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MitoVin SIGNED

Mechanism and Consequences of the Interplay between Mitosis and Human Papillomavirus Initial Infection

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MitoVin project word cloud

Explore the words cloud of the MitoVin project. It provides you a very rough idea of what is the project "MitoVin" about.

mechanism damage envelope import differentiation malignant hijacked tissue spatial hpv papillomavirus influence epithelia infects initial function nuclear temporal arise biochemistry mitotic elucidate differentially causes revealed beneficiary endocytosis viruses prolonged cycle paradigm regulatory squamous breakdown indicated microscopy errors interactions virology aging host advantage incoming turn ascertain infection 16 coupled valuable segregation manner understudied takes requirement occurs hpv16 human tools nonenveloped metaphase unravel complexity cellular serve reveal biology l2 life space temporally virus machinery thereof minimal uncover dna prolongation proteomics mimics cell mitosis cancer cells recruitment mediate protein chromatin association causing regulate insights tissues viral modulates small

Project "MitoVin" data sheet

The following table provides information about the project.

Coordinator	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: Munster postcode: 48149 website: www.uni-muenster.de/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	1˙868˙993 €
EC max contribution	1˙868˙993 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-CoG
Funding Scheme	ERC-COG
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: Munster postcode: 48149 website: www.uni-muenster.de/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Munster)	coordinator	1˙868˙993.00

Map

Project objective

Human Papillomavirus Type 16 (HPV16), the paradigm cancer-causing HPV type, is a small, nonenveloped, DNA virus characterized by its complex life cycle coupled to differentiation of squamous epithelia. Due to this complexity, how HPV16 infects cells is an understudied field of research. Our previous work to define the cellular pathways that are hijacked for initial infection revealed uptake by a novel endocytosis mechanism, and the requirement for mitosis for nuclear delivery. Our findings indicated that nuclear envelope breakdown was required to access the nuclear space, and that the virus associated with mitotic chromatin during metaphase. This prolonged mitosis, a process beneficiary for infection. The viral L2 protein as part of incoming viruses mimics this on its own. The aim of this proposal is to reveal how HPV16 differentially modulates or takes advantage of the mitotic machinery for nuclear import in cells, tissues or during aging, and whether malignant cellular consequences arise. On the viral side, we will define the minimal properties of L2 to mediate association with cell chromatin and mitosis prolongation. On the cellular side, we will identify the protein(s) that mediate recruitment, and how it occurs in a detailed temporal/spatial manner. To elucidate the mechanism of mitotic prolongation and consequences thereof, we will identify which regulatory complex of mitosis is targeted, how it is induced, and whether it causes DNA damage or segregation errors. Finally, we will ascertain the influence of tissue differentiation and aging on this process. Using systems biology, proteomics, virology, cell biology, biochemistry, and a wide range of microscopy approaches we will unravel the complex interactions between HPV and the host cell mitosis machinery. In turn, as viruses often serve as valuable tools to study cell function, this work is likely to uncover new insights into how cells spatially and temporally regulate mitosis in differentiation and aging.

Publications

List of publications.
year	authors and title	journal	last update
2019	Victor U. Weiss, Ronja Pogan, Samuele Zoratto, Kevin M. Bond, Pascale Boulanger, Martin F. Jarrold, Nicholas Lyktey, Dominik Pahl, Nicole Puffler, Mario Schelhaas, Ekaterina Selivanovitch, Charlotte Uetrecht, GÃ¼nter Allmaier Virus-like particle size and molecular weight/mass determination applying gas-phase electrophoresis (native nES GEMMA) published pages: 5951-5962, ISSN: 1618-2642, DOI: 10.1007/s00216-019-01998-6	Analytical and Bioanalytical Chemistry 411/23	2019-12-16
2019	Mario Schelhaas Interviewâ€”Mario Schelhaas published pages: , ISSN: 1462-5814, DOI: 10.1111/cmi.13139	Cellular Microbiology	2019-12-16
2017	Mario Schelhaas Viruses and cancer: molecular relations and perspectives published pages: 815-816, ISSN: 1431-6730, DOI: 10.1515/hsz-2017-0176	Biological Chemistry 398/8	2019-11-07
2018	Theresia E. B. Stradal, Mario Schelhaas Actin dynamics in hostâ€“pathogen interaction published pages: 3658-3669, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13173	FEBS Letters 592/22	2019-11-07

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