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AGeing effects on human aORta: from shApe to flowS

Total Cost €


EC-Contrib. €






 AGORAs project word cloud

Explore the words cloud of the AGORAs project. It provides you a very rough idea of what is the project "AGORAs" about.

streamline    remodeling    alterations    validating    subjects    missing    time    computational    politecnico    underlie    months    accelerated    interplay    cfd    training    operator    synergistic    dynamics    tools    characterization    canada    toolkit    prognostic    temporal    purposes    acquired    wall    vascular    fluid    consuming    36    technique    incorporated    monitoring    encumbered    shear    accuracy    resonance    source    dataset    subject    stress    cardiovascular    aortic    pcmri    aorta    aortas    simulations    cross    global    morphometric    imaging    sectional    toronto    velocity    data    hemodynamics    clinical    hemodynamic    aneurysm    risk    italy    districts    di    torino    utility    diagnosis    mainly    ageing    contrast    complemented    assumptions    solver    descriptors    university    quantification    morphological    quantifiable    suggesting    diseases    quantitative    age    overcome    morphology    diagnostic    simplify    carotid    limitations    numeric    successful    assimilation    dependent    fellowship    4d    culprits    vivo    return    flow    spatial    magnetic    resolution    cvds   

Project "AGORAs" data sheet

The following table provides information about the project.


Organization address
city: TORINO
postcode: 10129

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 229˙761 €
 EC max contribution 229˙761 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-05-16   to  2019-05-15


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 229˙761.00


 Project objective

Age-related remodeling of the aorta is associated with alterations in morphology and hemodynamics . These alterations are involved and accelerated in the presence of cardiovascular diseases (CVDs), suggesting that they are the likely culprits that underlie the increased cardiovascular risk associated with ageing . However, an advanced characterization of the age-related morphological/hemodynamic alterations and on their synergistic interplay is missing, mainly because encumbered by time-consuming operator-dependent tasks. In this 36 months global fellowship (University of Toronto, Canada and Politecnico di Torino, Italy), the potential clinical utility of such a characterization will be addressed, developing tools for the quantitative assessment of the age-associated alterations in a large-scale cross-sectional dataset of aortas from subjects with successful ageing. After training on phase-contrast magnetic resonance imaging (PCMRI) technique, for each subject the 4D velocity field will be acquired. Quantitative morphometric parameters will be defined and evaluated in vivo. To investigate aortic hemodynamics, PCMRI will be complemented by computational fluid dynamics (CFD) to overcome PCMRI limitations on temporal/spatial resolution and wall shear stress quantification . The impact of CFD assumptions will be assessed by validating CFD results with PCMRI measurements. To improve CFD results accuracy, in the return phase PCMRI data will be incorporated into the numeric simulations, through the assimilation of the acquired flow fields into the CFD solver. Descriptors quantifiable in vivo and able to simplify the understanding of the complex 4D hemodynamic and of age-associated remodeling will be defined. The new tools for diagnostic/prognostic purposes will be integrated within the open-source Vascular Modelling ToolKit, to facilitate and streamline the diagnosis and monitoring of a wider range of CVDs when applied to other vascular districts (e.g. carotid, aneurysm).

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The information about "AGORAS" are provided by the European Opendata Portal: CORDIS opendata.

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