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MAIT SIGNED

Evolutionary conserved T cells specific for a microbial metabolite: deciphering their development in the thymus and mapping their interactions with the gut microbiota in vivo.

Total Cost €

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EC-Contrib. €

0

Partnership

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 Outcomes and results

 MAIT project word cloud

Explore the words cloud of the MAIT project. It provides you a very rough idea of what is the project "MAIT" about.

class    immune    ib    express    overcome    inter    expertise    commensals    blood    interactions    abundant    transcriptomic    integrate    periphery    first    dysbiosis    mucosal    conserved    evolutionary    anti    metabolite    molecule    liver    infers    ligands    bacteria    implicated    leads    pathologies    acquired    invariant    peripheral    maits    microbiota    microbial    50    admittedly    lineage    lab    species    recognizing    cells    conservation    antigens    tools    ago    ibd    bounds    technologies    remained    flora    diabetes    thymus    host    frequency    gut    mice    transfer    germ    memory    laboratory    obesity    adaptive    free    commensal    subset    mouse    map    limited    mhc    model    transgenic    mr1    biological    vivo    15    colonization    permanently    expand    competitiveness    presented    models    acquire    phenotype    polyclonal    ms    expansion    differentiation    re    scarcity    insights    modified    building    creation    strain    indicating    specificity    human    play    tcr    mucosa    microbes    guarantee    elucidate    me    mechanisms    semi   

Project "MAIT" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Project website https://science.institut-curie.org/research/integrated-biology/u932-immunity-and-cancer/team-lantz/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Mucosal Associated Invariant T cells (MAITs) represent an evolutionary conserved subset that express a semi-invariant TCR recognizing a new class of microbial metabolite antigens presented by the MHC class Ib molecule, MR1. In addition to their wide anti-microbial specificity, the high inter-species conservation of both MR1 and invariant TCR infers an important biological role for MAITs. MAITs are abundant in human blood (1-8 % of T cells), mucosa and liver (20-50%). After development in the thymus, MAITs reach the periphery where they acquire a memory phenotype and expand in a process that requires a commensal flora, indicating that MAITs play a role in host-commensals interactions. Admittedly MAITs blood frequency is modified in several pathologies in which dysbiosis of the gut microbiota has been implicated such as IBD, MS, type 2 diabetes and obesity. MAITs were first described over 15 years ago by the Host lab, but the understanding of their development has remained limited because of their scarcity in laboratory mice. Here we will overcome this challenge by using a new mouse strain with increased frequency of polyclonal MAITs. Using my expertise acquired in the US and building on unique tools, we will: 1) Define MAITs lineage: we will use a transcriptomic approach together with dedicated transgenic mouse models to determine how MAITs selection leads to their specific differentiation program in the thymus. 2) Elucidate the mechanisms of MAITs peripheral expansion: we will use germ-free mice and modified bacteria to map the in vivo availability of MAITs ligands upon colonization with commensal microbes. The proposal will provide insights into an evolutionary conserved model of interactions between the adaptive immune system and the gut microbiota. By enabling me to permanently re-integrate the EU, this project will also guarantee transfer of technologies and creation of new bounds between the US and the EU, and will increase the EU competitiveness.

 Publications

year authors and title journal last update
List of publications.
2017 Olivier Lantz, François Legoux
MAIT cells: an historical and evolutionary perspective
published pages: , ISSN: 0818-9641, DOI: 10.1111/imcb.1034 		Immunology and Cell Biology 2019-06-13

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