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TROJANANOHORSE SIGNED

Hybrid immune-eluding nanocrystals as smart and active theranostic weapons against cancer

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TROJANANOHORSE" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.polito.it/TNHlab
 Total cost 1˙489˙219 €
 EC max contribution 1˙489˙219 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 1˙489˙219.00

Map

 Project objective

Nanomedicine tools for cancer treatment comprise many nanosized systems, so far developed with smart functions such as efficient drug delivery and cell targeting abilities. However they remain still under-characterized in terms of immunogenicity, potential toxicity due to the materials itself or the unwanted release of drugs. To overcome these challenges this project aims to develop a new generation of multifunctional therapeutic and diagnostic (thus theranostics) nanosystems displaying non-immunogenicity, improved cancer treatment, cell imaging, and high safety for the hosting organism. The innovative concept behind this approach relies on a TrojaNanoHorse (TNH) system, here validated against leukaemia. The injectable TNH have a biomimetic non-immunogenic shell. Studies will show the intrinsic therapeutic activity of the nanocrystalline core for cancer killing, without the use of chemotherapeutic drugs, and its light emission. The hemocompatibility, anti-thrombogenicity, and targeting ability toward malignant blood cells will be proved during this project. The whole TNH would go beyond the state-of-the-art due to its biomimetic shell, absence of drugs, its safety and biodegrading fate, and light emissions for diagnosis. This project will also develop novel set-up for based therapy and diagnosis, impacting on future technology, new standardized protocols for nanomaterial safety assessment, and study chemical and biological mechanism of cancer cell killing. Achieving the ultimate goal of a multifunctional TNH will require multidisciplinary expertise in chemistry, material science, biology, medicine and engineering, opening new horizons as nanomedicine tools for efficient cancer therapy with strong scientific, technological and socio-economic benefits.

 Publications

year authors and title journal last update
List of publications.
2019 Francesca Susa, Tania Limongi, Bianca Dumontel, Veronica Vighetto, Valentina Cauda
Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine
published pages: 1979, ISSN: 2072-6694, DOI: 10.3390/cancers11121979
Cancers 11/12 2020-02-13
2019 Veronica Vighetto, Andrea Ancona, Luisa Racca, Tania Limongi, Adriano Troia, Giancarlo Canavese, Valentina Cauda
The Synergistic Effect of Nanocrystals Combined With Ultrasound in the Generation of Reactive Oxygen Species for Biomedical Applications
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00374
Frontiers in Bioengineering and Biotechnology 7 2020-02-13
2019 Bianca Dumontel, Francesca Susa, Tania Limongi, Marta Canta, Luisa Racca, Angelica Chiodoni, Nadia Garino, Giulia Chiabotto, Maria L. Centomo, Ymera Pignochino, Valentina Cauda
ZnO nanocrystals shuttled by extracellular vesicles as effective Trojan nano-horses against cancer cells
published pages: 2815-2833, ISSN: 1743-5889, DOI: 10.2217/nnm-2019-0231
Nanomedicine 14/21 2020-02-13
2018 Matteo Battaglini, Christos Tapeinos, Ivana Cavaliere, Attilio Marino, Andrea Ancona, Nadia Garino, Valentina Cauda, Francisco Palazon, Doriana Debellis, Gianni Ciofani
Design, Fabrication, and In Vitro Evaluation of Nanoceria-Loaded Nanostructured Lipid Carriers for the Treatment of Neurological Diseases
published pages: 670-682, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.8b01033
ACS Biomaterials Science & Engineering 5/2 2020-02-13
2019 Tania Limongi, Francesca Susa, Valentina Cauda
Nanoparticles for hematologic diseases detection and treatment
published pages: 1-12, ISSN: 2398-8495, DOI: 10.15761/hmo.1000183
Hematology and Medical Oncology 4/2 2020-02-13
2018 Giancarlo Canavese, Andrea Ancona, Luisa Racca, Marta Canta, Bianca Dumontel, Federica Barbaresco, Tania Limongi, Valentina Cauda
Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer
published pages: 155-172, ISSN: 1385-8947, DOI: 10.1016/j.cej.2018.01.060
Chemical Engineering Journal 340 2019-07-08
2018 Luisa Racca, Marta Canta, Bianca Dumontel, Andrea Ancona, Tania Limongi, Nadia Garino, Marco Laurenti, Giancarlo Canavese, Valentina Cauda
Zinc Oxide Nanostructures in Biomedicine
published pages: 171-187, ISSN: , DOI: 10.1016/B978-0-12-814156-4.00012-4
Smart Nanoparticles for Biomedicine 2019-07-08
2017 B. Dumontel, M. Canta, H. Engelke, A. Chiodoni, L. Racca, A. Ancona, T. Limongi, G. Canavese, V. Cauda
Enhanced biostability and cellular uptake of zinc oxide nanocrystals shielded with a phospholipid bilayer
published pages: 8799-8813, ISSN: 2050-7518, DOI: 10.1039/c7tb02229h
Journal of Materials Chemistry B 5/44 2019-07-08
2018 Andrea Ancona, Bianca Dumontel, Nadia Garino, Benjamin Demarco, Dimitra Chatzitheodoridou, Walter Fazzini, Hanna Engelke, Valentina Cauda
Lipid-Coated Zinc Oxide Nanoparticles as Innovative ROS-Generators for Photodynamic Therapy in Cancer Cells
published pages: 143, ISSN: 2079-4991, DOI: 10.3390/nano8030143
Nanomaterials 8/3 2019-07-08
2019 Nadia Garino, Tania Limongi, Bianca Dumontel, Marta Canta, Luisa Racca, Marco Laurenti, Micaela Castellino, Alberto Casu, Andrea Falqui, Valentina Cauda
A Microwave-Assisted Synthesis of Zinc Oxide Nanocrystals Finely Tuned for Biological Applications
published pages: 212, ISSN: 2079-4991, DOI: 10.3390/nano9020212
Nanomaterials 9/2 2019-05-22
2019 Tania Limongi, Marta Canta, Luisa Racca, Andrea Ancona, Stefania Tritta, Veronica Vighetto, Valentina Cauda
Improving dispersal of therapeutic nanoparticles in the human body
published pages: 797-801, ISSN: 1743-5889, DOI: 10.2217/nnm-2019-0070
Nanomedicine 14/7 2019-05-22
2019 Nadia Garino, Pasquale Sanvitale, Bianca Dumontel, Marco Laurenti, Montserrat Colilla, Isabel Izquierdo-Barba, Valentina Cauda, Maria Vallet-Regì
Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent
published pages: 11312-11321, ISSN: 2046-2069, DOI: 10.1039/c8ra10236h
RSC Advances 9/20 2019-05-22
2019 Carmine Lops, Andrea Ancona, Katia Di Cesare, Bianca Dumontel, Nadia Garino, Giancarlo Canavese, Simelys Hérnandez, Valentina Cauda
Sonophotocatalytic degradation mechanisms of Rhodamine B dye via radicals generation by micro- and nano-particles of ZnO
published pages: 629-640, ISSN: 0926-3373, DOI: 10.1016/j.apcatb.2018.10.078
Applied Catalysis B: Environmental 243 2019-05-22

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