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InjectCHA

Local delivery of PTH(1-34) from an injectable collagen-hydroxyapatite scaffold for non-invasive treatment of bisphosphonate associated atypical femoral fractures

Total Cost €

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EC-Contrib. €

0

Partnership

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 InjectCHA project word cloud

Explore the words cloud of the InjectCHA project. It provides you a very rough idea of what is the project "InjectCHA" about.

orthopaedic    returned    input    innovative    bisphosphonate    lecturer    femoral    commercialisation    pth    backed    career    complementary    supervision    newly    scientific    employed    dublin    site    fractures    mortality    devastating    atypical    scaffold    msca    hope    revolutionary    lab    reporting    34    expert    requisite    levels    college    skills    outlines    attain    australia    university    therapeutic    clinical    fellow    treatment    david    osteoporotic    training    excruciating    recruit    load    bearing    active    supervise    ucd    summary    regenerative    equipping    embarking    local    remobilisation    invasive    financial    biomaterial    bone    tissue    postdoctoral    planning    morbidity    brayden    integrate    reintegration    filing    tackle    staff    successfully    drug    avail    injectable    me    academic    appointed    prof    utilising    away    having    pioneering    niche    colleagues    repair    group    aff    induce    affs    teriparatide    expertise    combines    works    invaluable    engineering    pain    independent    bp    tools    patent    grant    students    strategy    patients   

Project "InjectCHA" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website https://www.rcsi.com/people/profile/ciaramurphy
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2019-05-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 87˙933.00
2    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 87˙933.00

Map

 Project objective

Having recently returned to the EU following Postdoctoral training in Australia, I hope to work as a MSCA Reintegration Fellow to tackle a devastating clinical orthopaedic challenge for which there is currently no effective treatment. Specifically, bisphosphonate (BP) associated atypical femoral fractures (AFFs) in osteoporotic patients which are associated with excruciating pain and high levels of morbidity and mortality. The scientific goal of this proposal is to integrate my tools in bone tissue engineering with the advanced drug delivery expertise of Prof. David Brayden’s group at University College Dublin (UCD) to develop a novel injectable therapeutic scaffold as a non-invasive treatment for AFFs. This proposal outlines an innovative research project that aims to implement a revolutionary strategy utilising Teriparatide (PTH-(1-34)) to target BP remobilisation away from AFF site and induce bone repair. In addition, a tissue engineering strategy will be employed that combines a regenerative, load bearing biomaterial for controlled local delivery of PTH(1-34) as a pioneering advance for AFF treatment. As a newly appointed academic, the training objective of this grant is to attain the requisite scientific and complementary skills to successfully develop an independent research programme. This will be achieved through the expert supervision and input of Prof. Brayden and backed up by colleagues in the lab and UCD staff training activities. In addition, by managing the project, I will further develop skills relating to planning and reporting, financial management, dissemination, patent filing and commercialisation. I will also avail of opportunities to recruit and supervise students on this project or related works. In summary, this grant will provide invaluable help to establish an independent research niche in active and emerging research fields, while equipping me with the skills needed as a newly appointed lecturer embarking on an independent research career.

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The information about "INJECTCHA" are provided by the European Opendata Portal: CORDIS opendata.

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