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SELFORGANICELL SIGNED

Self-Organization of the Bacterial Cell

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SELFORGANICELL project word cloud

Explore the words cloud of the SELFORGANICELL project. It provides you a very rough idea of what is the project "SELFORGANICELL" about.

interact    vivo    organizing    quantitatively    regulated    reconstitution    time    biochemical    answer    collective    organize    avenues    experiments    analyze    membrane    proteins    largely    extremely    microscopy    peptidoglycan    organization    remodeling    synthetic    biological    molecular    machinery    living    coli    assembly    intracellular    self    relatively    mechanochemical    found    give    giving    interactions    machine    cell    remarkable    uncover    networks    vitro    protein    combined    division    itself    link    wall    generate    components    mechanistic    clear    theoretical    biophysics    precisely    sophisticated    divisome    controls    resolution    fundamental    emerges    dynamic    escherichia    biology    space    invagination    synthases    cellular    constantly    eukaryotic    measured    perform    act    fluorescence    anatomy    group    assemble    principles    force    one    questions    ten    dynamics    network    individual    for    modeling    underlying    bacterium    bacterial    emergent   

Project "SELFORGANICELL" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://looselab.org/research
 Total cost 1˙496˙686 €
 EC max contribution 1˙496˙686 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙496˙686.00

Map

 Project objective

One of the most remarkable features of biological systems is their ability to self-organize in space and time. Even a relatively simple cell like the bacterium Escherichia coli has a precisely regulated cellular anatomy, which emerges from dynamic interactions between proteins and the cell membrane. Self-organization allows the cell to perform extremely challenging tasks. For example, for cell division, more than ten different proteins assemble into a complex, yet highly dynamic machine, which controls the invagination of the cell while constantly remodeling itself. Although the individual components involved have been largely identified, how they act together to accomplish this challenge is not understood. It has become clear that sophisticated biochemical networks give rise to intracellular organization, but we have yet to uncover the underlying mechanistic principles. In this research proposal, I aim to develop a detailed mechanistic understanding of the self-organizing, emergent properties of the cell. To this end, my research group will develop novel in vitro reconstitution experiments combined with high-resolution fluorescence microscopy and theoretical modeling. Following this “bottom-up” approach, we will quantitatively analyze collective protein dynamics and emergent mechanochemical properties of the bacterial cell division machinery. I aim to answer the following fundamental questions: 1) What is the biochemical network giving rise to the dynamic assembly of the divisome? 2) How do the components of the divisome interact to generate force? 3) How do peptidoglycan synthases build the cell wall? By comparing protein dynamics in vitro with those measured in vivo, we will provide a link between molecular properties and the processes found in the living cell. This project will not only improve our understanding of the bacterial cell, but also open new research avenues for eukaryotic cell biology, synthetic biology and biophysics.

 Publications

year authors and title journal last update
List of publications.
2017 N. Baranova, M. Loose
Single-molecule measurements to study polymerization dynamics of FtsZ-FtsA copolymers
published pages: 355-370, ISSN: 0091-679X, DOI: 10.1016/bs.mcb.2016.03.036
Methods in Cell Biology 137 , 2017-01-01 2020-03-20
2019 Paulo Caldas, Mar López-Pelegrín, Daniel J.G. Pearce, Nazmi B. Budanur, Jan Brugués, Martin Loose
ZapA stabilizes FtsZ filament bundles without slowing down treadmilling dynamics
published pages: , ISSN: , DOI: 10.1101/580944
2020-03-20
2018 Natalia Baranova, Philipp Radler, Victor M. Hernandez-Rocamora, Carlos Alfonso, Mar Lopez-Pelegrin, German Rivas, Waldemar Vollmer, Martin Loose.
FtsZ assembles the bacterial cell division machinery by a diffusion-and-capture mechanism.
published pages: , ISSN: , DOI: 10.1101/485656
2020-03-20

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