzalo Jiménez‐Osés, Gonçalo J. L. Bernardes
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
published pages: 6712-6716, ISSN: 0044-8249, DOI: 10.1002/ange.201901405
Angewandte Chemie 131/20 2020-03-06
2019 Barbara Bernardim, Maria J. Matos, Xhenti Ferhati, Ismael Compañón, Ana Guerreiro, Padma Akkapeddi, Antonio C. B. Burtoloso, Gonzalo Jiménez-Osés, Francisco Corzana, Gonçalo J. L. Bernardes
Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents
published pages: 86-99, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0083-9
Nature Protocols 14/1 2020-03-06
2019 Charlotte Baker, Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, Gonçalo J.L. Bernardes
Natural product–drug conjugates for modulation of TRPV1-expressing tumors
published pages: 2531-2536, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.03.025​
Bioorganic & Medicinal Chemistry 27/12 2020-03-06
2019 Marco Hebel, Andreas Riegger, Maksymilian M. Zegota, Gönül Kizilsavas, Jasmina Gačanin, Michaela Pieszka, Thorsten Lückerath, Jaime A. S. Coelho, Manfred Wagner, Pedro M. P. Gois, David Y. W. Ng, Tanja Weil
Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes
published pages: 14026-14031, ISSN: 0002-7863, DOI: 10.1021/jacs.9b03107
Journal of the American Chemical Society 141/36 2020-03-06
2018 Ludger Johannes, Marco Lucchino
Current Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAs
published pages: 178-193, ISSN: 2159-3337, DOI: 10.1089/nat.2017.0716
Nucleic Acid Therapeutics 28/3 2020-03-06
2019 Giorgia Del Favero, Friedrich Bialas, Stephanie Grabher, Anja Wittig, Birgit Bräuer, Dagmar Gerthsen, Cécile Echalier, Meder Kamalov, Doris Marko, Christian F. W. Becker
Silica particles with a quercetin–R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus
published pages: 9649-9652, ISSN: 1359-7345, DOI: 10.1039/c9cc02215e
Chemical Communications 55/65 2020-03-06
2018 Seah Ling Kuan, Stephan Fischer, Susanne Hafner, Tao Wang, Tatiana Syrovets, Weina Liu, Yu Tokura, David Yuen Wah Ng, Andreas Riegger, Christina Förtsch, Daniela Jäger, Thomas F. E. Barth, Thomas Simmet, Holger Barth, Tanja Weil
Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins
published pages: 1701036, ISSN: 2198-3844, DOI: 10.1002/advs.201701036
Advanced Science 5/8 2020-03-06
2017 Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, João T. Barata
From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia
published pages: 10-25, ISSN: 0898-6568, DOI: 10.1016/j.cellsig.2017.06.011
Cellular Signalling 38 2020-03-06
2019 Shuang Sun, Padma Akkapeddi, Marta C. Marques, Nuria Martínez-Sáez, Vukosava M. Torres, Carlos Cordeiro, Omar Boutureira, Gonçalo J. L. Bernardes
One-pot stapling of interchain disulfides of antibodies using an isobutylene motif
published pages: 2005-2012, ISSN: 1477-0520, DOI: 10.1039/c8ob02877j
Organic & Biomolecular Chemistry 17/7 2020-03-06
2018 Stefanie Sieste, Thomas Mack, Christopher V. Synatschke, Corinna Schilling, Christopher Meyer zu Reckendorf, Laura Pendi, Sean Harvey, Francesco S. Ruggeri, Tuomas P. J. Knowles, Christoph Meier, David Y. W. Ng, Tanja Weil, Bernd Knöll
Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion
published pages: 1701485, ISSN: 2192-2640, DOI: 10.1002/adhm.201701485
Advanced Healthcare Materials 7/11 2020-03-06
2017 Allyson M. Freedy, Maria J. Matos, Omar Boutureira, Francisco Corzana, Ana Guerreiro, Padma Akkapeddi, Víctor J. Somovilla, Tiago Rodrigues, Karl Nicholls, Bangwen Xie, Gonzalo Jiménez-Osés, Kevin M. Brindle, André A. Neves, Gonçalo J. L. Bernardes
Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation
published pages: 18365-18375, ISSN: 0002-7863, DOI: 10.1021/jacs.7b10702
Journal of the American Chemical Society 139/50 2020-03-06
2018 Tiago Rodrigues, Markus Werner, Jakob Roth, Eduardo H. G. da Cruz, Marta C. Marques, Padma Akkapeddi, Susana A. Lobo, Andreas Koeberle, Francisco Corzana, Eufrânio N. da Silva Júnior, Oliver Werz, Gonçalo J. L. Bernardes
Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
published pages: 6899-6903, ISSN: 2041-6520, DOI: 10.1039/c8sc02634c
Chemical Science 9/34 2020-03-06
2018 Christiane Seidler, Maksymilian Marek Zegota, Marco Raabe, Seah Ling Kuan, David Y. W. Ng, Tanja Weil
Dynamic Core-Shell Bioconjugates for Targeted Protein Delivery and Release
published pages: 3474-3479, ISSN: 1861-4728, DOI: 10.1002/asia.201800843
Chemistry - An Asian Journal 13/22 2020-03-06
2019 João P. M. António, Roberto Russo, Cátia Parente Carvalho, Pedro M. S. D. Cal, Pedro M. P. Gois
Boronic acids as building blocks for the construction of therapeutically useful bioconjugates
published pages: 3513-3536, ISSN: 0306-0012, DOI: 10.1039/c9cs00184k
Chemical Society Reviews 48/13 2020-03-06
2019 Mariana L. Oliveira, Padma Akkapeddi, Daniel Ribeiro, Alice Melão, João T. Barata
IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update
published pages: 88-96, ISSN: 2212-4926, DOI: 10.1016/j.jbior.2018.09.012
Advances in Biological Regulation 71 2020-03-06
2019 João C. F. Nogueira, Michelle K. Greene, Daniel A. Richards, Alexander O. Furby, John Steven, Andrew Porter, Caroline Barelle, Christopher J. Scott, Vijay Chudasama
Oriented attachment of V NAR proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
published pages: 7671-7674, ISSN: 1359-7345, DOI: 10.1039/c9cc02655j
Chemical Communications 55/53 2020-03-06
2018 Jean-Marie Carpier, Andres E. Zucchetti, Laurence Bataille, Stéphanie Dogniaux, Massiullah Shafaq-Zadah, Sabine Bardin, Marco Lucchino, Mathieu Maurin, Leonel D. Joannas, Joao Gamelas Magalhaes, Ludger Johannes, Thierry Galli, Bruno Goud, Claire Hivroz
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation
published pages: 1245-1265, ISSN: 0022-1007, DOI: 10.1084/jem.20162042
The Journal of Experimental Medicine 215/4 2020-03-06
2018 Maksymilian Marek Zegota, Tao Wang, Christiane Seidler, David Yuen Wah Ng, Seah Ling Kuan, Tanja Weil
“Tag and Modify” Protein Conjugation with Dynamic Covalent Chemistry
published pages: 2665-2670, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00358
Bioconjugate Chemistry 29/8 2020-01-28

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