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MOZART SIGNED

MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs

Total Cost €

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EC-Contrib. €

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Partnership

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 MOZART project word cloud

Explore the words cloud of the MOZART project. It provides you a very rough idea of what is the project "MOZART" about.

months    smart    candidates    bone    liquid    significantly    considering    transition    gel    proof    carbons    ordered    thermosensitive    cu2    biomolecules    chosen    nm    effect    environment    delayed    doped    minimum    inflammation    elegant    sr2    drugs    radically    platforms    people    therapies    release    incorporated    harmonious    time    350    sol    million    mtgs    extraordinarily    suffer    omcs    potentially    library    skin    keep    societal       size    site    suffering    temperature    wounds    immolative    gels    synthesised    vs    manufactured    invasive    li    patients    b3    ions    orchestra    clinical    adjustable    reduce    therapeutic    nanopores    inorganic    synergistic    ce3    union    perfect    ag    undergoes    room    heal    coated    healing    physiological    enormous    glasses    directed    infection    nanomatrices    polymer    treat    mozart    place    50    loaded    pathological    introduce    chronic    created    coatings    least    impacts    integration    host    payload    characterised    fractures    self    mesoporous    symphony    12    ph   

Project "MOZART" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.mozartproject.eu/
 Total cost 4˙651˙228 €
 EC max contribution 4˙651˙228 € (100%)
 Programme 1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
2. H2020-EU.2.1.2.5. (Developing and standardisation of capacity-enhancing techniques, measuring methods and equipment)
3. H2020-EU.2.1.2.3. (Developing the societal dimension of nanotechnology)
 Code Call H2020-NMP-PILOTS-2015
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 925˙000.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 709˙000.00
3    ASHLAND SPECIALTIES IRELAND LIMITED IE (Dublin) participant 536˙875.00
4    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 500˙930.00
5    FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG DE (ERLANGEN) participant 381˙975.00
6    "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" EL (AGIA PARASKEVI) participant 369˙300.00
7    NOBIL BIO RICERCHE SRL IT (CONCESIO) participant 322˙500.00
8    NANOLITH SVERIGE AB SE (BROMMA) participant 321˙898.00
9    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 265˙000.00
10    DELSITECH OY FI (TURKU) participant 225˙000.00
11    CELLOGIC GMBH DE (BERLIN) participant 93˙750.00

Map

 Project objective

The concept behind MOZART is to develop a library of inorganic nanomatrices to be used as smart platforms for effective, non-invasive and highly targeted therapies. MOZART will address, as proof of concept, nanomatrices to treat delayed bone healing and non-healing chronic skin wounds, which are both characterised by an inflammation and often infection. Mesoporous therapeutic glasses (MTGs), doped with selected ions (e.g. Ag, Li, Cu2, Sr2, Ce3, B3) and having nanopores of adjustable size within 2-50 nm, will be synthesised and then loaded with the chosen payload. Ordered mesoporous carbons (OMCs) will also be manufactured to host a wide range of biomolecules and higher payload. As in an orchestra, where the integration among the different participants allows a harmonious symphony to be created, in MOZART the synergistic release of ions and drugs will be directed to achieve a radically improved therapeutic effect. The exploitation of the response of self-immolative polymer coatings upon pH changes will be used as an elegant and effective way for triggering the payload release. The (coated) nanomatrices will be incorporated in a thermosensitive gel that is liquid at room temperature and undergoes sol-gel transition in the physiological environment. These gels are perfect candidates to develop non-invasive procedures to introduce MOZART nanomatrices to the pathological site and keep them in place for the required time. Clinical and societal impacts of MOZART will be enormous, considering the extraordinarily high number of pathological cases potentially involved. Only in EU, 350 000 patients per year are affected by non-union bone fractures and 2.2 million people suffer from chronic wounds. We expect that MOZART approaches will significantly reduce the healing time of non-union bone fractures (within 4 months vs. a minimum of 12 months) and will allow at least 50% of people suffering from chronic wounds to heal fully.

 Publications

year authors and title journal last update
List of publications.
2019 Elisa Torre, Dimitra Giasafaki, Theodore Steriotis, Clara Cassinelli, Marco Morra, Sonia Fiorilli, Chiara Vitale-Brovarone, Georgia Charalambopoulou, Giorgio Iviglia

Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context


published pages: 10147-10164, ISSN: 1178-2013, DOI: 10.2147/ijn.s234393
International Journal of Nanomedicine Volume 14 2020-04-06
2019 M. Boffito, C. Pontremoli, S. Fiorilli, R. Laurano, G. Ciardelli, C. Vitale-Brovarone
Injectable thermosensitive polyurethane hydrogels for sustained co-delivery of functional ions and drugs
published pages: , ISSN: 1999-4923, DOI:
Pharmaceutics 2020-04-06
2017 Gisbert-Garzarán M, Manzano M, Vallet-Regí M.
Self-immolative chemistry in nanomedicine.
published pages: , ISSN: 1385-8947, DOI: 10.1016/j.cej.2017.12.098
Chemical Engineering Journal 2020-04-06
2019 Kai Zheng, Preethi Balasubramanian, Thomas E. Paterson, Rene Stein, Sheila MacNeil, Sonia Fiorilli, Chiara Vitale-Brovarone, Joanna Shepherd, Aldo R. Boccaccini
Ag modified mesoporous bioactive glass nanoparticles for enhancedantibacterial activity in 3D infected skin model
published pages: , ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.109764
Material Sciences & Engineering C 2020-04-06
2019 Anthony J. Bullock, Marcela Garcia, Joanna Shepherd, Ihtesham Rehman & MacNeil Sheila
Bacteria induced pH changes in tissue-engineered human skin detected noninvasively using Raman confocal spectroscop
published pages: , ISSN: 0570-4928, DOI:
Applied Spectroscopy Reviews 2020-04-06
2018 Sonia Fiorilli, Giulia Molino, Carlotta Pontremoli, Giorgio Iviglia, Elisa Torre, Clara Cassinelli, Marco Morra, Chiara Vitale-Brovarone
The Incorporation of Strontium to Improve Bone-Regeneration Ability of Mesoporous Bioactive Glasses
published pages: 678, ISSN: 1996-1944, DOI: 10.3390/ma11050678
Materials 11/5 2020-04-06
2017 Taimoor H. Qazi, Shahzad Hafeez, Jochen Schmidt, Georg N. Duda, Aldo R. Boccaccini, Evi Lippens
Comparison of the effects of 45S5 and 1393 bioactive glass microparticles on hMSC behavior
published pages: 2772-2782, ISSN: 1549-3296, DOI: 10.1002/jbm.a.36131
Journal of Biomedical Materials Research Part A 105/10 2020-04-06
2017 H. Schell, G. N. Duda, A. Peters, S. Tsitsilonis, K. A. Johnson, K. Schmidt-Bleek
The haematoma and its role in bone healing
published pages: , ISSN: 2197-1153, DOI: 10.1186/s40634-017-0079-3
Journal of Experimental Orthopaedics 4/1 2020-04-06
2017 Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giorgia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale-Brovarone
Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration
published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.04.012
Acta Biomaterialia 2020-04-06
2017 M. Gisbert-Garzaran, D. Lozano, M. Vallet-Regí, M. Manzano
Self-immolative polymers as novel pH-responsive gate keepers for drug delivery
published pages: 132-136, ISSN: 2046-2069, DOI: 10.1039/C6RA26771H
RSC Adv. 7/1 2020-04-06
2017 Francesco Baino, Sonia Fiorilli, Chiara Vitale-Brovarone
Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review
published pages: 15, ISSN: 2306-5354, DOI: 10.3390/bioengineering4010015
Bioengineering 4/1 2020-04-06
2018 C. Pontremoli, M. Boffito, S. Fiorilli, R. Laurano, A. Torchio, A. Bari, C. Tonda-Turo, G. Ciardelli, C. Vitale-Brovarone
Hybrid injectable platforms for the in situ delivery of therapeutic ions from mesoporous glasses
published pages: 103-113, ISSN: 1385-8947, DOI: 10.1016/j.cej.2018.01.073
Chemical Engineering Journal 340 2020-04-06
2017 Miguel Gisbert-Garzarán, Miguel Manzano, María Vallet-Regí
pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery
published pages: 3, ISSN: 2306-5354, DOI: 10.3390/bioengineering4010003
Bioengineering 4/1 2020-04-06
2017 Juan L. Paris, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano, María Vallet-Regí
Tuning mesoporous silica dissolution in physiological environments: a review
published pages: , ISSN: 0022-2461, DOI: 10.1007/s10853-017-0787-1
Journal of Materials Science 2020-04-06

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