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WntELECT SIGNED

Wnt Enhancer LandscapE CharacTerization

Total Cost €

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EC-Contrib. €

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Partnership

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 WntELECT project word cloud

Explore the words cloud of the WntELECT project. It provides you a very rough idea of what is the project "WntELECT" about.

innovative    dynamic    experimental    patterns    envisage    differentiation    screening    mammary    career    bioinformatics    combine    uncovering    beta    environment    breast    signals    screen    wnt    cancer    enhancers    stem    regulatory    self    balance    deregulated    determinants    functional    aberrant    individual    clear    carefully    act    serves    renewal    death    fate    environmental    intrinsic    benefit    transduction    half    intricate    receive    almost    tissues    mammalian    human    underlying    genes    alterations    gland    essence    maintenance    scientific    cell    hallmark    adult    mechanisms    efforts    multidisciplinary    intervention    epigenetic    validate    vivo    expression    therapeutic    significantly    sequences    genome    multiple    pipeline    cells    gap    paradigm    coordinated    temporal    catenin    excellent    homeostasis    respect    tissue    activation    training    precise    despite    regarding    attractive    ligands    signal    proliferation    hence    frequently    tumors    health    basis    normal    engineering    decisions   

Project "WntELECT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: SPUI 21
city: AMSTERDAM
postcode: 1012WX
website: www.uva.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 165˙598.00

Map

 Project objective

Despite significant efforts, cancer remains one of the major health challenges in Europe. In essence, cancer can be seen as the result of alterations in the intricate balance between cell proliferation, differentiation and death during tissue homeostasis. Hence, pathways that are essential for the development and maintenance of mammalian tissues are frequently deregulated in human tumors and represent attractive targets for therapeutic intervention. In that respect, the Wnt signal transduction pathway serves as a paradigm: On the one hand, Wnt ligands are crucial determinants of cell fate decisions and can act as self-renewal factors for adult stem cells in multiple tissues, including the mammary gland. On the other hand, aberrant activation of the Wnt/beta-catenin pathway is a hallmark of many human (breast) tumors. While it is clear that Wnt activity has to be carefully coordinated in precise temporal and tissue-specific patterns, there is a significant knowledge gap regarding the underlying control mechanisms. In this project, I will combine bioinformatics, state-of-the-art genome engineering and an innovative screening approach to identify Wnt-associated enhancers in the mammary gland. I aim to: 1. Establish an effective experimental pipeline for an epigenetic screen. 2. Identify functional regulatory sequences for almost half of the mammalian Wnt genes. 3. Validate individual enhancers in vivo. The proposed research together with the training I will receive in an excellent, multidisciplinary research environment will significantly benefit my scientific career development. Finally, I envisage that my results will provide the basis for uncovering how environmental and intrinsic signals are integrated to control dynamic Wnt expression patterns in both normal development and cancer.

 Publications

year authors and title journal last update
List of publications.
2017 Daphne S Bindels, Lindsay Haarbosch, Laura van Weeren, Marten Postma, Katrin E Wiese, Marieke Mastop, Sylvain Aumonier, Guillaume Gotthard, Antoine Royant, Mark A Hink, Theodorus W J Gadella
mScarlet: a bright monomeric red fluorescent protein for cellular imaging
published pages: 53-56, ISSN: 1548-7091, DOI: 10.1038/nmeth.4074
Nature Methods 14/1 2019-06-13
2018 Katrin E. Wiese, Roel Nusse, Renée van Amerongen
Wnt signalling: conquering complexity
published pages: dev165902, ISSN: 0950-1991, DOI: 10.1242/dev.165902
Development 145/12 2019-06-13
2017 Katrin E. Wiese, Romain J. Amante, Maria dM. Vivanco, Mohamed Bentires-Alj, Richard D. Iggo
The ninth ENBDC Weggis meeting: growth and in-depth characterisation of normal and neoplastic breast cells
published pages: , ISSN: 1465-542X, DOI: 10.1186/s13058-017-0891-9
Breast Cancer Research 19/1 2019-06-13

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