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NanoMembR

Nanoscale Effects within Biological Membranes caused by Radiation

Total Cost €

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EC-Contrib. €

0

Partnership

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 NanoMembR project word cloud

Explore the words cloud of the NanoMembR project. It provides you a very rough idea of what is the project "NanoMembR" about.

remote    perturbation    robustness    combined    instability    scheduled    space    monitor    correlate    earth    scientists    hopanoids    mapping    anoxic    significantly    planetary    technique    subtle    nano    biological    scattering    radiation    spatial    structure    cosmic    near    longevity    missions    damage    uv    model    found    influence    environments    resolution    functioning    micro    station    membranes    fragmentation    microscopy    altered    vary    structural    attracted    planets    domains    peroxidation    membrane    modifiers    composition    stability    platforms    cutting    edge    feed    lipid    chain    fourier    experiments    alteration    homeostasis    solar    nanoscopy    environmental    combine    infrared    break    database    detectable    scanning    molecules    intercalating    living    reactions    nanoscale    situ    transform    patterns    functional    spectroscopy    nanometre    exposure    pigments    elucidate    life    scientific    chemical    oxic    nanosatellite    sterols    detection    ftir    monitoring    international    implications    integrity    spectroscopic    nanomembr    final    iss    intriguing    snom    biomarkers   

Project "NanoMembR" data sheet

The following table provides information about the project.

Coordinator
FREIE UNIVERSITAET BERLIN 

Organization address
address: KAISERSWERTHER STRASSE 16-18
city: BERLIN
postcode: 14195
website: www.fu-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.physik.fu-berlin.de/en/einrichtungen/ag/ag-elsaesser/Projects/Membranes.html
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-16   to  2019-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FREIE UNIVERSITAET BERLIN DE (BERLIN) coordinator 171˙460.00

Map

 Project objective

The NanoMembR project will elucidate key elements of membrane stability under the influence of UV radiation. The stability of biological membranes is of great importance for the structure, homeostasis and functioning of all living systems. Membrane molecules have also attracted, due to their robustness and longevity, strong interest from planetary and space scientists as potential biomarkers for life detection missions to other planets. Membrane damage, perturbation, instability and fragmentation upon UV exposure will be investigated on the nanoscale using cutting-edge infrared nanoscopy. Scattering-type scanning near-field microscopy (s-SNOM) combined with Fourier transform infrared (FTIR) spectroscopy allows to combine spatial information of nanometre resolution with chemical mapping. This novel technique will enable us to study subtle changes in the structural integrity of model membranes and monitor changes in the micro- and nano-domains. In addition, we will be able to correlate membrane stability and membrane composition by intercalating structural and functional modifiers such as sterols, hopanoids and pigments. Upon radiation in oxic environments, the lipid structure of a membrane is known to be altered by peroxidation chain reactions. Under anoxic conditions radiation induced changes in lipid alteration could vary significantly, with intriguing implications for the stability of membrane molecules under different environmental conditions than found on Earth. Understanding fragmentation patterns of membranes and identifying final break-down products will provide scientific support and a database for key biomarkers detectable in remote environments. Results from this work will feed directly into planned experiments on the International Space Station (ISS), which are scheduled on new nanosatellite-technology-based exposure platforms with in-situ infrared spectroscopic capabilities, monitoring membrane stability under the influence of solar and cosmic radiation.

 Publications

year authors and title journal last update
List of publications.
2019 Jean-Pierre de Vera, Mashal Alawi, Theresa Backhaus, Mickael Baqué, Daniela Billi, Ute Böttger, Thomas Berger, Maria Bohmeier, Charles Cockell, René Demets, Rosa de la Torre Noetzel, Howell Edwards, Andreas Elsaesser, Claudia Fagliarone, Annelie Fiedler, Bernard Foing, Frédéric Foucher, Jörg Fritz, Franziska Hanke, Thomas Herzog, Gerda Horneck, Heinz-Wilhelm Hübers, Björn Huwe, Jasmin Josh
Limits of Life and the Habitability of Mars: The ESA Space Experiment BIOMEX on the ISS
published pages: 145-157, ISSN: 1531-1074, DOI: 10.1089/ast.2018.1897
Astrobiology 19/2 2019-12-02
2018 Elsaesser A., Perfumo A., Mattioda A.L., Ricco A.J., Danelon C., Wagner D., Salama F., Canganella F., Löhmannsröben H.-G., Linnartz H., Fani R., Quinn R.C., Parro V., Nicholson W. L., Martins Z.
Exocube: a miniaturised in-situ space laboratory for astrobiological exposure experiments on the international space station
published pages: , ISSN: 0074-1795, DOI:
Proceedings of the International Astronautical Congress, IAC 2019-12-02
2019 Adriana Blachowicz, Abby J. Chiang, Andreas Elsaesser, Markus Kalkum, Pascale Ehrenfreund, Jason E. Stajich, Tamas Torok, Clay C. C. Wang, Kasthuri Venkateswaran
Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.01013
Frontiers in Microbiology 10 2019-12-02

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The information about "NANOMEMBR" are provided by the European Opendata Portal: CORDIS opendata.

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