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SensoNMDA SIGNED

Impact of NMDA receptor diversity in sensory information processing

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SensoNMDA project word cloud

Explore the words cloud of the SensoNMDA project. It provides you a very rough idea of what is the project "SensoNMDA" about.

composition    subunit    despite    techniques    neuronal    plan    varies    cortical    dendritic    documented    remarkable    primary    computations    sensory    optogenetic    density    capacities    s1    vivo    photon    combination    highlighted    compute    nmdars    computation    recruitment    heterogeneity    synapses    excitatory    nmda    diversity    decompose    model    interneurons    context    integration    poorly    original    provides    simulations    fundamental    modulators    plasticity    biophysical    relationship    thought    glutamatergic    tools    shapes    variability    strategies    question    possibility    considerably    relevance    influenced    mostly    stimulation    consequence    somatosensory    electrophysiological    synaptic    nmdar    electrophysiology    genetic    receptors    imaging    connections    computational    densities    signal    inhibitory    tuning    neurons    adult    relative    functional    neuron    cortex    demonstrating    array    broad    shaping    single    pharmacological    brain    data    endogenous    reveal    plays    stimuli   

Project "SensoNMDA" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙200˙000 €
 EC max contribution 1˙200˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙200˙000.00

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 Project objective

Synaptic variability between neuronal connections is thought to contribute to brain’s remarkable information processing capacities. In the adult brain, the density as well as subunit composition of synaptic NMDA receptors (NMDARs) varies considerably between synapses and between neurons. Despite the well documented heterogeneity of NMDARs the functional relevance of such diversity is poorly known. In the past, the functional relevance of such NMDAR diversity has been mostly considered in the context of neuronal development and long-term synaptic plasticity. Model simulations have highlighted that dendritic computations are strongly influenced by synaptic NMDARs densities and biophysical properties. Here I propose to directly study the consequence of NMDAR diversity in shaping integration properties of single neurons in primary somatosensory cortex (S1). To achieve this I will decompose this broad question into three specific tasks. 1-Assessment of NMDAR heterogeneity in glutamatergic neurons and study how this variability shapes dendritic integration. 2-Study the impact of NMDARs in signal computation among cortical interneurons. 3-Investigate the functional relationship between endogenous NMDAR modulators and NMDAR diversity. I plan to use an array of genetic, optogenetic and pharmacological tools in combination with imaging and electrophysiological techniques to achieve the proposed objectives. Importantly, in vivo electrophysiology and two-photon imaging will be used to assess the functional relevance of NMDARs heterogeneity in single neuron computational strategies during sensory stimulation. I expect to reveal that NMDAR diversity plays a fundamental role in sensory information processing by tuning the relative recruitment of inhibitory and excitatory neurons during sensory stimuli. This work will provide an original and important data set demonstrating how NMDARs diversity provides cortical neurons with the possibility to compute complex sensory information.

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The information about "SENSONMDA" are provided by the European Opendata Portal: CORDIS opendata.

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