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GALAXY SIGNED

GALAXY: Gut-and-liver axis in alcoholic liver fibrosis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GALAXY project word cloud

Explore the words cloud of the GALAXY project. It provides you a very rough idea of what is the project "GALAXY" about.

irreversible cross bioinformatics healthcare respectively population galaxy 22 susceptible biomarkers microbial strategies life liver signatures proposes clinical diagnosis progressive billion monitoring combination competences precursor western accelerate 5th interventions reversible time exploited gut disease reduce brings crosstalk medicine sme cirrhosis stratification lifestyle societal microbiome omics individuals progression prevention commercially talk fibrosis restore risk integrate economic lost leads hepatology 20 alcohol host detected stages gt 7th modulate alcoholic eastern overuse interplay 15 annual mitigation influences healthy translate microbiota personalised tools treatments treatment dysbiotic

Project "GALAXY" data sheet

The following table provides information about the project.

Coordinator	SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://www.livergalaxy.eu
Total cost	6˙408˙782 €
EC max contribution	6˙305˙654 € (98%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SYDDANSK UNIVERSITET SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE M)	coordinator	639˙843.00
2	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	1˙387˙000.00
3	ODENSE UNIVERSITETSHOSPITAL ODENSE UNIVERSITETSHOSPITAL Organization address address: Sdr. Boulevard 29 city: ODENSE postcode: 5000 website: www.ouh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE)	participant	1˙187˙082.00
4	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	928˙752.00
5	IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Organization address address: SORANOU EFESIOU 4 city: ATHINA postcode: 115 27 website: www.bioacademy.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	427˙987.00
6	UNIVERSITATSKLINIKUM BONN UNIVERSITATSKLINIKUM BONN Organization address address: VENUSBERG-CAMPUS 1 city: BONN postcode: 53127 website: www.ukb.uni-bonn.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	353˙240.00
7	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	328˙685.00
8	NORDIC BIOSCIENCE A/S NORDIC BIOSCIENCE A/S Organization address address: HERLEV HOVEDGADE 205-207 city: HERLEV postcode: 2730 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HERLEV)	participant	301˙381.00
9	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	247˙369.00
10	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	195˙127.00
11	NORDISK REBALANCE AS NORDISK REBALANCE AS Organization address address: M D MADSENSVEJ 14 16 1ST FLOOR city: ALLERD postcode: 3450 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ALLERD)	participant	178˙907.00
12	NOVO NORDISK INVEST 4 A/S NOVO NORDISK INVEST 4 A/S Organization address address: NOVO ALLE 1 city: BAGSVAERD postcode: 2880 website: www.steno.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BAGSVAERD)	participant	130˙279.00
13	NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S Organization address address: Herlev Hovedgade 207 city: Helev postcode: 2730 website: www.nordicbioscience.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (Helev)	participant	0.00
14	NORGINE BV NORGINE BV Organization address address: HOGEHILWEG 7 city: AMSTERDAM postcode: 1101 CA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	0.00

Map

Project objective

Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY proposes that crosstalk between the gut microbiome and the liver influences the development and progression of alcoholic liver fibrosis. Here, a ‘dysbiotic’ microbiome in susceptible individuals leads to progressive liver fibrosis in combination with alcohol overuse. Therefore, interventions aiming to restore a healthy gut microbiome will reduce disease development. We will use state-of-the-art systems medicine tools to improve understanding of the complex interplay present during alcoholic liver fibrosis, to identify at-risk individuals in time and to develop personalised healthcare strategies for alcohol over-users (20% of the EU population >15 years old). GALAXY brings together partners with unique research competences in clinical hepatology, microbiome, multi-omics, biomarkers and bioinformatics. Our aim is to develop novel systems medicine tools which integrate clinical, multi-omics and lifestyle information from alcohol over-users at various stages of the disease and healthy individuals in order to: 1) identify signatures of host-microbial cross-talk during disease development and progression, 2) translate this into biomarkers for diagnosis, stratification and treatment monitoring in alcohol over users, and 3) evaluate new interventions to modulate gut microbiota towards prevention and mitigation of the disease in at-risk individuals. We will also study societal and economic impact of GALAXY biomarkers and treatments to accelerate future development. The GALAXY consortium includes strong SME partners who will enable the results to be exploited commercially.

Deliverables

List of deliverables.
Project infrastructure established	Documents, reports	2020-04-14 21:24:09
Approvals obtained for SYN-ALD	Documents, reports	2020-04-14 21:24:09
Identified and included 100 healthy controls in GALA-HP	Other	2020-04-14 21:24:08
Collaborative website ready to use	Websites, patent fillings, videos etc.	2020-04-14 21:24:08
Included first 300 (75%) patients in GALA-ALD	Other	2020-04-14 21:24:08
Data management plan	Documents, reports	2020-04-14 21:24:08

Take a look to the deliverables list in detail: detailed list of GALAXY deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Michael Praktiknjo, Viktoria Krabbe, Alessandra Pohlmann, Matthias Sampels, Christian Jansen, Carsten Meyer, Christian P. Strassburg, Jonel Trebicka, Maria A. Gonzalez Carmona Evolution of nodule stiffness might predict response to local ablative therapy: A series of patients with hepatocellular carcinoma published pages: e0192897, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0192897	PLOS ONE 13/2	2020-04-14
2018	BjÃ¸rn StÃ¦hr Madsen, Jonel Trebicka, Maja Thiele, Mads Israelsen, Manimozhiyan Arumugan, Troels Havelund, Aleksander Krag Antifibrotic and molecular aspects of rifaximin in alcoholic liver disease: study protocol for a randomized controlled trial published pages: , ISSN: 1745-6215, DOI: 10.1186/s13063-018-2523-9	Trials 19/1	2020-04-14
2019	Sabine Klein, Franziska Frohn, Fernando Magdaleno, Catharina Reker-Smit, Robert Schierwagen, Irela Schierwagen, Frank Erhard Uschner, Fransien van Dijk, Dieter O. FÃ¼rst, Sonja Djudjaj, Peter Boor, Klaas Poelstra, Leonie Beljaars, Jonel Trebicka Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-38678-5	Scientific Reports 9/1	2020-04-14
2018	Maja Thiele, Vanessa Rausch, Gabriele Fluhr, Maria KjÃ¦rgaard, Felix Piecha, Johannes Mueller, Beate Katharina Straub, Monica LupÈ™or-Platon, Victor De-Ledinghen, Helmut Karl Seitz, SÃ¶nke Detlefsen, BjÃ¸rn Madsen, Aleksander Krag, Sebastian Mueller Controlled attenuation parameter and alcoholic hepatic steatosis: Diagnostic accuracy and role of alcohol detoxification published pages: 1025-1032, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.12.029	Journal of Hepatology 68/5	2020-04-14
2019	Christian Jansen, Anna SchrÃ¶der, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E. Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P. Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt published pages: , ISSN: 2471-254X, DOI: 10.1002/hep4.1308	Hepatology Communications	2020-04-14
2018	M. Welz, S. Eickhoff, Z. Abdullah, J. Trebicka, K. H. Gartlan, J. A. Spicer, A. J. Demetris, H. Akhlaghi, M. Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. A. Trapani, P. Knolle, D. Wohlleber, W. KastenmÃ¼ller Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07213-x	Nature Communications 9/1	2020-04-14
2016	GÃ¶rtzen, Jan; Hunka, Lena M.; Vonnahme, Maria; Praktiknjo, Michael; Kaifie, Andrea; Fimmers, Rolf; Jansen, Christian; Heine, Annkristin; Lehmann, Jennifer; Goethert, Joachim R.; Gattermann, Norbert; Goekkurt, Eray; Platzbecker, Uwe; Brossart, Peter; Strassburg, Christian P.; Brummendorf, Tim H.; Koschmieder, Steffen; Wolf, Dominik; Trebicka, Jonel Î³-Glutamyl Transferase Is an Independent Biomarker of Splanchnic Thrombosis in Patients With Myeloproliferative Neoplasm published pages: , ISSN: 0025-7974, DOI: 10.18154/RWTH-CONV-211209	Medicine 95(20), e3355 (2016). doi:10.18154/RWTH-CONV-211209 6	2020-04-14
2018	Philipp Schwabl, Ksenia Brusilovskaya, Paul Supper, David Bauer, Philipp KÃ¶nigshofer, Florian Riedl, Hubert Hayden, Claudia Daniela Fuchs, Judith Stift, Georg Oberhuber, Stefan Aschauer, Diana Bonderman, Thorsten Gnad, Alexander Pfeifer, Frank Erhard Uschner, Jonel Trebicka, Nataliya Rohr-Udilova, Bruno Karl Podesser, Markus Peck-Radosavljevic, Michael Trauner, Thomas Reiberger The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27656-y	Scientific Reports 8/1	2020-04-14
2018	Michael Praktiknjo, Jennifer Lehmann, Mette J. Nielsen, Robert Schierwagen, Frank E. Uschner, Carsten Meyer, Daniel Thomas, Christian P. Strassburg, Flemming Bendtsen, SÃ¸ren MÃ¸ller, Aleksander Krag, Morten A. Karsdal, Diana J. Leeming, Jonel Trebicka Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis published pages: 211-222, ISSN: 2471-254X, DOI: 10.1002/hep4.1135	Hepatology Communications 2/2	2020-04-14
2017	Jaime Huerta-Cepas, Kristoffer Forslund, Luis Pedro Coelho, Damian Szklarczyk, Lars Juhl Jensen, Christian von Mering, Peer Bork Fast Genome-Wide Functional Annotation through Orthology Assignment by eggNOG-Mapper published pages: 2115-2122, ISSN: 0737-4038, DOI: 10.1093/molbev/msx148	Molecular Biology and Evolution 34/8	2020-04-14
2019	Camila Alvarez-Silva, Robert Schierwagen, Alessandra Pohlmann, Fernando Magdaleno, Frank E. Uschner, Patrick Ryan, Maria J. G. T. Vehreschild, Joan Claria, Eicke Latz, Benjamin Lelouvier, Manimozhiyan Arumugam, Jonel Trebicka Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00069	Frontiers in Immunology 10	2020-04-14
2018	Maja Thiele, BjÃ¸rn StÃ¦hr Madsen, Janne Fuglsang Hansen, SÃ¶nke Detlefsen, Steen Antonsen, Aleksander Krag Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease published pages: 1369-1379, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.01.005	Gastroenterology 154/5	2020-04-14
2018	Tilman Sauerbruch, Robert Schierwagen, Jonel Trebicka Managing portal hypertension in patients with liver cirrhosis published pages: 533, ISSN: 2046-1402, DOI: 10.12688/f1000research.13943.1	F1000Research 7	2020-04-14
2017	Daniel R. Mende, Ivica Letunic, Jaime Huerta-Cepas, Simone S. Li, Kristoffer Forslund, Shinichi Sunagawa, Peer Bork proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes published pages: D529-D534, ISSN: 0305-1048, DOI: 10.1093/nar/gkw989	Nucleic Acids Research 45/D1	2020-04-14
2017	Philipp Lutz, Mohamed MÂ´haimid, Alessandra Pohlmann, Jennifer Lehmann, Christian Jansen, Robert Schierwagen, Sabine Klein, Christian P. Strassburg, Ulrich Spengler, Jonel Trebicka MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis published pages: , ISSN: 2045-2322, DOI: 10.1038/srep40556	Scientific Reports 7/1	2020-04-14
2019	Jennifer Lehmann, Michael Praktiknjo, Mette Juul Nielsen, Robert Schierwagen, Carsten Meyer, Daniel Thomas, Francesco Violi, Christian P. Strassburg, Flemming Bendtsen, SÃ¸ren MÃ¸ller, Aleksander Krag, Morten Asser Karsdal, Diana Julie Leeming, Jonel Trebicka Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis published pages: , ISSN: 1478-3223, DOI: 10.1111/liv.14070	Liver International	2020-04-14

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