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BUNGEE-TOOLS SIGNED

Building Next-Generation Computational Tools for High Resolution Neuroimaging Studies

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BUNGEE-TOOLS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://sites.google.com/site/jeiglesias/bungee-tools
 Total cost 1˙450˙075 €
 EC max contribution 1˙450˙075 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 1˙450˙075.00

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 Project objective

Recent advances in magnetic resonance (MR) acquisition technology are providing us with images of the human brain of increasing detail and resolution. While these images hold promise to greatly increase our understanding of such a complex organ, the neuroimaging community relies on tools (e.g. SPM, FSL, FreeSurfer) which, being over a decade old, were designed to work at much lower resolutions. These tools do not consider brain substructures that are visible in present-day scans, and this inability to capitalize on the vast improvement of MR is hampering progress in the neuroimaging field.

In this ambitious project, which lies at the nexus of medical histology, neuroscience, biomedical imaging, computer vision and statistics, we propose to build a set of next-generation computational tools that will enable neuroimaging studies to take full advantage of the increased resolution of modern MR technology. The core of the tools will be an ultra-high resolution probabilistic atlas of the human brain, built upon multimodal data combining from histology and ex vivo MR. The resulting atlas will be used to analyze in vivo brain MR scans, which will require the development of Bayesian segmentation methods beyond the state of the art.

The developed tools, which will be made freely available to the scientific community, will enable the analysis of MR data at a superior level of structural detail, opening completely new opportunities of research in neuroscience. Therefore, we expect the tools to have a tremendous impact on the quest to understand the human brain (in health and in disease), and ultimately on public health and the economy.

 Publications

year authors and title journal last update
List of publications.
2018 Juan Eugenio Iglesias, Shauna Crampsie, Catherine Strand, Mohamed Tachrount, David L Thomas, Janice L Holton
Effect of Fluorinert on the Histological Properties of Formalin-Fixed Human Brain Tissue
published pages: 1085-1090, ISSN: 0022-3069, DOI: 10.1093/jnen/nly098
Journal of Neuropathology & Experimental Neurology 77/12 2019-05-27
2019 Martina Bocchetta, Juan Eugenio Iglesias, David M. Cash, Jason D. Warren, Jonathan D. Rohrer
Amygdala subnuclei are differentially affected in the different genetic and pathological forms of frontotemporal dementia
published pages: 136-141, ISSN: 2352-8729, DOI: 10.1016/j.dadm.2018.12.006
Alzheimer\'s & Dementia: Diagnosis, Assessment & Disease Monitoring 11 2019-05-27
2018 Ignacio Arganda-Carreras, Tudor Manoliu, Nicolas Mazuras, Florian Schulze, Juan E. Iglesias, Katja Bühler, Arnim Jenett, François Rouyer, Philippe Andrey
A Statistically Representative Atlas for Mapping Neuronal Circuits in the Drosophila Adult Brain
published pages: , ISSN: 1662-5196, DOI: 10.3389/fninf.2018.00013
Frontiers in Neuroinformatics 12 2019-05-27
2018 Sebastiano Ferraris, Johannes van der Merwe, Lennart Van Der Veeken, Ferran Prados, Juan-Eugenio Iglesias, Andrew Melbourne, Marco Lorenzi, Marc Modat, Willy Gsell, Jan Deprest, Tom Vercauteren
A magnetic resonance multi-atlas for the neonatal rabbit brain
published pages: 187-198, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.06.029
NeuroImage 179 2019-05-27
2019 Martina Bocchetta, Juan Eugenio Iglesias, Lucy L. Russell, Caroline V. Greaves, Charles R. Marshall, Marzia A. Scelsi, David M. Cash, Sebastien Ourselin, Jason D. Warren, Jonathan D. Rohrer
Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-019-0489-9
Alzheimer\'s Research & Therapy 11/1 2019-09-17
2019 William Stewart, Kieren Allinson, Safa Al-Sarraj, Corbin Bachmeier, Karen Barlow, Antonio Belli, Mark P Burns, Alan Carson, Fiona Crawford, Kristen Dams-O\'Connor, Ramon Diaz-Arrastia, C Edward Dixon, Brian L Edlow, Scott Ferguson, Bruce Fischl, Rebecca D Folkerth, Steve Gentleman, Christopher C Giza, M Sean Grady, Adel Helmy, Mark Herceg, Janice L Holton, David Howell, Peter J Hutchinson, Diego Iacono, Juan E Iglesias, Milos D Ikonomovic, Victoria E Johnson, C Dirk Keene, Julia K Kofler, Vassilis E Koliatsos, Edward B Lee, Harvey Levin, Jonathan Lifshitz, Helen Ling, David J Loane, Seth Love, Andrew IR Maas, Niklas Marklund, Christina L Master, Damien M McElvenny, David F Meaney, David K Menon, Thomas J Montine, Benoit Mouzon, Elliott J Mufson, Joseph O Ojo, Mayumi Prins, Tamas Revesz, Craig W Ritchie, Colin Smith, Richard Sylvester, Cheuk Y Tang, John Q Trojanowski, Kathryn Urankar, Robert Vink, Cheryl Wellington, Elisabeth A Wilde, Lindsay Wilson, Keith Yeates, Douglas H Smith
Primum non nocere: a call for balance when reporting on CTE
published pages: 231-233, ISSN: 1474-4422, DOI: 10.1016/s1474-4422(19)30020-1
The Lancet Neurology 18/3 2019-05-10
2018 Lyon W. Chen, Delin Sun, Sarah L. Davis, Courtney C. Haswell, Emily L. Dennis, Chelsea A. Swanson, Christopher D. Whelan, Boris Gutman, Neda Jahanshad, Juan Eugenio Iglesias, Paul Thompson, H. Ryan Wagner, Philipp Saemann, Kevin S. LaBar, Rajendra A. Morey
Smaller hippocampal CA1 subfield volume in posttraumatic stress disorder
published pages: 1018-1029, ISSN: 1091-4269, DOI: 10.1002/da.22833
Depression and Anxiety 35/11 2019-05-10
2018 Juan Eugenio Iglesias, Marc Modat, Loïc Peter, Allison Stevens, Roberto Annunziata, Tom Vercauteren, Ed Lein, Bruce Fischl, Sebastien Ourselin
Joint registration and synthesis using a probabilistic model for alignment of MRI and histological sections
published pages: 127-144, ISSN: 1361-8415, DOI: 10.1016/j.media.2018.09.002
Medical Image Analysis 50 2019-05-10
2018 Juan Eugenio Iglesias, Ricardo Insausti, Garikoitz Lerma-Usabiaga, Martina Bocchetta, Koen Van Leemput, Douglas N. Greve, Andre van der Kouwe, Bruce Fischl, César Caballero-Gaudes, Pedro M. Paz-Alonso
A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology
published pages: 314-326, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.08.012
NeuroImage 183 2019-05-10
2018 Martina Bocchetta, Juan Eugenio Iglesias, Marzia A. Scelsi, David M. Cash, M. Jorge Cardoso, Marc Modat, Andre Altmann, Sebastien Ourselin, Jason D. Warren, Jonathan D. Rohrer
Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia
published pages: 497-504, ISSN: 1387-2877, DOI: 10.3233/JAD-180195
Journal of Alzheimer\'s Disease 64/2 2019-05-10
2017 New Fei Ho, Daphne J Holt, Mike Cheung, Juan Eugenio Iglesias, Alex Goh, Mingyuan Wang, Joseph KW Lim, Joshua de Souza, Joann S Poh, Yuen Mei See, Alison R Adcock, Stephen J Wood, Michael WL Chee, Jimmy Lee, Juan Zhou
Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study
published pages: 1361-1370, ISSN: 0893-133X, DOI: 10.1038/npp.2017.5
Neuropsychopharmacology 42/6 2019-06-19
2017 Z.M. Saygin, D. Kliemann, J.E. Iglesias, A.J.W. van der Kouwe, E. Boyd, M. Reuter, A. Stevens, K. Van Leemput, A. McKee, M.P. Frosch, B. Fischl, J.C. Augustinack
High-resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas
published pages: 370-382, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.04.046
NeuroImage 155 2019-06-19
2017 Juan Eugenio Iglesias
Globally Optimal Coupled Surfaces for Semi-automatic Segmentation of Medical Images
published pages: 610-621, ISSN: , DOI: 10.1007/978-3-319-59050-9_48
International Conference on Information Processing in Medical Imaging 2019-06-19
2017 New Fei Ho, Daphne J Holt, Mike Cheung, Juan Eugenio Iglesias, Alex Goh, Mingyuan Wang, Joseph KW Lim, Joshua de Souza, Joann S Poh, Yuen Mei See, Alison R Adcock, Stephen J Wood, Michael WL Chee, Jimmy Lee, Juan Zhou
Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study
published pages: 1361-1370, ISSN: 0893-133X, DOI: 10.1038/npp.2017.5
Neuropsychopharmacology 42/6 2019-05-10
2018 Jonas Pichat, Juan Eugenio Iglesias, Tarek Yousry, Sébastien Ourselin, Marc Modat
A Survey of Methods for 3D Histology Reconstruction
published pages: , ISSN: 1361-8415, DOI: 10.1016/j.media.2018.02.004
Medical Image Analysis 2019-06-19
2017 Iman Aganj, Juan Eugenio Iglesias, Martin Reuter, Mert Rory Sabuncu, Bruce Fischl
Mid-space-independent deformable image registration
published pages: 158-170, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.02.055
NeuroImage 152 2019-06-19
2018 Marcel Tella-Amo, Loic Peter, Dzhoshkun I. Shakir, Jan Deprest, Danail Stoyanov, Juan Eugenio Iglesias, Tom Vercauteren, Sebastien Ourselin
Probabilistic visual and electromagnetic data fusion for robust drift-free sequential mosaicking: application to fetoscopy
published pages: 1, ISSN: 2329-4302, DOI: 10.1117/1.JMI.5.2.021217
Journal of Medical Imaging 5/02 2019-06-19

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The information about "BUNGEE-TOOLS" are provided by the European Opendata Portal: CORDIS opendata.

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