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MAIT SIGNED

Evolutionary conserved T cells specific for a microbial metabolite: deciphering their development in the thymus and mapping their interactions with the gut microbiota in vivo.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MAIT project word cloud

Explore the words cloud of the MAIT project. It provides you a very rough idea of what is the project "MAIT" about.

model    mice    15    germ    obesity    microbial    biological    vivo    tools    commensal    bacteria    transcriptomic    ago    modified    transfer    guarantee    mr1    acquired    invariant    mucosa    expansion    first    express    admittedly    lineage    adaptive    blood    dysbiosis    microbiota    host    maits    expertise    bounds    50    mhc    acquire    phenotype    gut    pathologies    conserved    anti    molecule    immune    colonization    infers    scarcity    implicated    peripheral    metabolite    transgenic    conservation    mouse    recognizing    flora    evolutionary    strain    limited    commensals    inter    class    laboratory    polyclonal    free    play    lab    competitiveness    insights    mechanisms    ib    re    memory    creation    human    ms    ibd    diabetes    differentiation    liver    map    remained    overcome    me    subset    specificity    mucosal    permanently    technologies    ligands    periphery    presented    interactions    cells    integrate    species    building    semi    abundant    microbes    frequency    models    thymus    elucidate    tcr    indicating    expand    leads    antigens   

Project "MAIT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://science.institut-curie.org/research/integrated-biology/u932-immunity-and-cancer/team-lantz/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Mucosal Associated Invariant T cells (MAITs) represent an evolutionary conserved subset that express a semi-invariant TCR recognizing a new class of microbial metabolite antigens presented by the MHC class Ib molecule, MR1. In addition to their wide anti-microbial specificity, the high inter-species conservation of both MR1 and invariant TCR infers an important biological role for MAITs. MAITs are abundant in human blood (1-8 % of T cells), mucosa and liver (20-50%). After development in the thymus, MAITs reach the periphery where they acquire a memory phenotype and expand in a process that requires a commensal flora, indicating that MAITs play a role in host-commensals interactions. Admittedly MAITs blood frequency is modified in several pathologies in which dysbiosis of the gut microbiota has been implicated such as IBD, MS, type 2 diabetes and obesity. MAITs were first described over 15 years ago by the Host lab, but the understanding of their development has remained limited because of their scarcity in laboratory mice. Here we will overcome this challenge by using a new mouse strain with increased frequency of polyclonal MAITs. Using my expertise acquired in the US and building on unique tools, we will: 1) Define MAITs lineage: we will use a transcriptomic approach together with dedicated transgenic mouse models to determine how MAITs selection leads to their specific differentiation program in the thymus. 2) Elucidate the mechanisms of MAITs peripheral expansion: we will use germ-free mice and modified bacteria to map the in vivo availability of MAITs ligands upon colonization with commensal microbes. The proposal will provide insights into an evolutionary conserved model of interactions between the adaptive immune system and the gut microbiota. By enabling me to permanently re-integrate the EU, this project will also guarantee transfer of technologies and creation of new bounds between the US and the EU, and will increase the EU competitiveness.

 Publications

year authors and title journal last update
List of publications.
2017 Olivier Lantz, François Legoux
MAIT cells: an historical and evolutionary perspective
published pages: , ISSN: 0818-9641, DOI: 10.1111/imcb.1034
Immunology and Cell Biology 2019-06-13

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