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CSI.interface SIGNED

A molecular interface science approach: Decoding single molecular reactions and interactions at dynamic solid/liquid interfaces

Total Cost €


EC-Contrib. €






 CSI.interface project word cloud

Explore the words cloud of the CSI.interface project. It provides you a very rough idea of what is the project "CSI.interface" about.

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Project "CSI.interface" data sheet

The following table provides information about the project.


Organization address
address: KARLSPLATZ 13
city: WIEN
postcode: 1040

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 1˙499˙750 €
 EC max contribution 1˙499˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 1˙146˙875.00


 Project objective

After decades of truly transformative advancements in single molecule (bio)physics and surface science, it is still no more than a vision to predict and control macroscopic phenomena such as adhesion or electrochemical reaction rates at solid/liquid interfaces based on well-characterized single molecular interactions. How exactly do inherently dynamic and simultaneous interactions of a countless number of interacting “crowded” molecules lead to a concerted outcome/property on a macroscopic scale? Here, I propose a unique approach that will allow us to unravel the scaling of single molecule interactions towards macroscopic properties at adhesive and redox-active solid/liquid interfaces. Combining Atomic Force Microscopy (AFM) based single molecule force spectroscopy and macroscopic Surface Forces Apparatus (SFA) experiments CSI.interface will (1) derive rules for describing nonlinearities observed in complex, crowded (water and ions) and chemically diverse adhesive solid/liquid interfaces; (2) uniquely characterize all relevant kinetic parameters (interaction free energy and transition states) of electrochemical and adhesive reactions/interactions of single molecules at chemically defined surfaces as well as electrified single crystal facets and step edges. Complementary, (3) my team and I will build a novel molecular force apparatus in order to measure single-molecule steady-state dynamics of both redox cycles as well as binding unbinding cycles of specific interactions, and how these react to environmental triggers. CSI.interface goes well beyond present applications of AFM and SFA and has the long-term potential to revolutionize our understanding of interfacial interaction under steady state, responsive and dynamic conditions. This work will pave the road for knowledge based designing of next-generation technologies in gluing, coating, bio-adhesion, materials design and much beyond.


year authors and title journal last update
List of publications.
2017 Philipp Stock, Jacob I. Monroe, Thomas Utzig, David J. Smith, M. Scott Shell, Markus Valtiner
Unraveling Hydrophobic Interactions at the Molecular Scale Using Force Spectroscopy and Molecular Dynamics Simulations
published pages: 2586-2597, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b06360
ACS Nano 11/3 2019-06-19
2017 Qingyun Hu, Christian Weber, Hsiu-Wei Cheng, Frank Uwe Renner, Markus Valtiner
Anion Layering and Steric Hydration Repulsion on Positively Charged Surfaces in Aqueous Electrolytes
published pages: 3056-3065, ISSN: 1439-4235, DOI: 10.1002/cphc.201700865
ChemPhysChem 18/21 2019-06-19
2019 Claudia Merola, Hsiu‐Wei Cheng, Dominik Dworschak, Ching‐Shun Ku, Ching‐Yu Chiang, Frank Uwe Renner, Markus Valtiner
Nanometer Resolved Real Time Visualization of Acidification and Material Breakdown in Confinement
published pages: 1802069, ISSN: 2196-7350, DOI: 10.1002/admi.201802069
Advanced Materials Interfaces 2019-05-27
2019 Kai A. Schwenzfeier, Andreas Erbe, Pierluigi Bilotto, Maximilian Lengauer, Claudia Merola, Hsiu-Wei Cheng, Laura L. E. Mears, Markus Valtiner
Optimizing multiple beam interferometry in the surface forces apparatus: Novel optics, reflection mode modeling, metal layer thicknesses, birefringence, and rotation of anisotropic layers
published pages: 43908, ISSN: 0034-6748, DOI: 10.1063/1.5085210
Review of Scientific Instruments 90/4 2019-05-27
2017 Laila Moreno Ostertag, Thomas Utzig, Christine Klinger, Markus Valtiner
Tether-Length Dependence of Bias in Equilibrium Free-Energy Estimates for Surface-to-Molecule Unbinding Experiments
published pages: 766-772, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.7b02844
Langmuir 34/3 2019-03-12

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