Explore the words cloud of the NanoStaph project. It provides you a very rough idea of what is the project "NanoStaph" about.
The following table provides information about the project.
UNIVERSITE CATHOLIQUE DE LOUVAIN
|Coordinator Country||Belgium [BE]|
|Total cost||2˙481˙437 €|
|EC max contribution||2˙481˙437 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-10-01 to 2021-09-30|
Take a look of project's partnership.
|1||UNIVERSITE CATHOLIQUE DE LOUVAIN||BE (LOUVAIN LA NEUVE)||coordinator||2˙481˙437.00|
Staphylococcus aureus is a leading cause of hospital-acquired infections, which are often complicated by the ability of this pathogen to grow as biofilms on indwelling medical devices. Because biofilms protect the bacteria from host defenses and are resistant to many antibiotics, biofilm-related infections are difficult to fight and represent a tremendous burden on our healthcare system. Today, a true molecular understanding of the fundamental interactions driving staphylococcal adhesion and biofilm formation is lacking owing to the lack of high-resolution probing techniques. This knowledge would greatly contribute to the development of novel anti-adhesion therapies for combating biofilm infections.
We recently established advanced atomic force microscopy (AFM) techniques for analyzing the nanoscale surface architecture and interactions of microbial cells, allowing us to elucidate key cellular functions. This multidisciplinary project aims at developing an innovative AFM-based force nanoscopy platform in biofilm research, enabling us to understand the molecular mechanisms of S. aureus adhesion in a way that was not possible before, and to optimize the use of anti-adhesion compounds capable to inhibit biofilm formation by this pathogen.
NanoStaph will have strong scientific, societal and economical impacts. From the technical perspective, force nanoscopy will represent an unconventional methodology for the high throughput and high resolution characterization of adhesion forces in living cells, especially in bacterial pathogens. In microbiology, the results will radically transform our perception of the molecular bases of biofilm formation by S. aureus. In medicine, the project will provide a new screening method for the fast, label-free analysis of anti-adhesion compounds targeting S. aureus strains, including antibiotic-resistant clinical isolates that are notoriously difficult to treat, thus paving the way to the development of anti-adhesion therapies.
|year||authors and title||journal||last update|
Valeria Prystopiuk, CÃ©cile Feuillie, Philippe Herman-Bausier, Felipe Viela, David Alsteens, Giampiero Pietrocola, Pietro Speziale, Yves F. DufrÃªne
Mechanical Forces Guiding Staphylococcus aureus Cellular Invasion
published pages: 3609-3622, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b00716
|ACS Nano 12/4||2019-12-16|
Philippe Herman-Bausier, Giampiero Pietrocola, Timothy J. Foster, Pietro Speziale, Yves F. DufrÃªne
Fibrinogen Activates the Capture of Human Plasminogen by Staphylococcal Fibronectin-Binding Proteins
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01067-17
CÃ©cile Feuillie, CÃ©cile Formosa-Dague, Leanne M. C. Hays, OphÃ©lie Vervaeck, Sylvie Derclaye, Marian P. Brennan, Timothy J. Foster, Joan A. Geoghegan, Yves F. DufrÃªne
Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC
published pages: 3738-3743, ISSN: 0027-8424, DOI: 10.1073/pnas.1616805114
|Proceedings of the National Academy of Sciences 114/14||2019-06-13|
Claire Valotteau, Valeria Prystopiuk, Giampiero Pietrocola, Simonetta Rindi, Daniele Peterle, Vincenzo De Filippis, Timothy J. Foster, Pietro Speziale, Yves F. DufrÃªne
Single-Cell and Single-Molecule Analysis Unravels the Multifunctionality of the Staphylococcus aureus Collagen-Binding Protein Cna
published pages: 2160-2170, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b08404
|ACS Nano 11/2||2019-06-13|
Philippe Herman-Bausier, Yves F. DufrÃªne
Force matters in hospital-acquired infections
published pages: 1464-1465, ISSN: 0036-8075, DOI: 10.1126/science.aat3764
Joan A. Geoghegan, Timothy J. Foster, Pietro Speziale, Yves F. DufrÃªne
Live-Cell Nanoscopy in Antiadhesion Therapy
published pages: 512-514, ISSN: 0966-842X, DOI: 10.1016/j.tim.2017.04.002
|Trends in Microbiology 25/7||2019-06-06|
Philippe Herman-Bausier, Cristina Labate, Aisling M. Towell, Sylvie Derclaye, Joan A. Geoghegan, Yves F. DufrÃªne
Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion
published pages: 5564-5569, ISSN: 0027-8424, DOI: 10.1073/pnas.1718104115
|Proceedings of the National Academy of Sciences 115/21||2019-06-06|
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The information about "NANOSTAPH" are provided by the European Opendata Portal: CORDIS opendata.
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