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CATA-LUX SIGNED

Light-Driven Asymmetric Organocatalysis

Total Cost €

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EC-Contrib. €

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Partnership

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 CATA-LUX project word cloud

Explore the words cloud of the CATA-LUX project. It provides you a very rough idea of what is the project "CATA-LUX" about.

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Project "CATA-LUX" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 1˙895˙407.00
2    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 104˙592.00

Map

 Project objective

Visible light photocatalysis and metal-free organocatalytic processes are powerful strategies of modern chemical research with extraordinary potential for the sustainable preparation of organic molecules. However, these environmentally respectful approaches have to date remained largely unrelated. The proposed research seeks to merge these fields of molecule activation to redefine their synthetic potential. Light-driven processes considerably enrich the modern synthetic repertoire, offering a potent way to build complex organic frameworks. In contrast, it is extremely challenging to develop asymmetric catalytic photoreactions that can create chiral molecules with a well-defined three-dimensional arrangement. By developing innovative methodologies to effectively address this issue, I will provide a novel reactivity framework for conceiving light-driven enantioselective organocatalytic processes. I will translate the effective tools governing the success of ground state asymmetric organocatalysis into the realm of photochemical reactivity, exploiting the potential of key organocatalytic intermediates to directly participate in the photoexcitation of substrates. At the same time, the chiral organocatalyst will ensure effective stereochemical control. This single catalyst system, where stereoinduction and photoactivation merge in a sole organocatalyst, will serve for developing novel enantioselective photoreactions. In a complementary dual catalytic approach, the synergistic activities of an organocatalyst and a metal-free photosensitiser will combine to realise asymmetric variants of venerable photochemical processes, which have never before succumbed to a stereocontrolled approach. This proposal challenges the current perception that photochemistry is too unselective to parallel the impressive levels of efficiency reached by the asymmetric catalysis of thermal reactions, expanding the way chemists think about making chiral molecules

 Publications

year authors and title journal last update
List of publications.
2019 Sara Cuadros, Matthew A. Horwitz, Bertrand Schweitzer-Chaput, Paolo Melchiorre
A visible-light mediated three-component radical process using dithiocarbamate anion catalysis
published pages: 5484-5488, ISSN: 2041-6520, DOI: 10.1039/c9sc00833k
Chemical Science 10/21 2019-08-30
2019 Bertrand Schweitzer-Chaput, Matthew A. Horwitz, Eduardo de Pedro Beato, Paolo Melchiorre
Photochemical generation of radicals from alkyl electrophiles using a nucleophilic organic catalyst
published pages: 129-135, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0173-x
Nature Chemistry 11/2 2019-08-30
2018 Mattia Silvi, Paolo Melchiorre
Enhancing the potential of enantioselective organocatalysis with light
published pages: 41-49, ISSN: 0028-0836, DOI: 10.1038/nature25175
Nature 554/7690 2019-08-30
2019 Luca Buzzetti, Giacomo E. M. Crisenza, Paolo Melchiorre
Mechanistic Studies in Photocatalysis
published pages: 3730-3747, ISSN: 1433-7851, DOI: 10.1002/anie.201809984
Angewandte Chemie International Edition 58/12 2019-08-30
2019 Daniele Mazzarella, Giandomenico Magagnano, Bertrand Schweitzer-Chaput, Paolo Melchiorre
Photochemical Organocatalytic Borylation of Alkyl Chlorides, Bromides, and Sulfonates
published pages: 5876-5880, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b01482
ACS Catalysis 2019-08-30
2019 Giulio Goti, Bartosz Bieszczad, Alberto Vega-Peñaloza, Paolo Melchiorre
Stereocontrolled Synthesis of 1,4-Dicarbonyl Compounds by Photochemical Organocatalytic Acyl Radical Addition to Enals
published pages: 1213-1217, ISSN: 1433-7851, DOI: 10.1002/anie.201810798
Angewandte Chemie International Edition 58/4 2019-08-30
2017 Sara Cuadros, Luca Dell\'Amico, Paolo Melchiorre
Forging Fluorine-Containing Quaternary Stereocenters by a Light-Driven Organocatalytic Aldol Desymmetrization Process
published pages: 11875-11879, ISSN: 1433-7851, DOI: 10.1002/anie.201706763
Angewandte Chemie International Edition 56/39 2019-08-30
2017 Luca Dell\'Amico, Victor M. Fernández-Alvarez, Feliu Maseras, Paolo Melchiorre
Light-Driven Enantioselective Organocatalytic β-Benzylation of Enals
published pages: 3304-3308, ISSN: 1433-7851, DOI: 10.1002/anie.201612159
Angewandte Chemie International Edition 56/12 2019-08-30
2017 Ana Bahamonde, John J. Murphy, Marika Savarese, Éric Brémond, Andrea Cavalli, Paolo Melchiorre
Studies on the Enantioselective Iminium Ion Trapping of Radicals Triggered by an Electron-Relay Mechanism
published pages: 4559-4567, ISSN: 0002-7863, DOI: 10.1021/jacs.7b01446
Journal of the American Chemical Society 139/12 2019-08-30
2017 Mattia Silvi, Charlie Verrier, Yannick P. Rey, Luca Buzzetti, Paolo Melchiorre
Visible-light excitation of iminium ions enables the enantioselective catalytic β-alkylation of enals
published pages: 868-873, ISSN: 1755-4330, DOI: 10.1038/nchem.2748
Nature Chemistry 9/9 2019-08-30
2018 Łukasz Woźniak, Giandomenico Magagnano, Paolo Melchiorre
Enantioselective Photochemical Organocascade Catalysis
published pages: 1068-1072, ISSN: 1433-7851, DOI: 10.1002/anie.201711397
Angewandte Chemie International Edition 57/4 2019-08-30
2017 Luca Buzzetti, Alexis Prieto, Sudipta Raha Roy, Paolo Melchiorre
Radical-Based C−C Bond-Forming Processes Enabled by the Photoexcitation of 4-Alkyl-1,4-dihydropyridines
published pages: 15039-15043, ISSN: 1433-7851, DOI: 10.1002/anie.201709571
Angewandte Chemie International Edition 56/47 2019-08-30
2017 Giacomo Filippini, Mattia Silvi, Paolo Melchiorre
Enantioselective Formal α-Methylation and α-Benzylation of Aldehydes by Means of Photo-organocatalysis
published pages: 4447-4451, ISSN: 1433-7851, DOI: 10.1002/anie.201612045
Angewandte Chemie International Edition 56/16 2019-08-30
2018 Zhong-Yan Cao, Tamal Ghosh, Paolo Melchiorre
Enantioselective radical conjugate additions driven by a photoactive intramolecular iminium-ion-based EDA complex
published pages: 3274, ISSN: 2041-1723, DOI: 10.1038/s41467-018-05375-2
Nature Communications 9/1 2019-08-30
2018 Pablo Bonilla, Yannick P. Rey, Catherine M. Holden, Paolo Melchiorre
Photo-Organocatalytic Enantioselective Radical Cascade Reactions of Unactivated Olefins
published pages: 12819-12823, ISSN: 1433-7851, DOI: 10.1002/anie.201808183
Angewandte Chemie International Edition 57/39 2019-08-30
2018 Daniele Mazzarella, Giacomo E. M. Crisenza, Paolo Melchiorre
Asymmetric Photocatalytic C–H Functionalization of Toluene and Derivatives
published pages: 8439-8443, ISSN: 0002-7863, DOI: 10.1021/JACS.8B05240
Journal of the American Chemical Society 140/27 2019-08-30

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