REPLACES
Restorative Plasticity At Corticostriatal Excitatory Synapses
| Coordinatore | UNIVERSITA DEGLI STUDI DI MILANO
Organization address
address: Via Festa Del Perdono 7 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Sito del progetto | http://www.replaces-pd.org |
| Totale costo | 5˙454˙740 € |
| EC contributo | 4˙219˙766 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-B |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-11-01 - 2013-04-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITA DEGLI STUDI DI MILANO
Organization address
address: Via Festa Del Perdono 7 contact info |
IT (MILANO) | coordinator | 0.00 |
| 2 |
ASSOCIATION EUROPEENNE POUR LA MALADIE DE PARKINSON
Organization address
address: AVENUE NESTOR PLISSART 4 contact info |
BE (BRUXELLES) | participant | 0.00 |
| 3 |
CARDIFF UNIVERSITY
Organization address
address: Newport Road 30-36 contact info |
UK (CARDIFF) | participant | 0.00 |
| 4 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 0.00 |
| 5 |
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Organization address
address: Via Giuseppe Mussi 1 contact info |
IT (MILANO) | participant | 0.00 |
| 6 |
FONDAZIONE SANTA LUCIA
Organization address
address: VIA ARDEATINA 306 contact info |
IT (Roma) | participant | 0.00 |
| 7 |
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Organization address
address: AVENIDA DE PIO XII 55 contact info |
ES (PAMPLONA) | participant | 0.00 |
| 8 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | participant | 0.00 |
| 9 |
LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE
Organization address
address: BRENNECKESTRASSE 6 contact info |
DE (MAGDEBURG) | participant | 0.00 |
| 10 |
LUNDS UNIVERSITET
Organization address
address: Paradisgatan 5c contact info |
SE (LUND) | participant | 0.00 |
| 11 |
UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
UK (LONDON) | participant | 0.00 |
| 12 |
XIGEN SA
Organization address
address: rue des Terraux 17 contact info |
CH (LAUSANNE) | participant | 0.00 |
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Obiettivo del progetto (Objective)
'Long-lasting, activity-dependent synaptic changes are thought to underlie the ability of the brain to translate experiences into memories and seem to represent the cellular model underlying learning and memory processes. Alteration of brain plasticity may lead to the motor and cognitive disturbances observed in neurodegenerative diseases. Therapeutic approaches targeting synaptic plasticity could prevent neuronal degeneration and restore altered motor and cognitive functions. Long-term synaptic plasticity, long-term potentiation and long-term depression, are widely expressed at excitatory synapses throughout the brain and have both been described at corticostriatal connections, at which they might underlie motor-skill learning, cognitive performance and reward mechanisms. Unique feature of corticostriatal plasticity is the observation that the loss of these opposite forms of synaptic plasticity has been observed in experimental models of neurodegenerative disorders such as Parkinson’s disease (PD). REPLACES will use cortical striatal plasticity and its alterations in experimental PD to explore basic mechanisms of brain plasticity and repair and to translate the new generated knowledge into novel restorative therapeutic approaches. The long-term efficacy of new treatments for PD will be conditioned by their ability to restore, structurally and functionally, the synaptic wiring of striatal neurons and physiological synaptic plasticity. REPLACES addresses the potential restorative effects of either novel pharmacological treatments or neuronal transplants on the corticostriatal microcircuitry. Since chronic treatment with DA precursor L-DOPA induces in the majority of PD patients a maladaptative plasticity causing dyskinesia, innovative strategies should prevent the development of this disabling condition. REPLACES will characterize corticostriatal synaptic plasticity from molecular aspects to clinical neurophysiology involving behavioural and morphological analysis.'