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Unravelling mammalian mechanosensor diversity by functional genomics

Total Cost €


EC-Contrib. €






 MECHANOGENOMICS project word cloud

Explore the words cloud of the MECHANOGENOMICS project. It provides you a very rough idea of what is the project "MECHANOGENOMICS" about.

ago    billion    hearing    life    transduction    structures    pain    proprioception    stimuli    forms    mechanical    channel    first    view    somatosensory    candidates    texture    rigidity    unambiguously    somatosensation    expression    mammals    transcriptome    skin    mammalian    family    methodology    helps    light    activated    signaling    patch    determined    function    combination    clamp    embryogenesis    bioinformatics    modalities    bone    ion    axons    diversity    combine    neurons    fundamental    explore    mechanosensors    generate    components    mechanically    sensory    characterization    single    map    signals    converted    mouse    world    identity    profile    physiological    gene    touch    external    cell    populations    body    appeared    molecular    deeper    mechanotransduction    expressed    compelling    biological    functions    perception    sensation    probe    identification    regulated    endings    detection    channels    genes    nerve    mechanosensitive    mechanosensory    constitutes    electrophysiological    sequencing   

Project "MECHANOGENOMICS" data sheet

The following table provides information about the project.


Organization address
address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 1˙491˙708 €
 EC max contribution 1˙491˙708 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE D'AIX MARSEILLE FR (Marseille) coordinator 1˙491˙708.00


 Project objective

Mechanotransduction is the signaling by which external mechanical stimuli are converted into biological signals within the cell. It helps to probe and map the rigidity and texture of external world and appeared with the first life forms some 3.8 billion years ago. In mammals, many fundamental physiological functions are regulated by mechanotransduction. The somatosensory system is involved in the perception of touch, pain and proprioception. Molecular mechanosensors of this sensory system are mechanically-activated ion channels. These channels are expressed at the nerve endings of sensory neurons that project long axons to the skin and to deeper body structures. The identification of these channels constitutes one of the most important challenges in the field of sensory transduction. So far only one gene family has been unambiguously associated with mammalian mechanosensory function and is specifically involved in light-touch sensation. Therefore, the identity of mechanotransduction channels involved in the detection of other mechanosensory modalities including proprioception and mechanical pain remain to be determined. We will combine patch-clamp methodology and single-cell transcriptome sequencing to generate the specific expression profile of distinct populations of mouse mechanosensitive neurons. Combination of bioinformatics, expression analysis and electrophysiological approaches will be used to identify molecular components of mechanotransduction channels. We will explore the role of identified genes in somatosensory functions. The long-term objective is to provide a compelling view of mechanosensitive process diversity in mammalian somatosensation through molecular identification of mechanotransduction channels and characterization of their physiological functions in touch, pain and proprioception. This proposal will also provide novel channel candidates that may be involved other mechanosensory functions such as embryogenesis, bone development and hearing.


year authors and title journal last update
List of publications.
2017 Thibaud Parpaite, Bertrand Coste
Piezo channels
published pages: R250-R252, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.01.048
Current Biology 27/7 2019-04-18
2017 Adrienne E. Dubin, Swetha Murthy, Amanda H. Lewis, Lucie Brosse, Stuart M. Cahalan, Jörg Grandl, Bertrand Coste, Ardem Patapoutian
Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization
published pages: 266-270.e3, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.03.039
Neuron 94/2 2019-04-18

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