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GALAXY SIGNED

GALAXY: Gut-and-liver axis in alcoholic liver fibrosis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "GALAXY" data sheet

The following table provides information about the project.

Coordinator
SYDDANSK UNIVERSITET 

Organization address
address: CAMPUSVEJ 55
city: ODENSE M
postcode: 5230
website: www.sdu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.livergalaxy.eu
 Total cost 6˙408˙782 €
 EC max contribution 6˙305˙654 € (98%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SYDDANSK UNIVERSITET DK (ODENSE M) coordinator 639˙843.00
2    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 1˙387˙000.00
3    ODENSE UNIVERSITETSHOSPITAL DK (ODENSE) participant 1˙187˙082.00
4    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 928˙752.00
5    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) participant 427˙987.00
6    UNIVERSITATSKLINIKUM BONN DE (BONN) participant 353˙240.00
7    REGION HOVEDSTADEN DK (HILLEROD) participant 328˙685.00
8    NORDIC BIOSCIENCE A/S DK (HERLEV) participant 301˙381.00
9    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 247˙369.00
10    UNIVERSITETET I OSLO NO (OSLO) participant 195˙127.00
11    NORDISK REBALANCE AS DK (ALLERD) participant 178˙907.00
12    NOVO NORDISK INVEST 4 A/S DK (BAGSVAERD) participant 130˙279.00
13    NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S DK (Helev) participant 0.00
14    NORGINE BV NL (AMSTERDAM) participant 0.00

Map

 Project objective

Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY proposes that crosstalk between the gut microbiome and the liver influences the development and progression of alcoholic liver fibrosis. Here, a ‘dysbiotic’ microbiome in susceptible individuals leads to progressive liver fibrosis in combination with alcohol overuse. Therefore, interventions aiming to restore a healthy gut microbiome will reduce disease development. We will use state-of-the-art systems medicine tools to improve understanding of the complex interplay present during alcoholic liver fibrosis, to identify at-risk individuals in time and to develop personalised healthcare strategies for alcohol over-users (20% of the EU population >15 years old). GALAXY brings together partners with unique research competences in clinical hepatology, microbiome, multi-omics, biomarkers and bioinformatics. Our aim is to develop novel systems medicine tools which integrate clinical, multi-omics and lifestyle information from alcohol over-users at various stages of the disease and healthy individuals in order to: 1) identify signatures of host-microbial cross-talk during disease development and progression, 2) translate this into biomarkers for diagnosis, stratification and treatment monitoring in alcohol over users, and 3) evaluate new interventions to modulate gut microbiota towards prevention and mitigation of the disease in at-risk individuals. We will also study societal and economic impact of GALAXY biomarkers and treatments to accelerate future development. The GALAXY consortium includes strong SME partners who will enable the results to be exploited commercially.

 Deliverables

List of deliverables.
Project infrastructure established Documents, reports 2020-04-14 21:24:09
Approvals obtained for SYN-ALD Documents, reports 2020-04-14 21:24:09
Identified and included 100 healthy controls in GALA-HP Other 2020-04-14 21:24:08
Collaborative website ready to use Websites, patent fillings, videos etc. 2020-04-14 21:24:08
Included first 300 (75%) patients in GALA-ALD Other 2020-04-14 21:24:08
Data management plan Documents, reports 2020-04-14 21:24:08

Take a look to the deliverables list in detail:  detailed list of GALAXY deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Michael Praktiknjo, Viktoria Krabbe, Alessandra Pohlmann, Matthias Sampels, Christian Jansen, Carsten Meyer, Christian P. Strassburg, Jonel Trebicka, Maria A. Gonzalez Carmona
Evolution of nodule stiffness might predict response to local ablative therapy: A series of patients with hepatocellular carcinoma
published pages: e0192897, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0192897
PLOS ONE 13/2 2020-04-14
2018 Bjørn Stæhr Madsen, Jonel Trebicka, Maja Thiele, Mads Israelsen, Manimozhiyan Arumugan, Troels Havelund, Aleksander Krag
Antifibrotic and molecular aspects of rifaximin in alcoholic liver disease: study protocol for a randomized controlled trial
published pages: , ISSN: 1745-6215, DOI: 10.1186/s13063-018-2523-9
Trials 19/1 2020-04-14
2019 Sabine Klein, Franziska Frohn, Fernando Magdaleno, Catharina Reker-Smit, Robert Schierwagen, Irela Schierwagen, Frank Erhard Uschner, Fransien van Dijk, Dieter O. Fürst, Sonja Djudjaj, Peter Boor, Klaas Poelstra, Leonie Beljaars, Jonel Trebicka
Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-38678-5
Scientific Reports 9/1 2020-04-14
2018 Maja Thiele, Vanessa Rausch, Gabriele Fluhr, Maria Kjærgaard, Felix Piecha, Johannes Mueller, Beate Katharina Straub, Monica Lupșor-Platon, Victor De-Ledinghen, Helmut Karl Seitz, Sönke Detlefsen, Bjørn Madsen, Aleksander Krag, Sebastian Mueller
Controlled attenuation parameter and alcoholic hepatic steatosis: Diagnostic accuracy and role of alcohol detoxification
published pages: 1025-1032, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.12.029
Journal of Hepatology 68/5 2020-04-14
2019 Christian Jansen, Anna Schröder, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E. Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P. Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka
Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt
published pages: , ISSN: 2471-254X, DOI: 10.1002/hep4.1308
Hepatology Communications 2020-04-14
2018 M. Welz, S. Eickhoff, Z. Abdullah, J. Trebicka, K. H. Gartlan, J. A. Spicer, A. J. Demetris, H. Akhlaghi, M. Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. A. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller
Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07213-x
Nature Communications 9/1 2020-04-14
2016 Görtzen, Jan; Hunka, Lena M.; Vonnahme, Maria; Praktiknjo, Michael; Kaifie, Andrea; Fimmers, Rolf; Jansen, Christian; Heine, Annkristin; Lehmann, Jennifer; Goethert, Joachim R.; Gattermann, Norbert; Goekkurt, Eray; Platzbecker, Uwe; Brossart, Peter; Strassburg, Christian P.; Brummendorf, Tim H.; Koschmieder, Steffen; Wolf, Dominik; Trebicka, Jonel
γ-Glutamyl Transferase Is an Independent Biomarker of Splanchnic Thrombosis in Patients With Myeloproliferative Neoplasm
published pages: , ISSN: 0025-7974, DOI: 10.18154/RWTH-CONV-211209
Medicine 95(20), e3355 (2016). doi:10.18154/RWTH-CONV-211209 6 2020-04-14
2018 Philipp Schwabl, Ksenia Brusilovskaya, Paul Supper, David Bauer, Philipp Königshofer, Florian Riedl, Hubert Hayden, Claudia Daniela Fuchs, Judith Stift, Georg Oberhuber, Stefan Aschauer, Diana Bonderman, Thorsten Gnad, Alexander Pfeifer, Frank Erhard Uschner, Jonel Trebicka, Nataliya Rohr-Udilova, Bruno Karl Podesser, Markus Peck-Radosavljevic, Michael Trauner, Thomas Reiberger
The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27656-y
Scientific Reports 8/1 2020-04-14
2018 Michael Praktiknjo, Jennifer Lehmann, Mette J. Nielsen, Robert Schierwagen, Frank E. Uschner, Carsten Meyer, Daniel Thomas, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten A. Karsdal, Diana J. Leeming, Jonel Trebicka
Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis
published pages: 211-222, ISSN: 2471-254X, DOI: 10.1002/hep4.1135
Hepatology Communications 2/2 2020-04-14
2017 Jaime Huerta-Cepas, Kristoffer Forslund, Luis Pedro Coelho, Damian Szklarczyk, Lars Juhl Jensen, Christian von Mering, Peer Bork
Fast Genome-Wide Functional Annotation through Orthology Assignment by eggNOG-Mapper
published pages: 2115-2122, ISSN: 0737-4038, DOI: 10.1093/molbev/msx148
Molecular Biology and Evolution 34/8 2020-04-14
2019 Camila Alvarez-Silva, Robert Schierwagen, Alessandra Pohlmann, Fernando Magdaleno, Frank E. Uschner, Patrick Ryan, Maria J. G. T. Vehreschild, Joan Claria, Eicke Latz, Benjamin Lelouvier, Manimozhiyan Arumugam, Jonel Trebicka
Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00069
Frontiers in Immunology 10 2020-04-14
2018 Maja Thiele, Bjørn Stæhr Madsen, Janne Fuglsang Hansen, Sönke Detlefsen, Steen Antonsen, Aleksander Krag
Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease
published pages: 1369-1379, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.01.005
Gastroenterology 154/5 2020-04-14
2018 Tilman Sauerbruch, Robert Schierwagen, Jonel Trebicka
Managing portal hypertension in patients with liver cirrhosis
published pages: 533, ISSN: 2046-1402, DOI: 10.12688/f1000research.13943.1
F1000Research 7 2020-04-14
2017 Daniel R. Mende, Ivica Letunic, Jaime Huerta-Cepas, Simone S. Li, Kristoffer Forslund, Shinichi Sunagawa, Peer Bork
proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes
published pages: D529-D534, ISSN: 0305-1048, DOI: 10.1093/nar/gkw989
Nucleic Acids Research 45/D1 2020-04-14
2017 Philipp Lutz, Mohamed M´haimid, Alessandra Pohlmann, Jennifer Lehmann, Christian Jansen, Robert Schierwagen, Sabine Klein, Christian P. Strassburg, Ulrich Spengler, Jonel Trebicka
MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep40556
Scientific Reports 7/1 2020-04-14
2019 Jennifer Lehmann, Michael Praktiknjo, Mette Juul Nielsen, Robert Schierwagen, Carsten Meyer, Daniel Thomas, Francesco Violi, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten Asser Karsdal, Diana Julie Leeming, Jonel Trebicka
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
published pages: , ISSN: 1478-3223, DOI: 10.1111/liv.14070
Liver International 2020-04-14

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