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DENDRITECIRCUITS SIGNED

The origins of dendritic computation within mammalian neural circuits

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Project "DENDRITECIRCUITS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.dendrites.org
 Total cost 2˙495˙563 €
 EC max contribution 2˙495˙563 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 2˙495˙563.00

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 Project objective

This proposal aims to address a simple question: what is the fundamental unit of computation in the brain? Answering this question is crucial not only for understanding how the brain works, but also if we are to build accurate models of brain function, which require abstraction based on identification of the essential elements for carrying out computations relevant to behaviour. In this proposal, we will build on recent work demonstrating that dendrites are highly electrically excitable to test the possibility that single dendritic branches may act as individual computational units during behaviour, challenging the classical view that the neuron is the fundamental unit of computation. We will address this question using a combination of electrophysiolgical, anatomical, imaging, molecular, and modeling approaches to probe dendritic integration in pyramidal cells and Purkinje cells in mouse cortex and cerebellum.

We will first define the computational rules for integration of synaptic input in single and multiple dendrites by examining the somatic and dendritic responses to different spatiotemporal patterns of excitatory and inhibitory inputs in brain slices. Next, we will determine how these rules are engaged by patterns of sensory stimulation in vivo, by using various strategies to map the spatiotemporal patterns of synaptic inputs onto single dendrites. To understand how physiological patterns of activity in the circuit engage these dendritic computations, we will use anatomical approaches to map the wiring diagram of synaptic inputs to individual dendrites. Finally, we will perturb the dendritic computational rules by manipulating dendritic function using molecular and optogenetic tools, in order to provide causal links between specific dendritic computations and sensory processing relevant to behaviour.

These experiments will provide us with deeper insights into how single neurons act as computing devices.

 Publications

year authors and title journal last update
List of publications.
2017 Christoph Schmidt-Hieber, Gabija Toleikyte, Laurence Aitchison, Arnd Roth, Beverley A Clark, Tiago Branco, Michael Häusser
Active dendritic integration as a mechanism for robust and precise grid cell firing
published pages: 1114-1121, ISSN: 1097-6256, DOI: 10.1038/nn.4582
Nature Neuroscience 20/8 2019-08-05
2018 Zihui Zhang, Lloyd E. Russell, Adam M. Packer, Oliver M. Gauld, Michael Häusser
Closed-loop all-optical interrogation of neural circuits in vivo
published pages: 1037-1040, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0183-z
Nature Methods 15/12 2019-08-06
2019 Dimitar Kostadinov, Maxime Beau, Marta Blanco Pozo, Michael Häusser
Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells
published pages: 950-962, ISSN: 1097-6256, DOI: 10.1038/s41593-019-0381-8
Nature Neuroscience 22/6 2019-08-05
2016 Zachary F. Mainen, Michael Häusser, Alexandre Pouget
A better way to crack the brain
published pages: 159-161, ISSN: 0028-0836, DOI: 10.1038/539159a
Nature 539/7628 2019-08-06
2017 Lorenza Magno, Caswell Barry, Christoph Schmidt-Hieber, Polyvios Theodotou, Michael Häusser, Nicoletta Kessaris
NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory
published pages: 1572-1584, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.07.053
Cell Reports 20/7 2019-08-06
2017 Nicholas A. Steinmetz, Christina Buetfering, Jerome Lecoq, Christian R. Lee, Andrew J. Peters, Elina A. K. Jacobs, Philip Coen, Douglas R. Ollerenshaw, Matthew T. Valley, Saskia E. J. de Vries, Marina Garrett, Jun Zhuang, Peter A. Groblewski, Sahar Manavi, Jesse Miles, Casey White, Eric Lee, Fiona Griffin, Joshua D. Larkin, Kate Roll, Sissy Cross, Thuyanh V. Nguyen, Rachael Larsen, Julie Pendergra
Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines
published pages: ENEURO.0207-17.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0207-17.2017
eneuro 4/5 2019-08-06
2016 Joshua T. Vogelstein, Brett Mensh, Michael Häusser, Nelson Spruston, Alan C. Evans, Konrad Kording, Katrin Amunts, Christoph Ebell, Jeff Muller, Martin Telefont, Sean Hill, Sandhya P. Koushika, Corrado Calì, Pedro Antonio Valdés-Sosa, Peter B. Littlewood, Christof Koch, Stephan Saalfeld, Adam Kepecs, Hanchuan Peng, Yaroslav O. Halchenko, Gregory Kiar, Mu-Ming Poo, Jean-Baptiste Poline, Michael
To the Cloud! A Grassroots Proposal to Accelerate Brain Science Discovery
published pages: 622-627, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.10.033
Neuron 92/3 2019-08-06
2017 James J. Jun, Nicholas A. Steinmetz, Joshua H. Siegle, Daniel J. Denman, Marius Bauza, Brian Barbarits, Albert K. Lee, Costas A. Anastassiou, Alexandru Andrei, Çağatay Aydın, Mladen Barbic, Timothy J. Blanche, Vincent Bonin, João Couto, Barundeb Dutta, Sergey L. Gratiy, Diego A. Gutnisky, Michael Häusser, Bill Karsh, Peter Ledochowitsch, Carolina Mora Lopez, Catalin Mitelut, Silke Musa, Micha
Fully integrated silicon probes for high-density recording of neural activity
published pages: 232-236, ISSN: 0028-0836, DOI: 10.1038/nature24636
Nature 551/7679 2019-08-06
2017 Larry F. Abbott, Dora E. Angelaki, Matteo Carandini, Anne K. Churchland, Yang Dan, Peter Dayan, Sophie Deneve, Ila Fiete, Surya Ganguli, Kenneth D. Harris, Michael Häusser, Sonja Hofer, Peter E. Latham, Zachary F. Mainen, Thomas Mrsic-Flogel, Liam Paninski, Jonathan W. Pillow, Alexandre Pouget, Karel Svoboda, Ilana B. Witten, Anthony M. Zador
An International Laboratory for Systems and Computational Neuroscience
published pages: 1213-1218, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.12.013
Neuron 96/6 2019-08-06
2016 Ingrid van Welie, Arnd Roth, Sara S.N. Ho, Shoji Komai, Michael Häusser
Conditional Spike Transmission Mediated by Electrical Coupling Ensures Millisecond Precision-Correlated Activity among Interneurons In Vivo
published pages: 810-823, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.04.013
Neuron 90/4 2019-06-07
2017 Thomas Lissek, Michelle Adams, John Adelman, Ehud Ahissar, Mohammed Akaaboune, Huda Akil, Mustafa al’Absi, Fazal Arain, Juan Carlos Arango-Lasprilla, Deniz Atasoy, Jesus Avila, Ashraf Badawi, Hilmar Bading, Abdul Mannan Baig, Jimena Baleriola, Carlos Belmonte, Ilaria Bertocchi, Heinrich Betz, Colin Blakemore, Olaf Blanke, Philipp Boehm-Sturm, Tobias Bonhoeffer, Paolo Bonifazi, Nils Brose, Patrizia Campolongo, Tansu Celikel, Cathy C. Chang, Ta-Yuan Chang, Ami Citri, Hollis T. Cline, Jesus M. Cortes, Kathleen Cullen, Kellie Dean, José M. Delgado-Garcia, Mathieu Desroches, John F. Disterhoft, John E. Dowling, Andreas Draguhn, Sherif F. El-Khamisy, Abdeljabbar El Manira, S. Ather Enam, Juan M. Encinas, Asier Erramuzpe, José A. Esteban, Isabel Fariñas, Edmond Fischer, Izumi Fukunaga, Iñigo Gabilondo, Detlev Ganten, Albert Gidon, Juan Carlos Gomez-Esteban, Paul Greengard, Valery Grinevich, Agnés Gruart, Roger Guillemin, Ahmad R. Hariri, Bassem Hassan, Michael Häusser, Yasunori Hayashi, Natasha K. Hussain, Adnan Abdul Jabbar, Mohamed Jaber, Reinhardt Jahn, Essam Mohammed Janahi, Mohamed Kabbaj, Helmut Kettenmann, Merel Kindt, Shira Knafo, Georg Köhr, Shoji Komai, Harm Krugers, Bernd Kuhn, Nouria Lakhdar Ghazal, Matthew E. Larkum, Mickey London, Beat Lutz, Carlos Matute, Luis Martinez-Millan, Mouna Maroun, James McGaugh, Ahmed A. Moustafa, Anwar Nasim, Klaus-Armin Nave, Erwin Neher, Karoly Nikolich, Tiago Outeiro, Lucy M. Palmer, Olga Penagarikano, Isabel Perez-Otano, Donald W. Pfaff, Bruno Poucet, Atta-ur Rahman, Pedro Ramos-Cabrer, Ali Rashidy-Pour, Richard J. Roberts, Serafim Rodrigues, Joshua R. Sanes, Andreas T. Schaefer, Menahem Segal, Idan Segev, Saad Shafqat, Nikhat Ahmed Siddiqui, Hermona Soreq, Eduardo Soriano-García, Rainer Spanagel, Rolf Sprengel, Greg Stuart, Thomas C. Südhof, Jan Tønnesen, Mario Treviño, Basim M. Uthman, J. Craig Venter, Alexei Verkhratsky, Craig Weiss, Torsten N. Wiesel, Emre Yaksi, Ofer Yizhar, Larry J. Young, Paul Young, Nasser H. Zawia, José L. Zugaza, Mazahir T. Hasan
Building Bridges through Science
published pages: 730-735, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.09.028
Neuron 96/4 2019-06-07
2016 Anatoly Buchin, Sarah Rieubland, Michael Häusser, Boris S. Gutkin, Arnd Roth
Inverse Stochastic Resonance in Cerebellar Purkinje Cells
published pages: e1005000, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1005000
PLOS Computational Biology 12/8 2019-08-06

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