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EndoNaut

EndoNaut Delivery Platform

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 EndoNaut project word cloud

Explore the words cloud of the EndoNaut project. It provides you a very rough idea of what is the project "EndoNaut" about.

physical    first    biological    cell    prime    reagents    hydrophobic    nanotechnology    prnewswire    throughput    predicted    commercial    company    laboratory    consists    generating    allowed    therapies    powerful    sensitive    ph    helped    entities    carriers    reagent    form    world    life    grow    vesicles    endosomal    drugs    contrast    ones    encapsulate    few    opportunity       pmpc    molecular    methacrylate    stg    usd    engineer    maintaining    copolymer    chemical    pharmaceutical    science    companies    di    libraries    phosphorylcholine    poly    functions    perform    whilst    macromolecules    viability    translating    pdpa    mevic    commercialisation    billions    water    surprising    erc    encapsulation    polymersomes    imaging    combination    polymeric    grant    nanoscopic    metabolic    endonaut    screening    award    molecules    agents    option    hydrophilic    tools    core    dyes    compounds    intracellular    assembly    ethyl    isopropylamino    advent    revenue    yearly    translation    methacryloyloxy    platform    diblock    market    collaborating   

Project "EndoNaut" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 149˙929 €
 EC max contribution 149˙929 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 149˙929.00

Map

 Project objective

Translating intracellular delivery to the market The advent of nanotechnology allowed the combination of new chemical and physical tools to engineer carriers able to perform specific functions at the molecular level. In recent years the ERC award ERC-STG-MEViC, helped to develop a powerful new technology called EndoNaut. This can be used to encapsulate and deliver dyes, imaging and contrast agents and drugs. EndoNaut technology consists of pH sensitive polymeric vesicles with the unique characteristics of endosomal delivery whilst maintaining cell viability and metabolic activity. The core technology, is based on the assembly in water of diblock copolymer poly(2-(methacryloyloxy)ethyl phosphorylcholine)–poly(2-(di-isopropylamino)ethyl methacrylate) (PMPC–PDPA) into vesicles (also known as polymersomes). These nanoscopic carriers enable the encapsulation of both hydrophilic and hydrophobic compounds including large biological macromolecules. Intracellular delivery is of prime importance for several applications and it can enhance existing therapies as well as allowing new ones. It is not surprising that EndoNaut is now generating significant commercial interest from several our collaborating pharmaceutical and non-pharmaceutical partners. There are two major areas of application for EndoNaut that offer opportunity for short term commercialisation. The first application is as a reagent in life science research and the second is as screening platform for new chemical entities libraries of pharmaceutical companies with few or no other option to deliver their molecules. The world market for both intracellular reagents and high-throughput screening are predicted to grow yearly by 8-9% generating revenue in the order of billions of USD (PRNewswire). The aim of this project is to form a new company dedicated to the exploitation of EndoNaut technology. The current grant would be enabling in the translation process from laboratory to market.

 Publications

year authors and title journal last update
List of publications.
2017 Adrian Joseph, Claudia Contini, Denis Cecchin, Sophie Nyberg, Lorena Ruiz-Perez, Jens Gaitzsch, Gavin Fullstone, Xiaohe Tian, Juzaili Azizi, Jane Preston, Giorgio Volpe, Giuseppe Battaglia
Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing
published pages: e1700362, ISSN: 2375-2548, DOI: 10.1126/sciadv.1700362
Science Advances 3/8 2019-07-26

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