Explore the words cloud of the HOW2WALKAGAIN project. It provides you a very rough idea of what is the project "HOW2WALKAGAIN" about.
The following table provides information about the project.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
|Coordinator Country||Switzerland [CH]|
|Total cost||1˙998˙715 €|
|EC max contribution||1˙998˙715 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-07-01 to 2021-06-30|
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|1||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||coordinator||1˙998˙715.00|
Severe spinal cord injury leads to a range of disabilities, including permanent motor impairments that seriously diminish the patients’ quality of life. In the framework of an ERC Starting Grant, my team and I developed a pragmatic therapy that restored supraspinal control of leg movement after complete paralysis in rats. However, the mechanisms underlying the effects of this intervention remain unknown. This fundamental knowledge is pivotal to operate a disruptive conversion from our empirical approach to an evidence-based strategy with clinical perspectives. Our therapy, termed neuroprosthetic rehabilitation, acts over two time windows. Immediately, electrical and chemical spinal cord stimulations mediate motor control of the paralysed hindlimbs. In the long term, will-powered training regimens enabled by electrochemical stimulation and robotic assistance promote neuroplasticity of residual connections—an extensive rewiring that reestablishes voluntary movement. Here, we propose to identify the circuit-level remodelling, computational principles, and molecular cues that govern the immediate and long-term recovery of motor functions. To address this knowledge gap, we will use our unique neuroprosthetic platform and next-generation experimental techniques for longitudinal assessment of neuroplasticity and function in freely behaving mice. These techniques combine optogenetics, circuit-level inactivation techniques, unconstrained chronic calcium imaging, virus-mediated tract-tracing and genetic manipulations. Our strategy consists of deploying a judicious association of these experimental techniques to establish causality between the reorganisation of the motor circuitry and functional recovery. This project will fertilize frontier research with new knowledge and ideas, ultimately accelerating clinical implementation of safer and more efficacious therapies to improve the quality of life for spinal cord injured individuals.
|year||authors and title||journal||last update|
Marco Bonizzato, Galyna Pidpruzhnykova, Jack DiGiovanna, Polina Shkorbatova, Natalia Pavlova, Silvestro Micera, GrÃ©goire Courtine
Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05282-6
|Nature Communications 9/1||2019-02-25|
Marco Capogrosso, Fabien B. Wagner, Jerome Gandar, Eduardo Martin Moraud, Nikolaus Wenger, Tomislav Milekovic, Polina Shkorbatova, Natalia Pavlova, Pavel Musienko, Erwan Bezard, Jocelyne Bloch, GrÃ©goire Courtine
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics
published pages: 2031-2061, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0030-9
|Nature Protocols 13/9||2019-02-25|
Leonie Asboth, Lucia Friedli, Janine Beauparlant, Cristina Martinez-Gonzalez, Selin Anil, Elodie Rey, Laetitia Baud, Galyna Pidpruzhnykova, Mark A. Anderson, Polina Shkorbatova, Laura Batti, Stephane PagÃ¨s, Julie Kreider, Bernard L. Schneider, Quentin Barraud, Gregoire Courtine
Corticoâ€“reticuloâ€“spinal circuit reorganization enables functional recovery after severe spinal cord contusion
published pages: 576-588, ISSN: 1097-6256, DOI: 10.1038/s41593-018-0093-5
|Nature Neuroscience 21/4||2019-02-25|
Mark A. Anderson, Timothy M. Oâ€™Shea, Joshua E. Burda, Yan Ao, Sabry L. Barlatey, Alexander M. Bernstein, Jae H. Kim, Nicholas D. James, Alexandra Rogers, Brian Kato, Alexander L. Wollenberg, Riki Kawaguchi, Giovanni Coppola, Chen Wang, Timothy J. Deming, Zhigang He, Gregoire Courtine, Michael V. Sofroniew
Required growth facilitators propel axon regeneration across complete spinal cord injury
published pages: 396-400, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0467-6
Marco Capogrosso, Jerome Gandar, Nathan Greiner, Eduardo Martin Moraud, Nikolaus Wenger, Polina Shkorbatova, Pavel Musienko, Ivan Minev, Stephanie Lacour, GrÃ©goire Courtine
Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord
published pages: 26024, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aaa87a
|Journal of Neural Engineering 15/2||2018-06-26|
Eduardo Martin Moraud, Joachim von Zitzewitz, Jenifer Miehlbradt, Sophie Wurth, Emanuele Formento, Jack DiGiovanna, Marco Capogrosso, GrÃ©goire Courtine, Silvestro Micera
Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-18293-y
|Scientific Reports 8/1||2018-06-26|
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