Explore the words cloud of the WntELECT project. It provides you a very rough idea of what is the project "WntELECT" about.
The following table provides information about the project.
UNIVERSITEIT VAN AMSTERDAM
|Coordinator Country||Netherlands [NL]|
|Total cost||165˙598 €|
|EC max contribution||165˙598 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-05-01 to 2018-04-30|
Take a look of project's partnership.
|1||UNIVERSITEIT VAN AMSTERDAM||NL (AMSTERDAM)||coordinator||165˙598.00|
Despite significant efforts, cancer remains one of the major health challenges in Europe. In essence, cancer can be seen as the result of alterations in the intricate balance between cell proliferation, differentiation and death during tissue homeostasis. Hence, pathways that are essential for the development and maintenance of mammalian tissues are frequently deregulated in human tumors and represent attractive targets for therapeutic intervention. In that respect, the Wnt signal transduction pathway serves as a paradigm: On the one hand, Wnt ligands are crucial determinants of cell fate decisions and can act as self-renewal factors for adult stem cells in multiple tissues, including the mammary gland. On the other hand, aberrant activation of the Wnt/beta-catenin pathway is a hallmark of many human (breast) tumors. While it is clear that Wnt activity has to be carefully coordinated in precise temporal and tissue-specific patterns, there is a significant knowledge gap regarding the underlying control mechanisms. In this project, I will combine bioinformatics, state-of-the-art genome engineering and an innovative screening approach to identify Wnt-associated enhancers in the mammary gland. I aim to: 1. Establish an effective experimental pipeline for an epigenetic screen. 2. Identify functional regulatory sequences for almost half of the mammalian Wnt genes. 3. Validate individual enhancers in vivo. The proposed research together with the training I will receive in an excellent, multidisciplinary research environment will significantly benefit my scientific career development. Finally, I envisage that my results will provide the basis for uncovering how environmental and intrinsic signals are integrated to control dynamic Wnt expression patterns in both normal development and cancer.
|year||authors and title||journal||last update|
Daphne S Bindels, Lindsay Haarbosch, Laura van Weeren, Marten Postma, Katrin E Wiese, Marieke Mastop, Sylvain Aumonier, Guillaume Gotthard, Antoine Royant, Mark A Hink, Theodorus W J Gadella
mScarlet: a bright monomeric red fluorescent protein for cellular imaging
published pages: 53-56, ISSN: 1548-7091, DOI: 10.1038/nmeth.4074
|Nature Methods 14/1||2019-06-13|
Katrin E. Wiese, Roel Nusse, RenÃ©e van Amerongen
Wnt signalling: conquering complexity
published pages: dev165902, ISSN: 0950-1991, DOI: 10.1242/dev.165902
Katrin E. Wiese, Romain J. Amante, Maria dM. Vivanco, Mohamed Bentires-Alj, Richard D. Iggo
The ninth ENBDC Weggis meeting: growth and in-depth characterisation of normal and neoplastic breast cells
published pages: , ISSN: 1465-542X, DOI: 10.1186/s13058-017-0891-9
|Breast Cancer Research 19/1||2019-06-13|
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