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NanoMembR

Nanoscale Effects within Biological Membranes caused by Radiation

Total Cost €

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EC-Contrib. €

0

Partnership

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 NanoMembR project word cloud

Explore the words cloud of the NanoMembR project. It provides you a very rough idea of what is the project "NanoMembR" about.

mapping    platforms    membrane    uv    modifiers    scientists    subtle    solar    hopanoids    attracted    functioning    homeostasis    exposure    altered    remote    station    nanoscale    nanoscopy    missions    nanosatellite    domains    international    anoxic    monitor    alteration    intriguing    molecules    elucidate    nanometre    combine    ftir    space    vary    influence    reactions    implications    significantly    transform    pigments    detection    nanomembr    longevity    scientific    fourier    spectroscopic    perturbation    final    edge    lipid    patterns    robustness    combined    composition    database    membranes    damage    scheduled    microscopy    oxic    experiments    planetary    environments    instability    chemical    snom    structural    peroxidation    spatial    micro    planets    radiation    cutting    break    sterols    technique    living    monitoring    earth    situ    near    spectroscopy    feed    scanning    found    life    model    structure    environmental    functional    correlate    cosmic    biomarkers    iss    infrared    integrity    biological    chain    scattering    fragmentation    intercalating    stability    detectable    nano    resolution   

Project "NanoMembR" data sheet

The following table provides information about the project.

Coordinator
FREIE UNIVERSITAET BERLIN 

Organization address
address: KAISERSWERTHER STRASSE 16-18
city: BERLIN
postcode: 14195
website: www.fu-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.physik.fu-berlin.de/en/einrichtungen/ag/ag-elsaesser/Projects/Membranes.html
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-16   to  2019-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FREIE UNIVERSITAET BERLIN DE (BERLIN) coordinator 171˙460.00

Map

 Project objective

The NanoMembR project will elucidate key elements of membrane stability under the influence of UV radiation. The stability of biological membranes is of great importance for the structure, homeostasis and functioning of all living systems. Membrane molecules have also attracted, due to their robustness and longevity, strong interest from planetary and space scientists as potential biomarkers for life detection missions to other planets. Membrane damage, perturbation, instability and fragmentation upon UV exposure will be investigated on the nanoscale using cutting-edge infrared nanoscopy. Scattering-type scanning near-field microscopy (s-SNOM) combined with Fourier transform infrared (FTIR) spectroscopy allows to combine spatial information of nanometre resolution with chemical mapping. This novel technique will enable us to study subtle changes in the structural integrity of model membranes and monitor changes in the micro- and nano-domains. In addition, we will be able to correlate membrane stability and membrane composition by intercalating structural and functional modifiers such as sterols, hopanoids and pigments. Upon radiation in oxic environments, the lipid structure of a membrane is known to be altered by peroxidation chain reactions. Under anoxic conditions radiation induced changes in lipid alteration could vary significantly, with intriguing implications for the stability of membrane molecules under different environmental conditions than found on Earth. Understanding fragmentation patterns of membranes and identifying final break-down products will provide scientific support and a database for key biomarkers detectable in remote environments. Results from this work will feed directly into planned experiments on the International Space Station (ISS), which are scheduled on new nanosatellite-technology-based exposure platforms with in-situ infrared spectroscopic capabilities, monitoring membrane stability under the influence of solar and cosmic radiation.

 Publications

year authors and title journal last update
List of publications.
2019 Jean-Pierre de Vera, Mashal Alawi, Theresa Backhaus, Mickael Baqué, Daniela Billi, Ute Böttger, Thomas Berger, Maria Bohmeier, Charles Cockell, René Demets, Rosa de la Torre Noetzel, Howell Edwards, Andreas Elsaesser, Claudia Fagliarone, Annelie Fiedler, Bernard Foing, Frédéric Foucher, Jörg Fritz, Franziska Hanke, Thomas Herzog, Gerda Horneck, Heinz-Wilhelm Hübers, Björn Huwe, Jasmin Josh
Limits of Life and the Habitability of Mars: The ESA Space Experiment BIOMEX on the ISS
published pages: 145-157, ISSN: 1531-1074, DOI: 10.1089/ast.2018.1897
Astrobiology 19/2 2019-12-02
2018 Elsaesser A., Perfumo A., Mattioda A.L., Ricco A.J., Danelon C., Wagner D., Salama F., Canganella F., Löhmannsröben H.-G., Linnartz H., Fani R., Quinn R.C., Parro V., Nicholson W. L., Martins Z.
Exocube: a miniaturised in-situ space laboratory for astrobiological exposure experiments on the international space station
published pages: , ISSN: 0074-1795, DOI:
Proceedings of the International Astronautical Congress, IAC 2019-12-02
2019 Adriana Blachowicz, Abby J. Chiang, Andreas Elsaesser, Markus Kalkum, Pascale Ehrenfreund, Jason E. Stajich, Tamas Torok, Clay C. C. Wang, Kasthuri Venkateswaran
Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.01013
Frontiers in Microbiology 10 2019-12-02

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The information about "NANOMEMBR" are provided by the European Opendata Portal: CORDIS opendata.

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