Opendata, web and dolomites


Novel Pesticides for a Sustainable Agriculture

Total Cost €


EC-Contrib. €






 NoPest project word cloud

Explore the words cloud of the NoPest project. It provides you a very rough idea of what is the project "NoPest" about.

pollution    innocuous    benefits    oomycetes    efficiency    threat    inorganic    metals    adverse    selecting    molecules    inhibit    amino    food    relies    massive    co    chemical    specificity    aptamers    peptidomimetics    probability    leads    cyclic    toxicity    alternatives    peptides    market    instance    inspired    protection    stability    phylum    agent    compounds    mildew    blight    confer    bacteria    wall    copper    protein    acids    pesticide    heavy    chemo    fungicides    infestans    members    residual    natural    frequent    farming    vital    viticola    aptamer    precision    optimizing    sensing    counteract    treatments    crop    libraries    conventional    designed    discovery    select    affinity    strategy    searching    nopest    tools    combinatorial    environmentally    linear    pharmaceutical    downy    pathogens    infections    medical    informatics    consist    animal    countries    grapevine    global    invasive    oomycete    enzymes    small    competitive    human    environmental    health    potato    alternative    antimicrobial    cell    resistant    pathogen    security    strains    additional    risk    resistance    mimic    peptide    pesticides   

Project "NoPest" data sheet

The following table provides information about the project.


Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙236˙820 €
 EC max contribution 3˙236˙820 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 858˙701.00
3    SIPCAM OXON SPA IT (MILANO) participant 460˙625.00
4    UNIVERSIDAD DE LA RIOJA ES (LA RIOJA) participant 432˙481.00
5    UNIVERSITE PARIS-SACLAY FR (SAINT AUBIN) participant 414˙762.00
6    BAR ILAN UNIVERSITY IL (RAMAT GAN) participant 214˙250.00


 Project objective

Members of the oomycete phylum represent highly problematic crop pathogens and a threat for global food security. For instance, P. infestans is the agent of potato late blight, and P. viticola of grapevine downy mildew. Oomycete infections are currently controlled by frequent applications of copper-based compounds, but the massive use of these compounds leads to pollution, residual toxicity and adverse effects on human health. The discovery of innocuous and reliable alternatives to traditional inorganic fungicides remains challenging and has been set as a high priority by EU and other countries. NoPest aims to develop an environmentally friendly approach for crop protection as an alternative to conventional chemical pesticides. The strategy, inspired by medical and pharmaceutical research, relies on peptide aptamers to counteract oomycetes infections by i) identifying small peptides (linear/cyclic peptide aptamers) that inhibit vital enzymes involved in oomycete cell wall formation and cell stability; ii) optimizing aptamer efficiency through peptidomimetics designed for field applications; iii) searching, using chemo-informatics approaches, for non-peptide small molecules that mimic the activity of aptamers. These objectives will be addressed by selecting peptide aptamers from combinatorial libraries, based on their affinity and specificity for selected protein targets. Key benefits will be i) low probability to select resistant oomycete strains and no risk of co-selection of bacteria resistant to heavy metals; ii) no impact on animal and human health; iii) low environmental impact, as the approach is based on peptides that consist of natural amino-acids; iv) potential to develop additional products that confer antimicrobial resistance to any crop pathogen. Furthermore, in order to make the new molecules competitive in the pesticide market, precision farming non-invasive sensing tools will be developed, leading to reduced pesticide usage for field treatments.

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The information about "NOPEST" are provided by the European Opendata Portal: CORDIS opendata.

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