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FutureAgriculture SIGNED

Transforming the future of agriculture through synthetic photorespiration

Total Cost €

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EC-Contrib. €

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Partnership

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 FutureAgriculture project word cloud

Explore the words cloud of the FutureAgriculture project. It provides you a very rough idea of what is the project "FutureAgriculture" about.

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Project "FutureAgriculture" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.futureagriculture.eu/
 Total cost 4˙871˙410 €
 EC max contribution 4˙871˙410 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙934˙025.00
2    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 955˙215.00
3    EVOGENE LTD IL (REHOVOT) participant 902˙532.00
4    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 875˙887.00
5    IN SRL IT (UDINE) participant 203˙750.00

Map

 Project objective

For a new green revolution to feed the continually increasing population, agriculture productivity will have to be significantly improved. Photorespiration represents a big challenge in this respect, because it dissipates energy and leads to the futile loss of CO2, thereby limiting plant growth yield. Implementing an efficient metabolic bypass for photorespiration can therefore increase the photosynthetic efficiency of many cultivated crops. Several such routes were previously proposed. However, these routes were limited to existing enzymes and pathways and provided only partial improvement. Here, we propose a radically different approach: to engineer entirely novel CO2-neutral or CO2-positive photorespiration bypasses based on novel enzyme chemistry that support significantly higher agricultural yields. These bypass routes could support 60% higher biomass yield per turn of the Calvin Cycle and >30% higher yield per ATP. Our project innovatively integrates different research disciplines and combines academic research with industrial implementation. In silico studies will integrate biochemical logic and pathway modelling to explore all possible photorespiration pathways and identify the most efficient routes. In vitro research will establish novel enzyme functions via enzyme engineering and directed evolution. Full pathways will be reconstituted and optimized in vitro using a novel mass spectrometry based platform. High in vivo activity will be selected by implementing the pathways in engineered E. coli strains. Enhanced photosynthetic efficiency will be demonstrated in cyanobacteria expressing the synthetic pathways. Finally, the most promising synthetic pathways will be implemented in higher plants and growth phenotypes will be monitored. The proposed project comprises a significant advance in synthetic biology – applying biochemical principles to modify the very core of carbon metabolism with synthetic pathways that carry multiple novel enzymatic functions.

 Deliverables

List of deliverables.
Model of plant photosynthesis Documents, reports 2019-10-29 14:07:51
Synthetic pathways in E. coli Documents, reports 2019-10-29 14:07:43
In vitro reconstructed pathways Documents, reports 2019-10-29 14:07:34
Project website Websites, patent fillings, videos etc. 2019-06-05 14:21:33

Take a look to the deliverables list in detail:  detailed list of FutureAgriculture deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Devin L. Trudeau, Christian Edlich-Muth, Jan Zarzycki, Marieke Scheffen, Moshe Goldsmith, Olga Khersonsky, Ziv Avizemer, Sarel J. Fleishman, Charles A. R. Cotton, Tobias J. Erb, Dan S. Tawfik, Arren Bar-Even
Design and in vitro realization of carbon-conserving photorespiration
published pages: E11455-E11464, ISSN: 0027-8424, DOI: 10.1073/pnas.1812605115
Proceedings of the National Academy of Sciences 115/49 2019-08-29
2016 Tobias J Erb, Jan Zarzycki
Biochemical and synthetic biology approaches to improve photosynthetic CO2-fixation
published pages: 72-79, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2016.06.026
Current Opinion in Chemical Biology 34 2019-06-05
2019 Armin Kubis, Arren Bar-Even
Synthetic biology approaches for improving photosynthesis
published pages: 1425-1433, ISSN: 0022-0957, DOI: 10.1093/jxb/erz029
Journal of Experimental Botany 70/5 2019-08-29

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The information about "FUTUREAGRICULTURE" are provided by the European Opendata Portal: CORDIS opendata.

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