NanoStaph SIGNED
Force nanoscopy of staphylococcal biofilms
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the NanoStaph project. It provides you a very rough idea of what is the project "NanoStaph" about.
Project "NanoStaph" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITE CATHOLIQUE DE LOUVAIN
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Project website | https://uclouvain.be/fr/node/23992 |
| Total cost | 2˙481˙437 € |
| EC max contribution | 2˙481˙437 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2021-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITE CATHOLIQUE DE LOUVAIN | BE (LOUVAIN LA NEUVE) | coordinator | 2˙481˙437.00 |
Map
Project objective
Staphylococcus aureus is a leading cause of hospital-acquired infections, which are often complicated by the ability of this pathogen to grow as biofilms on indwelling medical devices. Because biofilms protect the bacteria from host defenses and are resistant to many antibiotics, biofilm-related infections are difficult to fight and represent a tremendous burden on our healthcare system. Today, a true molecular understanding of the fundamental interactions driving staphylococcal adhesion and biofilm formation is lacking owing to the lack of high-resolution probing techniques. This knowledge would greatly contribute to the development of novel anti-adhesion therapies for combating biofilm infections.
We recently established advanced atomic force microscopy (AFM) techniques for analyzing the nanoscale surface architecture and interactions of microbial cells, allowing us to elucidate key cellular functions. This multidisciplinary project aims at developing an innovative AFM-based force nanoscopy platform in biofilm research, enabling us to understand the molecular mechanisms of S. aureus adhesion in a way that was not possible before, and to optimize the use of anti-adhesion compounds capable to inhibit biofilm formation by this pathogen.
NanoStaph will have strong scientific, societal and economical impacts. From the technical perspective, force nanoscopy will represent an unconventional methodology for the high throughput and high resolution characterization of adhesion forces in living cells, especially in bacterial pathogens. In microbiology, the results will radically transform our perception of the molecular bases of biofilm formation by S. aureus. In medicine, the project will provide a new screening method for the fast, label-free analysis of anti-adhesion compounds targeting S. aureus strains, including antibiotic-resistant clinical isolates that are notoriously difficult to treat, thus paving the way to the development of anti-adhesion therapies.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Valeria Prystopiuk, Cécile Feuillie, Philippe Herman-Bausier, Felipe Viela, David Alsteens, Giampiero Pietrocola, Pietro Speziale, Yves F. Dufrêne Mechanical Forces Guiding Staphylococcus aureus Cellular Invasion published pages: 3609-3622, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b00716 |
ACS Nano 12/4 | 2019-12-16 |
| 2017 |
Philippe Herman-Bausier, Giampiero Pietrocola, Timothy J. Foster, Pietro Speziale, Yves F. Dufrêne Fibrinogen Activates the Capture of Human Plasminogen by Staphylococcal Fibronectin-Binding Proteins published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01067-17 |
mBio 8/5 | 2019-06-13 |
| 2017 |
Cécile Feuillie, Cécile Formosa-Dague, Leanne M. C. Hays, Ophélie Vervaeck, Sylvie Derclaye, Marian P. Brennan, Timothy J. Foster, Joan A. Geoghegan, Yves F. Dufrêne Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC published pages: 3738-3743, ISSN: 0027-8424, DOI: 10.1073/pnas.1616805114 |
Proceedings of the National Academy of Sciences 114/14 | 2019-06-13 |
| 2017 |
Claire Valotteau, Valeria Prystopiuk, Giampiero Pietrocola, Simonetta Rindi, Daniele Peterle, Vincenzo De Filippis, Timothy J. Foster, Pietro Speziale, Yves F. Dufrêne Single-Cell and Single-Molecule Analysis Unravels the Multifunctionality of the Staphylococcus aureus Collagen-Binding Protein Cna published pages: 2160-2170, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b08404 |
ACS Nano 11/2 | 2019-06-13 |
| 2018 |
Philippe Herman-Bausier, Yves F. Dufrêne Force matters in hospital-acquired infections published pages: 1464-1465, ISSN: 0036-8075, DOI: 10.1126/science.aat3764 |
Science 359/6383 | 2019-06-07 |
| 2017 |
Joan A. Geoghegan, Timothy J. Foster, Pietro Speziale, Yves F. Dufrêne Live-Cell Nanoscopy in Antiadhesion Therapy published pages: 512-514, ISSN: 0966-842X, DOI: 10.1016/j.tim.2017.04.002 |
Trends in Microbiology 25/7 | 2019-06-06 |
| 2018 |
Philippe Herman-Bausier, Cristina Labate, Aisling M. Towell, Sylvie Derclaye, Joan A. Geoghegan, Yves F. Dufrêne Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion published pages: 5564-5569, ISSN: 0027-8424, DOI: 10.1073/pnas.1718104115 |
Proceedings of the National Academy of Sciences 115/21 | 2019-06-06 |
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