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NanoMembR

Nanoscale Effects within Biological Membranes caused by Radiation

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 NanoMembR project word cloud

Explore the words cloud of the NanoMembR project. It provides you a very rough idea of what is the project "NanoMembR" about.

technique    platforms    pigments    international    nanomembr    damage    combine    transform    spectroscopic    database    found    nanoscopy    structure    hopanoids    missions    scattering    oxic    nanoscale    feed    patterns    planetary    ftir    elucidate    scheduled    membrane    space    scientific    spectroscopy    final    uv    combined    alteration    modifiers    sterols    planets    integrity    peroxidation    detectable    correlate    functional    mapping    radiation    scientists    iss    longevity    living    membranes    situ    fragmentation    monitoring    molecules    attracted    implications    chain    environments    lipid    resolution    stability    detection    micro    cosmic    scanning    homeostasis    fourier    infrared    earth    anoxic    influence    chemical    near    solar    domains    functioning    structural    nano    break    altered    nanometre    nanosatellite    subtle    experiments    cutting    intercalating    biomarkers    microscopy    edge    instability    significantly    reactions    environmental    exposure    biological    intriguing    snom    robustness    perturbation    composition    station    life    model    monitor    vary    spatial    remote   

Project "NanoMembR" data sheet

The following table provides information about the project.

Coordinator		 FREIE UNIVERSITAET BERLIN 

Organization address
address: KAISERSWERTHER STRASSE 16-18
city: BERLIN
postcode: 14195
website: www.fu-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website http://www.physik.fu-berlin.de/en/einrichtungen/ag/ag-elsaesser/Projects/Membranes.html
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-16   to  2019-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FREIE UNIVERSITAET BERLIN DE (BERLIN) coordinator 171˙460.00

Map

 Project objective

The NanoMembR project will elucidate key elements of membrane stability under the influence of UV radiation. The stability of biological membranes is of great importance for the structure, homeostasis and functioning of all living systems. Membrane molecules have also attracted, due to their robustness and longevity, strong interest from planetary and space scientists as potential biomarkers for life detection missions to other planets. Membrane damage, perturbation, instability and fragmentation upon UV exposure will be investigated on the nanoscale using cutting-edge infrared nanoscopy. Scattering-type scanning near-field microscopy (s-SNOM) combined with Fourier transform infrared (FTIR) spectroscopy allows to combine spatial information of nanometre resolution with chemical mapping. This novel technique will enable us to study subtle changes in the structural integrity of model membranes and monitor changes in the micro- and nano-domains. In addition, we will be able to correlate membrane stability and membrane composition by intercalating structural and functional modifiers such as sterols, hopanoids and pigments. Upon radiation in oxic environments, the lipid structure of a membrane is known to be altered by peroxidation chain reactions. Under anoxic conditions radiation induced changes in lipid alteration could vary significantly, with intriguing implications for the stability of membrane molecules under different environmental conditions than found on Earth. Understanding fragmentation patterns of membranes and identifying final break-down products will provide scientific support and a database for key biomarkers detectable in remote environments. Results from this work will feed directly into planned experiments on the International Space Station (ISS), which are scheduled on new nanosatellite-technology-based exposure platforms with in-situ infrared spectroscopic capabilities, monitoring membrane stability under the influence of solar and cosmic radiation.

 Publications

year authors and title journal last update
List of publications.
2019 Jean-Pierre de Vera, Mashal Alawi, Theresa Backhaus, Mickael Baqué, Daniela Billi, Ute Böttger, Thomas Berger, Maria Bohmeier, Charles Cockell, René Demets, Rosa de la Torre Noetzel, Howell Edwards, Andreas Elsaesser, Claudia Fagliarone, Annelie Fiedler, Bernard Foing, Frédéric Foucher, Jörg Fritz, Franziska Hanke, Thomas Herzog, Gerda Horneck, Heinz-Wilhelm Hübers, Björn Huwe, Jasmin Josh
Limits of Life and the Habitability of Mars: The ESA Space Experiment BIOMEX on the ISS
published pages: 145-157, ISSN: 1531-1074, DOI: 10.1089/ast.2018.1897 		Astrobiology 19/2 2019-12-02
2018 Elsaesser A., Perfumo A., Mattioda A.L., Ricco A.J., Danelon C., Wagner D., Salama F., Canganella F., Löhmannsröben H.-G., Linnartz H., Fani R., Quinn R.C., Parro V., Nicholson W. L., Martins Z.
Exocube: a miniaturised in-situ space laboratory for astrobiological exposure experiments on the international space station
published pages: , ISSN: 0074-1795, DOI: 		Proceedings of the International Astronautical Congress, IAC 2019-12-02
2019 Adriana Blachowicz, Abby J. Chiang, Andreas Elsaesser, Markus Kalkum, Pascale Ehrenfreund, Jason E. Stajich, Tamas Torok, Clay C. C. Wang, Kasthuri Venkateswaran
Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.01013 		Frontiers in Microbiology 10 2019-12-02

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The information about "NANOMEMBR" are provided by the European Opendata Portal: CORDIS opendata.

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