EU H2020 Project "ENDONAUT (EndoNaut Delivery Platform)": description, partecipants, costs and EC-fundings

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EndoNaut project word cloud

Explore the words cloud of the EndoNaut project. It provides you a very rough idea of what is the project "EndoNaut" about.

imaging molecules polymersomes grant laboratory opportunity functions chemical powerful assembly cell physical sensitive drugs polymeric platform nanoscopic vesicles tools libraries throughput compounds commercial helped hydrophobic reagents stg endosomal therapies poly phosphorylcholine prime copolymer isopropylamino metabolic entities combination contrast surprising core encapsulate few translating yearly ph world intracellular endonaut screening consists engineer allowed collaborating option macromolecules biological pharmaceutical commercialisation maintaining pmpc usd nanotechnology award methacrylate science ones agents market dyes molecular translation form grow perform methacryloyloxy whilst erc company hydrophilic revenue carriers life companies water mevic di reagent 9 diblock billions viability predicted encapsulation advent ethyl first generating prnewswire pdpa

Project "EndoNaut" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	149˙929 €
EC max contribution	149˙929 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-PoC
Funding Scheme	ERC-POC
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2017-06-30

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON	UK (LONDON)	coordinator	149˙929.00

UNIVERSITY COLLEGE LONDON

UK (LONDON)

coordinator

149˙929.00

Project objective

Translating intracellular delivery to the market The advent of nanotechnology allowed the combination of new chemical and physical tools to engineer carriers able to perform specific functions at the molecular level. In recent years the ERC award ERC-STG-MEViC, helped to develop a powerful new technology called EndoNaut. This can be used to encapsulate and deliver dyes, imaging and contrast agents and drugs. EndoNaut technology consists of pH sensitive polymeric vesicles with the unique characteristics of endosomal delivery whilst maintaining cell viability and metabolic activity. The core technology, is based on the assembly in water of diblock copolymer poly(2-(methacryloyloxy)ethyl phosphorylcholine)–poly(2-(di-isopropylamino)ethyl methacrylate) (PMPC–PDPA) into vesicles (also known as polymersomes). These nanoscopic carriers enable the encapsulation of both hydrophilic and hydrophobic compounds including large biological macromolecules. Intracellular delivery is of prime importance for several applications and it can enhance existing therapies as well as allowing new ones. It is not surprising that EndoNaut is now generating significant commercial interest from several our collaborating pharmaceutical and non-pharmaceutical partners. There are two major areas of application for EndoNaut that offer opportunity for short term commercialisation. The first application is as a reagent in life science research and the second is as screening platform for new chemical entities libraries of pharmaceutical companies with few or no other option to deliver their molecules. The world market for both intracellular reagents and high-throughput screening are predicted to grow yearly by 8-9% generating revenue in the order of billions of USD (PRNewswire). The aim of this project is to form a new company dedicated to the exploitation of EndoNaut technology. The current grant would be enabling in the translation process from laboratory to market.

Publications

List of publications.
year	authors and title	journal	last update
2017	Adrian Joseph, Claudia Contini, Denis Cecchin, Sophie Nyberg, Lorena Ruiz-Perez, Jens Gaitzsch, Gavin Fullstone, Xiaohe Tian, Juzaili Azizi, Jane Preston, Giorgio Volpe, Giuseppe Battaglia Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing published pages: e1700362, ISSN: 2375-2548, DOI: 10.1126/sciadv.1700362	Science Advances 3/8	2019-07-26

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The information about "ENDONAUT" are provided by the European Opendata Portal: CORDIS opendata.

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