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SELFORGANICELL SIGNED

Self-Organization of the Bacterial Cell

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SELFORGANICELL project word cloud

Explore the words cloud of the SELFORGANICELL project. It provides you a very rough idea of what is the project "SELFORGANICELL" about.

mechanochemical    perform    assembly    emerges    peptidoglycan    controls    reconstitution    wall    interact    for    anatomy    give    vitro    avenues    largely    precisely    invagination    self    act    networks    interactions    intracellular    constantly    remodeling    assemble    escherichia    protein    force    fundamental    collective    generate    division    eukaryotic    experiments    ten    biological    machine    organize    living    individual    components    measured    modeling    itself    bacterial    uncover    remarkable    regulated    combined    biophysics    mechanistic    synthases    time    sophisticated    dynamic    questions    link    organizing    relatively    microscopy    found    biochemical    synthetic    space    giving    vivo    cellular    molecular    proteins    dynamics    one    underlying    clear    quantitatively    bacterium    organization    biology    coli    machinery    network    principles    emergent    membrane    theoretical    analyze    fluorescence    group    answer    divisome    cell    extremely    resolution   

Project "SELFORGANICELL" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://looselab.org/research
 Total cost 1˙496˙686 €
 EC max contribution 1˙496˙686 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙496˙686.00

Map

 Project objective

One of the most remarkable features of biological systems is their ability to self-organize in space and time. Even a relatively simple cell like the bacterium Escherichia coli has a precisely regulated cellular anatomy, which emerges from dynamic interactions between proteins and the cell membrane. Self-organization allows the cell to perform extremely challenging tasks. For example, for cell division, more than ten different proteins assemble into a complex, yet highly dynamic machine, which controls the invagination of the cell while constantly remodeling itself. Although the individual components involved have been largely identified, how they act together to accomplish this challenge is not understood. It has become clear that sophisticated biochemical networks give rise to intracellular organization, but we have yet to uncover the underlying mechanistic principles. In this research proposal, I aim to develop a detailed mechanistic understanding of the self-organizing, emergent properties of the cell. To this end, my research group will develop novel in vitro reconstitution experiments combined with high-resolution fluorescence microscopy and theoretical modeling. Following this “bottom-up” approach, we will quantitatively analyze collective protein dynamics and emergent mechanochemical properties of the bacterial cell division machinery. I aim to answer the following fundamental questions: 1) What is the biochemical network giving rise to the dynamic assembly of the divisome? 2) How do the components of the divisome interact to generate force? 3) How do peptidoglycan synthases build the cell wall? By comparing protein dynamics in vitro with those measured in vivo, we will provide a link between molecular properties and the processes found in the living cell. This project will not only improve our understanding of the bacterial cell, but also open new research avenues for eukaryotic cell biology, synthetic biology and biophysics.

 Publications

year authors and title journal last update
List of publications.
2017 N. Baranova, M. Loose
Single-molecule measurements to study polymerization dynamics of FtsZ-FtsA copolymers
published pages: 355-370, ISSN: 0091-679X, DOI: 10.1016/bs.mcb.2016.03.036
Methods in Cell Biology 137 , 2017-01-01 2020-03-20
2019 Paulo Caldas, Mar López-Pelegrín, Daniel J.G. Pearce, Nazmi B. Budanur, Jan Brugués, Martin Loose
ZapA stabilizes FtsZ filament bundles without slowing down treadmilling dynamics
published pages: , ISSN: , DOI: 10.1101/580944
2020-03-20
2018 Natalia Baranova, Philipp Radler, Victor M. Hernandez-Rocamora, Carlos Alfonso, Mar Lopez-Pelegrin, German Rivas, Waldemar Vollmer, Martin Loose.
FtsZ assembles the bacterial cell division machinery by a diffusion-and-capture mechanism.
published pages: , ISSN: , DOI: 10.1101/485656
2020-03-20

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