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Big Data and models for personalized Head and Neck Cancer Decision support

Total Cost €


EC-Contrib. €






 BD2Decide project word cloud

Explore the words cloud of the BD2Decide project. It provides you a very rough idea of what is the project "BD2Decide" about.

uncover    severe    6th    deadly    first    tumors    impacts    life    validates    cancers    risk    size    tailor    epidemiology    patients    multicentric    dss    lymph    alcohol    smoking    prediction    learning    graphical    70    visualization    tumor    population    stage    care    realizes    fact    data    inadequate    biomolecular    toxicity    validate    virtuous    behavioral    line    links    deteriorate    precise    patient    contrast    hnc    implementing    decision    neck    tnm    bd2decide    provides    participation    maximizes    minimizes    big    prognostic    metastasis    functionalities    quality    pathology    mortality    abuse    usual    majority    head    genomic    treatments    morbidity    hpv    capture    fits    multiscale    intrinsic    treatment    die    create    therapy    circle    few    techniques    imaging    patterns    hard    worldwide    co    models    nodes    diagnosed    region    tools    heterogeneity    therapeutic    150    clinical    aesthetics    clinicians    disclosure    detected   

Project "BD2Decide" data sheet

The following table provides information about the project.


Organization address
address: VIA GRAMSCI 14
city: PARMA
postcode: 43100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 4˙845˙000 €
 EC max contribution 4˙845˙000 € (100%)
 Programme 1. H2020-EU.3.1.5. (Methods and data)
 Code Call H2020-PHC-2015-single-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
3    STICHTING VUMC NL (AMSTERDAM) participant 760˙937.00
4    ALL-IN-IMAGE LTD IL (HERTZELIA) participant 495˙750.00
10    POLITECNICO DI MILANO IT (MILANO) participant 308˙750.00
11    MULTIMED ENGINEERS SRL IT (PARMA) participant 150˙000.00
12    UNIVERSITA DEGLI STUDI DI PARMA IT (PARMA) participant 60˙000.00
13    STICHTING VU NL (AMSTERDAM) participant 0.00


 Project objective

'Cancers of the Head and Neck Region (HNC) are the 6th more deadly cancers worldwide: in Europe ~150.000 new cases are detected and ~70.000 patients die every year. The main reasons for high mortality are the fact that the majority of cases are diagnosed in advanced Stage and the intrinsic heterogeneity of such tumors. At present the only adopted treatment decision method is based on TNM (Tumor-lymph-Nodes-Metastasis) prognostic system, that considers only a few risk factors such as smoking, alcohol abuse and more recently HPV. The TNM system is therefore inadequate to capture the patient-specific biomolecular characteristics of the tumor. HNC treatments can have hard impact on patient’s aesthetics and functionalities and, due to their toxicity, can cause severe morbidity and greatly deteriorate patient’s quality of life. A more precise prognostic prediction than the current TNM system is needed that allows implementing the first-line treatment that maximizes the therapeutic result and minimizes the impacts of therapy. BD2Decide DSS provides clinicians with the 'means' and all the necessary information to tailor treatment and care delivery pathway to each and any HNC patient during their usual practice, in contrast to current “one-size-fits-all approach”. BD2Decide realizes and validates an Integrated Decision Support System that links population-specific epidemiology and behavioral data, patient-specific genomic, pathology, clinical and imaging data with big data techniques, multiscale prognostic models. Advanced graphical visualization tools are developed for prognostic data disclosure and patient co-participation to the selected treatment. BD2Decide will improve the clinical decision process, uncover new patient-specific patterns that can improve care, and create a virtuous circle of learning. A multicentric clinical study with more than 1.000 patients will be used to validate the system. '


List of deliverables.
Cost-utility analysis tool Other 2020-02-07 15:51:59
Technology validation report Documents, reports 2020-02-07 15:51:53
Impacts assessment Documents, reports 2020-02-07 15:51:59
The IPDA prototype Other 2019-05-30 14:12:51
The BD2Decide visualization mock-ups concepts Demonstrators, pilots, prototypes 2019-05-30 14:12:48
Dissemination materials - second release Demonstrators, pilots, prototypes 2019-05-30 14:12:48
Quality Plan and Risk assessment Documents, reports 2019-05-30 14:12:44
Dissemination materials - first release Demonstrators, pilots, prototypes 2019-05-30 14:12:45
Communications plan and strategy - second release Documents, reports 2019-05-30 14:12:43
User interaction sketches Demonstrators, pilots, prototypes 2019-05-30 14:12:43
Collected population data Documents, reports 2019-05-30 14:12:43
Multilayer data acquisition and management services Other 2019-05-30 14:12:48
Communication plan and strategy Documents, reports 2019-05-30 14:12:39
Project web site Websites, patent fillings, videos etc. 2019-05-30 14:12:49
User needs and use cases Documents, reports 2019-05-30 14:12:46
Tumor & Lymph-nodes segmentation features Documents, reports 2019-05-30 14:12:42
Ethics report Documents, reports 2019-05-30 14:12:51
System architecture Documents, reports 2019-05-30 14:12:50
The Visual Analytics tool Other 2019-05-09 18:04:11
The Clinical DSS tool suite Other 2019-05-09 18:04:11
The BD2Decide visualization mock-ups Demonstrators, pilots, prototypes 2019-05-09 18:04:11
Communication plan and strategy - final edition Documents, reports 2019-05-09 18:04:11
Knowledge Management System Other 2019-05-09 18:04:11
Usability Evaluation results Documents, reports 2019-05-09 18:04:11
Dissemination materials - third release Demonstrators, pilots, prototypes 2019-05-09 18:04:11
Security and Standards for Clinical data Documents, reports 2019-05-09 18:04:11

Take a look to the deliverables list in detail:  detailed list of BD2Decide deliverables.


year authors and title journal last update
List of publications.
2019 Marco Bologna, Valentina Corino, Luca Mainardi
Technical Note: Virtual phantom analyses for preprocessing evaluation and detection of a robust feature set for MRI‐radiomics of the brain
published pages: , ISSN: 0094-2405, DOI: 10.1002/mp.13834
Medical Physics 2019-10-15
2017 Giuseppe Fico
published pages: , ISSN: , DOI:
39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2019-06-17
2017 Kathrin Scheckenbach, Lena Colter, Martin Wagenmann
Radiomics in Head and Neck Cancer: Extracting Valuable Information from Data beyond Recognition
published pages: 65-71, ISSN: 0301-1569, DOI: 10.1159/000455704
ORL 79/1-2 2019-06-17
2017 Luca Tonella, Marco Giannoccaro, Salvatore Alfieri, Silvana Canevari, Loris De Cecco
Gene Expression Signatures for Head and Neck Cancer Patient Stratification: Are Results Ready for Clinical Application?
published pages: , ISSN: 1527-2729, DOI: 10.1007/s11864-017-0472-2
Current Treatment Options in Oncology 18/5 2019-06-17
2017 Valentina D.A. Corino, Eros Montin, Antonella Messina, Paolo G. Casali, Alessandro Gronchi, Alfonso Marchianò, Luca T. Mainardi
Radiomic analysis of soft tissues sarcomas can distinguish intermediate from high-grade lesions
published pages: , ISSN: 1053-1807, DOI: 10.1002/jmri.25791
Journal of Magnetic Resonance Imaging 2019-06-17
2017 Janna E. van Timmeren, Ralph T. H. Leijenaar, Wouter van Elmpt, Bart Reymen, Philippe Lambin
Feature selection methodology for longitudinal cone-beam CT radiomics
published pages: 1537-1543, ISSN: 0284-186X, DOI: 10.1080/0284186x.2017.1350285
Acta Oncologica 56/11 2019-06-17
2017 Dan Ou, Pierre Blanchard, Silvia Rosellini, Antonin Levy, France Nguyen, Ralph T.H. Leijenaar, Ingrid Garberis, Philippe Gorphe, François Bidault, Charles Ferté, Charlotte Robert, Odile Casiraghi, Jean-Yves Scoazec, Philippe Lambin, Stephane Temam, Eric Deutsch, Yungan Tao
Predictive and prognostic value of CT based radiomics signature in locally advanced head and neck cancers patients treated with concurrent chemoradiotherapy or bioradiotherapy and its added value to Human Papillomavirus status
published pages: 150-155, ISSN: 1368-8375, DOI: 10.1016/j.oraloncology.2017.06.015
Oral Oncology 71 2019-06-17
2017 Paolo Bossi, Marco Siano, Cristiana Bergamini, Maria Cossu Rocca, Andrea P. Sponghini, Marco Giannoccaro, Luca Tonella, Alessandro Paoli, Edoardo Marchesi, Federica Perrone, Silvana Pilotti, Laura D. Locati, Silvana Canevari, Lisa Licitra, Loris De Cecco
Are Fusion Transcripts in Relapsed/Metastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?
published pages: 1-9, ISSN: 0278-0240, DOI: 10.1155/2017/6870614
Disease Markers 2017 2019-06-17
2017 Aniek J.G. Even, Olga Hamming-Vrieze, Wouter van Elmpt, Véronique J.L. Winnepenninckx, Jolien Heukelom, Margot E.T. Tesselaar, Wouter V. Vogel, Ann Hoeben, Catharina M.L. Zegers, Daniëlle J. Vugts, Guus A.M.S. van Dongen, Harry Bartelink, Felix M. Mottaghy, Frank Hoebers, Philippe Lambin
Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: a theragnostic approach
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.13910
Oncotarget 2019-06-17
2017 Laura Lopez Perez, Liss Hernandez, Giuseppe Fico, and Maria Teresa Arredondo
Definition of a Decision Support System to Support Research on Head and Neck Cancer
published pages: , ISSN: , DOI:
39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Korea, July 2017 2019-06-17
2018 Marco Bologna, Valentina D. A. Corino, Eros Montin, Antonella Messina, Giuseppina Calareso, Francesca G. Greco, Silvana Sdao, Luca T. Mainardi
Assessment of Stability and Discrimination Capacity of Radiomic Features on Apparent Diffusion Coefficient Images
published pages: 879-894, ISSN: 0897-1889, DOI: 10.1007/s10278-018-0092-9
Journal of Digital Imaging 31/6 2019-05-09
2018 Sebastian Sanduleanu, Henry C. Woodruff, Evelyn E.C. de Jong, Janna E. van Timmeren, Arthur Jochems, Ludwig Dubois, Philippe Lambin
Tracking tumor biology with radiomics: A systematic review utilizing a radiomics quality score
published pages: 349-360, ISSN: 0167-8140, DOI: 10.1016/j.radonc.2018.03.033
Radiotherapy and Oncology 127/3 2019-05-09
2018 Alberto Vazquez, Liss Hernandez, Laura Lopez-Perez, Ana Ugena, Sergio Guillen, Maria T. Arredondo and Giuseppe Fico, Member
Integration of Radiomics Information in a Computerized Decision Support System for Research on Head and Neck Cancer. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
published pages: , ISSN: , DOI:
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Annually 2019-05-09
2018 Hernandez, L., Lopez-Perez, L., Fico, G., Fernández, A., Ugena, A., Guillén, S., Cabrera, M. F., Arredondo, M. T.
A computerized decision support system for head and neck cancer. In IEEE Conference on Biomedical and Health Informatics.
published pages: , ISSN: , DOI:
IEEE Conference on Biomedical and Health Informatics Annually 2019-05-09
2018 Kathrin Scheckenbach
Radiomics: Big Data statt Biopsie in der Zukunft?
published pages: S114-S141, ISSN: 0935-8943, DOI: 10.1055/s-0043-121964
Laryngo-Rhino-Otologie 97/S 01 2019-05-09
2017 Bogowicz M, Leijenaar RTH, Tanadini-Lang S, Riesterer O, Pruschy M, Studer G, Unkelbach J, Guckenberger M, Konukoglu E, Lambin P.
Post-radiochemotherapy PET radiomics in head and neck cancer - The influence of radiomics implementation on the reproducibility of local control tumor models
published pages: 385-391, ISSN: 0167-8140, DOI:
Radiother Oncol. 2019-05-09
2018 Timo M. Deist, Frank J. W. M. Dankers, Gilmer Valdes, Robin Wijsman, I-Chow Hsu, Cary Oberije, Tim Lustberg, Johan van Soest, Frank Hoebers, Arthur Jochems, Issam El Naqa, Leonard Wee, Olivier Morin, David R. Raleigh, Wouter Bots, Johannes H. Kaanders, José Belderbos, Margriet Kwint, Timothy Solberg, René Monshouwer, Johan Bussink, Andre Dekker, Philippe Lambin
Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers
published pages: 3449-3459, ISSN: 0094-2405, DOI: 10.1002/mp.12967
Medical Physics 45/7 2019-05-09
2018 Ruben T. H. M. Larue, Remy Klaassen, Arthur Jochems, Ralph T. H. Leijenaar, Maarten C. C. M. Hulshof, Mark I. van Berge Henegouwen, Wendy M. J. Schreurs, Meindert N. Sosef, Wouter van Elmpt, Hanneke W. M. van Laarhoven, Philippe Lambin
Pre-treatment CT radiomics to predict 3-year overall survival following chemoradiotherapy of esophageal cancer
published pages: 1475-1481, ISSN: 0284-186X, DOI: 10.1080/0284186X.2018.1486039
Acta Oncologica 57/11 2019-05-09
2018 Ralph TH Leijenaar, Marta Bogowicz, Arthur Jochems, Frank JP Hoebers, Frederik WR Wesseling, Sophie H Huang, Biu Chan, John N Waldron, Brian O\'Sullivan, Derek Rietveld, C Rene Leemans, Ruud H Brakenhoff, Oliver Riesterer, Stephanie Tanadini-Lang, Matthias Guckenberger, Kristian Ikenberg, Philippe Lambin
Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study
published pages: 20170498, ISSN: 0007-1285, DOI: 10.1259/bjr.20170498
The British Journal of Radiology 2018 Jun;91(1086) 2019-05-09
2017 Dennis E. te Beest, Steven W. Mes, Saskia M. Wilting, Ruud H. Brakenhoff, Mark A. van de Wiel
Improved high-dimensional prediction with Random Forests by the use of co-data
published pages: , ISSN: 1471-2105, DOI: 10.1186/s12859-017-1993-1
BMC Bioinformatics 18/1 2019-05-09
2018 E E W Cohen, K J Harrington, D S Hong, R Mesia, I Brana, P Perez Segura, T Wise-Draper, M L Scott, P D Mitchell, G M Mugundu, P McCoon, C E Cook, M Mehta, U Keilholz
1044OA phase Ib/II study (SCORES) of durvalumab (D) plus danvatirsen (DAN; AZD9150) or AZD5069 (CX2i) in advanced solid malignancies and recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC): Updated results
published pages: viii372-viii399, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy287
Annals of Oncology 29/suppl_8 2019-05-09
2018 I H Nauta, M M Rietbergen, A A J D van Bokhoven, E Bloemena, B I Lissenberg-Witte, D A M Heideman, R J Baatenburg de Jong, R H Brakenhoff, C R Leemans
Evaluation of the eighth TNM classification on p16-positive oropharyngeal squamous cell carcinomas in the Netherlands and the importance of additional HPV DNA testing
published pages: 1273-1279, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy060
Annals of Oncology 29/5 2019-05-09

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The information about "BD2DECIDE" are provided by the European Opendata Portal: CORDIS opendata.

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