Opendata, web and dolomites


Wnt Enhancer LandscapE CharacTerization

Total Cost €


EC-Contrib. €






 WntELECT project word cloud

Explore the words cloud of the WntELECT project. It provides you a very rough idea of what is the project "WntELECT" about.

tissue    significantly    therapeutic    intervention    training    decisions    human    tissues    act    cancer    environmental    uncovering    signal    half    career    environment    cells    patterns    renewal    signals    health    breast    catenin    respect    enhancers    clear    basis    combine    precise    fate    mechanisms    adult    almost    homeostasis    determinants    engineering    validate    benefit    multiple    aberrant    hence    hallmark    genes    cell    functional    mammalian    differentiation    maintenance    innovative    gap    underlying    receive    coordinated    mammary    envisage    alterations    proliferation    carefully    genome    stem    attractive    regulatory    pipeline    regarding    intrinsic    multidisciplinary    death    tumors    transduction    frequently    experimental    intricate    efforts    beta    epigenetic    temporal    despite    bioinformatics    excellent    paradigm    dynamic    screening    serves    wnt    deregulated    screen    activation    normal    scientific    sequences    essence    expression    vivo    balance    individual    self    ligands    gland   

Project "WntELECT" data sheet

The following table provides information about the project.


Organization address
address: SPUI 21
postcode: 1012WX

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Despite significant efforts, cancer remains one of the major health challenges in Europe. In essence, cancer can be seen as the result of alterations in the intricate balance between cell proliferation, differentiation and death during tissue homeostasis. Hence, pathways that are essential for the development and maintenance of mammalian tissues are frequently deregulated in human tumors and represent attractive targets for therapeutic intervention. In that respect, the Wnt signal transduction pathway serves as a paradigm: On the one hand, Wnt ligands are crucial determinants of cell fate decisions and can act as self-renewal factors for adult stem cells in multiple tissues, including the mammary gland. On the other hand, aberrant activation of the Wnt/beta-catenin pathway is a hallmark of many human (breast) tumors. While it is clear that Wnt activity has to be carefully coordinated in precise temporal and tissue-specific patterns, there is a significant knowledge gap regarding the underlying control mechanisms. In this project, I will combine bioinformatics, state-of-the-art genome engineering and an innovative screening approach to identify Wnt-associated enhancers in the mammary gland. I aim to: 1. Establish an effective experimental pipeline for an epigenetic screen. 2. Identify functional regulatory sequences for almost half of the mammalian Wnt genes. 3. Validate individual enhancers in vivo. The proposed research together with the training I will receive in an excellent, multidisciplinary research environment will significantly benefit my scientific career development. Finally, I envisage that my results will provide the basis for uncovering how environmental and intrinsic signals are integrated to control dynamic Wnt expression patterns in both normal development and cancer.


year authors and title journal last update
List of publications.
2017 Daphne S Bindels, Lindsay Haarbosch, Laura van Weeren, Marten Postma, Katrin E Wiese, Marieke Mastop, Sylvain Aumonier, Guillaume Gotthard, Antoine Royant, Mark A Hink, Theodorus W J Gadella
mScarlet: a bright monomeric red fluorescent protein for cellular imaging
published pages: 53-56, ISSN: 1548-7091, DOI: 10.1038/nmeth.4074
Nature Methods 14/1 2019-06-13
2018 Katrin E. Wiese, Roel Nusse, Renée van Amerongen
Wnt signalling: conquering complexity
published pages: dev165902, ISSN: 0950-1991, DOI: 10.1242/dev.165902
Development 145/12 2019-06-13
2017 Katrin E. Wiese, Romain J. Amante, Maria dM. Vivanco, Mohamed Bentires-Alj, Richard D. Iggo
The ninth ENBDC Weggis meeting: growth and in-depth characterisation of normal and neoplastic breast cells
published pages: , ISSN: 1465-542X, DOI: 10.1186/s13058-017-0891-9
Breast Cancer Research 19/1 2019-06-13

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