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NanoMembR

Nanoscale Effects within Biological Membranes caused by Radiation

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 NanoMembR project word cloud

Explore the words cloud of the NanoMembR project. It provides you a very rough idea of what is the project "NanoMembR" about.

chemical    hopanoids    exposure    environments    iss    nano    functioning    subtle    modifiers    homeostasis    sterols    cutting    vary    situ    nanoscale    perturbation    snom    oxic    break    fragmentation    intercalating    nanomembr    near    fourier    spatial    structural    nanometre    spectroscopic    altered    combined    earth    significantly    chain    mapping    nanoscopy    elucidate    integrity    biological    implications    living    microscopy    stability    intriguing    international    lipid    planetary    environmental    feed    scheduled    micro    scattering    database    correlate    biomarkers    influence    detection    membrane    robustness    attracted    life    monitor    uv    platforms    technique    cosmic    resolution    molecules    ftir    station    spectroscopy    instability    planets    scientists    detectable    infrared    space    scanning    composition    transform    domains    model    peroxidation    functional    alteration    nanosatellite    radiation    damage    solar    missions    experiments    found    combine    pigments    scientific    membranes    longevity    final    patterns    remote    monitoring    edge    anoxic    reactions    structure   

Project "NanoMembR" data sheet

The following table provides information about the project.

Coordinator		 FREIE UNIVERSITAET BERLIN 

Organization address
address: KAISERSWERTHER STRASSE 16-18
city: BERLIN
postcode: 14195
website: www.fu-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website http://www.physik.fu-berlin.de/en/einrichtungen/ag/ag-elsaesser/Projects/Membranes.html
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-16   to  2019-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FREIE UNIVERSITAET BERLIN DE (BERLIN) coordinator 171˙460.00

Map

 Project objective

The NanoMembR project will elucidate key elements of membrane stability under the influence of UV radiation. The stability of biological membranes is of great importance for the structure, homeostasis and functioning of all living systems. Membrane molecules have also attracted, due to their robustness and longevity, strong interest from planetary and space scientists as potential biomarkers for life detection missions to other planets. Membrane damage, perturbation, instability and fragmentation upon UV exposure will be investigated on the nanoscale using cutting-edge infrared nanoscopy. Scattering-type scanning near-field microscopy (s-SNOM) combined with Fourier transform infrared (FTIR) spectroscopy allows to combine spatial information of nanometre resolution with chemical mapping. This novel technique will enable us to study subtle changes in the structural integrity of model membranes and monitor changes in the micro- and nano-domains. In addition, we will be able to correlate membrane stability and membrane composition by intercalating structural and functional modifiers such as sterols, hopanoids and pigments. Upon radiation in oxic environments, the lipid structure of a membrane is known to be altered by peroxidation chain reactions. Under anoxic conditions radiation induced changes in lipid alteration could vary significantly, with intriguing implications for the stability of membrane molecules under different environmental conditions than found on Earth. Understanding fragmentation patterns of membranes and identifying final break-down products will provide scientific support and a database for key biomarkers detectable in remote environments. Results from this work will feed directly into planned experiments on the International Space Station (ISS), which are scheduled on new nanosatellite-technology-based exposure platforms with in-situ infrared spectroscopic capabilities, monitoring membrane stability under the influence of solar and cosmic radiation.

 Publications

year authors and title journal last update
List of publications.
2019 Jean-Pierre de Vera, Mashal Alawi, Theresa Backhaus, Mickael Baqué, Daniela Billi, Ute Böttger, Thomas Berger, Maria Bohmeier, Charles Cockell, René Demets, Rosa de la Torre Noetzel, Howell Edwards, Andreas Elsaesser, Claudia Fagliarone, Annelie Fiedler, Bernard Foing, Frédéric Foucher, Jörg Fritz, Franziska Hanke, Thomas Herzog, Gerda Horneck, Heinz-Wilhelm Hübers, Björn Huwe, Jasmin Josh
Limits of Life and the Habitability of Mars: The ESA Space Experiment BIOMEX on the ISS
published pages: 145-157, ISSN: 1531-1074, DOI: 10.1089/ast.2018.1897 		Astrobiology 19/2 2019-12-02
2018 Elsaesser A., Perfumo A., Mattioda A.L., Ricco A.J., Danelon C., Wagner D., Salama F., Canganella F., Löhmannsröben H.-G., Linnartz H., Fani R., Quinn R.C., Parro V., Nicholson W. L., Martins Z.
Exocube: a miniaturised in-situ space laboratory for astrobiological exposure experiments on the international space station
published pages: , ISSN: 0074-1795, DOI: 		Proceedings of the International Astronautical Congress, IAC 2019-12-02
2019 Adriana Blachowicz, Abby J. Chiang, Andreas Elsaesser, Markus Kalkum, Pascale Ehrenfreund, Jason E. Stajich, Tamas Torok, Clay C. C. Wang, Kasthuri Venkateswaran
Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.01013 		Frontiers in Microbiology 10 2019-12-02

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The information about "NANOMEMBR" are provided by the European Opendata Portal: CORDIS opendata.

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