Opendata, web and dolomites

MAIT SIGNED

Evolutionary conserved T cells specific for a microbial metabolite: deciphering their development in the thymus and mapping their interactions with the gut microbiota in vivo.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MAIT project word cloud

Explore the words cloud of the MAIT project. It provides you a very rough idea of what is the project "MAIT" about.

microbiota    re    differentiation    acquire    50    ligands    memory    limited    phenotype    lab    implicated    permanently    anti    models    species    mr1    remained    obesity    liver    gut    technologies    elucidate    germ    blood    express    semi    expand    expertise    tcr    antigens    ibd    leads    invariant    conservation    human    ms    transfer    play    mouse    interactions    colonization    biological    flora    mucosal    creation    mhc    laboratory    15    diabetes    recognizing    bacteria    strain    tools    competitiveness    pathologies    microbes    conserved    subset    dysbiosis    specificity    integrate    abundant    adaptive    inter    thymus    metabolite    indicating    infers    lineage    scarcity    host    bounds    presented    peripheral    commensals    commensal    cells    mechanisms    frequency    periphery    transgenic    microbial    insights    molecule    mice    ago    immune    ib    guarantee    me    evolutionary    modified    polyclonal    maits    vivo    admittedly    free    class    first    map    acquired    transcriptomic    overcome    mucosa    model    building    expansion   

Project "MAIT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://science.institut-curie.org/research/integrated-biology/u932-immunity-and-cancer/team-lantz/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Mucosal Associated Invariant T cells (MAITs) represent an evolutionary conserved subset that express a semi-invariant TCR recognizing a new class of microbial metabolite antigens presented by the MHC class Ib molecule, MR1. In addition to their wide anti-microbial specificity, the high inter-species conservation of both MR1 and invariant TCR infers an important biological role for MAITs. MAITs are abundant in human blood (1-8 % of T cells), mucosa and liver (20-50%). After development in the thymus, MAITs reach the periphery where they acquire a memory phenotype and expand in a process that requires a commensal flora, indicating that MAITs play a role in host-commensals interactions. Admittedly MAITs blood frequency is modified in several pathologies in which dysbiosis of the gut microbiota has been implicated such as IBD, MS, type 2 diabetes and obesity. MAITs were first described over 15 years ago by the Host lab, but the understanding of their development has remained limited because of their scarcity in laboratory mice. Here we will overcome this challenge by using a new mouse strain with increased frequency of polyclonal MAITs. Using my expertise acquired in the US and building on unique tools, we will: 1) Define MAITs lineage: we will use a transcriptomic approach together with dedicated transgenic mouse models to determine how MAITs selection leads to their specific differentiation program in the thymus. 2) Elucidate the mechanisms of MAITs peripheral expansion: we will use germ-free mice and modified bacteria to map the in vivo availability of MAITs ligands upon colonization with commensal microbes. The proposal will provide insights into an evolutionary conserved model of interactions between the adaptive immune system and the gut microbiota. By enabling me to permanently re-integrate the EU, this project will also guarantee transfer of technologies and creation of new bounds between the US and the EU, and will increase the EU competitiveness.

 Publications

year authors and title journal last update
List of publications.
2017 Olivier Lantz, François Legoux
MAIT cells: an historical and evolutionary perspective
published pages: , ISSN: 0818-9641, DOI: 10.1111/imcb.1034
Immunology and Cell Biology 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MAIT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MAIT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MultiSeaSpace (2019)

Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.

Read More  

MOSAiC (2019)

Multimode cOrrelations in microwave photonics with Superconducting quAntum Circuits

Read More  

Topo-circuit (2019)

Exploring topological phenomenon in RF circuits

Read More