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Functional optical probes for otology

Total Cost €


EC-Contrib. €






 FOIPO project word cloud

Explore the words cloud of the FOIPO project. It provides you a very rough idea of what is the project "FOIPO" about.

tympanic    travel    time    drum    capturing    vibrations    designed    pathological    speed    critical    coupled    infections    inner    globally    prevalent    series    depends    various    suffer    miniaturized    incus    speaker    optics    static    technique    ing    pathologies    people    membrane    ear    mode    structures    displacement    electrical    stimuli    oct    tomography    thereby    validated    human    million    probes    signals    malleus    sounds    foundation    360    conduction    middle    coherence    treatments    quantifying    rapid    termed    dynamic    clinical    demonstrated    oscillations    nanometer    operation    captured    surface    impede    tm    vibrography    air    first    acoustic    structure    excite    vivo    khz    conductive    frequencies    disorders    frequency    functional    optical    diseases    motions    primary    imaging    losses    chain    health    biofilms    hearing    modes    ex    portal    issue    eardrum    canal    ossicular    accurate    pico    waves    events    vibration    probe    tissue    flexible    worldwide    diagnosis    specimens    visualizing    sound    simultaneously    stapes    operate   

Project "FOIPO" data sheet

The following table provides information about the project.


Organization address
address: DE BOELELAAN 1105
postcode: 1081 HV

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2019-04-23


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 110˙760.00


 Project objective

Various pathologies directly impede the conduction of sound through the human middle ear, and thereby produce a ‘conductive’ hearing loss which is the second most prevalent health issue globally. According to Hearing Health Foundation more than 360 million people suffer from hearing disorders worldwide. Hearing depends on a series of events that change sound waves in the air into electrical signals. Sounds that travel down the ear canal set the surface of the flexible eardrum or tympanic membrane (TM) into rapid pico- to nanometer scale vibrations. These motions are coupled to the inner ear by the ossicular chain (the malleus, incus, and stapes). Since the TM and ossicular chain are the primary portal through which acoustic stimuli reach the inner ear, pathological changes in the TM or ossicular chain result in conductive hearing losses. Accurate diagnosis of middle-ear diseases is critical to effective and timely treatments of hearing loss. No currently available clinical technique is capable of simultaneously visualizing and quantifying the structure and sound-induced vibration of the middle ear in vivo. Recently, a new functional imaging technique based on optical coherence tomography (OCT) and the principle of vibrography for middle ear imaging was demonstrated. In this method, termed OCT-vibrography, a speaker is used to excite acoustic vibration in the tissue, and the resulting tissue displacement is captured by OCT. The goal of this project is to make for the first time a miniaturized OCT-vibrography probe for middle ear imaging at high frequencies. The miniaturized probe will be designed through integrated optics which will enable high-speed imaging. The system will operate in two modes: static imaging mode for examining biofilms and ear infections behind the ear drum; dynamic imaging mode for capturing high frequency (up to 20 kHz) oscillations in the middle ear structures. The operation of the miniaturized probes will be validated on ex vivo specimens.


year authors and title journal last update
List of publications.
2018 B. Imran Akca
Integrated-optics Solutions for Biomedical Optical Imaging,
published pages: , ISSN: , DOI:
2017 B. Imran Akca, N. Weiss, F. Coumans, and T. G van Leeuwen,
Integrated-optics based multi-beam imaging for speed improvement of OCT systems
published pages: , ISSN: , DOI:
Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 100560Q 2020-01-20
2018 Ton G. van Leeuwen, Imran B. Akca, Nikolaos Angelou, Nicolas Weiss, Marcel Hoekman, Arne Leinse, Rene G. Heideman
On-chip Mach-Zehnder interferometer for OCT systems
published pages: 103-106, ISSN: 2192-8584, DOI: 10.1515/aot-2017-0061
Advanced Optical Technologies 7/1-2 2020-01-20

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