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NoPest SIGNED

Novel Pesticides for a Sustainable Agriculture

Total Cost €

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EC-Contrib. €

0

Partnership

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 NoPest project word cloud

Explore the words cloud of the NoPest project. It provides you a very rough idea of what is the project "NoPest" about.

chemical    bacteria    compounds    crop    precision    linear    nopest    chemo    additional    aptamers    viticola    pathogen    acids    consist    peptides    cyclic    conventional    pesticide    phylum    small    invasive    vital    peptide    leads    innocuous    competitive    inspired    grapevine    medical    select    threat    aptamer    peptidomimetics    market    treatments    alternatives    environmental    frequent    wall    benefits    protection    adverse    health    pollution    infections    oomycetes    molecules    mimic    relies    toxicity    mildew    alternative    antimicrobial    agent    designed    metals    residual    combinatorial    cell    inorganic    probability    stability    food    countries    infestans    specificity    searching    fungicides    efficiency    protein    security    confer    pathogens    copper    optimizing    potato    farming    animal    inhibit    counteract    strains    environmentally    massive    oomycete    amino    heavy    libraries    enzymes    tools    affinity    downy    members    selecting    instance    global    pharmaceutical    strategy    blight    discovery    resistant    sensing    risk    co    resistance    natural    informatics    pesticides    human   

Project "NoPest" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI MILANO 

Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122
website: www.unimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙236˙820 €
 EC max contribution 3˙236˙820 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 858˙701.00
2    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 856˙000.00
3    SIPCAM OXON SPA IT (MILANO) participant 460˙625.00
4    UNIVERSIDAD DE LA RIOJA ES (LA RIOJA) participant 432˙481.00
5    UNIVERSITE PARIS-SACLAY FR (SAINT AUBIN) participant 414˙762.00
6    BAR ILAN UNIVERSITY IL (RAMAT GAN) participant 214˙250.00
7    UNIVERSITE PARIS-SUD FR (ORSAY CEDEX) participant 0.00

Map

 Project objective

Members of the oomycete phylum represent highly problematic crop pathogens and a threat for global food security. For instance, P. infestans is the agent of potato late blight, and P. viticola of grapevine downy mildew. Oomycete infections are currently controlled by frequent applications of copper-based compounds, but the massive use of these compounds leads to pollution, residual toxicity and adverse effects on human health. The discovery of innocuous and reliable alternatives to traditional inorganic fungicides remains challenging and has been set as a high priority by EU and other countries. NoPest aims to develop an environmentally friendly approach for crop protection as an alternative to conventional chemical pesticides. The strategy, inspired by medical and pharmaceutical research, relies on peptide aptamers to counteract oomycetes infections by i) identifying small peptides (linear/cyclic peptide aptamers) that inhibit vital enzymes involved in oomycete cell wall formation and cell stability; ii) optimizing aptamer efficiency through peptidomimetics designed for field applications; iii) searching, using chemo-informatics approaches, for non-peptide small molecules that mimic the activity of aptamers. These objectives will be addressed by selecting peptide aptamers from combinatorial libraries, based on their affinity and specificity for selected protein targets. Key benefits will be i) low probability to select resistant oomycete strains and no risk of co-selection of bacteria resistant to heavy metals; ii) no impact on animal and human health; iii) low environmental impact, as the approach is based on peptides that consist of natural amino-acids; iv) potential to develop additional products that confer antimicrobial resistance to any crop pathogen. Furthermore, in order to make the new molecules competitive in the pesticide market, precision farming non-invasive sensing tools will be developed, leading to reduced pesticide usage for field treatments.

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The information about "NOPEST" are provided by the European Opendata Portal: CORDIS opendata.

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