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NanoStaph SIGNED

Force nanoscopy of staphylococcal biofilms

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NanoStaph project word cloud

Explore the words cloud of the NanoStaph project. It provides you a very rough idea of what is the project "NanoStaph" about.

surface    label    medicine    tremendous    defenses    afm    perception    paving    economical    bases    staphylococcus    resolution    interactions    transform    platform    pathogens    force    functions    burden    impacts    forces    compounds    fight    microbiology    clinical    aureus    microbial    treat    optimize    mechanisms    methodology    throughput    analyzing    biofilms    inhibit    atomic    radically    unconventional    complicated    true    characterization    adhesion    free    notoriously    acquired    hospital    grow    architecture    antibiotic    perspective    molecular    biofilm    healthcare    nanoscale    nanoscopy    multidisciplinary    scientific    protect    driving    medical    resistant    antibiotics    techniques    fundamental    host    strains    cells    understand    lacking    infections    combating    bacteria    probing    innovative    societal    therapies    cellular    screening    elucidate    living    nanostaph    fast    anti    difficult    owing    isolates    bacterial    microscopy    indwelling    staphylococcal    lack    pathogen   

Project "NanoStaph" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE CATHOLIQUE DE LOUVAIN 

Organization address
address: PLACE DE L UNIVERSITE 1
city: LOUVAIN LA NEUVE
postcode: 1348
website: www.uclouvain.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://uclouvain.be/fr/node/23992
 Total cost 2˙481˙437 €
 EC max contribution 2˙481˙437 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) coordinator 2˙481˙437.00

Map

 Project objective

Staphylococcus aureus is a leading cause of hospital-acquired infections, which are often complicated by the ability of this pathogen to grow as biofilms on indwelling medical devices. Because biofilms protect the bacteria from host defenses and are resistant to many antibiotics, biofilm-related infections are difficult to fight and represent a tremendous burden on our healthcare system. Today, a true molecular understanding of the fundamental interactions driving staphylococcal adhesion and biofilm formation is lacking owing to the lack of high-resolution probing techniques. This knowledge would greatly contribute to the development of novel anti-adhesion therapies for combating biofilm infections.

We recently established advanced atomic force microscopy (AFM) techniques for analyzing the nanoscale surface architecture and interactions of microbial cells, allowing us to elucidate key cellular functions. This multidisciplinary project aims at developing an innovative AFM-based force nanoscopy platform in biofilm research, enabling us to understand the molecular mechanisms of S. aureus adhesion in a way that was not possible before, and to optimize the use of anti-adhesion compounds capable to inhibit biofilm formation by this pathogen.

NanoStaph will have strong scientific, societal and economical impacts. From the technical perspective, force nanoscopy will represent an unconventional methodology for the high throughput and high resolution characterization of adhesion forces in living cells, especially in bacterial pathogens. In microbiology, the results will radically transform our perception of the molecular bases of biofilm formation by S. aureus. In medicine, the project will provide a new screening method for the fast, label-free analysis of anti-adhesion compounds targeting S. aureus strains, including antibiotic-resistant clinical isolates that are notoriously difficult to treat, thus paving the way to the development of anti-adhesion therapies.

 Publications

year authors and title journal last update
List of publications.
2018 Valeria Prystopiuk, Cécile Feuillie, Philippe Herman-Bausier, Felipe Viela, David Alsteens, Giampiero Pietrocola, Pietro Speziale, Yves F. Dufrêne
Mechanical Forces Guiding Staphylococcus aureus Cellular Invasion
published pages: 3609-3622, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b00716
ACS Nano 12/4 2019-12-16
2017 Philippe Herman-Bausier, Giampiero Pietrocola, Timothy J. Foster, Pietro Speziale, Yves F. Dufrêne
Fibrinogen Activates the Capture of Human Plasminogen by Staphylococcal Fibronectin-Binding Proteins
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01067-17
mBio 8/5 2019-06-13
2017 Cécile Feuillie, Cécile Formosa-Dague, Leanne M. C. Hays, Ophélie Vervaeck, Sylvie Derclaye, Marian P. Brennan, Timothy J. Foster, Joan A. Geoghegan, Yves F. Dufrêne
Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC
published pages: 3738-3743, ISSN: 0027-8424, DOI: 10.1073/pnas.1616805114
Proceedings of the National Academy of Sciences 114/14 2019-06-13
2017 Claire Valotteau, Valeria Prystopiuk, Giampiero Pietrocola, Simonetta Rindi, Daniele Peterle, Vincenzo De Filippis, Timothy J. Foster, Pietro Speziale, Yves F. Dufrêne
Single-Cell and Single-Molecule Analysis Unravels the Multifunctionality of the Staphylococcus aureus Collagen-Binding Protein Cna
published pages: 2160-2170, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b08404
ACS Nano 11/2 2019-06-13
2018 Philippe Herman-Bausier, Yves F. Dufrêne
Force matters in hospital-acquired infections
published pages: 1464-1465, ISSN: 0036-8075, DOI: 10.1126/science.aat3764
Science 359/6383 2019-06-07
2017 Joan A. Geoghegan, Timothy J. Foster, Pietro Speziale, Yves F. Dufrêne
Live-Cell Nanoscopy in Antiadhesion Therapy
published pages: 512-514, ISSN: 0966-842X, DOI: 10.1016/j.tim.2017.04.002
Trends in Microbiology 25/7 2019-06-06
2018 Philippe Herman-Bausier, Cristina Labate, Aisling M. Towell, Sylvie Derclaye, Joan A. Geoghegan, Yves F. Dufrêne
Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion
published pages: 5564-5569, ISSN: 0027-8424, DOI: 10.1073/pnas.1718104115
Proceedings of the National Academy of Sciences 115/21 2019-06-06

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