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Mechanisms of recovery after severe spinal cord injury

Total Cost €


EC-Contrib. €






 HOW2WALKAGAIN project word cloud

Explore the words cloud of the HOW2WALKAGAIN project. It provides you a very rough idea of what is the project "HOW2WALKAGAIN" about.

operate    inactivation    mice    robotic    deploying    experimental    platform    pragmatic    cues    association    mediated    leg    ultimately    optogenetics    stimulations    recovery    chemical    disruptive    leads    spinal    rewiring    judicious    consists    seriously    generation    hindlimbs    underlying    enabled    neuroplasticity    injury    quality    remodelling    rehabilitation    diminish    longitudinal    virus    conversion    connections    clinical    functional    movement    function    starting    unknown    grant    govern    functions    principles    genetic    powered    therapies    fundamental    combine    paralysis    rats    team    supraspinal    acts    circuitry    individuals    perspectives    chronic    fertilize    immediately    mediate    assistance    calcium    cord    safer    severe    life    electrochemical    extensive    electrical    reorganisation    erc    windows    complete    restored    regimens    circuit    training    empirical    techniques    manipulations    ideas    termed    paralysed    stimulation    molecular    pivotal    behaving    residual    disabilities    mechanisms    causality    voluntary    unconstrained    frontier    reestablishes    injured    efficacious    intervention    gap    permanent    impairments    tracing    therapy    computational    motor    patients    strategy    tract    imaging    accelerating    time    framework    neuroprosthetic   

Project "HOW2WALKAGAIN" data sheet

The following table provides information about the project.


Organization address
address: BATIMENT CE 3316 STATION 1
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website
 Total cost 1˙998˙715 €
 EC max contribution 1˙998˙715 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Severe spinal cord injury leads to a range of disabilities, including permanent motor impairments that seriously diminish the patients’ quality of life. In the framework of an ERC Starting Grant, my team and I developed a pragmatic therapy that restored supraspinal control of leg movement after complete paralysis in rats. However, the mechanisms underlying the effects of this intervention remain unknown. This fundamental knowledge is pivotal to operate a disruptive conversion from our empirical approach to an evidence-based strategy with clinical perspectives. Our therapy, termed neuroprosthetic rehabilitation, acts over two time windows. Immediately, electrical and chemical spinal cord stimulations mediate motor control of the paralysed hindlimbs. In the long term, will-powered training regimens enabled by electrochemical stimulation and robotic assistance promote neuroplasticity of residual connections—an extensive rewiring that reestablishes voluntary movement. Here, we propose to identify the circuit-level remodelling, computational principles, and molecular cues that govern the immediate and long-term recovery of motor functions. To address this knowledge gap, we will use our unique neuroprosthetic platform and next-generation experimental techniques for longitudinal assessment of neuroplasticity and function in freely behaving mice. These techniques combine optogenetics, circuit-level inactivation techniques, unconstrained chronic calcium imaging, virus-mediated tract-tracing and genetic manipulations. Our strategy consists of deploying a judicious association of these experimental techniques to establish causality between the reorganisation of the motor circuitry and functional recovery. This project will fertilize frontier research with new knowledge and ideas, ultimately accelerating clinical implementation of safer and more efficacious therapies to improve the quality of life for spinal cord injured individuals.


year authors and title journal last update
List of publications.
2018 Marco Bonizzato, Galyna Pidpruzhnykova, Jack DiGiovanna, Polina Shkorbatova, Natalia Pavlova, Silvestro Micera, Grégoire Courtine
Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05282-6
Nature Communications 9/1 2019-02-25
2018 Marco Capogrosso, Fabien B. Wagner, Jerome Gandar, Eduardo Martin Moraud, Nikolaus Wenger, Tomislav Milekovic, Polina Shkorbatova, Natalia Pavlova, Pavel Musienko, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics
published pages: 2031-2061, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0030-9
Nature Protocols 13/9 2019-02-25
2018 Leonie Asboth, Lucia Friedli, Janine Beauparlant, Cristina Martinez-Gonzalez, Selin Anil, Elodie Rey, Laetitia Baud, Galyna Pidpruzhnykova, Mark A. Anderson, Polina Shkorbatova, Laura Batti, Stephane Pagès, Julie Kreider, Bernard L. Schneider, Quentin Barraud, Gregoire Courtine
Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion
published pages: 576-588, ISSN: 1097-6256, DOI: 10.1038/s41593-018-0093-5
Nature Neuroscience 21/4 2019-02-25
2018 Mark A. Anderson, Timothy M. O’Shea, Joshua E. Burda, Yan Ao, Sabry L. Barlatey, Alexander M. Bernstein, Jae H. Kim, Nicholas D. James, Alexandra Rogers, Brian Kato, Alexander L. Wollenberg, Riki Kawaguchi, Giovanni Coppola, Chen Wang, Timothy J. Deming, Zhigang He, Gregoire Courtine, Michael V. Sofroniew
Required growth facilitators propel axon regeneration across complete spinal cord injury
published pages: 396-400, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0467-6
Nature 561/7723 2019-02-25
2018 Marco Capogrosso, Jerome Gandar, Nathan Greiner, Eduardo Martin Moraud, Nikolaus Wenger, Polina Shkorbatova, Pavel Musienko, Ivan Minev, Stephanie Lacour, Grégoire Courtine
Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord
published pages: 26024, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aaa87a
Journal of Neural Engineering 15/2 2018-06-26
2018 Eduardo Martin Moraud, Joachim von Zitzewitz, Jenifer Miehlbradt, Sophie Wurth, Emanuele Formento, Jack DiGiovanna, Marco Capogrosso, Grégoire Courtine, Silvestro Micera
Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-18293-y
Scientific Reports 8/1 2018-06-26

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