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InjectCHA

Local delivery of PTH(1-34) from an injectable collagen-hydroxyapatite scaffold for non-invasive treatment of bisphosphonate associated atypical femoral fractures

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 InjectCHA project word cloud

Explore the words cloud of the InjectCHA project. It provides you a very rough idea of what is the project "InjectCHA" about.

revolutionary    excruciating    drug    affs    reintegration    avail    financial    patients    having    input    morbidity    supervision    osteoporotic    utilising    college    commercialisation    strategy    bone    scaffold    local    appointed    planning    regenerative    levels    treatment    induce    bisphosphonate    pain    successfully    university    tackle    equipping    away    lecturer    me    summary    complementary    backed    aff    group    site    mortality    employed    fellow    expertise    invaluable    orthopaedic    biomaterial    requisite    filing    bp    remobilisation    bearing    teriparatide    repair    invasive    combines    patent    returned    niche    scientific    injectable    expert    lab    embarking    active    students    innovative    colleagues    grant    brayden    attain    ucd    34    femoral    outlines    prof    clinical    fractures    staff    pioneering    therapeutic    supervise    load    works    reporting    msca    engineering    integrate    academic    training    postdoctoral    pth    skills    devastating    tissue    david    atypical    recruit    independent    career    dublin    hope    newly    australia    tools   

Project "InjectCHA" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website https://www.rcsi.com/people/profile/ciaramurphy
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2019-05-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 87˙933.00
2    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 87˙933.00

Map

 Project objective

Having recently returned to the EU following Postdoctoral training in Australia, I hope to work as a MSCA Reintegration Fellow to tackle a devastating clinical orthopaedic challenge for which there is currently no effective treatment. Specifically, bisphosphonate (BP) associated atypical femoral fractures (AFFs) in osteoporotic patients which are associated with excruciating pain and high levels of morbidity and mortality. The scientific goal of this proposal is to integrate my tools in bone tissue engineering with the advanced drug delivery expertise of Prof. David Brayden’s group at University College Dublin (UCD) to develop a novel injectable therapeutic scaffold as a non-invasive treatment for AFFs. This proposal outlines an innovative research project that aims to implement a revolutionary strategy utilising Teriparatide (PTH-(1-34)) to target BP remobilisation away from AFF site and induce bone repair. In addition, a tissue engineering strategy will be employed that combines a regenerative, load bearing biomaterial for controlled local delivery of PTH(1-34) as a pioneering advance for AFF treatment. As a newly appointed academic, the training objective of this grant is to attain the requisite scientific and complementary skills to successfully develop an independent research programme. This will be achieved through the expert supervision and input of Prof. Brayden and backed up by colleagues in the lab and UCD staff training activities. In addition, by managing the project, I will further develop skills relating to planning and reporting, financial management, dissemination, patent filing and commercialisation. I will also avail of opportunities to recruit and supervise students on this project or related works. In summary, this grant will provide invaluable help to establish an independent research niche in active and emerging research fields, while equipping me with the skills needed as a newly appointed lecturer embarking on an independent research career.

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The information about "INJECTCHA" are provided by the European Opendata Portal: CORDIS opendata.

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