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NoPest SIGNED

Novel Pesticides for a Sustainable Agriculture

Total Cost €

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EC-Contrib. €

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Partnership

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 NoPest project word cloud

Explore the words cloud of the NoPest project. It provides you a very rough idea of what is the project "NoPest" about.

farming    stability    wall    alternative    select    acids    additional    frequent    enzymes    benefits    bacteria    food    optimizing    designed    risk    innocuous    chemical    infections    combinatorial    conventional    agent    sensing    copper    oomycetes    peptides    cyclic    confer    residual    vital    small    blight    chemo    inspired    potato    probability    cell    aptamers    members    amino    precision    compounds    pathogen    competitive    strains    instance    aptamer    linear    pesticide    consist    mimic    nopest    countries    pharmaceutical    natural    grapevine    libraries    heavy    treatments    protein    toxicity    relies    molecules    downy    animal    co    adverse    protection    affinity    resistant    peptidomimetics    resistance    strategy    security    pollution    selecting    efficiency    massive    peptide    threat    inhibit    phylum    health    oomycete    fungicides    metals    antimicrobial    environmental    environmentally    specificity    infestans    crop    tools    invasive    global    informatics    searching    pathogens    counteract    leads    alternatives    discovery    human    mildew    pesticides    viticola    inorganic    market    medical   

Project "NoPest" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI MILANO 

Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122
website: www.unimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙236˙820 €
 EC max contribution 3˙236˙820 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 858˙701.00
2    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 856˙000.00
3    SIPCAM OXON SPA IT (MILANO) participant 460˙625.00
4    UNIVERSIDAD DE LA RIOJA ES (LA RIOJA) participant 432˙481.00
5    UNIVERSITE PARIS-SACLAY FR (SAINT AUBIN) participant 414˙762.00
6    BAR ILAN UNIVERSITY IL (RAMAT GAN) participant 214˙250.00
7    UNIVERSITE PARIS-SUD FR (ORSAY CEDEX) participant 0.00

Map

 Project objective

Members of the oomycete phylum represent highly problematic crop pathogens and a threat for global food security. For instance, P. infestans is the agent of potato late blight, and P. viticola of grapevine downy mildew. Oomycete infections are currently controlled by frequent applications of copper-based compounds, but the massive use of these compounds leads to pollution, residual toxicity and adverse effects on human health. The discovery of innocuous and reliable alternatives to traditional inorganic fungicides remains challenging and has been set as a high priority by EU and other countries. NoPest aims to develop an environmentally friendly approach for crop protection as an alternative to conventional chemical pesticides. The strategy, inspired by medical and pharmaceutical research, relies on peptide aptamers to counteract oomycetes infections by i) identifying small peptides (linear/cyclic peptide aptamers) that inhibit vital enzymes involved in oomycete cell wall formation and cell stability; ii) optimizing aptamer efficiency through peptidomimetics designed for field applications; iii) searching, using chemo-informatics approaches, for non-peptide small molecules that mimic the activity of aptamers. These objectives will be addressed by selecting peptide aptamers from combinatorial libraries, based on their affinity and specificity for selected protein targets. Key benefits will be i) low probability to select resistant oomycete strains and no risk of co-selection of bacteria resistant to heavy metals; ii) no impact on animal and human health; iii) low environmental impact, as the approach is based on peptides that consist of natural amino-acids; iv) potential to develop additional products that confer antimicrobial resistance to any crop pathogen. Furthermore, in order to make the new molecules competitive in the pesticide market, precision farming non-invasive sensing tools will be developed, leading to reduced pesticide usage for field treatments.

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The information about "NOPEST" are provided by the European Opendata Portal: CORDIS opendata.

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