Opendata, web and dolomites

SELFORGANICELL SIGNED

Self-Organization of the Bacterial Cell

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SELFORGANICELL project word cloud

Explore the words cloud of the SELFORGANICELL project. It provides you a very rough idea of what is the project "SELFORGANICELL" about.

generate    largely    division    remodeling    uncover    coli    link    time    quantitatively    analyze    reconstitution    emerges    cell    avenues    components    organization    molecular    vitro    precisely    dynamic    interact    remarkable    perform    individual    proteins    extremely    organizing    collective    clear    assembly    intracellular    anatomy    self    ten    one    mechanistic    bacterial    invagination    mechanochemical    vivo    fundamental    divisome    fluorescence    found    protein    microscopy    biology    regulated    dynamics    synthases    assemble    biochemical    questions    underlying    principles    group    combined    giving    experiments    for    give    wall    act    relatively    eukaryotic    modeling    organize    networks    emergent    biological    bacterium    escherichia    synthetic    space    membrane    controls    measured    peptidoglycan    network    machine    interactions    cellular    constantly    theoretical    itself    resolution    sophisticated    answer    force    biophysics    machinery    living   

Project "SELFORGANICELL" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://looselab.org/research
 Total cost 1˙496˙686 €
 EC max contribution 1˙496˙686 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙496˙686.00

Map

 Project objective

One of the most remarkable features of biological systems is their ability to self-organize in space and time. Even a relatively simple cell like the bacterium Escherichia coli has a precisely regulated cellular anatomy, which emerges from dynamic interactions between proteins and the cell membrane. Self-organization allows the cell to perform extremely challenging tasks. For example, for cell division, more than ten different proteins assemble into a complex, yet highly dynamic machine, which controls the invagination of the cell while constantly remodeling itself. Although the individual components involved have been largely identified, how they act together to accomplish this challenge is not understood. It has become clear that sophisticated biochemical networks give rise to intracellular organization, but we have yet to uncover the underlying mechanistic principles. In this research proposal, I aim to develop a detailed mechanistic understanding of the self-organizing, emergent properties of the cell. To this end, my research group will develop novel in vitro reconstitution experiments combined with high-resolution fluorescence microscopy and theoretical modeling. Following this “bottom-up” approach, we will quantitatively analyze collective protein dynamics and emergent mechanochemical properties of the bacterial cell division machinery. I aim to answer the following fundamental questions: 1) What is the biochemical network giving rise to the dynamic assembly of the divisome? 2) How do the components of the divisome interact to generate force? 3) How do peptidoglycan synthases build the cell wall? By comparing protein dynamics in vitro with those measured in vivo, we will provide a link between molecular properties and the processes found in the living cell. This project will not only improve our understanding of the bacterial cell, but also open new research avenues for eukaryotic cell biology, synthetic biology and biophysics.

 Publications

year authors and title journal last update
List of publications.
2017 N. Baranova, M. Loose
Single-molecule measurements to study polymerization dynamics of FtsZ-FtsA copolymers
published pages: 355-370, ISSN: 0091-679X, DOI: 10.1016/bs.mcb.2016.03.036
Methods in Cell Biology 137 , 2017-01-01 2020-03-20
2019 Paulo Caldas, Mar López-Pelegrín, Daniel J.G. Pearce, Nazmi B. Budanur, Jan Brugués, Martin Loose
ZapA stabilizes FtsZ filament bundles without slowing down treadmilling dynamics
published pages: , ISSN: , DOI: 10.1101/580944
2020-03-20
2018 Natalia Baranova, Philipp Radler, Victor M. Hernandez-Rocamora, Carlos Alfonso, Mar Lopez-Pelegrin, German Rivas, Waldemar Vollmer, Martin Loose.
FtsZ assembles the bacterial cell division machinery by a diffusion-and-capture mechanism.
published pages: , ISSN: , DOI: 10.1101/485656
2020-03-20

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SELFORGANICELL" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SELFORGANICELL" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More  

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

TRUST (2018)

Truth and Semantics

Read More