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EpiHope SIGNED

Epigenetic biomarkers for prediction of vascular complications and response to treatment in subjects with diabetes

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "EpiHope" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: Lund
postcode: 22100
website: www.lu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://www.ludc.lu.se/sonia-garcia-calzon
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (Lund) coordinator 173˙857.00

Map

 Project objective

Type 2 diabetes (T2D) is one of the leading causes of death through its deleterious effects on cardiovascular disease (CVD). The complications of T2D can be reduced through early and appropriate preventive and therapeutic interventions. Several studies suggest that epigenetics may play a key role in the pathogenesis of these diseases. However, additional studies are needed to improve primary prevention and treatment of T2D and vascular complications. Our overall objective is to identify novel epigenetic biomarkers of clinical relevance that predict, monitor progression and forecast response to treatment of T2D and CVD. First we aim to identify clinically useful epigenetic biomarkers (DNA methylation will be analysed genome-wide) that can predict the glycaemic response to metformin treatment and future risk of CVD in newly diagnosed T2D patients recruited from ANDIS cohort. Second, the most efficient epigenetic biomarkers identified will be validated in T2D patients from ANDIS using pyrosequencing. Third, we aim to make combined predictive risk scores with our novel epigenetic biomarkers, genetic and clinical risk factors to assess risk for CVD. Finally, we will test functional characterization of the validated epigenetic biomarkers in target tissues from T2D patients, and in vitro follow-up studies will be developed. This project represents an outstanding opportunity for personalized treatment for T2D, proposing for the first time pharmacoepigenetics in this field, and also for the development of a panel of high-quality epigenetic biomarkers together with combined risk scores, aiming to give a new reliable clinical tool for early prevention of CVD in T2D patients. Notably, epigenetic modifications can be manipulated more readily than genomic mutations, and thereby has much of potential for pharmacological applications. In summary, the findings of robust epigenetic biomarkers will optimize the therapeutics of T2D and the preventive care of vascular complications.

 Publications

year authors and title journal last update
List of publications.
2017 Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa D. de Mello, Emma Nilsson, Jussi Pihlajamäki, Charlotte Ling
Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver
published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-017-0400-0
Clinical Epigenetics 9/1 2019-06-13
2018 Cajsa Davegårdh, Sonia García-Calzón, Karl Bacos, Charlotte Ling
DNA methylation in the pathogenesis of type 2 diabetes in humans
published pages: 12-25, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2018.01.022
Molecular Metabolism 14 2019-06-13
2018 Sonia García-Calzón, Alexander Perfilyev, Vanessa D Mello, Jussi Pihlajamäki, Charlotte Ling
Sex differences in the methylome and transcriptome of the human liver and circulating HDL-cholesterol levels
published pages: , ISSN: 0021-972X, DOI: 10.1210/jc.2018-00423
The Journal of Clinical Endocrinology & Metabolism 2019-06-13

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The information about "EPIHOPE" are provided by the European Opendata Portal: CORDIS opendata.

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