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MitoVin SIGNED

Mechanism and Consequences of the Interplay between Mitosis and Human Papillomavirus Initial Infection

Total Cost €

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EC-Contrib. €

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Partnership

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 MitoVin project word cloud

Explore the words cloud of the MitoVin project. It provides you a very rough idea of what is the project "MitoVin" about.

mechanism    damage    envelope    import    differentiation    malignant    hijacked    tissue    spatial    hpv    papillomavirus    influence    epithelia    infects    initial    function    nuclear    temporal    arise    biochemistry    mitotic    elucidate    differentially    causes    revealed    beneficiary    endocytosis    viruses    prolonged    cycle    paradigm    regulatory    squamous    breakdown    indicated    microscopy    errors    interactions    virology    aging    host    advantage    incoming    turn    ascertain    infection    16    coupled    valuable    segregation    manner    understudied    takes    requirement    occurs    hpv16    human    tools    nonenveloped    metaphase    unravel    complexity    cellular    serve    reveal    biology    l2    life    space    temporally    virus    machinery    thereof    minimal    uncover    dna    prolongation    proteomics    mimics    cell    mitosis    cancer    cells    recruitment    mediate    protein    chromatin    association    causing    regulate    insights    tissues    viral    modulates    small   

Project "MitoVin" data sheet

The following table provides information about the project.

Coordinator
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER 

Organization address
address: SCHLOSSPLATZ 2
city: Munster
postcode: 48149
website: www.uni-muenster.de/en/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙868˙993 €
 EC max contribution 1˙868˙993 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (Munster) coordinator 1˙868˙993.00

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 Project objective

Human Papillomavirus Type 16 (HPV16), the paradigm cancer-causing HPV type, is a small, nonenveloped, DNA virus characterized by its complex life cycle coupled to differentiation of squamous epithelia. Due to this complexity, how HPV16 infects cells is an understudied field of research. Our previous work to define the cellular pathways that are hijacked for initial infection revealed uptake by a novel endocytosis mechanism, and the requirement for mitosis for nuclear delivery. Our findings indicated that nuclear envelope breakdown was required to access the nuclear space, and that the virus associated with mitotic chromatin during metaphase. This prolonged mitosis, a process beneficiary for infection. The viral L2 protein as part of incoming viruses mimics this on its own. The aim of this proposal is to reveal how HPV16 differentially modulates or takes advantage of the mitotic machinery for nuclear import in cells, tissues or during aging, and whether malignant cellular consequences arise. On the viral side, we will define the minimal properties of L2 to mediate association with cell chromatin and mitosis prolongation. On the cellular side, we will identify the protein(s) that mediate recruitment, and how it occurs in a detailed temporal/spatial manner. To elucidate the mechanism of mitotic prolongation and consequences thereof, we will identify which regulatory complex of mitosis is targeted, how it is induced, and whether it causes DNA damage or segregation errors. Finally, we will ascertain the influence of tissue differentiation and aging on this process. Using systems biology, proteomics, virology, cell biology, biochemistry, and a wide range of microscopy approaches we will unravel the complex interactions between HPV and the host cell mitosis machinery. In turn, as viruses often serve as valuable tools to study cell function, this work is likely to uncover new insights into how cells spatially and temporally regulate mitosis in differentiation and aging.

 Publications

year authors and title journal last update
List of publications.
2019 Victor U. Weiss, Ronja Pogan, Samuele Zoratto, Kevin M. Bond, Pascale Boulanger, Martin F. Jarrold, Nicholas Lyktey, Dominik Pahl, Nicole Puffler, Mario Schelhaas, Ekaterina Selivanovitch, Charlotte Uetrecht, Günter Allmaier
Virus-like particle size and molecular weight/mass determination applying gas-phase electrophoresis (native nES GEMMA)
published pages: 5951-5962, ISSN: 1618-2642, DOI: 10.1007/s00216-019-01998-6
Analytical and Bioanalytical Chemistry 411/23 2019-12-16
2019 Mario Schelhaas
Interview—Mario Schelhaas
published pages: , ISSN: 1462-5814, DOI: 10.1111/cmi.13139
Cellular Microbiology 2019-12-16
2017 Mario Schelhaas
Viruses and cancer: molecular relations and perspectives
published pages: 815-816, ISSN: 1431-6730, DOI: 10.1515/hsz-2017-0176
Biological Chemistry 398/8 2019-11-07
2018 Theresia E. B. Stradal, Mario Schelhaas
Actin dynamics in host–pathogen interaction
published pages: 3658-3669, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13173
FEBS Letters 592/22 2019-11-07

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